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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
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13591 (100.0%)

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Halaman 234 / 272
Siagoside DB12351
small molecule | CAS: 100345-64-0

Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. It is a naturally occurring substance in the nerve cell’s membrane that is thought to play a role in cell growth, development, and repair. Siagoside completed phase 2 trial…

Kategori:
Acidic GlycosphingolipidsCarbohydratesGangliosides +7
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sibeprenlimab DB18919
biotech | CAS: 2382896-07-1

Sibeprenlimab is under investigation in clinical trial NCT05248659 (Phase 2/3 Open-label Trial of Sibeprenlimab in the Treatment of Immunoglobulin a Nephropathy).

Waktu Paruh-
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Sibofimloc DB16400
small molecule | CAS: 1616113-45-1

Sibofimloc is under investigation in clinical trial NCT03943446 (TAK-018 for Prevention of the Recurrence of Postoperative Crohn's Disease (CD)).

Waktu Paruh-
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Sifalimumab DB12773
biotech | CAS: 1006877-41-3

Sifalimumab is a fully human monoclonal antibody targeting interferon-alpha. The levels of interferon-alpha are elevated in many patients with active systemic lupus erythematosus (SLE, or lupus) and other autoimmune disorders, and may be associated with disea…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Interferon alpha-2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SIG-007 DB17710
biotech

SIG-007 is a gene therapy that consists of cells that are genetically modified with a non-viral vector to express human alpha-galactosidase A. Developed by Sigilon Therapeutics, t is being investigated for the treatment of Fabry Disease.[L46153]

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siG12D LODER DB16329
biotech

siG12D LODER is under investigation in clinical trial NCT01676259 (A Phase 2 Study of Sig12d LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer).

Waktu Paruh-
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Silanol Approved DB11343
small molecule | CAS: 70131-67-8

Silanol is an FDA-approved food contact substance that is commonly used in organosilicon chemistry and silicate mineralogy.

Kategori:
Silicon Compounds
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Silatecan DB12384
small molecule | CAS: 220913-32-6

Silatecan has been used in trials studying the treatment of GBM, Tumors, Gliosarcoma, Solid Malignancies, and Glioblastoma Multiforme, among others.

Kategori:
Alkaloids
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sildenafil Approved DB00203
small molecule | CAS: 139755-83-2

In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The …

Kategori:
Agents Causing Muscle ToxicityAmidesCardiovascular Agents +33
Target Protein:
Plasma protease C1 inhibitorcGMP-specific 3',5'-cyclic phosphodiesteraseRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma +3
Gen Terkait:
ACE GNB3
Waktu ParuhThe terminal phase …
Vol. DistribusiThe mean steady-sta…
KlirensThe total body clea…
Genetik 2 Varian
Silicic acid DB14138
small molecule | CAS: 1343-98-2

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicSilicon Compounds
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Silicon Approved DB12982
small molecule | CAS: 7440-21-3

Silicon is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides).

Kategori:
Diet, Food, and NutritionElementsFood +5
Waktu Paruh-
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Genetik -
Silicon dioxide Approved DB11132
small molecule | CAS: 7631-86-9

Silicon dioxide, or silica, is an oxide of silicon with the chemical formula SiO2. It is found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite as transparent and tasteless crystals. Inhalation of fine crystals is tox…

Kategori:
ColloidsComplex MixturesCompounds used in a research, industrial, or household setting +6
Target Protein:
Macrophage receptor MARCO
Waktu Paruh-
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Genetik -
Silk sericin DB15531
biotech | CAS: 1190590-38-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsArthropod ProteinsBiopolymers +4
Waktu Paruh-
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Genetik -
Silmitasertib DB15408
small molecule | CAS: 1009820-21-6

Silmitasertib is under investigation in clinical trial NCT03904862 (Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery).

