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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Distribusi Wujud Zat

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Hasil Pencarian (16004)

Halaman 236 / 321
OTOF-GT DB18129
biotech

OTOF-GT is a dual vector AAV gene therapy being investigated for the restoration of hearing loss associated with otoferlin deficiency.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
OTX-008 DB13123
small molecule | CAS: 286936-40-1

OTX008 has been used in trials studying the treatment of Solid Tumors.

Target Protein:
Galectin-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
OTX-2002 DB17246
biotech

OTX-2002 is a bicistronic messenger ribonucleic acid (mRNA) encoding for ZF-DNMT and ZF-KRAB proteins, encapsulated in a lipid nanoparticle (LNP).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ouabain Approved DB01092
small molecule | CAS: 630-60-4

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchangin…

Kategori:
CarbohydratesCardanolidesCardenolides +16
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1Sodium/potassium-transporting ATPase subunit alpha-2Sodium/potassium-transporting ATPase subunit alpha-3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ovatodiolide DB19264
small molecule | CAS: 3484-37-5

Ovatodiolide is under investigation in clinical trial NCT04220411 (A Study for AR100DP1 in Mild to Moderate Atopic Dermatitis (AD)).

Kategori:
Terpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ovemotide DB19156
biotech | CAS: 181477-91-8

Ovemotide is under investigation in clinical trial NCT00357461 (Ipilimumab With or Without Vaccine Therapy in Treating Patients With Previously Treated Stage IV Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxabolone DB01500
small molecule | CAS: 4721-69-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1254-35-9

Oxabolone cipionate is the C17? cypionate ester and a prodrug of [DB01500]. A synthetic anabolic-androgenic (AAS) steroid, it is a derivative of 19-nortestosterone (nandrolone). It is considered as a performance enhancing drug thus is prohibited from use in s…

Kategori:
Alimentary Tract and MetabolismAnabolic Agents for Systemic UseAnabolic Steroids +11
Waktu Paruh-
Vol. Distribusi-
KlirensThe elimination on …
Genetik -
Oxaceprol DB13363
small molecule | CAS: 33996-33-7

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxacillin Approved DB00713
small molecule | CAS: 66-79-5

An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein 3Penicillin-binding protein 2aPenicillin-binding protein 1A +7
Waktu Paruh20 to 30 minutes
Vol. Distribusi-
Klirens-
Genetik -
Oxaflozane DB13457
small molecule | CAS: 26629-87-8

Deskripsi belum tersedia.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNervous System +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxalic Acid DB03902
small molecule | CAS: 144-62-7

A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent. […

Kategori:
Acids, AcyclicCompounds used in a research, industrial, or household settingDicarboxylic Acids +6
Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxaliplatin Approved DB00526
small molecule | CAS: 61825-94-3

Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect.[A797] However, this leads to …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +9
Target Protein:
DNA
Waktu ParuhThe decline of ultr…
Vol. DistribusiAfter a single 2-ho…
KlirensPlatinum was cleare…
Genetik -
small molecule | CAS: 328-42-7

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicDicarboxylic AcidsKeto Acids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxametacin DB13308
small molecule | CAS: 27035-30-9

Deskripsi belum tersedia.

Kategori:
Acetic Acid Derivatives and Related SubstancesAntiinflammatory and Antirheumatic ProductsAntiinflammatory and Antirheumatic Products, Non-Steroids +1
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxamic Acid DB03940
small molecule | CAS: 471-47-6

Amino-substituted glyoxylic acid derivative. [PubChem]

Kategori:
Acids, AldehydicAmino AcidsAmino Acids, Peptides, and Proteins +1
Target Protein:
4-aminobutyrate aminotransferase, mitochondrialL-lactate dehydrogenaseL-lactate dehydrogenase +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxamniquine Approved DB01096
small molecule | CAS: 21738-42-1

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesen…

Kategori:
AnthelminticsAnti-Infective AgentsAntihelminthic +15
Target Protein:
DNA
Waktu Paruh1-2.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Oxandrolone Approved DB00621
small molecule | CAS: 53-39-4

A synthetic hormone with anabolic and androgenic properties.

