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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 233 / 272
Sepantronium DB17062
small molecule | CAS: 753440-91-4

Sepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and causes broad-range apoptosis.[A253167]

Kategori:
NaphthalenesQuinones
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sepetaprost DB12043
small molecule | CAS: 1262873-06-2

Sepetaprost has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).

Kategori:
EthersEthers, Cyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sepiapterin DB16326
small molecule | CAS: 17094-01-8

Sepiapterin is under investigation in clinical trial NCT03519711 (A Study of CNSA-001 in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia).

Kategori:
Biological FactorsHeterocyclic Compounds, Fused-RingPigments, Biological +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sepofarsen DB16327
biotech | CAS: 2227173-68-2

Sepofarsen is under investigation in clinical trial NCT03913143 (A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)).

Kategori:
OphthalmologicalsSensory Organs
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seproxetine DB06731
small molecule | CAS: 126924-38-7

Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the d…

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsCytochrome P-450 CYP2C19 Inhibitors +14
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterSodium-dependent dopamine transporter
Waktu Paruh4-16 days
Vol. Distribusi-
Klirens-
Genetik -
Sequifenadine DB13566
small molecule | CAS: 57734-69-7

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic Use
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SER-100 DB16013
small molecule | CAS: 383123-18-0

SER-100 is under investigation in clinical trial NCT01987284 (SER100 in Isolated Systolic Hypertension).

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Nociceptin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serabelisib DB14935
small molecule | CAS: 1268454-23-4

Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117) in Healthy Participants).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingOxazines
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seractide acetate Approved DB09334
biotech | CAS: 39295-97-1

Seractide acetate is the acetate salt of full length human corticotropin.

Target Protein:
Adrenocorticotropic hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seralutinib DB18072
small molecule | CAS: 1619931-27-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seratrodast DB06739
small molecule | CAS: 112665-43-7

Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Asthmatic Agents +27
Target Protein:
Thromboxane A2 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serdexmethylphenidate Approved DB16629
small molecule | CAS: 1996626-29-9

Attention Deficit Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and is characterized by developmentally inappropriate and impaired attention, impulsivity, and motor hyperactivity.[A230698, A23070…

Kategori:
Agents that produce hypertensionCentral Nervous System AgentsCentral Nervous System Stimulants +12
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporter5-hydroxytryptamine receptor 1A
Waktu ParuhFollowing a single …
Vol. DistribusiSerdexmethylphenida…
KlirensSerdexmethylphenida…
Genetik -
Seribantumab DB11857
biotech | CAS: 1334296-12-6

Seribantumab has been used in trials studying the treatment of NSCLC, Heregulin, Adenocarcinoma, Colorectal Cancer, and Solid Tumor Cancers, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serine DB00133
small molecule | CAS: 56-45-1

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +3
Target Protein:
Cystathionine beta-synthaseL-serine dehydratase/L-threonine deaminaseSerine racemase +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serine vanadate DB04031
small molecule

Deskripsi belum tersedia.

Kategori:
Vanadates
Target Protein:
Alkaline phosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Threonine--tRNA ligase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serlopitant DB12973
small molecule | CAS: 860642-69-9

Serlopitant has been investigated for the treatment of Prurigo Nodularis.

Kategori:
Heterocyclic Compounds, Fused-RingNeurokinin-1 Receptor AntagonistsNeurotransmitter Agents
Target Protein:
Substance-P receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serotonin DB08839
small molecule | CAS: 50-67-9

For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.

Kategori:
AminesAntidepressive AgentsAutacoids +19
Target Protein:
5-hydroxytryptamine receptor 1B5-hydroxytryptamine receptor 75-hydroxytryptamine receptor 2B +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SerpinPC DB17698
biotech

SerpinPC is a mutated alpha-1-antitrypsin (?1AT) and serine protease inhibitor being investigated for the treatment of hemophilia.[A258993]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serplulimab DB17451
biotech | CAS: 2231029-82-4

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsMonoclonal antibodies and antibody drug conjugates +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Serrapeptase DB13131
biotech | CAS: 95077-02-4

Serrapeptase is a proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections. Serratiopeptidase is under investigation in clinical trial NCT02493179 (Efficacy Evaluation of the (Serodase 5 mg Tablet) in the Treatment of …

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sertaconazole Approved DB01153
small molecule | CAS: 99592-32-2

Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available in topical formulations for the treatment of skin infections such as athlete's foot.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +8
Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sertindole Approved DB06144
small molecule | CAS: 106516-24-9

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 …

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical]) +22
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2C +5
Waktu Paruh3 days
Vol. Distribusi-
Klirens-
Genetik -
Sertraline Approved DB01104
small molecule | CAS: 79617-96-2

Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSR…

Kategori:
Agents that reduce seizure thresholdAminesAntidepressive Agents +39
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent dopamine transporterSigma receptor +2
Gen Terkait:
CYP2C19 CYP2C19
Waktu ParuhThe elimination hal…
Vol. DistribusiSertraline is widel…
KlirensIn pharmacokinetic …
Genetik 2 Varian
Serum, horse Approved DB14613
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2379806-98-9

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setanaxib DB16869
small molecule | CAS: 1218942-37-0

Deskripsi belum tersedia.

Kategori:
PyrazolesPyridines
Target Protein:
NADPH oxidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setipiprant DB12562
small molecule | CAS: 866460-33-5

Setipiprant has been investigated for the treatment of Seasonal Allergic Rhinitis, asthma and scalp hair loss (Androgenetic Alopecia).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Prostaglandin D2 receptorProstaglandin D2 receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setiptiline DB09304
small molecule | CAS: 57262-94-9

Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). In Japan, the company Mochida started its commercialization for the treatment of depression started in 1989.

