Hasil Filter

14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (14063)

Halaman 228 / 282
Racemethionine Approved DB13972
small molecule | CAS: 59-51-8

A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Racemetyrosine DB16306
small molecule | CAS: 658-48-0

Racemetyrosine is under investigation in clinical trial NCT03512756 (A Randomized Phase 2/3 Multi-center Study of SM-88 in Patients With Metastatic Pancreatic Cancer).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Racephedrine Approved DB14752
small molecule | CAS: 90-81-3

Deskripsi belum tersedia.

Kategori:
Adrenergic AgonistsAdrenergic alpha-AgonistsAdrenergic beta-Agonists +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Racepinephrine Approved DB11124
small molecule | CAS: 329-65-7

Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. Epinephrine is a non-selective ?- and ?-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma includi…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +30
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorAlpha-2A adrenergic receptor +6
Waktu ParuhTo refer to the pha…
Vol. DistribusiTo refer to the pha…
KlirensTo refer to the pha…
Genetik -
Racivir DB12753
small molecule | CAS: 143491-54-7

Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of [emtricitabine] and its positive enantiomer. Racivir has been used in trials studying the preventio…

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxycytidine +5
Target Protein:
Reverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raclopride DB12518
small molecule | CAS: 84225-95-6

Raclopride has been used in trials studying Parkinson Disease.

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +13
Target Protein:
Insulin receptorD(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Racotumomab DB13045
biotech | CAS: 946832-34-4

Racotumomab has been used in trials studying the treatment of Glioma, Wilm's Tumor, Neuroblastoma, Retinoblastoma, and Ewing's Sarcoma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RAD 502 DB17328
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RAD-140 DB13939
small molecule | CAS: 1182367-47-0

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.

Kategori:
Oxazoles
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radafaxine DB11790
small molecule | CAS: 192374-14-4

Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.

Kategori:
KetonesPropiophenones
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radalbuvir DB12065
small molecule | CAS: 1314795-11-3

Radalbuvir has been used in trials studying the treatment of Chronic Hepatitis C, Chronic HCV Infection, and Chronic Hepatitis C Infection.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radavirsen DB15332
biotech | CAS: 1228284-45-4

Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).

Kategori:
Anti-Infective AgentsAntiviral AgentsMorpholines +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rademikibart DB18995
biotech | CAS: 2648260-80-2

Rademikibart is under investigation in clinical trial NCT04773678 (Efficacy and Safety of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radezolid DB12339
small molecule | CAS: 869884-78-6

Radezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsOxazoles
Target Protein:
Ribosome-binding protein 150S ribosomal protein L1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radgocitabine DB11667
small molecule | CAS: 135598-68-4

2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer.

Kategori:
ArabinonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radicicol DB03758
small molecule | CAS: 12772-57-5

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiparasitic Agents +5
Target Protein:
Heat shock protein HSP 90-alphaHeat shock protein HSP 90-betaEndoplasmin +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radiprodil DB12260
small molecule | CAS: 496054-87-6

Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.

Kategori:
AcetatesAcids, AcyclicAmides
Target Protein:
Glutamate receptor ionotropic, NMDA 2B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radium Ra 223 dichloride Approved DB08913
small molecule | CAS: 444811-40-9

Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of h…

Kategori:
Antineoplastic AgentsElementsElements, Radioactive +6
Waktu ParuhThe half-life is re…
Vol. DistribusiThe volume of distr…
KlirensThe clearance rate …
Genetik -
Radium Ra-223 DB12813
small molecule | CAS: 15623-45-7

Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).

Kategori:
ElementsElements, RadioactiveIsotopes +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
alpha-Particle Emitting ActivityRadioactive alpha-Particle Emitting Therapeutic Agent
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radotermin DB19127
biotech | CAS: 575458-75-2

Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the Treatment of Early Stage Lumbar Disc Degeneration).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radotinib DB12323
small molecule | CAS: 926037-48-1

Radotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Tyrosine-protein kinase ABL1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RAF-265 DB05984
small molecule | CAS: 927880-90-8

Deskripsi belum tersedia.

Target Protein:
Vascular endothelial growth factor receptor 2Serine/threonine-protein kinase B-raf
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raffinose DB16839
small molecule | CAS: 512-69-6

Deskripsi belum tersedia.

Kategori:
CarbohydratesOligosaccharidesPolysaccharides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ragaglitazar DB06533
small molecule | CAS: 222834-30-2

Deskripsi belum tersedia.

Kategori:
Acids, Carbocyclic
Target Protein:
Peroxisome proliferator-activated receptor alphaPeroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ragifilimab DB18853
biotech | CAS: 2207590-51-8

Ragifilimab is under investigation in clinical trial NCT04225039 (Anti-gitr/anti-pd1/stereotactic Radiosurgery, in Recurrent Glioblastoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ralimetinib DB11787
small molecule | CAS: 862505-00-8

Ralimetinib has been used in trials studying the treatment of Postmenopausal, Advanced Cancer, Adult Glioblastoma, Fallopian Tube Cancer, and Metastatic Breast Cancer, among others.

