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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 231 / 252
Theophylline Approved DB00277
small molecule | CAS: 58-55-9

A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histo…

Kategori:
Agents that reduce seizure thresholdAlkaloidsAnti-Asthmatic Agents +32
Target Protein:
Adenosine receptor A15'-nucleotidaseAdenosine receptor A2a +12
Gen Terkait:
CYP1A2
Waktu Paruh8 hours
Vol. Distribusi* 0.3 to 0.7 L/kg
Klirens* 0.29 mL/kg/min [P…
Genetik 1 Varian
Theralizumab DB15717
biotech | CAS: 906068-56-2

Theralizumab is a humanized anti-CD28 monoclonal antibody designed for treating autoimmune diseases and cancer. After the first human trial, it was withdrawn due to severe toxicity (likely due to lymphopenia and human cytokine release).[A216527,A216532]

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiamine Approved DB00152
small molecule | CAS: 70-16-6

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when research…

Kategori:
Alimentary Tract and MetabolismDiet, Food, and NutritionFood +10
Target Protein:
Thiamine pyrophosphokinase 1Pyruvate dehydrogenase E1 component
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 67-16-3

Deskripsi belum tersedia.

Kategori:
PyrimidinesSulfur CompoundsThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiamphenicol DB08621
small molecule | CAS: 15318-45-3

Deskripsi belum tersedia.

Kategori:
AlcoholsAmphenicolsAnti-Bacterial Agents +8
Target Protein:
Dr hemagglutinin structural subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiamylal Approved DB01154
small molecule | CAS: 77-27-0

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)

Kategori:
AnestheticsAnesthetics, GeneralAnesthetics, Intravenous +22
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3ATP-sensitive inward rectifier potassium channel 8ATP-sensitive inward rectifier potassium channel 11 +1
Waktu ParuhAlthough no studies…
Vol. Distribusi-
Klirens-
Genetik -
Thienylfentanyl DB09180
small molecule | CAS: 1165-22-6

Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the Federal Analog Act scheduled drugs based on structural similarity rather than scheduling drugs individually. Thienylfentanyl has a similar synthesis pathwa…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiethylperazine Approved DB00372
small molecule | CAS: 1420-55-9

A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sicknes…

Kategori:
AntiemeticsAntihistamines for Systemic UseAntipsychotic Agents +16
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thimerosal Approved DB11590
small molecule | CAS: 54-64-8

Thiomersal (INN), commonly known in the U.S. as thimerosal, is an organomercury compound. This compound is a well-established and widely used antiseptic and antifungal agent. Developed in 1927, thimerosal has been and is still being used as a preservative…

Kategori:
Alkylmercury CompoundsAntiseptics and DisinfectantsCell-mediated Immunity +11
Target Protein:
Methionine synthaseCystine/glutamate transporterSodium/potassium-transporting ATPase subunit gamma
Waktu ParuhA study was done to…
Vol. Distribusi266 L in one study …
KlirensThe high concentrat…
Genetik -
Thiocamphor DB02851
small molecule | CAS: 7519-74-6

Deskripsi belum tersedia.

Kategori:
Bicyclic MonoterpenesBornanesBridged-Ring Compounds +4
Target Protein:
Camphor 5-monooxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiocitrulline DB03953
small molecule | CAS: 156719-37-8

Deskripsi belum tersedia.

Kategori:
AmidesAmino AcidsAmino Acids, Diamino +4
Target Protein:
Nitric oxide synthase, inducible
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 602-41-5

Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of _Superba gloriosa_. It is a muscle relaxant with anti-inflammatory and analgesic effects. It has potent convul…

Kategori:
AlkaloidsCentral Nervous System DepressantsMuscle Relaxants +2
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Glycine receptor subunit alpha-2 +6
Waktu ParuhApproximately 7.7h …
Vol. DistribusiThe apparent volume…
KlirensPrimarily extrarena…
Genetik -
Thioctamide DB15963
small molecule | CAS: 940-69-2

Deskripsi belum tersedia.