Kategori:
Casein Kinase II, antagonists & inhibitorsHeterocyclic Compounds, Fused-Ring
Target Protein:
Casein kinase II subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Silodosin Approved DB06207
small molecule | CAS: 160970-54-7

Silodosin is a selective antagonist of alpha(?)-1 adrenergic receptors that binds to the ?<sub>1A</sub> subtype with the highest affinity. ?1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the ?<sub>1A</…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +15
Target Protein:
Alpha-1A adrenergic receptorAlpha-1D adrenergic receptorAlpha-1B adrenergic receptor +1
Waktu ParuhThe elimination hal…
Vol. DistribusiSilodosin has an ap…
KlirensAfter intravenous a…
Genetik -
Siltuximab Approved DB09036
biotech | CAS: 541502-14-1

Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by formi…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +20
Target Protein:
Interleukin-6
Waktu ParuhThe mean terminal h…
Vol. DistribusiBased on population…
KlirensBody weight was ide…
Genetik -
Silver Approved DB12965
small molecule | CAS: 7440-22-4

Silver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and minera…

Kategori:
Antiseptics and DisinfectantsDermatologicalsElements +4
Target Protein:
MetallothioneinCeruloplasminAlbumin +1
Waktu ParuhThe biological half…
Vol. DistribusiFollowing exposure …
Klirens-
Genetik -
Silver citrate DB11233
small molecule | CAS: 126-45-4

Deskripsi belum tersedia.

Waktu Paruh-
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Silver nitrate Approved DB11080
small molecule | CAS: 7761-88-8

Silver nitrate is an inorganic compound with the chemical formula AgNO3. In its solid form, silver nitrate is coordinated in a trigonal planar arrangement. It is often used as a precursor to other silver-containing compounds. It is used in making photographic…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiseptics and Disinfectants +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Silver oxide DB15668
small molecule | CAS: 20667-12-3

Deskripsi belum tersedia.

Kategori:
AnionsAnti-Infective AgentsElectrolytes +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 9015-51-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAnti-Infective Agents, Local +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Simendan DB12286
small molecule | CAS: 131741-08-7

Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).

Kategori:
Antiarrhythmic agentsCardiotonic AgentsCardiovascular Agents +11
Waktu Paruh-
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Genetik -
small molecule | CAS: 910562-13-9

Simenepag isopropyl has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.

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Simeprevir Approved DB06290
small molecule | CAS: 923604-59-5

Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, w…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +37
Target Protein:
Genome polyproteinNS3 proteaseGenome polyprotein
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of si…
Genetik -
Simethicone Approved DB09512
small molecule | CAS: 8050-81-5

Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.[A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in u…

Kategori:
Antifoaming AgentsCompounds used in a research, industrial, or household settingDermatologicals +9
Waktu ParuhSimethicone is not …
Vol. DistribusiSimethicone is not …
KlirensSimethicone is not …
Genetik -
Simfibrate DB13433
small molecule | CAS: 14929-11-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +10
Waktu Paruh-
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Genetik -
biotech | CAS: 1776942-10-9

RO6874281 is under investigation in clinical trial NCT03193190 (A Study of Multiple Immunotherapy-based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-pancreatic Cancer)).

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Simoctocog alfa Approved DB09108
biotech | CAS: 1219013-68-9

Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent use…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlycoconjugates +1
Target Protein:
von Willebrand factor
Waktu ParuhAt initial assessme…
Vol. DistribusiIt is observed that…
KlirensAt initial assessme…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
Simotaxel DB15384
small molecule | CAS: 791635-59-1

Simotaxel is under investigation in clinical trial NCT00088647 (Study Evaluating MST-997 in Advanced Malignant Solid Tumors).

Kategori:
CyclodecanesCycloparaffinsDiterpenes +1
Waktu Paruh-
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Genetik -
Simpinicline DB17065
small molecule | CAS: 753015-44-0

Deskripsi belum tersedia.

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Simtuzumab DB12152
biotech | CAS: 1318075-13-6

Simtuzumab has been used in trials studying the treatment and basic science of Myelofibrosis, Pancreatic Cancer, Colorectal Cancer, and Idiopathic Pulmonary Fibrosis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Simufilam DB18817
small molecule | CAS: 1224591-33-6

Deskripsi belum tersedia.

Target Protein:
Filamin-A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Simurosertib DB16330
small molecule | CAS: 1330782-76-7

Simurosertib is under investigation in clinical trial NCT03261947 (A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors).

