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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
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13591 (100.0%)

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Halaman 227 / 272
Rotenone DB11457
small molecule | CAS: 83-79-4

Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.

Kategori:
AgrochemicalsBenzopyransChromones +10
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Rotigaptide DB13067
small molecule | CAS: 355151-12-1

Rotigaptide is under investigation for the basic science of Heart Disease and Vascular Disease.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
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small molecule | CAS: 912809-27-9

Rovafovir etalafenamide is under investigation in clinical trial NCT03472326 (Efficacy of GS-9131 Functional Monotherapy in HIV-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen).

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +6
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biotech | CAS: 1613313-09-9

Rovalpituzumab Tesirine has been used in trials studying the treatment of GLIOBLASTOMA, Malignant Melanoma, Other Solid Tumors, Small Cell Lung Cancer, and Medullary Thyroid Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
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Rovanersen DB16982
biotech | CAS: 2072901-32-5

Deskripsi belum tersedia.

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Rovatirelin DB15338
small molecule | CAS: 204386-76-5

Rovatirelin is under investigation in clinical trial NCT01384435 (A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)).

Kategori:
Oxazoles
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Rovazolac DB16320
small molecule | CAS: 1454288-88-0

Rovazolac is under investigation in clinical trial NCT03175354 (A Study in Subjects With Moderate Atopic Dermatitis).

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biotech | CAS: 2163074-26-6

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
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ROX-888 DB05364
small molecule

ROX-888 is ROXRO's lead compound which is currently in Phase 3 trials for the treatment of acute pain, including post-operative pain.

Target Protein:
C-C motif chemokine 3
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Roxadustat Approved DB04847
small molecule | CAS: 808118-40-3

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that st…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntianemic Preparations +10
Target Protein:
Egl nine homolog 1Prolyl hydroxylase EGLN2Prolyl hydroxylase EGLN3
Waktu ParuhThe mean effective …
Vol. DistribusiThe blood-to-plasma…
KlirensThe apparent total …
Genetik -
Roxarsone DB11458
small molecule | CAS: 121-19-7

Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use i…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +3
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Roxithromycin Approved DB00778
small molecule | CAS: 80214-83-1

Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin]. It was shown to be more effective against certain Gram-negative bacteria, particularly _Legionel…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +19
Target Protein:
50S ribosomal protein L10ATP-dependent translocase ABCB1
Waktu Paruh12 hours
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Royal jelly DB14250
biotech | CAS: 8031-67-2

Royal jelly is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
BeesLipids
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Rozanolixizumab Approved DB14919
biotech | CAS: 1584645-37-3

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange.…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
IgG receptor FcRn large subunit p51
Waktu Paruh-
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Rozibafusp Alfa DB19233
biotech | CAS: 2143449-47-0

Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)).

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
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Rozrolimupab DB05209
biotech | CAS: 909402-77-3

Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Target Protein:
Rhesus blood group D antigen
Waktu Paruh-
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RP-67580 DB16742
small molecule | CAS: 135911-02-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingNeurokinin-1 Receptor AntagonistsNeurotransmitter Agents
Target Protein:
Substance-P receptor
Waktu Paruh-
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RP-A501 DB17647
biotech

RP-A501 is a gene therapy product consisting of a recombinant adeno-associated virus serotype 9 (rAAV9) capsid containing the human LAMP2B transgene (AAV9:LAMP2B), which encodes lysosome-associated membrane protein 2 (LAMP-2). It is being investigated for Dan…

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RP-A601 DB18339
biotech

RP-A601 is an adeno-associated virus serotype rhesus 10 vector expressing the human galactocerebrosidase (GALC) gene

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RP-L201 DB17595
biotech

Deskripsi belum tersedia.

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RP-L301 DB17661
biotech

RP-L301 is a lentiviral vector containing the human liver and erythroid pyruvate kinase gene.

