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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 235 / 282
Rose bengal Approved DB11182
small molecule

Rose bengal is a pink stain derived as an analogue of fluorescein. Its disodium salt in ophthalmic solutions has been used as a diagnostic agent in suspected damage to conjunctival and corneal cells. It is also used in laboratory settings, including the prepa…

Kategori:
Coloring AgentsColouring AgentsCompounds used in a research, industrial, or household setting +12
Waktu ParuhDoses between 0.01 …
Vol. DistribusiNo information avai…
KlirensNo information avai…
Genetik -
small molecule | CAS: 4159-77-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosemary DB14272
biotech

Rosemary is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosemary oil Approved DB14689
biotech | CAS: 8000-25-7

Deskripsi belum tersedia.

Kategori:
Biological ProductsLipidsOils +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosiglitazone Approved DB00412
small molecule | CAS: 122320-73-4

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like ot…

Kategori:
Alimentary Tract and MetabolismBlood Glucose Lowering AgentsBSEP/ABCB11 Substrates +33
Target Protein:
Peroxisome proliferator-activated receptor gammaLong-chain-fatty-acid--CoA ligase 4Peroxisome proliferator-activated receptor alpha +4
Waktu Paruh3-4 hours (single o…
Vol. Distribusi* 17.6 L [oral volu…
Klirens* Oral clearance (C…
Genetik -
Rosin Approved DB11165
biotech | CAS: 8050-09-7

Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin is used in various commercial and industrial applications, including…

Kategori:
Biological ProductsBiopolymersCell-mediated Immunity +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosmarinic acid DB16865
small molecule | CAS: 20283-92-5

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAldehyde Reductase, antagonists & inhibitorsAnalgesics +22
Target Protein:
TyrosinaseInduced myeloid leukemia cell differentiation protein Mcl-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosnilimab DB18851
biotech | CAS: 2412764-40-8

Rosnilimab is under investigation in clinical trial NCT06041269 (A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Rheumatoid Arthritis (RENOIR)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosoxacin Approved DB00817
small molecule | CAS: 40034-42-2

Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose …

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-betaDNA gyrase subunit B +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rostafuroxin DB12350
small molecule | CAS: 156722-18-8

Rostafuroxin has been used in trials studying the treatment of Essential Hypertension.

Kategori:
AndrostanesFused-Ring CompoundsSteroids
Target Protein:
Sodium/potassium-transporting ATPase subunit beta-1Sodium/potassium-transporting ATPase subunit beta-2Sodium/potassium-transporting ATPase subunit beta-3 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rostaporfin DB06659
small molecule | CAS: 284041-10-7

Deskripsi belum tersedia.

Kategori:
Biological FactorsDermatologicalsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosuvastatin Approved DB01098
small molecule | CAS: 287714-41-4

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous prod…

Kategori:
Agents Causing Muscle ToxicityAlimentary Tract and MetabolismAmides +32
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-L
Gen Terkait:
KIF6 HMGCR ABCG2
Waktu ParuhThe elimination hal…
Vol. DistribusiRosuvastatin underg…
Klirens-
Genetik 3 Varian
Rotavirus vaccine Approved DB10276
biotech

Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration.[L1117] Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live …

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseBiological Products +6
Waktu ParuhThe median duration…
Vol. Distribusi-
Klirens-
Genetik -
Rotenone DB11457
small molecule | CAS: 83-79-4

Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.

Kategori:
AgrochemicalsBenzopyransChromones +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rotigaptide DB13067
small molecule | CAS: 355151-12-1

Rotigaptide is under investigation for the basic science of Heart Disease and Vascular Disease.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rotigotine Approved DB05271
small molecule | CAS: 99755-59-6

Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and const…

Kategori:
Agents that produce hypertensionAnti-Parkinson Agents (Dopamine Agonist)Anti-Parkinson Drugs +23
Target Protein:
D(3) dopamine receptorD(4) dopamine receptorD(2) dopamine receptor +4
Waktu ParuhAfter removal of th…
Vol. DistribusiThe weight normaliz…
Klirens-
Genetik -
small molecule | CAS: 912809-27-9

Rovafovir etalafenamide is under investigation in clinical trial NCT03472326 (Efficacy of GS-9131 Functional Monotherapy in HIV-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen).

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rovanersen DB16982
biotech | CAS: 2072901-32-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Rovatirelin DB15338
small molecule | CAS: 204386-76-5

Rovatirelin is under investigation in clinical trial NCT01384435 (A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)).

