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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
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109 (0.9%)
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12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 239 / 252
Tulmimetostat DB19446
small molecule | CAS: 2567686-02-4

Tulmimetostat is under investigation in clinical trial NCT05467748 (EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer).

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Tulobuterol DB12248
small molecule | CAS: 41570-61-0

Tulobuterol has been used in trials studying the treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-Agonists +17
Target Protein:
Beta-2 adrenergic receptor
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Tulrampator DB16344
small molecule | CAS: 1038984-31-4

Tulrampator is under investigation in clinical trial NCT02626572 (Efficacy and Safety of 3 Doses of S47445 Versus Placebo in Patients With Alzheimer's Disease at Mild to Moderate Stages With Depressive Symptoms).

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TUM012 DB18652
biotech

TUM012 is a synthetic polymer PEG conjugated to a phospholipid anchor (2-dipalmitoyl-sn-glycerol-3-phosphatidylethanolamine)

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Tuna Approved DB10574
biotech

Tuna allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Tunicamycin DB13172
small molecule | CAS: 11089-65-9

Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsNucleic Acids, Nucleotides, and Nucleosides +3
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Tunlametinib DB18791
small molecule | CAS: 1801756-06-8

Deskripsi belum tersedia.

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Tuparstobart DB19118
biotech | CAS: 2649466-03-3

Tuparstobart is under investigation in clinical trial NCT05287113 (Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-line Treatment in Participants With Pd-l1-positive (CPS ? 1) Recurrent/metastatic Squamous Cell Carcinoma of the…

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Turkey Approved DB10575
biotech

Turkey allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Turnip Approved DB10652
biotech

Turnip allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
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Turoctocog alfa Approved DB09109
biotech | CAS: 1192451-26-5

Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chi…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Target Protein:
Coagulation factor IXCoagulation factor XProthrombin
Waktu ParuhIn pre-clinical stu…
Vol. DistribusiIn pre-clinical stu…
KlirensIn pre-clinical stu…
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Turoctocog alfa pegol Approved DB14738
biotech | CAS: 1309086-46-1

Turoctocog alfa pegol is a pegylated version of [turoctocog alfa]. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recom…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Target Protein:
Coagulation factor IXCoagulation factor XProthrombin +1
Waktu ParuhThe mean plasma hal…
Vol. DistribusiThe mean volume of …
KlirensThe mean clearance …
Genetik -
small molecule | CAS: 629664-81-9

Fxr 450 is under investigation in clinical trial NCT00509756 (Study Evaluating Turofexorate isopropyl in Healthy Japanese Men).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Bile acid receptor
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Turpentine Approved DB11120
small molecule | CAS: 9005-90-7

Turpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is …

Kategori:
Biological ProductsComplex MixturesCompounds used in a research, industrial, or household setting +9
Target Protein:
Mitogen-activated protein kinase 1
Waktu ParuhEight male voluntee…
Vol. DistribusiTurpentine, as a li…
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biotech | CAS: 2254086-60-5

Tusamitamab ravtansine is an antibody-drug conjugate that targets carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5).

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobulins +4
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Tuspetinib DB15343
small molecule

Tuspetinib (HM-43239) is under investigation in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).

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Tuvirumab DB17752
biotech | CAS: 138660-97-6

Deskripsi belum tersedia.

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Tuvusertib DB18790
small molecule

Deskripsi belum tersedia.

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TW-37 DB17059
small molecule | CAS: 877877-35-5

TW-37 is a small-molecule inhibitor of Bcl-2 investigated for its anti-cancer properties.[A253157]

Target Protein:
Apoptosis regulator Bcl-2Induced myeloid leukemia cell differentiation protein Mcl-1
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TY027 DB16500
biotech

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
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Tylosin DB11475
small molecule | CAS: 1401-69-0

Tylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. Tylosin is produced as a fermentation product o…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsLactones +1
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Tyloxapol Approved DB06439
small molecule | CAS: 25301-02-4

Tyloxapol is a non-ionic detergent often used as a surfactant.

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingCough and Cold Preparations +8
Target Protein:
Transcription factor RelBNuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit +3
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Tylvalosin DB11554
small molecule | CAS: 63409-12-1

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsLactonesMacrolides
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Typhoid Vaccine Live Approved DB11050
biotech

Salmonella typhi Ty21a live antigen is a live attenuated vaccine for oral administration only. It contains the attenuated strain *Salmonella typhi* Ty21a. The vaccine prevents the development of typhoid fever, an acute, febrile enteric disease caused by *Salm…

Kategori:
Actively Acquired ImmunityInactivated Salmonella Typhi VaccineLive Attenuated Salmonella Typhi Vaccine +2
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Tyramine DB08841
small molecule | CAS: 51-67-2

Tyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An important characteristic of thi…

Kategori:
Adrenergic AgentsAgents producing tachycardiaAgents that produce hypertension +9
Target Protein:
Trace amine-associated receptor 1
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Tyrosine Approved DB00135
small molecule | CAS: 60-18-4

Tyrosine is a non-essential amino acid. In animals it is synthesized from [phenylalanine]. It is also the precursor of [epinephrine], thyroid hormones, and melanin.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Target Protein:
Tyrosine 3-monooxygenaseTyrosine--tRNA ligase, mitochondrialTyrosine--tRNA ligase, cytoplasmic +1
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Tyrosol DB16855
small molecule | CAS: 501-94-0

Deskripsi belum tersedia.

