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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 230 / 252
small molecule | CAS: 1336-20-5

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial Agents
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Genetik -
small molecule | CAS: 300-52-7

Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins [L2031]. Sodium tetradecyl…

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Endothelial protein C receptor
Waktu Paruh-
Vol. DistribusiIn humans, a large …
Klirens-
Genetik -
small molecule

Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease.[A25965] Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2…

Kategori:
Anemia, Iron-DeficiencyDrugs for Treatment of Hyperkalemia and HyperphosphatemiaIron Compounds +2
Target Protein:
Transferrin receptor protein 1Iron(3+)-hydroxamate-binding protein FhuD
Waktu Paruh-
Vol. Distribusi-
KlirensData regarding the …
Genetik -
small molecule | CAS: 14874-70-5

Tetrafluoroborate is under investigation in clinical trial NCT02907073 (Positron Emission Tomography (PET) Imaging Studies With NIS Reporter).

Kategori:
AnionsBoric AcidsBoron Compounds +2
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small molecule | CAS: 53008-15-4

Deskripsi belum tersedia.

Kategori:
Blood and Blood Forming OrgansHemostaticsLocal Hemostatics
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Tetraglyme DB14000
small molecule | CAS: 143-24-8

Deskripsi belum tersedia.

Kategori:
AlcoholsGlycols
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small molecule | CAS: 31262-37-0

Tetrahydrocannabivarin (THCV) is a propyl analogue of tetrahydrocannabinol (?9-THC), one of the primary pharmacological components of [Medical Cannabis]. ?9-THC is currently available in several synthetic forms, including [Dronabinol], while purified or isola…

Kategori:
Agents that produce hypertensionAntidepressive AgentsCentral Nervous System Depressants +3
Target Protein:
Transient receptor potential cation channel subfamily V member 3Cannabinoid receptor 1G-protein coupled receptor 55 +5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cytidine deaminase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 135-16-0

Tetrahydrofolic acid is a folic acid derivative that is produced from dihydrofolic acid after conversion by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a soluble coenzyme in many react…

Kategori:
CoenzymesDietary SupplementsEnzymes and Coenzymes +7
Target Protein:
C-1-tetrahydrofolate synthase, cytoplasmicBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialAminomethyltransferase, mitochondrial +9
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 618903-56-3

Deskripsi belum tersedia.

Kategori:
Anabolic AgentsAndrogensFused-Ring Compounds +6
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18771-50-1

Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.

Kategori:
AntimetabolitesNoxaeNucleic Acids, Nucleotides, and Nucleosides +5
Target Protein:
Cytidine deaminase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 67-30-1

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Waktu Paruh-
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Tetramethrin DB13752
small molecule | CAS: 7696-12-0

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsCompounds used in a research, industrial, or household setting +9
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small molecule | CAS: 51-92-3

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsAutonomic Agents +4
Target Protein:
UDP-glucose 4-epimerase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 97-74-5

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicCarbamatesCell-mediated Immunity +5
Waktu Paruh-
Vol. Distribusi-
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Tetramisole DB16561
small molecule | CAS: 5036-02-2

Deskripsi belum tersedia.

Kategori:
ImidazolesSulfur CompoundsThiazoles
Waktu Paruh-
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Tetrandrine DB14066
small molecule | CAS: 518-34-3

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAlkaloidsAnti-Infective Agents +21
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
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small molecule | CAS: 16330-92-0

Tetrathiomolybdate is an oral, small-molecule, anticopper agent that is highly specific for lowering the levels of free copper in serum. COPREXA has completed pivotal clinical trials for the treatment of neurologic Wilson's disease. It is also developed for f…

Kategori:
Adenosine Triphosphatases, antagonists & inhibitorsAngiogenesis Modulating AgentsAntineoplastic Agents +10
Target Protein:
Amyloid-beta precursor protein
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Myoglobin
Waktu Paruh-
Vol. Distribusi-
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Tetrodotoxin DB05232
small molecule | CAS: 4368-28-9

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction. Tetrodotoxin is being investigat…

