Digital Pharmacy - Dashboard Peneliti

Zoledronic acid Approved DB00399

small molecule | CAS: 118072-93-8

Zoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid].[A203111] Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hy…

Kategori:

BisphosphonatesBone Density Conservation AgentsDrugs Affecting Bone Structure and Mineralization +5

Target Protein:

Geranylgeranyl pyrophosphate synthaseHydroxylapatiteFarnesyl pyrophosphate synthase

Waktu ParuhZoledronic acid has…

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KlirensZoledronic acid has…

Genetik -

Zoliflodacin DB12817

small molecule | CAS: 1620458-09-4

Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea.

Kategori:

Antineoplastic AgentsEnzyme InhibitorsOxazines +5

Target Protein:

DNA gyrase subunit ADNA gyrase subunit B

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Zolimidine DB13593

small molecule | CAS: 1222-57-7

Deskripsi belum tersedia.

Kategori:

Alimentary Tract and MetabolismDrugs for Acid Related DisordersDrugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)

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Zolmitriptan Approved DB00315

small molecule | CAS: 139264-17-8

Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)1B/1D/(1F) receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilic…

Kategori:

Agents that produce hypertensionAminesAnalgesics +24

Target Protein:

5-hydroxytryptamine receptor 1B5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1F +5

Gen Terkait:

GNB3

Waktu ParuhZolmitriptan has a …

Vol. DistribusiZolmitriptan has a …

KlirensZolmitriptan has a …

Genetik 1 Varian

Zolpidem Approved DB00425

small molecule | CAS: 82626-48-0

Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the ti…

Kategori:

Benzodiazepine hypnotics and sedativesCentral Nervous System AgentsCentral Nervous System Depressants +21

Target Protein:

Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-2 +2

Waktu ParuhThe average zolpide…

Vol. Distribusi0.54 to 0.68 L/kg (…

KlirensIn a clinical trial…

Genetik -

Zongertinib DB18762

small molecule | CAS: 2728667-27-2

Deskripsi belum tersedia.

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Zonisamide Approved DB00909

small molecule | CAS: 68291-97-4

Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel…

Kategori:

Agents causing hyperkalemiaAmidesAnti-epileptic Agent +32

Target Protein:

Sodium channel protein type 1 subunit alphaSodium channel protein type 2 subunit alphaSodium channel protein type 3 subunit alpha +29

Waktu ParuhIn plasma, the elim…

Vol. DistribusiFollowing a 400 mg …

KlirensIn patients not tak…

Genetik -

Zopiclone Approved DB01198

small molecule | CAS: 43200-80-2

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.

Kategori:

Aza CompoundsBenzodiazepine hypnotics and sedativesCentral Nervous System Agents +16

Target Protein:

Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +2

Waktu ParuhElimination half li…

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Zopolrestat DB08772

small molecule | CAS: 110703-94-1

Deskripsi belum tersedia.

Kategori:

Aldehyde Reductase, antagonists & inhibitorsAldose Reductase InhibitorsBlood Glucose Lowering Agents +4

Target Protein:

Aldo-keto reductase family 1 member B1Aldo-keto reductase family 1 member B10

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Zoptarelin doxorubicin DB12755

small molecule | CAS: 139570-93-7

Zoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.

Kategori:

Amino Acids, Peptides, and ProteinsAnthracyclinesCarbohydrates +12

Target Protein:

Gonadotropin-releasing hormone receptor

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Zosuquidar DB06191

small molecule | CAS: 167354-41-8

Zosuquidar is a compound of antineoplastic drug candidates currently under development. It is now in "Phase 3" of clinical tests in the United States. Its action mechanism consists of the inhibition of P-glycoproteins; other drugs with this mechanism include …

Kategori:

BenzocycloheptenesDrug Resistance, MultipleHeterocyclic Compounds, Fused-Ring +1

Target Protein:

ATP-dependent translocase ABCB1Phosphatidylcholine translocator ABCB4

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Zotarolimus DB18761

small molecule | CAS: 221877-54-9

Zotarolimus is an immunosuppressant under investigation for use in drug-eluting stents.

