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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Distribusi Wujud Zat

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Hasil Pencarian (16004)

Halaman 239 / 321
small molecule | CAS: 221227-05-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphatidylcholine transfer protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Palomid 529 DB12812
small molecule | CAS: 914913-88-5

Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.

Kategori:
Heterocyclic Compounds, Fused-RingPyrans
Target Protein:
Target of rapamycin complex 2 subunit MAPKAP1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Palonosetron Approved DB00377
small molecule | CAS: 135729-56-5

Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nause…

Kategori:
Alimentary Tract and MetabolismAntidepressive AgentsAntiemetic Serotonin 5-HT3 Receptor Antagonists +22
Target Protein:
5-hydroxytryptamine receptor 3A
Waktu ParuhApproximately 40 ho…
Vol. Distribusi* 8.3 ± 2.5 L/kg
Klirens* 160 +/- 35 mL/h/kg
Genetik -
Palopegteriparatide Approved DB18676
biotech | CAS: 2222514-07-8

Palopegteriparatide is a parathyroid hormone (PTH) analog. Palopegteriparatide is a prodrug consisting of PTH(1-34) conjugated to a methoxy polyethylene glycol carrier (mPEG) via a proprietary TransCon Linker.[L51134] PTH(1-34) contains the N-terminal part of…

Kategori:
Calcium HomeostasisParathyroid Hormones and AnaloguesSystemic Hormonal Preparations, Excl. Sex Hormones and Insulins +1
Target Protein:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Waktu ParuhThe apparent half-l…
Vol. DistribusiThe estimated appar…
KlirensThe estimated clear…
Genetik -
Palovarotene Approved DB05467
small molecule | CAS: 410528-02-8

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder.[A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progr…

Kategori:
BCRP/ABCG2 InhibitorsBenzene DerivativesBenzylidene Compounds +17
Target Protein:
Retinoic acid receptor gamma
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean (SD) appar…
KlirensThe apparent total …
Genetik -
Paltusotine DB16277
small molecule | CAS: 2172870-89-0

Paltusotine is under investigation in clinical trial NCT04261712 (A Study to Evaluate the Long-term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)).

Target Protein:
Somatostatin receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Palucorcel DB17955
biotech

Palucorcel is an investigational stem cell therapy consisting of human umbilical tissue-derived cells. Developed by Janssen Biotech, it is being investigated for the treatment of various conditions such as amyotrophic lateral sclerosis (ALS) and macular degen…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pam2csk4 DB16474
small molecule | CAS: 574741-81-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsDNA-Binding ProteinsExperimental Unapproved Treatments for COVID-19 +5
Target Protein:
Toll-like receptor 6Toll-like receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pamapimod DB19169
small molecule | CAS: 449811-01-2

Pamapimod is under investigation in clinical trial NCT05659459 (The KIN-FAST Trial (KIN001 for Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With Sars-cov-2).

Kategori:
p38 Mitogen-Activated Protein Kinases, antagonists & inhibitorsPyridines
Target Protein:
Mitogen-activated protein kinase 14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pamidronic acid Approved DB00282
small molecule | CAS: 40391-99-9

Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less comm…

Kategori:
Agents Causing Muscle ToxicityAntineoplastic AgentsBisphosphonates +7
Target Protein:
Farnesyl pyrophosphate synthaseHydroxylapatiteGeranylgeranyl pyrophosphate synthase +2
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
KlirensThe mean total clea…
Genetik -
Pamiparib DB14769
small molecule | CAS: 1446261-44-4

Pamiparib is under investigation in clinical trial NCT03933761 (Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsEnzyme Inhibitors +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pamrevlumab DB14952
biotech | CAS: 946415-13-0

Pamrevlumab is under investigation in clinical trial NCT00913393 (Study of FibroGen (FG)-3019 in Subjects With Type 2 Diabetes Mellitus and Kidney Disease on ACEi and/or ARB Therapy).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Panax ginseng fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsGinseng & Ginseng ExtractsPlant Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Panax ginseng root oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsGinseng & Ginseng ExtractsPlant Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Panax ginseng whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsAraliaceaeBiological Products +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Panax notoginseng root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesGinseng & Ginseng Extracts +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Panax quinquefolius whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsGinseng & Ginseng ExtractsPlant Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 59763-91-6

Pancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal AgentsHormones +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pancrelipase Approved DB00085
biotech | CAS: 53608-75-6

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmace…

Kategori:
Alimentary Tract and MetabolismCarboxylic Ester HydrolasesComplex Mixtures +10
Target Protein:
Dietary fatDietary proteinDietary starch
Waktu ParuhPancrelipase acts l…
Vol. DistribusiPancrelipase acts l…
KlirensPancrelipase acts l…
Genetik -
Pancrelipase amylase Approved DB11065
biotech | CAS: 9000-90-2

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The amylases are enzymes that help in the chemical process of digestion…

Kategori:
AmylasesAmylases, antagonists & inhibitorsEnzymes +3
Target Protein:
Dietary starch
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
Pancrelipase lipase Approved DB13147
biotech | CAS: 9001-62-1

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase lipase is an enzyme secreted by the pancreas that is r…

Kategori:
Carboxylic Ester HydrolasesEnzymesEnzymes and Coenzymes +4
Target Protein:
Dietary fat
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
Pancrelipase protease Approved DB11066
biotech | CAS: 9001-94-9

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase protease is a mix of enzymes, formed by trypsin and ch…

Kategori:
EnzymesEnzymes and CoenzymesHydrolases +1
Target Protein:
Dietary protein
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
Pancuronium Approved DB01337
small molecule | CAS: 16974-53-1

A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.