Kategori:
AnestheticsAnesthetics, LocalBiological Factors +15
Target Protein:
Sodium channel protein type 5 subunit alphaSodium channel protein type 1 subunit alphaSodium channel protein type 2 subunit alpha +2
Waktu Paruh-
Vol. Distribusi-
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Tetrofosmin Approved DB11180
small molecule | CAS: 127502-06-1

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofos…

Kategori:
Radioactive Diagnostic Agent
Waktu ParuhRefer to [DB09160]
Vol. DistribusiThis pharmacokineti…
KlirensRefer to [DB09160]
Genetik -
Tetroxoprim DB15976
small molecule | CAS: 53808-87-0

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +1
Waktu Paruh-
Vol. Distribusi-
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Tetryzoline Approved DB06764
small molecule | CAS: 84-22-0

Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (?)-adrenergic properties.[A231769] Available since the 1950s, tetryzoline is a selective ?<sub>1</sub>-receptor agonist [A231774] that is used as a…

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-Agonists +20
Target Protein:
Alpha-1 adrenergic receptorsAlpha-2C adrenergic receptorAlpha-2 adrenergic receptors
Waktu ParuhFollowing ocular ad…
Vol. DistribusiNo information is a…
KlirensNo information is a…
Genetik -
Teverelix DB05624
small molecule | CAS: 151272-78-5

A synthetic decapeptide, water-soluble Gonadotropin-releasing hormone antagonist. It has reached phase II clinical trials.

Kategori:
Amino Acids, Peptides, and ProteinsHormone AntagonistsHormones, Hormone Substitutes, and Hormone Antagonists +1
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu Paruh-
Vol. Distribusi-
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Tezacaftor Approved DB11712
small molecule | CAS: 1152311-62-0

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class.[L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to manage cystic fibrosis.[L6814] This drug was approv…

Kategori:
BCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesCytochrome P-450 CYP1A2 Inhibitors +33
Target Protein:
Cystic fibrosis transmembrane conductance regulator
Waktu ParuhThe apparent half-l…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Tezacitabine DB06433
small molecule | CAS: 171176-43-5

A synthetic purine nucleoside analogue with potential antineoplastic activity.

Kategori:
Antineoplastic AgentsDeoxyribonucleosidesEnzyme Inhibitors +6
Target Protein:
Ribonucleoside-diphosphate reductase subunit M2Ribonucleoside-diphosphate reductase large subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tezampanel DB06354
small molecule | CAS: 154652-83-2

Tezampanel is an AMPA receptor antagonist.

Kategori:
Heterocyclic Compounds, Fused-RingReceptors, AMPA, antagonists & inhibitors
Target Protein:
Glutamate receptor ionotropic, kainate 1Gamma-aminobutyric acid type B receptor subunit 1
Waktu Paruh-
Vol. Distribusi-
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Tezepelumab Approved DB15090
biotech | CAS: 1572943-04-4

Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate ple…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Target Protein:
Thymic stromal lymphopoietin
Waktu ParuhTezepelumab has an …
Vol. DistribusiTezepelumab has a c…
KlirensTezepelumab has an …
Genetik -
Tezosentan DB06558
small molecule | CAS: 180384-57-0

Tezosentan is an intravenous endothelin receptor A/B antagonist. Tezosentan was initially developed for vasodilation in patients with acute heart failure but studies have shown that it does not assist in the treatment of dyspnea or prevent cardiovascular even…

Kategori:
Cardiovascular AgentsReceptors, EndothelinVasodilating Agents
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhA pronounced and ra…
Vol. Distribusi-
Klirens-
Genetik -
TG-100801 DB05075
small molecule | CAS: 867331-82-6

TG100801 is a topically applied kinase inhibitor in macular degeneration patients. It is administered noninvasively as an eye drop and is designed to suppress VEGF mediated leakage and additional kinase targets associated with inflammation, edema, and angioge…

Kategori:
Benzene Derivatives
Target Protein:
Vascular endothelial growth factor CVascular endothelial growth factor DVascular endothelial growth factor A, long form +5
Waktu Paruh-
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TG-1042 DB18435
biotech

TG-1042 (formerly known as ASN-002) is a recombinant adenovirus carrying the cDNA coding sequence for the human interferon gamma gene.

