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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 225 / 321
Nesbuvir DB07238
small molecule | CAS: 691852-58-1

Nesbuvir has been investigated for the treatment of Hepatitis C.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
Genome polyproteinGenome polyproteinGenome polyprotein
Waktu Paruh-
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Genetik -
Nesiritide Approved DB04899
biotech | CAS: 124584-08-3

Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.

Kategori:
Amino Acids, Peptides, and ProteinsCardiac TherapyCardiovascular Agents +11
Target Protein:
Atrial natriuretic peptide receptor 1Atrial natriuretic peptide receptor 2Atrial natriuretic peptide receptor 3
Waktu ParuhApproximately 18 mi…
Vol. Distribusi* 0.19 L/kg
Klirens* 9.2 mL/min/k [pat…
Genetik -
Nesolicaftor DB15239
small molecule | CAS: 1953130-87-4

Nesolicaftor (PTI-428) is under investigation in clinical trial NCT03258424 (Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background Therapy).

Waktu Paruh-
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Nesuparib DB18110
small molecule | CAS: 2055357-64-5

Deskripsi belum tersedia.

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Nesvacumab DB15330
biotech | CAS: 1296818-77-3

Nesvacumab is under investigation in clinical trial NCT01997164 (Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular (Wet) Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME)).

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Nesvategrast DB19337
small molecule | CAS: 1621332-91-9

Nesvategrast is under investigation in clinical trial NCT05409235 (Nesvategrast (OTT166) in Diabetic Retinopathy (DR)).

Waktu Paruh-
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Netakimab DB18870
biotech | CAS: 1796570-08-5

Netakimab is under investigation in clinical trial NCT03447704 (International Multicenter Comparative Randomized Placebo-controlled Clinical Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Netarsudil Approved DB13931
small molecule | CAS: 1254032-66-0

A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elev…

Kategori:
Acids, CarbocyclicAlanineAmino Acids +8
Target Protein:
Rho-associated protein kinase 1Rho-associated protein kinase 2Sodium-dependent noradrenaline transporter
Waktu ParuhThe half-life of ne…
Vol. DistribusiAs netarsudil and i…
KlirensThe clearance of ne…
Genetik -
Netazepide DB12355
small molecule | CAS: 155488-25-8

Netazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others.

Kategori:
AmidesBenzazepinesBenzene Derivatives +2
Target Protein:
Gastrin/cholecystokinin type B receptor
Waktu Paruh-
Vol. Distribusi-
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Netilmicin Approved DB00955
small molecule | CAS: 56391-56-1

Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S r…

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +14
Target Protein:
30S ribosomal protein S1216S ribosomal RNA
Waktu Paruh2.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Netivudine DB12606
small molecule | CAS: 84558-93-0

Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections.

Kategori:
Anti-Infective AgentsAntiviral AgentsArabinonucleosides +4
Target Protein:
DNA polymerase catalytic subunit
Waktu Paruh-
Vol. Distribusi-
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Netoglitazone DB09199
small molecule | CAS: 161600-01-7

Netoglitazone (MCC-555) is a hypoglycemic agent.

Kategori:
Blood Glucose Lowering AgentsCytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (strength unknown) +8
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Netupitant Approved DB09048
small molecule | CAS: 290297-26-6

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant …

Kategori:
AcetamidesAmidesBCRP/ABCG2 Inhibitors +15
Target Protein:
Substance-P receptor
Waktu Paruh96 hours with CV% o…
Vol. DistribusiIn cancer patients,…
KlirensEstimated systemic …
Genetik -
NeuroCell-HD DB17915
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
NeuroCell-PD DB17941
biotech

Deskripsi belum tersedia.

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Neuropeptide Y Approved DB11788
biotech | CAS: 82785-45-3

Neuropeptide Y is under investigation for the basic science of Type 2 Diabetes Mellitus.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsNeuropeptide Y, drug effects +3
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NeuroVax DB16941
biotech | CAS: 1007558-71-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 503621-56-5

Deskripsi belum tersedia.

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Nevanimibe DB16254
small molecule | CAS: 133825-80-6

Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome).

Kategori:
AmidesBenzene Derivatives
Target Protein:
Sterol O-acyltransferase 1Sterol O-acyltransferase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nevirapine Approved DB00238
small molecule | CAS: 129618-40-2

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemica…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +39
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh45 hours
Vol. Distribusi* 1.21 ± 0.09 L/kg …
Klirens-
Genetik -
Nezastomig DB19061
biotech | CAS: 2657613-60-8

Nezastomig is under investigation in clinical trial NCT06085664 (A Pilot Presurgical Trial of REGN5678 (Anti-psma X CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy).

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NF-kappaB Decoy DB05559
small molecule

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
Target Protein:
Nuclear factor NF-kappa-B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
NFS-02 DB18422
biotech

NFS-02 is a recombinant adeno-associated virus serotype 2 containing human mitochondrial ND1 codon optimized gene (rAAV2-ND1).

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NGD-4715 DB06027
small molecule | CAS: 476322-70-0

NGD-4715 is an investigational compound developed for the treatment of Obesity. NGD-4715 functions as a melanin-concentrating hormone receptor 1 antagonist.

Target Protein:
Melanin-concentrating hormone receptor 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
NGGT-002 DB17881
biotech

NGGT-002 is a recombinant adeno-associated virus serotype 8 vector encoding human phenylalanine hydroxylase (PAH).