Kategori:

Anti-Bacterial AgentsLactonesMacrolides

Target Protein:

Serine/threonine-protein kinase mTOR

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Zotatifin DB16408

small molecule | CAS: 2098191-53-6

Zotatifin is under investigation in clinical trial NCT04092673 (Study of Eft226 in Subjects With Selected Advanced Solid Tumor Malignancies).

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Zotepine Approved DB09225

small molecule | CAS: 26615-21-4

Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd.[A31855] It has been used as an antipsychotic in Japan, India and some places in Europe…

Kategori:

Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical]) +21

Target Protein:

D(1) dopamine receptorD(2) dopamine receptor5-hydroxytryptamine receptor 2A +4

Waktu ParuhThe half-life of zo…

Vol. DistribusiThe apparent volume…

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Genetik -

Zotiraciclib DB16656

small molecule | CAS: 1204918-72-8

Zotiraciclib is under investigation in clinical trial NCT02942264 (Zotiraciclib (TG02) Plus Dose-dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent…

Kategori:

Cyclin-Dependent Kinases, antagonists & inhibitorsHeterocyclic Compounds, Fused-Ring

Target Protein:

Cyclin-dependent kinase 2Cyclin-dependent kinase 9Tyrosine-protein kinase Fyn +1

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Zoxazolamine DB19372

small molecule | CAS: 61-80-3

Deskripsi belum tersedia.

Kategori:

Antigout PreparationsAntirheumatic AgentsBenzoxazoles and derivatives +8

Target Protein:

Small conductance calcium-activated potassium channel protein 2

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ZSTK-474 DB12904

small molecule | CAS: 475110-96-4

ZSTK474 has been used in trials studying the treatment of Neoplasms.

Target Protein:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

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Zucapsaicin Approved DB09120

small molecule | CAS: 25775-90-0

Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid o…

Kategori:

AlkaloidsAlkenesAlkynes +25

Target Protein:

Transient receptor potential cation channel subfamily V member 1

Waktu ParuhIn rats, the elimin…

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Zuclopenthixol Approved DB01624

small molecule | CAS: 53772-83-1

Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine rece…

Kategori:

Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +34

Target Protein:

D(1A) dopamine receptorD(1B) dopamine receptorD(2) dopamine receptor +4

Waktu Paruh20 hours (range 12-…

Vol. Distribusi20 L/kg.

Klirensapproximately 0.9 L…

Genetik -

Zunsemetinib DB16502

small molecule | CAS: 1640282-42-3

ATI-450 was under investigation in clinical trials (NCT05279417 and NCT05216224) for treating patients with rheumatoid arthritis and hidradenitis suppurativa, respectively. Additionally, ATI-450 was studied in a terminated trial (NCT05511519) to treat patient…

Kategori:

Experimental Unapproved Treatments for COVID-19

Target Protein:

MAP kinase-activated protein kinase 2

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Zuranolone Approved DB15490

small molecule | CAS: 1632051-40-1

Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors. Unlike other more common GABAA positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synap…

Kategori:

Antidepressive AgentsCentral Nervous System AgentsCentral Nervous System Depressants +9

Target Protein:

Gamma-aminobutyric acid receptor subunit gamma-3GABA(A) Receptor

Waktu ParuhThe terminal half-l…

Vol. DistribusiThe volume of distr…

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Genetik -

ZYCOV-D DB15892

biotech

The ZYCOV-D vaccine candidate was developed by Cadila Healthcare Ltd. based in India[A219758]. The vaccine was developed using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of interest[L16503]. Once the plasmid D…

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Zytron Approved DB11768

small molecule | CAS: 299-85-4

Zytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic). DMPA has been investigated for the prevention, treatment, and basic science o…

Kategori:

AminesOrganophosphorus CompoundsSulfur Compounds

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[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester DB04107

small molecule

Deskripsi belum tersedia.

Target Protein:

Serine protease 1

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[(1R)-1-acetamido-2-(4-chlorophenyl)ethyl]-[(2S)-2-amino-3-hydroxy-3-oxo-propoxy]-dihydroxy-boron DB03607

small molecule

Deskripsi belum tersedia.

Target Protein:

Subtilisin Carlsberg

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[(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID DB07680

small molecule

Deskripsi belum tersedia.