Kategori:
CoenzymesEnzymes and CoenzymesFatty Acids +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 137314-40-0

A salt of alpha-lipoic acid and tromethamine; may be useful in treating vascular stress in patients with diabetes.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 51555-87-4

Thiodigalactoside is a solid. This compound belongs to the dihexoses. These are disaccharides containing two hexose carbohydrates. This medication is known to target galectin-1, heat-labile enterotoxin b chain, neurocan core protein, and lactose permease.

Kategori:
CarbohydratesGalactosidesGlycosides +2
Target Protein:
Heat-labile enterotoxin B chainLactose permeaseNeurocan core protein +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68-11-1

Thioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light).

Kategori:
AcetatesAcids, AcyclicSulfhydryl Compounds +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiohexam Approved DB14200
small molecule | CAS: 95-33-0

Thiohexam is a rubber cure accelerator. It is also a known allergen and dermatological sensitizer. Sensitivity to Thiohexam may be identified with a clinical patch test.

Kategori:
Cell-mediated ImmunityHeterocyclic Compounds, Fused-RingIncreased Histamine Release +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiopental Approved DB00599
small molecule | CAS: 76-75-5

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical p…

Kategori:
AnestheticsAnesthetics, GeneralAnesthetics, Intravenous +27
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +9
Waktu Paruh3-8 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiopropazate DB13557
small molecule | CAS: 84-06-0

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thioredoxin Approved DB11298
small molecule | CAS: 52500-60-4

Thioredoxin is a small dithiol protein and specific reductant for major allergenic proteins present in foods from animal and plant products. It is a 12-kD oxidoreductase enzyme encoded by TXN and TXN2 genes that contains a dithiol-disulfide active site. It pl…

Kategori:
Amino Acids, Peptides, and ProteinsProteinsThioredoxins +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thioridazine Approved DB00679
small molecule | CAS: 50-52-2

A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +37
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorAlpha-1A adrenergic receptor +3
Waktu Paruh21-25 hours
Vol. Distribusi-
Klirens-
Genetik -
Thiosulfuric acid Approved DB09499
small molecule | CAS: 13686-28-7

Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preserv…

Kategori:
AcidsAnti-Infective AgentsAntidotes +14
Waktu ParuhThe half-life of th…
Vol. DistribusiThiosulfate has a m…
KlirensIn patients with fu…
Genetik -
Thiotepa Approved DB04572
small molecule | CAS: 52-24-4

N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, o…

Kategori:
Alkylating ActivityAlkylating DrugsAntineoplastic Agents +23
Target Protein:
DNA
Waktu Paruh1.5 to 4.1 hours
Vol. Distribusi-
Klirens* 446 +/- 63 mL/min…
Genetik -
Thiram Approved DB13245
small molecule | CAS: 137-26-8

Thiram may be used in dermatology as a scabicide [T436]. Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada [L5425].

Kategori:
Acids, AcyclicAgrochemicalsAntiparasitic Products, Insecticides and Repellents +16
Target Protein:
Tyrosine-protein kinase JAK2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
THK-5351 DB19222
small molecule | CAS: 1707147-26-9

Deskripsi belum tersedia.

Kategori:
AminesFluorine RadioisotopesHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
THK-5351 F-18 DB19223
small molecule | CAS: 1707148-68-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thonzonium Approved DB09552
small molecule | CAS: 25466-36-8

Thonzonium is a monocationic surface-active agent with surfactant and detergent properties. It is widely used as an additive to in ear and nasal drops to enhance dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of th…

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +2
Target Protein:
V-type proton ATPase subunit C 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thonzylamine Approved DB11235
small molecule | CAS: 91-85-0

Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with [DB04837] or [DB00388] for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.

Kategori:
Agents producing tachycardiaAntiallergic Agents, Excl. CorticosteroidsAnticholinergic Agents +11
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6061-13-8

Deskripsi belum tersedia.