Kategori:
Agents producing tachycardiaAndrostanesAndrostanols +19
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3
Waktu Paruh1.5 to 2.7 hours.
Vol. Distribusi* 241 to 280 mL/kg
Klirens* Plasma cl=1.1–1.9…
Genetik -
Panitumumab Approved DB01269
biotech | CAS: 339177-26-3

Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006.[L17663]

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +16
Target Protein:
Epidermal growth factor receptor
Waktu Paruh7.5 days (range: 4-…
Vol. Distribusi-
Klirens* 4.9+/- 1.4 mL/kg/…
Genetik -
Panobacumab DB15342
biotech | CAS: 885053-97-4

Panobacumab is under investigation in clinical trial NCT00851435 (Safety and Pharmacokinetics of KBPA-101 in Hospital Acquired Pneumonia Caused by O11 Pseudomonas Aeruginosa).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Panobinostat Approved DB06603
small molecule | CAS: 404950-80-7

Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate cl…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +21
Target Protein:
Histone deacetylase 1Histone deacetylase
Waktu Paruh30 hours
Vol. Distribusi-
Klirens-
Genetik -
Pantethine Approved DB11190
small molecule | CAS: 16816-67-4

Pantethine is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine. It consists of two molecules of pantetheine that form a dimer via disufide linkages, and acts as an intermediate in the product…

Kategori:
Alimentary Tract and MetabolismSulfhydryl CompoundsSulfur Compounds +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Panthenol Approved DB11204
small molecule | CAS: 16485-10-2

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the…

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pantoprazole Approved DB00213
small molecule | CAS: 102625-70-7

Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatmen…

Kategori:
2-PyridinylmethylsulfinylbenzimidazolesAcid ReducersAlimentary Tract and Metabolism +27
Target Protein:
Potassium-transporting ATPase alpha chain 1Potassium-transporting ATPase subunit betaN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Waktu ParuhAbout 1 hour[F3202]
Vol. DistribusiThe apparent volume…
Klirens**Adults**: With in…
Genetik -
Pantothenic acid Approved DB01783
small molecule | CAS: 79-83-4

Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient as it is required to synthesize coenzyme-A (CoA), as well a…

Kategori:
AlanineAlimentary Tract and MetabolismAmino Acids +9
Target Protein:
Pantothenate kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphopantothenoylcysteine decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Acetyl-CoA acetyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Acetyl-CoA acetyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Papain Approved DB11193
biotech | CAS: 9001-73-4

Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme that is found in species of papaya, _Carica papaya_ and _Vasconcellea cundinamarcensis_. The enzyme is found to be localized in the skin of papaya, and is collected from sl…

Kategori:
Cysteine EndopeptidasesCysteine ProteasesEndopeptidases +6
Target Protein:
Toll-like receptor 4
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Papaverine Approved DB01113
small molecule | CAS: 58-74-2

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodila…

Kategori:
Alimentary Tract and MetabolismAlkaloidsBenzylisoquinolines +18
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4DcGMP-specific 3',5'-cyclic phosphodiesterase3',5'-cyclic-AMP phosphodiesterase 4B +2
Waktu Paruh0.5-2 hours
Vol. Distribusi-
Klirens-
Genetik -
Paquinimod DB13118
small molecule | CAS: 248282-01-1

Paquinimod is developed for the treatment of SLE (Systemic Lupus Erythematosus), which is an autoimmune disease. The disease affects mainly women of fertile age and progresses in flares with relatively symptom free periods in between. Current treatments of SL…

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Protein S100-A9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 873-75-6

Deskripsi belum tersedia.

Kategori:
AlcoholsBenzene DerivativesBenzyl Compounds
Target Protein:
Alcohol dehydrogenase 1C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Bacterial leucyl aminopeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Estrogen receptor betaGalectin-10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lactase-like protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parachlorophenol Approved DB13154
small molecule | CAS: 106-48-9

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalBenzene Derivatives +4
Target Protein:
Sodium channel protein type 4 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paraldehyde Approved DB09117
small molecule | CAS: 123-63-7

Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypno…

Kategori:
AcetaldehydeAnticonvulsantsCentral Nervous System Agents +4
Waktu ParuhThe mean half life …
Vol. Distribusi-
Klirens-
Genetik -
Paramethadione Approved DB00617
small molecule | CAS: 115-67-3

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.

Kategori:
AnticonvulsantsCentral Nervous System DepressantsCytochrome P-450 CYP2C8 Substrates +7
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1GVoltage-dependent T-type calcium channel subunit alpha-1I
Waktu Paruh12 to 24 hours (how…
Vol. Distribusi-
Klirens-
Genetik -
Paramethasone DB01384
small molecule | CAS: 53-33-8

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +27
Target Protein:
Corticosteroid-binding globulinGlucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paramethasone acetate Approved DB14657
small molecule | CAS: 1597-82-6

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paraoxon DB13495
small molecule | CAS: 311-45-5

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiglaucoma Preparations and MioticsCholinergic Agents +12
Target Protein:
Carbonic anhydrase 1Cannabinoid receptor 1Acetylcholinesterase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parasorbic acid DB14121
small molecule | CAS: 10048-32-5

Sole constituent of "Vogelbeerol" oil obtained by steam distillation of the acidified juice of the ripe berries of the mountain ash.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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