Kategori:
AlcoholsAntiarrhythmic agentsAntioxidants +5
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small molecule

Deskripsi belum tersedia.

Target Protein:
Tyrosine--tRNA ligase
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Tyrothricin Approved DB13503
small molecule | CAS: 1404-88-2

Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis [L4019, L4021, A32851] which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus [A36353]. This complex…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
Phospholipid membraneAcetylcholinesteraseBeta-galactosidase
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small molecule | CAS: 133550-34-2

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBenzylidene CompoundsHeterocyclic Compounds, Fused-Ring +2
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small molecule | CAS: 133550-37-5

Deskripsi belum tersedia.

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Tyrphostin B44 DB16762
small molecule | CAS: 133550-32-0

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBenzylidene CompoundsHeterocyclic Compounds, Fused-Ring +2
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Tyrphostin B48 DB16774
small molecule | CAS: 133550-35-3

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBenzylidene CompoundsHeterocyclic Compounds, Fused-Ring +3
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Tyrphostin B56 DB16775
small molecule | CAS: 149092-35-3

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBenzylidene CompoundsHeterocyclic Compounds, Fused-Ring +3
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Tyvelose DB04028
small molecule | CAS: 5658-12-8

Deskripsi belum tersedia.

Kategori:
CarbohydratesMonosaccharides
Target Protein:
Tail fiber protein
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TZP-102 DB16129
small molecule | CAS: 1008993-65-4

TZP-102 is under investigation in clinical trial NCT01452815 (Affects of Once-daily Oral Administration of TZP-102 on the Treatment of Symptoms Associated With Diabetic Gastroparesis).

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U-0126 DB17060
small molecule | CAS: 218601-62-8

U-0126 is a direct inhibitor of the mitogen-activated protein-kinase kinase family members, MEK-1 and MEK-2.[A253162]

Kategori:
AlkadienesAlkenesEnzyme Inhibitors +2
Target Protein:
Mitogen-activated protein kinase kinase kinase 2Mitogen-activated protein kinase kinase kinase 1
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UB-612 DB16444
biotech

The UB-612 COVID-19 vaccine was developed by United Biomedical Inc Asia in Taipei as the first COVID-19 “multi-tope” protein-peptide vaccine made up of eight rationally designed components[L30653]. The vaccine incorporates a strong S1-RBD component linked to …

Kategori:
Biological ProductsComplex MixturesVaccines +1
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Ubamatamab DB18875
biotech | CAS: 2305629-50-7

Ubamatamab is under investigation in clinical trial NCT03564340 (Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers).

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Ubenimex DB03424
small molecule | CAS: 58970-76-6

Ubenimex (also known as bestatin) is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.

Kategori:
Adjuvants, ImmunologicAmino AcidsAmino Acids, Branched-Chain +9
Target Protein:
Leukotriene A-4 hydrolaseBacterial leucyl aminopeptidase
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Ubiquinone Q1 DB08689
small molecule | CAS: 727-81-1

Deskripsi belum tersedia.

Kategori:
BenzoquinonesCoenzymesEnzymes and Coenzymes +1
Target Protein:
Photosynthetic reaction center cytochrome c subunitReaction center protein H chainReaction center protein L chain +10
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Ublituximab Approved DB11850
biotech | CAS: 1174014-05-1

CD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions.[A244195, A244200, A244205] Monoclonal antibodies for B cell depletion rely on their binding affinity and ability to clear bo…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
B-lymphocyte antigen CD20
Waktu ParuhThe estimated mean …
Vol. DistribusiThe estimated centr…
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Ubrogepant Approved DB15328
small molecule | CAS: 1374248-77-7

Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults.[L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the ac…

Kategori:
AnalgesicsAntimigraine PreparationsBCRP/ABCG2 Substrates +23
Target Protein:
Calcitonin gene-related peptide type 1 receptor
Waktu ParuhUbrogepant has an e…
Vol. DistribusiThe apparent centra…
KlirensThe apparent oral c…
Genetik -
UC-781 DB05871
small molecule | CAS: 178870-32-1

UC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a topical microbicide targeted against the AIDS virus.

Kategori:
AmidesAnti-Infective AgentsAnti-Retroviral Agents +2
Target Protein:
Gag-Pol polyprotein
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UCB7362 DB17096
small molecule

UCB7362 is an orally active plasmepsin X (PMX) inhibitor currently investigated for the treatment of malaria.[A254222] Plasmepsins are aspartyl proteases produced by the malaria parasite _Plasmodium falciparum_, and PMX is considered to be essential for paras…

Target Protein:
Plasmepsin XPlasmepsin X
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UCPVax DB17509
biotech

Deskripsi belum tersedia.

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Udenafil Approved DB06267
small molecule | CAS: 268203-93-6

Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. It is not yet approved for use in the U.S., E.U., or Canada.

Kategori:
AmidesBenzene DerivativesCytochrome P-450 CYP3A Substrates +14
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesterase
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Udifitimod DB19053
small molecule | CAS: 1883345-06-9

Udifitimod is under investigation in clinical trial NCT05014438 (A Study of BMS-986166 or Branebrutinib for the Treatment of Participants With Atopic Dermatitis).

Kategori:
Naphthalenes
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Udonitrectag DB18013
small molecule | CAS: 1458063-04-1

Deskripsi belum tersedia.

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small molecule

Deskripsi belum tersedia.

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