Kategori:
Alimentary Tract and MetabolismAnabolic AgentsAnabolic Agents for Systemic Use +13
Target Protein:
Androgen receptor
Waktu Paruh0.55 hours (1st pha…
Vol. Distribusi-
Klirens-
Genetik -
Oxantel DB13670
small molecule | CAS: 36531-26-7

Deskripsi belum tersedia.

Kategori:
AnthelminticsAnti-Infective AgentsAntinematodal Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxaprotiline DB09307
small molecule | CAS: 56433-44-4

Oxaprotiline is a norepinephrine reuptake inhibitor of the tetracyclic antidepressant family that is related to maprotiline. This drug was never marketed. Oxaprotiline is a racemic mixture of the isomers levoprotiline and dextroprotiline. Levoprotiline is the…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAnthracenes +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxaprozin Approved DB00991
small molecule | CAS: 21256-18-8

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +22
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh54.9 hours
Vol. Distribusi* 11 to 17 L/70 kg
Klirens-
Genetik -
Oxatomide Approved DB12877
small molecule | CAS: 60607-34-3

Oxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.

Kategori:
Anti-Allergic AgentsAnti-Asthmatic AgentsAntihistamines for Systemic Use +8
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxazepam Approved DB00842
small molecule | CAS: 604-75-1

Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on p…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepine hypnotics and sedatives +16
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1824-74-4

Deskripsi belum tersedia.

Kategori:
BenzazepinesBenzodiazepines and benzodiazepine derivativesBenzodiazepinones +2
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxazolam DB15491
small molecule | CAS: 24143-17-7

Deskripsi belum tersedia.

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
OXB-301 DB19269
biotech

OXB-301 is under investigation in clinical trial NCT00397345 (Trovax Renal Immunotherapy Survival Trial).

Kategori:
Amino Acids, Peptides, and ProteinsAntigensBiological Factors +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxcarbazepine Approved DB00776
small molecule | CAS: 28721-07-5

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of i…

Kategori:
Anti-epileptic AgentAnticonvulsantsCarboxamide Derivatives +29
Target Protein:
Sodium channel protein type 11 subunit alphaSodium channel protein
Gen Terkait:
HLA-B
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe apparent volume…
KlirensPlasma clearance of…
Genetik 1 Varian
Oxeladin Approved DB04822
small molecule | CAS: 468-61-1

Withdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.

Kategori:
Acids, CarbocyclicAntitussive AgentsCentral Nervous System Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxelumab DB16663
biotech | CAS: 1186098-83-8

Oxelumab is under investigation in clinical trial NCT00983658 (A Study of HuMAb OX40L in the Prevention of Allergen-induced Airway Obstruction in Adults With Mild Allergic Asthma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxerutins DB15826
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxetacaine Approved DB12532
small molecule | CAS: 126-27-2

Oxetacaine, also called oxethazaince, is a potent surface analgesic with the molecular formula N, N-bis-(N-methyl-N-phenyl-t-butyl-acetamide)-beta-hydroxyethylamine that conserves its unionized form at low pH levels. Its actions have shown to relieve dysphagi…

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnestheticsAnesthetics, Local +5
Target Protein:
Gastrin
Waktu ParuhOxetacaine presents…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Oxetorone DB13463
small molecule | CAS: 26020-55-3

Deskripsi belum tersedia.

Kategori:
AnalgesicsAntimigraine PreparationsHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxfendazole DB11446
small molecule | CAS: 53716-50-0

Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.

Kategori:
AnthelminticsAnti-Infective AgentsAntinematodal Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxfenicine DB04291
small molecule | CAS: 32462-30-9

Oxfenicine in an inhibitor of myocardial metabolism of nonesterified fatty acids (NEFA).