Target Protein:

Chymase

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[(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium DB03710

small molecule

Deskripsi belum tersedia.

Target Protein:

Nitric oxide synthase 1

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[(1S)-4-[[Amino-[(2R)-2-amino-2-carboxyethyl]sulfanylmethylidene]amino]-1-carboxybutyl]azanium DB04671

small molecule

Deskripsi belum tersedia.

Target Protein:

Arginine deiminase

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[(2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLYLACETYL)AMINO]METHYLBORONIC ACID DB07599

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-lactamase TEM

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[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-pyrrolidinyl]methyl dihydrogen phosphate DB02075

small molecule

Deskripsi belum tersedia.

Target Protein:

Hypoxanthine-guanine-xanthine phosphoribosyltransferase

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[(2R,3S,4R,5R)-5-(4-acetonyl-3-carbamoyl-pyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphate DB02732

small molecule

Deskripsi belum tersedia.

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[(2S)-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-yl]acetic acid DB08717

small molecule

Deskripsi belum tersedia.

Target Protein:

Carboxylesterase

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[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID DB07771

small molecule

Deskripsi belum tersedia.

Target Protein:

GTPase KRasProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaProtein farnesyltransferase subunit beta

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[(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid DB07719

small molecule

Deskripsi belum tersedia.

Target Protein:

Tyrosine-protein phosphatase non-receptor type 1

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[(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL DB07906

small molecule

Deskripsi belum tersedia.

Target Protein:

Phenylethanolamine N-methyltransferase

Waktu Paruh-

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[(3R,4S,5S,7R)-4,8-DIHYDROXY-3,5,7-TRIMETHYL-2-OXOOCTYL]PHOSPHONIC ACID DB08759

small molecule

Deskripsi belum tersedia.

Target Protein:

Type I polyketide synthase PikAIV

Waktu Paruh-

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[(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid DB06887

small molecule

Deskripsi belum tersedia.

Target Protein:

Tyrosine-protein phosphatase non-receptor type 1

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[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl hydrogen hex-5-enylphosphonate DB08475

small molecule

Deskripsi belum tersedia.

Target Protein:

Lipase EstA

Waktu Paruh-

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[1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester DB01871

small molecule

Deskripsi belum tersedia.

Target Protein:

Cathepsin FCruzipain

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[1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER DB07956

small molecule

Deskripsi belum tersedia.

Target Protein:

Chymotrypsin-like elastase family member 1

Waktu Paruh-

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[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid DB07546

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha'

Waktu Paruh-

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[1-HYDROXY-2-(1,1':3',1''-TERPHENYL-3-YLOXY)ETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID) DB07426

small molecule

Deskripsi belum tersedia.

Target Protein:

Farnesyl pyrophosphate synthaseDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

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[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA DB07247

small molecule

Deskripsi belum tersedia.

Target Protein:

Coagulation factor VIITissue factor

Waktu Paruh-

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[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala DB02597

small molecule

Deskripsi belum tersedia.

Target Protein:

NeprilysinPoly [ADP-ribose] polymerase 1Thermolysin +1

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[2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine DB04172

small molecule

Deskripsi belum tersedia.

Target Protein:

Urokinase-type plasminogen activator

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[2-(1-Amino-2-Hydroxy-Propyl)-4-(4-Fluoro-1h-Indol-3-Ylmethyl)-5-Hydroxy-Imidazol-1-Yl]-Acetic Acid DB01674

small molecule

Deskripsi belum tersedia.

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[2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID DB07410

small molecule

Deskripsi belum tersedia.

Target Protein:

Farnesyl pyrophosphate synthaseGeranylgeranyl pyrophosphate synthaseDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

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[2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester DB07987

small molecule

Deskripsi belum tersedia.

Target Protein:

Stromelysin-1

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[2-Aminomethyl-5-Oxo-4-(4-Oxo-Cyclohexa-2,5-Dienylmethyl)-4,5-Dihydro-Imidazol-1-Yl] -Acetaldehyde DB02275

small molecule

Deskripsi belum tersedia.

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[3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium DB01736

small molecule

Deskripsi belum tersedia.

Target Protein:

ADP/ATP translocase 1

Waktu Paruh-

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