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NGN-101 DB18335
biotech

NGN-101 is an adeno-associated virus serotype 9 vector with engineered transgene encoding the human CLN5 gene

Waktu Paruh-
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NGN-401 DB18594
biotech

NGN-401 is a recombinant serotype 9 adeno-associated virus (AAV) encoding an intron encoding a miRNA generating sequence, complementary miRNA binding sites and a full-length human methyl cytosine binding protein 2 (MECP2). Developed by Neurogene Inc., it is b…

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NGX267 DB05152
small molecule | CAS: 503431-81-0

NGX267 is a muscarinic agonist. It is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression.

Kategori:
Cholinergic AgentsCholinergic AgonistsMuscarinic Agonists +2
Target Protein:
Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
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Niacin Approved DB00627
small molecule | CAS: 59-67-6

Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565]

Kategori:
Agents Causing Muscle ToxicityCardiovascular AgentsCytochrome P-450 CYP2D6 Inhibitors +31
Target Protein:
Hydroxycarboxylic acid receptor 3Diacylglycerol O-acyltransferase 2Hydroxycarboxylic acid receptor 2 +2
Waktu ParuhThe half life of ni…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Niacinamide ascorbate Approved DB14486
small molecule | CAS: 1987-71-9

Deskripsi belum tersedia.

Kategori:
Urinary Acidifying AgentsVitamin B ComplexVitamin C and analogues +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nialamide Approved DB04820
small molecule | CAS: 51-12-7

Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +11
Target Protein:
Amine oxidase [flavin-containing] BAmine oxidase [flavin-containing] ACatechol O-methyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Niaouli oil DB16618
biotech | CAS: 8014-68-4

Deskripsi belum tersedia.

Kategori:
Oils, Volatile
Waktu Paruh-
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Genetik -
Niaprazine DB13687
small molecule | CAS: 27367-90-4

Niaprazine is a selective brain catecholamine depletor.

Kategori:
Central Nervous System DepressantsHypnotics and SedativesNervous System +3
Waktu Paruh-
Vol. Distribusi-
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Nicaraven DB06397
small molecule | CAS: 79455-30-4

Deskripsi belum tersedia.

Kategori:
AntioxidantsBiological FactorsCompounds used in a research, industrial, or household setting +3
Target Protein:
Poly [ADP-ribose] polymerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nicarbazin DB11434
small molecule | CAS: 330-95-0

Deskripsi belum tersedia.

Kategori:
AmidesAminesAnilides +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nicardipine Approved DB00622
small molecule | CAS: 55985-32-5

A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma an…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +48
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent L-type calcium channel subunit beta-2Voltage-dependent calcium channel subunit alpha-2/delta-1 +16
Waktu Paruh8.6 hours
Vol. Distribusi* 8.3 L/kg
Klirens* 0.4 L/hr?kg [Foll…
Genetik -
Nicergoline Approved DB00699
small molecule | CAS: 27848-84-6

An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +14
Target Protein:
Alpha-1A adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Niceritrol DB13441
small molecule | CAS: 5868-05-3

Deskripsi belum tersedia.

Kategori:
Hypolipidemic AgentsLipid Modifying AgentsLipid Modifying Agents, Plain +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nickel cation DB14204
small molecule | CAS: 14701-22-5

Deskripsi belum tersedia.

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Nickel sulfate Approved DB14180
small molecule | CAS: 7786-81-4

Nickel sulfate is used in allergenic testing.

Kategori:
Compounds used in a research, industrial, or household settingElementsIrritants +5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Niclosamide Approved DB06803
small molecule | CAS: 50-65-7

Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nema…

Kategori:
AgrochemicalsAmidesAmines +22
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Nicoboxil Approved DB12911
small molecule | CAS: 13912-80-6

Nicoboxil has been investigated for the treatment of Acute Low Back Pain, where it is typically considered an effective and safe therapeutic option. Nevertheless, it is predominantly found paired with nonivamide as a combination topical analgesic product wher…

Kategori:
Drugs that are Mainly Renally ExcretedPyridines
Waktu ParuhThe half-life of es…
Vol. DistribusiDespite the fact th…
KlirensThe elimination of …
Genetik -
Nicofetamide DB13531
small molecule | CAS: 553-06-0

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Functional Gastrointestinal DisordersSynthetic Antispasmodics, Amides With Tertiary Amines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nicofuranose DB13422
small molecule | CAS: 15351-13-0

Deskripsi belum tersedia.

Kategori:
Cardiovascular AgentsLipid Modifying AgentsLipid Modifying Agents, Plain +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nicomorphine DB13454
small molecule | CAS: 639-48-5

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nicorandil Approved DB09220
small molecule | CAS: 65141-46-0

Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. It is not an approved drug by FDA. It is a niacinamide derivative that induces vasod…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +10
Target Protein:
ATP-binding cassette sub-family C member 9
Waktu ParuhThe elimination hal…
Vol. DistribusiAfter oral (and i.v…
KlirensThe total body clea…
Genetik -
Nicotinaldehyde DB15905
small molecule | CAS: 500-22-1

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
Nicotinamide Approved DB02701
small molecule | CAS: 98-92-0

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency …

Kategori:
Alimentary Tract and MetabolismCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strength unknown) +13
Target Protein:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Exotoxin APoly [ADP-ribose] polymerase 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
6-phosphogluconate dehydrogenase, decarboxylating
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

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Menampilkan 11201–11250 dari 16004
Sebelumnya Halaman 225 / 321 Berikutnya