Kategori:
Mitogen-Activated Protein Kinase 14, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ralinepag DB12462
small molecule | CAS: 1187856-49-0

Ralinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Prostacyclin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ralmitaront DB19128
small molecule | CAS: 2133417-13-5

Ralmitaront is under investigation in clinical trial NCT04512066 (A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raloxifene Approved DB00481
small molecule | CAS: 84449-90-1

Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific …

Kategori:
BCRP/ABCG2 SubstratesBenzene DerivativesBenzylidene Compounds +23
Target Protein:
Estrogen receptorEstrogen receptor betaSerpin B9 +1
Waktu ParuhThe average plasma …
Vol. DistribusiFollowing oral admi…
KlirensFollowing intraveno…
Genetik -
Raltegravir Approved DB06817
small molecule | CAS: 518048-05-0

Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive suc…

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +13
Target Protein:
Gag-Pol polyproteinIntegrase
Waktu Paruh9 hours
Vol. DistribusiApproximately 83% b…
KlirensThe major mechanism…
Genetik -
Raltitrexed Approved DB00293
small molecule | CAS: 112887-68-0

Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +11
Target Protein:
Thymidylate synthaseThymidylate synthaseFolylpolyglutamate synthase, mitochondrial
Waktu Paruh198 hours
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2610074-57-0

Raludotatug deruxtecan is under investigation in clinical trial NCT06660654 (A Study of Raludotatug Deruxtecan in Participants With Advanced/metastatic Solid Tumors (Rejoice-pantumor01)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raluridine DB12894
small molecule | CAS: 119644-22-3

Raluridine has been used in trials studying the treatment of HIV Infections.

Kategori:
DeoxyribonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ramatercept DB15116
biotech | CAS: 1169766-01-1

Ramatercept is under investigation in clinical trial NCT00952887 (A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ramelteon Approved DB00980
small molecule | CAS: 196597-26-9

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has…

Kategori:
Central Nervous System DepressantsCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2C19 Substrates +9
Target Protein:
Melatonin receptor type 1BMelatonin receptor type 1A
Waktu Paruh~1-2.6 hours
Vol. Distribusi* 73.6 L
Klirens-
Genetik -
Ramipril Approved DB00178
small molecule | CAS: 87333-19-5

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsi…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +14
Target Protein:
Angiotensin-converting enzymeB1 bradykinin receptor
Gen Terkait:
ACE
Waktu ParuhPlasma concentratio…
Vol. Distribusi-
KlirensThe renal clearance…
Genetik 1 Varian
Ramiprilat DB14208
small molecule | CAS: 87269-97-4

The active metabolite of the prodrug [Ramipril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ramoplanin DB04952
biotech | CAS: 76168-82-6

Ramoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ramosetron DB09290
small molecule | CAS: 132036-88-5

Ramosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists s…

Kategori:
Antidepressive AgentsAntiemeticsAutonomic Agents +10
Target Protein:
5-hydroxytryptamine receptor 3A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ramucirumab Approved DB05578
biotech | CAS: 947687-13-0

Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligan…

Kategori:
Amino Acids, Peptides, and ProteinsAngiogenesis InhibitorsAngiogenesis Modulating Agents +20
Target Protein:
Vascular endothelial growth factor receptor 2
Waktu Paruh15 days
Vol. Distribusi5.5 L
Klirens0.014 L/hour
Genetik -
Ranibizumab Approved DB01270
biotech | CAS: 347396-82-1

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of age-related macular degeneration.[A2301, …

Kategori:
Amino Acids, Peptides, and ProteinsAngiogenesis InhibitorsAngiogenesis Modulating Agents +19
Target Protein:
Vascular endothelial growth factor A, long form
Waktu ParuhThe estimated avera…
Vol. DistribusiThe apparent volume…
KlirensIn patients with re…
Genetik -
Ranimustine DB13832
small molecule | CAS: 58994-96-0

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAmidesAntineoplastic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ranirestat DB05327
small molecule | CAS: 147254-64-6

Ranirestat is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide ring that undergoes ring-opening at physiological pH levels. It has been used in trials studying the treatment of M…

Kategori:
Aldehyde Reductase, antagonists & inhibitorsEnzyme Inhibitors
Target Protein:
Aldo-keto reductase family 1 member B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ranitidine Approved DB00863
small molecule | CAS: 66357-35-5

Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of it…

Kategori:
Acid ReducersAgents Causing Muscle ToxicityAlimentary Tract and Metabolism +29
Target Protein:
Histamine H2 receptorAcetylcholinesterase
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensRenal clearance is …
Genetik -
Ranolazine Approved DB00243
small molecule | CAS: 95635-55-5

Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition…

Kategori:
AcetamidesAntianginal AgentsBSEP/ABCB11 Substrates +26
Target Protein:
PlasminogenSodium channel proteinInward rectifier potassium channel +4
Waktu ParuhThe apparent termin…
Vol. DistribusiThe mean apparent v…
KlirensThe reported cleara…
Genetik -
Ranpirnase DB04950
biotech | CAS: 196488-72-9

Ranpirnase is a ribonuclease enzyme found in <i>Rana pipiens</i> oocytes. It is being studied in the treatment of cancer. It is manufactured by Alfacell Corporation. It is the first ribonuclease to enter cancer clinical trials.

Kategori:
Antineoplastic AgentsEgg ProteinsEnzyme Inhibitors +6
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2143578-32-7

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RAPA-201 DB18446
biotech

RAPA-201 is an autologous rapamycin-resistant T-cell therapy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rapacuronium Approved DB04834
small molecule | CAS: 465499-11-0

Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm.

Kategori:
Agents producing tachycardiaAndrostanesAndrostanols +9
Target Protein:
Muscarinic acetylcholine receptor M2
Waktu Paruh141 minutes (mean)
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 11351–11400 dari 14063
Sebelumnya Halaman 228 / 282 Berikutnya