Kategori:
Antidepressive Agents, TetracyclicDibenzazepinesHeterocyclic Compounds, Fused-Ring
Target Protein:
Alpha-2 adrenergic receptorsSerotonin Receptors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setmelanotide Approved DB11700
small molecule | CAS: 920014-72-8

Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies.[L24474] It is an agonist of the melanocortin 4 receptor.[A224449] Earlier attempts at agonizing MC4R (such as LY2…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Obesity Agents +19
Target Protein:
Melanocortin receptor 4
Waktu ParuhThe elimination had…
Vol. DistribusiThe apparent volume…
KlirensA 3mg subcutaneous …
Genetik -
Setogepram DB15447
small molecule | CAS: 1002101-19-0

Setogepram is under investigation in clinical trial NCT03184584 (Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
G-protein coupled receptor 84Free fatty acid receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setrobuvir DB12051
small molecule | CAS: 1071517-39-9

Setrobuvir has been used in trials studying the treatment of Hepatitis C, Chronic.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolinesSulfonamides +2
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setrusumab DB14778
biotech | CAS: 1847394-95-9

Setrusumab is under investigation in clinical trial NCT01406548 (Safety and Efficacy of Multiple Dosing Regimens of BPS804 in Post Menopausal Women With Low Bone Mineral Density).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sevasemten DB18983
small molecule | CAS: 2417395-15-2

Sevasemten is under investigation in clinical trial NCT05291091 (Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seviprotimut-L DB16328
biotech

Seviprotimut-L is under investigation in clinical trial NCT01546571 (Study of a Melanoma Vaccine in Stage Iib, Iic, and III Melanoma Patients).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sevirumab DB17771
biotech | CAS: 138660-96-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seviteronel DB12275
small molecule | CAS: 1610537-15-9

Seviteronel has been used in trials studying the treatment of CRPC, Prostate Cancer, and Castration-resistant Prostate Cancer.

Kategori:
Antineoplastic AgentsCytochrome P-450 Enzyme InhibitorsEnzyme Inhibitors
Target Protein:
Steroid 17-alpha-hydroxylase/17,20 lyase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sevoflurane Approved DB01236
small molecule | CAS: 28523-86-6

Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia.[L42340] It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient.[L42340] Sevoflurane was patented in 1972, w…

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +17
Target Protein:
GABA(A) ReceptorGlycine receptor subunit alpha-1Glutamate receptor 1 +3
Waktu ParuhThe terminal elimin…
Vol. DistribusiPatients given low-…
KlirensIn patients given l…
Genetik -
Sevuparin DB15007
small molecule

Sevuparin is under investigation in clinical trial NCT03853421 (Placebo-controlled Study to Determine the Safety and Tolerability of Subcutaneous Doses of Sevuparin).

Kategori:
CarbohydratesGlycosaminoglycansPolysaccharides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SF1126 DB05210
small molecule

SF1126 is an integrin-targeted PI3 kinase inhibitor.

Kategori:
Amino Acids, Peptides, and ProteinsBenzopyransHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Phosphatidylinositol 3-kinase regulatory subunit alphaPhosphatidylinositol 3-kinase regulatory subunit betaPhosphatidylinositol 3-kinase regulatory subunit gamma +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SGI-1776 DB12494
small molecule | CAS: 1025065-69-3

SGI-1776 has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SGN-1 DB18135
biotech

SGN-1 is a genetically modified strain of _Salmonella enterica_ comprising methioninase.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SGN-30 DB05471
biotech

SGN-30 is an engineered monoclonal antibody (mAb) that reacts with significant affinity to the CD30 antigen, which is highly expressed on a variety of hematologic malignancies as compared to on normal cells. SGN-30 has been shown to induce direct anti-cancer…

Target Protein:
Nuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SGN-B6A DB18377
biotech | CAS: 2764774-91-4

Sigvotatug vedotin (SGN-B6A) is a humanized immunoglobulin G1 anti-integrin beta-6 monoclonal antibody conjugated to monomethyl auristatin E.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SGS-742 DB05010
small molecule | CAS: 123690-78-8

SGS-742 has been used in trials studying the treatment of Seizures and Metabolic Disease.

Kategori:
Central Nervous System AgentsCompounds used in a research, industrial, or household settingGABA Agents +4
Target Protein:
Gamma-aminobutyric acid type B receptor subunit 1Gamma-aminobutyric acid type B receptor subunit 2
Waktu Paruh4 hours
Vol. Distribusi-
Klirens-
Genetik -
SGX-523 DB06314
small molecule | CAS: 1022150-57-7

A MET receptor tyrosine kinase inhibitor.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Shark liver oil DB11088
biotech | CAS: 68990-63-6

Shark oil is extracted from the livers of sharks, which can account for up to 25% of their total body weight. The 3 main targeted species are the deep sea shark (Centrophorus squamosus), the dogfish (Sqaulus acanthias), and the basking shark (Cetorhinus maxim…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Shea butter DB14311
biotech | CAS: 194043-92-0

Shea butter is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicCyclohexanecarboxylic AcidsCyclohexanes +3
Target Protein:
3-phosphoshikimate 1-carboxyvinyltransferase3-phosphoshikimate 1-carboxyvinyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 11601–11650 dari 13591
Sebelumnya Halaman 233 / 272 Berikutnya