Target Protein:
Methylaspartate ammonia-lyase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Threonine Approved DB00156
small molecule | CAS: 72-19-5

An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.

Kategori:
Amino AcidsAmino Acids, EssentialAmino Acids, Neutral +5
Target Protein:
Threonine--tRNA ligase 1, cytoplasmicThreonine--tRNA ligase, mitochondrialBeta-lactamase Toho-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thrombin alfa Approved DB11572
biotech | CAS: 869858-13-9

Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa pre…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +12
Target Protein:
Coagulation factor VCoagulation factor VIIIFibrinogen alpha chain +2
Waktu ParuhFollowing intraveno…
Vol. DistribusiTraditional absorpt…
KlirensTraditional absorpt…
Genetik -
Thrombomodulin Alfa Approved DB05777
biotech | CAS: 120313-91-9

Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as di…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlycoconjugates +7
Target Protein:
ProthrombinCoagulation factor V
Waktu Paruh2–3 days after sc i…
Vol. Distribusi-
Klirens7-10 days
Genetik -
Thrombopoietin DB06534
biotech | CAS: 9014-42-0

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCarbohydrates +9
Target Protein:
Thrombopoietin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymalfasin DB04900
biotech | CAS: 62304-98-7

Thymalfasin is a chemically synthesized version of thymosin alpha 1 that is identical to human thymosin alpha 1. Thymosin alpha 1 is an acetylated polypeptide. Thymosin alpha 1 is now approved in 35 developing countries for the treatment of Hepatitis B and C.…

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntineoplastic Agents +7
Waktu ParuhApproximately 2 hou…
Vol. Distribusi-
Klirens-
Genetik -
Thymectacin DB05116
small molecule | CAS: 232925-18-7

Thymectacin, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule anticancer agent. Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS), a critical enzyme in DNA …

Kategori:
DeoxyribonucleosidesDeoxyuridineNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Thymidylate synthaseThymidylate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymidine DB04485
small molecule | CAS: 50-89-5

Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase.

Kategori:
DeoxyribonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Target Protein:
Thymidylate kinaseUridine phosphorylaseThymidine kinase +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 365-08-2

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +2
Target Protein:
DNA polymerase catalytic subunitGag-Pol polyproteinThymidine kinase, cytosolic +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 365-07-1

5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Thymidylate synthaseThymidine kinase, cytosolicThymidylate kinase +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
DNA topoisomerase 1Thermonuclease
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Nucleoside diphosphate kinase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Nuclease P1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
dTDP-glucose 4,6-dehydrataseDTDP-4-dehydrorhamnose 3,5-epimerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
DNA polymerase I
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymine DB03462
small molecule | CAS: 65-71-4

Deskripsi belum tersedia.

Kategori:
PyrimidinesPyrimidinones
Target Protein:
Thymidine phosphorylaseDeoxyribodipyrimidine photo-lyaseThymidine phosphorylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymol Approved DB02513
small molecule | CAS: 89-83-8

A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntifungal Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymopentin DB11996
small molecule | CAS: 69558-55-0

Thymopentin has been used in trials studying the treatment and prevention of HIV Infections and Hepatocellular Carcinoma.

Kategori:
Adjuvants, ImmunologicAntineoplastic and Immunomodulating AgentsHormones +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymoquinone DB16447
small molecule | CAS: 490-91-5

Thymoquinone is a natural compound with widespread protective effects, including anti-oxidative, anti-inflammatory, immunomodulatory, anti-cancer, and anti-microbial.

Kategori:
Experimental Unapproved Treatments for COVID-19Quinones
Target Protein:
Cellular tumor antigen p53Apoptosis regulator Bcl-2Apoptosis regulator BAX
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thyroglobulin Approved DB01584
biotech | CAS: 9010-34-8

Thyroglobulin (also known as Tg) is an enzyme thyroid hormone used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The active form of thyroxine, triiodothyronine, is produced both within the thyroid gland and per…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlobulins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 11501–11550 dari 12560
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