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsCarnitine O-Palmitoyltransferase, antagonists & inhibitors +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
OXI-4503 DB05143
small molecule | CAS: 288847-35-8

OXI-4503 is investigated in clinical trials for treating cancer/tumors. OXI-4503 is a solid. OXI-4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. OXI-4503 (combretastatin A1 di-phosphate / CA1P) is a unique and…

Kategori:
AcidsAcids, NoncarboxylicAnions +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxibendazole DB04910
small molecule | CAS: 20559-55-1

Oxibendazole is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections.

Kategori:
AnthelminticsAnti-Infective AgentsAntiparasitic Agents +1
Target Protein:
Tubulin beta-4B chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxiconazole Approved DB00239
small molecule | CAS: 64211-45-6

Oxiconazole is an antifungal agent that is commonly found in topical formulations. It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +13
Target Protein:
Lanosterol 14-alpha demethylaseLanosterol synthaseNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 9032-53-5

Deskripsi belum tersedia.

Kategori:
BiopolymersBlood and Blood Forming OrgansCarbohydrates +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxidronic acid Approved DB14159
small molecule | CAS: 15468-10-7

Deskripsi belum tersedia.

Kategori:
OrganophosphonatesOrganophosphorus Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxilofrine Approved DB11610
small molecule | CAS: 365-26-4

Oxilofrine is used in combination with [DB11609] as an antitussive. It is currently marketed in Canada by Valeant under the tradename Cophylac.

Kategori:
AlcoholsAminesAmino Alcohols +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxiracetam DB13601
small molecule | CAS: 62613-82-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsNervous System +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxitriptan Approved DB02959
small molecule | CAS: 4350-09-8

5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietar…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +8
Target Protein:
Tryptophan--tRNA ligase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxitropium DB12086
small molecule | CAS: 99571-64-9

Oxitropium has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.

Kategori:
Agents producing tachycardiaAlkaloidsAnticholinergic Agents +9
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxogluric acid DB08845
small molecule | CAS: 328-50-7

Oxogluric acid (?-Ketoglutarate) is not approved for any indication in the world but is an investigational drug in the United States. In the United States a phase I clinical trial is investigating whether oxogluric acid precursors found in nutritional supplem…

Kategori:
Acids, AcyclicDicarboxylic AcidsGlutarates +2
Target Protein:
Aspartate aminotransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxolamine Approved DB13216
small molecule | CAS: 959-14-8

Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant [L5416]. It is listed as a prescription drug in New Zealand legislation [L5419]. Oxolamine is also approved in Taiwan for the treatment of respiratory tr…

Kategori:
Antitussive AgentsCentral Nervous System AgentsCough and Cold Preparations +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxolinic acid DB13627
small molecule | CAS: 14698-29-4

Deskripsi belum tersedia.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxomemazine DB13820
small molecule | CAS: 3689-50-7

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UseHeterocyclic Compounds, Fused-RingPhenothiazine Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 19771-63-2

Procysteine has been used in trials studying the treatment of HIV Infections.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Cyclic +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxprenolol Approved DB01580
small molecule | CAS: 6452-71-7

A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +32
Target Protein:
Beta-1 adrenergic receptorBeta-3 adrenergic receptorBeta-2 adrenergic receptor
Waktu Paruh1-2 hours
Vol. Distribusi-
Klirens-
Genetik -
Oxtriphylline Approved DB01303
small molecule | CAS: 4499-40-5

Oxtriphylline is the choline salt form of [theophylline]. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bron…

Kategori:
AlcoholsAlkaloidsAmines +19
Target Protein:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A3',5'-cyclic-AMP phosphodiesterase 4AAdenosine receptor A2a +2
Waktu ParuhThe serum half life…
Vol. DistribusiTheophylline has an…
KlirensTheophylline has an…
Genetik -
Menampilkan 11751–11800 dari 16004
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