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RPI-MN DB17957
biotech

RPI-MN is a detoxified or chemically modified alpha-cobratoxin with antiviral properties.[A260132] Being developed by Nutra Pharma under the trade name PEPTERON, it is being investigated for the treatment of neurological and immune disorders.[L47107]

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RPR131247 DB02744
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
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RR001 DB17369
biotech

RR001 is an investigational gene therapy consisting of autologous human adipose perivascular stromal cells genetically modified to secrete soluble tumour necrosis factor-related apoptosis-inducing ligand (AD-PC sTRAIL).[L44276]

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RRx-001 DB12060
small molecule | CAS: 925206-65-1

RRx-001 has been used in trials studying the treatment of Lymphomas, Brain Metastases, Cholangiocarcinoma, Colorectal Neoplasms, and Malignant Solid Tumor, among others.

Kategori:
AzetinesCarbon Radioisotopes
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RS-39604 DB17050
small molecule | CAS: 161362-65-8

RS-39604 is a selective 5-HT4 receptor antagonist.[A253112]

Kategori:
AlkanesHydrocarbons, Acyclic
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rsPSMA Vaccine Approved DB06361
biotech

Prostate-specific membrane antigen (PSMA) is an ?100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPS…

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RST-001 DB17843
biotech

RST-001 is a non-replicating recombinant adeno-associated virus vector containing a fragment of the gene encoding channel rhodopsin-2 protein.

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RSV-604 DB15197
small molecule | CAS: 676128-63-5

RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.).

Kategori:
AmidesBenzazepinesBenzene Derivatives +1
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RTL-1000 DB17946
biotech | CAS: 1391875-03-8

RTL-1000 is a recombinant T-Cell receptor ligand being investigated for the treatment of multiple sclerosis.

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RU78299 DB03828
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU78300 DB03306
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU78783 DB02908
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU79073 DB03525
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU82197 DB03268
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU82209 DB03591
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU83876 DB02336
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU84687 DB01678
small molecule

RU84687 is a subnanomolar and Src SH2 selective binder.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU85053 DB03712
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU85493 DB01908
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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RU90395 DB02432
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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Rubella virus vaccine Approved DB10317
biotech

Rubella virus vaccine is a live attenuated virus vaccine for active immunization against rubella (German measles) that is subcutaneously administered. It is prepared from RA 27/3 strain of live attenuated rubella virus. Rubella is a common childhood disease, …

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseLive Attenuated Rubella Virus Vaccine +5
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Rubidium Approved DB11346
small molecule | CAS: 7440-17-7

Deskripsi belum tersedia.

Kategori:
ElementsMetalsMetals, Alkali +1
Waktu Paruh-
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Rubitecan DB06159
small molecule | CAS: 91421-42-0

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntineoplastic AgentsEnzyme Inhibitors +2
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
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Ruboxistaurin DB11829
small molecule | CAS: 169939-94-0

Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus.

Kategori:
Acids, AcyclicDicarboxylic AcidsEnzyme Inhibitors +4
Target Protein:
Peptide deformylase, mitochondrialProtein kinase C beta type
Waktu Paruh-
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Rucaparib Approved DB12332
small molecule | CAS: 283173-50-2

Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair.[A18745] Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +47
Target Protein:
Poly [ADP-ribose] polymerase 1Poly [ADP-ribose] polymerase 2Protein mono-ADP-ribosyltransferase PARP3
Waktu ParuhThe mean (coefficie…
Vol. DistribusiThe mean (coefficie…
KlirensThe mean (coefficie…
Genetik -
Rufinamide Approved DB06201
small molecule | CAS: 106308-44-5

Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.

Kategori:
AnticonvulsantsCarboxamide DerivativesCardiovascular Agents +14
Target Protein:
Sodium channel protein type 9 subunit alphaMetabotropic glutamate receptor 5
Waktu ParuhElimination half-li…
Vol. DistribusiRufinamide was even…
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Rufloxacin DB13772
small molecule | CAS: 101363-10-4

Rufloxacin is a quinolone antibiotic. [A31894]

Kategori:
4-QuinolonesAnti-Bacterial AgentsAntibacterials for Systemic Use +13
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Rugonersen DB18662
biotech | CAS: 2591587-57-2

Rugonersen is a locked nucleic acid antisense oligonucleotide under investigation for the treatment of Angelman Syndrome.

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Rumex acetosella pollen Approved DB10359
biotech

Rumex acetosella pollen is the pollen of the Rumex acetosella plant. Rumex acetosella pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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