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TG01 vaccine DB17123
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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TG100-115 DB05552
small molecule | CAS: 677297-51-7

An NSAID that inhibits PI-3K gamma and delta.

Kategori:
Benzene DerivativesHeterocyclic Compounds, Fused-RingPhosphatidylinositol 3-Kinases, antagonists & inhibitors
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
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TG4010 DB06584
biotech | CAS: 350485-85-7

A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. Originally developed for the eradication of smallpox, M…

Kategori:
Amino Acids, Peptides, and ProteinsBiological ProductsCarbohydrates +6
Target Protein:
Mucin-1Interleukin-2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
TGAAC94 DB06175
small molecule

tgAAC94 is a recombinant adeno-associated virus serotype 2 (AAV2) vector containing the cDNA for a human tumor necrosis factor receptor (TNFR)-immunoglobulin (IgG1) Fc fusion (TNFR:Fc) gene. It was under investigation in clinical trials to treat Inflammatory …

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tgAAG-76 DB18421
biotech

tgAAG-76 consists of a recombinant adeno-associated virus (serotype 2) (rAAV2) gene transfer agent expressing RPE65.

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tgAAVCF DB17849
biotech

tgAAVCF is an adeno-associated virus (AAV) vector encoding the human cystic fibrosis transmembrane conductance regulator protein (CFTR) cDNA. It is being investigated for the treatment of cystic fibrosis.[A259821, A259826]

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small molecule | CAS: 1373958-68-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingXanthenes
Waktu Paruh-
Vol. Distribusi-
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Genetik -
TH0318 DB05145
biotech

TH0318 is a stabilized analogue of human GLP-1 (glucagon-like peptide-1) under investigation for the treatment of type 2 diabetes.

Waktu Paruh-
Vol. Distribusi-
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Thalagen DB17714
biotech

Thalagen is a branded product developed by San Rocco Therapeutics. It consists of autologous CD34-positive hematopoietic progenitor cells transduced with TNS9.3.55, a lentiviral vector encoding the normal human beta-globin gene. It is being investigated for t…

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Thalidomide Approved DB01041
small molecule | CAS: 50-35-1

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immun…

Kategori:
Angiogenesis InhibitorsAngiogenesis Modulating AgentsAntineoplastic Agents +38
Target Protein:
Tumor necrosis factorProtein cereblonDNA +1
Waktu ParuhThe half-life of th…
Vol. DistribusiThe volume of distr…
KlirensThe oral clearance …
Genetik -
Thallium Tl-201 DB15361
small molecule | CAS: 15064-65-0

Thallium Tl-201 is under investigation in clinical trial NCT02697760 (The CZT Dynamic Myocardial Perfusion Imaging).

Kategori:
IsotopesRadioisotopes
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
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Thallous chloride Tl-201 Approved DB16624
small molecule | CAS: 55172-29-7

Deskripsi belum tersedia.

Kategori:
Diagnostic Radiopharmaceuticals
Waktu Paruh-
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THE-630 DB16750
small molecule

Deskripsi belum tersedia.

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Theanine DB12444
small molecule | CAS: 3081-61-6

Theanine, a precursor of ethylamine, is found in green tea. It is under investigation in clinical trial NCT00291070 (Effects of L-Theanine in Boys With ADHD).

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +1
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Thebacon DB13458
small molecule | CAS: 466-90-0

Deskripsi belum tersedia.

Kategori:
Cough and Cold PreparationsOpium Alkaloids and Derivatives
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small molecule | CAS: 326-91-0

Thenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration.

Kategori:
ButanonesChelating AgentsCompounds used in a research, industrial, or household setting +4
Target Protein:
Liver carboxylesterase 1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Waktu Paruh-
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Theobroma cacao whole Approved DB15608
biotech

Theobroma cacao, whole, allergenic extract is used in allergenic testing.

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Theodrenaline DB12927
small molecule | CAS: 13460-98-5

Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).

Kategori:
Adrenergic and Dopaminergic AgentsAgents that produce hypertensionAlcohols +20
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Genetik -
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