Kategori:
Pyrazoles
Target Protein:
Cell division cycle 7-related protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Simvastatin Approved DB00641
small molecule | CAS: 79902-63-9

Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular dis…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBSEP/ABCB11 Substrates +37
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-LHistone deacetylase 2
Gen Terkait:
KIF6 HMGCR SLCO1B1
Waktu Paruh4.85 hours[A181571]
Vol. DistribusiRat studies indicat…
Klirens-
Genetik 3 Varian
Sinapic acid DB08587
small molecule | CAS: 7362-37-0

Sinapic acid is a matrix for matrix-assisted laser desorption technique for protein MW determination. It is also a constituent of propolis.

Kategori:
Acids, CarbocyclicCinnamatesCompounds used in a research, industrial, or household setting +2
Target Protein:
Endo-1,4-beta-xylanase Y
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Catechol O-methyltransferase domain-containing protein 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sinapultide Approved DB11332
small molecule | CAS: 138531-07-4

Sinapultide (also known as KL4 peptide) is a synthetic protein used to mimic human lung surfactant protein B.[L2502] This protein has a weight of 2469.40.[L2502] Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the se…

Kategori:
Amino Acids, Peptides, and ProteinsPulmonary Surfactants
Target Protein:
Lung epithelial cells
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sinbaglustat DB17619
small molecule | CAS: 441061-33-2

Deskripsi belum tersedia.

Kategori:
CarbohydratesImines
Waktu Paruh-
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Genetik -
Sincalide Approved DB09142
biotech | CAS: 25126-32-3

Sincalide is a medication given by injection to assist in the diagnosis of gallbladder and pancreas disorders. It is identified as the 8-amino acid C-terminal segment of cholecystokinin and is also known as _CCK-8_. Naturally occurring cholecystokinin is a ga…

Kategori:
Amino Acids, Peptides, and ProteinsCholecystokinin AnalogDiagnostic Agents +7
Target Protein:
Cholecystokinin receptor type AGastrin/cholecystokinin type B receptor
Waktu ParuhLimited information…
Vol. DistribusiLimited information…
Klirens-
Genetik -
Sinecatechins Approved DB01266
small molecule | CAS: 188265-33-0

Sinecatechins is a botanical drug product for topical use. It is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. Catechins constitute 85 to 95% (by we…

Kategori:
Antiviral AgentsBenzopyransChromans +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sinefungin DB01910
small molecule | CAS: 58944-73-3

Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include RdmB, modification methylase TaqI, rRNA (adenine-N6-)-m…

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiparasitic Agents +7
Target Protein:
Modification methylase RsrIAclacinomycin 10-hydroxylase RdmBrRNA adenine N-6-methyltransferase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sinomenine DB16892
small molecule | CAS: 115-53-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntirheumatic AgentsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sintilimab DB15765
biotech | CAS: 2072873-06-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Programmed cell death protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siplizumab DB06371
biotech | CAS: 288392-69-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
T-cell surface antigen CD2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sipoglitazar DB19312
small molecule | CAS: 342026-92-0

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +4
Target Protein:
Peroxisome proliferator-activated receptor gammaPeroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siponimod Approved DB12371
small molecule | CAS: 1230487-00-9

Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 [L5792] and by Health Canada on February 20, 2020.[L12171] This drug is considered a _sphingo…

Kategori:
Agents that produce hypertensionAntineoplastic and Immunomodulating AgentsAzetines +18
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 5
Waktu ParuhThe apparent elimin…
Vol. DistribusiSiponimod distribut…
KlirensApparent systemic c…
Genetik -
Sipuleucel-T Approved DB06688
biotech | CAS: 917381-47-6

Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expres…

Kategori:
Adjuvants, ImmunologicAntineoplastic and Immunomodulating AgentsAutologous Cellular Immunotherapy +6
Target Protein:
Prostatic acid phosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siramesine DB06555
small molecule | CAS: 147817-50-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Alpha-1A adrenergic receptorAlpha-1D adrenergic receptorAlpha-1B adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siremadlin DB16331
small molecule | CAS: 1448867-41-1

Deskripsi belum tersedia.

Target Protein:
E3 ubiquitin-protein ligase Mdm2Cellular tumor antigen p53
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 11651–11700 dari 13591
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