Kategori:
Oxazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rovazolac DB16320
small molecule | CAS: 1454288-88-0

Rovazolac is under investigation in clinical trial NCT03175354 (A Study in Subjects With Moderate Atopic Dermatitis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2163074-26-6

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Roxadustat Approved DB04847
small molecule | CAS: 808118-40-3

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that st…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntianemic Preparations +10
Target Protein:
Egl nine homolog 1Prolyl hydroxylase EGLN2Prolyl hydroxylase EGLN3
Waktu ParuhThe mean effective …
Vol. DistribusiThe blood-to-plasma…
KlirensThe apparent total …
Genetik -
Roxarsone DB11458
small molecule | CAS: 121-19-7

Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use i…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 78628-28-1

Roxatidine acetate is a specific and competitive H2 receptor antagonist. It is currently approved in South Africa under the tradename Roxit.

Kategori:
Acid ReducersAlimentary Tract and MetabolismAnti-Ulcer Agents +8
Target Protein:
Histamine H2 receptor
Waktu Paruh5-6 hours
Vol. Distribusi-
Klirens-
Genetik -
Roxithromycin Approved DB00778
small molecule | CAS: 80214-83-1

Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin]. It was shown to be more effective against certain Gram-negative bacteria, particularly _Legionel…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +19
Target Protein:
50S ribosomal protein L10ATP-dependent translocase ABCB1
Waktu Paruh12 hours
Vol. Distribusi-
Klirens-
Genetik -
Royal jelly DB14250
biotech | CAS: 8031-67-2

Royal jelly is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
BeesLipids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rozanolixizumab Approved DB14919
biotech | CAS: 1584645-37-3

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange.…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
IgG receptor FcRn large subunit p51
Waktu Paruh-
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Rozibafusp Alfa DB19233
biotech | CAS: 2143449-47-0

Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)).

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rozrolimupab DB05209
biotech | CAS: 909402-77-3

Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Target Protein:
Rhesus blood group D antigen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RP-67580 DB16742
small molecule | CAS: 135911-02-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingNeurokinin-1 Receptor AntagonistsNeurotransmitter Agents
Target Protein:
Substance-P receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RP-72 DB17156
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RP-A501 DB17647
biotech

RP-A501 is a gene therapy product consisting of a recombinant adeno-associated virus serotype 9 (rAAV9) capsid containing the human LAMP2B transgene (AAV9:LAMP2B), which encodes lysosome-associated membrane protein 2 (LAMP-2). It is being investigated for Dan…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RP-L201 DB17595
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RPI-MN DB17957
biotech

RPI-MN is a detoxified or chemically modified alpha-cobratoxin with antiviral properties.[A260132] Being developed by Nutra Pharma under the trade name PEPTERON, it is being investigated for the treatment of neurological and immune disorders.[L47107]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RPR128515 DB04424
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RPR131247 DB02744
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
rPSGL-Ig DB06256
biotech

Recombinant P-selectin glycoprotein ligand IgG fusion protein (rPSGL-Ig) is a fusion protein of human P-selectin ligand and IgG1-Fc.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RR001 DB17369
biotech

RR001 is an investigational gene therapy consisting of autologous human adipose perivascular stromal cells genetically modified to secrete soluble tumour necrosis factor-related apoptosis-inducing ligand (AD-PC sTRAIL).[L44276]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RRx-001 DB12060
small molecule | CAS: 925206-65-1

RRx-001 has been used in trials studying the treatment of Lymphomas, Brain Metastases, Cholangiocarcinoma, Colorectal Neoplasms, and Malignant Solid Tumor, among others.

Kategori:
AzetinesCarbon Radioisotopes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RS-39604 DB17050
small molecule | CAS: 161362-65-8

RS-39604 is a selective 5-HT4 receptor antagonist.[A253112]

Kategori:
AlkanesHydrocarbons, Acyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
rsPSMA Vaccine Approved DB06361
biotech

Prostate-specific membrane antigen (PSMA) is an ?100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPS…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
RST-001 DB17843
biotech

RST-001 is a non-replicating recombinant adeno-associated virus vector containing a fragment of the gene encoding channel rhodopsin-2 protein.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RSV-604 DB15197
small molecule | CAS: 676128-63-5

RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.).

Kategori:
AmidesBenzazepinesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RTA 744 DB05920
small molecule

RTA 744 is a novel anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of primary and metastatic brain cancers. Anthracyclines are one of the most broadly used and effective classes of cancer therapi…

Target Protein:
DNA topoisomerase 2-alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RU78262 DB01947
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RU78299 DB03828
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RU78783 DB02908
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RU79072 DB02762
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RU79073 DB03525
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RU79256 DB01866
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 11701–11750 dari 14063
Sebelumnya Halaman 235 / 282 Berikutnya