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16004

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12010 (75.0%)
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9041 (56.5%)
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112 (0.7%)
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16004 (100.0%)

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Halaman 224 / 321
Neihulizumab DB16698
biotech

Neihulizumab is a novel immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), thereby preferentially inducing apoptosis in late stage activated T cells.[L34450]

Target Protein:
P-selectin glycoprotein ligand 1
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biotech

Neisseria meningitidis group w-135 capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
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biotech

Neisseria meningitidis group w-135 capsular polysaccharide diphtheria toxoid conjugate antigen is an active intramuscular immunization for the prophylaxis of invasive meningococcal disease caused by *Neisseria meningitidis* serogroup W-135. The vaccine contai…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
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biotech

Neisseria meningitidis group y capsular polysaccharide diphtheria toxoid conjugate antigen is an active intramuscular immunization for the prophylaxis of invasive meningococcal disease caused by *Neisseria meningitidis* serogroup W-135. The vaccine contains* …

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
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small molecule | CAS: 1239309-58-0

Neladenoson bialanate has been investigated for the treatment of Heart Failure.

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Target Protein:
Adenosine receptor A1
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Nelarabine Approved DB01280
small molecule | CAS: 121032-29-9

Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease h…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +8
Target Protein:
DNADNA polymerase alpha catalytic subunitDNA ligase 1 +2
Waktu ParuhNelarabine and ara-…
Vol. DistribusiNelarabine and ara-…
KlirensRenal clearance ave…
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Nelatimotide DB17249
small molecule | CAS: 1629213-88-2

Deskripsi belum tersedia.

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Nelfinavir Approved DB00220
small molecule | CAS: 159989-64-7

Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, …

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +45
Target Protein:
HIV-1 protease
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensOral clearance esti…
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Nelipepimut-S DB06226
biotech | CAS: 160212-35-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Surface +25
Target Protein:
Receptor tyrosine-protein kinase erbB-2HLA class I histocompatibility antigen, A-3 alpha chain
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Nelistotug DB19334
biotech | CAS: 2645437-82-5

Nelistotug is under investigation in clinical trial NCT06062420 (A Platform Study of Novel Immunotherapy Combinations as First-line Treatment in Participants With PD-L1 Positive Recurrent/metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-2…

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Nelivaptan DB12643
small molecule | CAS: 439687-69-1

Nelivaptan has been used in trials studying the treatment of Anxiety Disorders, Depressive Disorder, and Major Depressive Disorder.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Vasopressin V1b receptorVasopressin V2 receptorOxytocin receptor +1
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Nelmastobart DB19000
biotech | CAS: 2669823-48-5

Nelmastobart is under investigation in clinical trial NCT05990543 (Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer).

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Nelonicline DB19040
small molecule | CAS: 1026134-63-3

Nelonicline is under investigation in clinical trial NCT01678755 (A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia).

Kategori:
Sulfur CompoundsThiazoles
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Nelotanserin DB12555
small molecule | CAS: 839713-36-9

Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sl…

Kategori:
AmidesBenzene Derivatives
Target Protein:
5-hydroxytryptamine receptor 2A
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Neltenexine DB13239
small molecule | CAS: 99453-84-6

Neltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.

Kategori:
AminesAniline CompoundsCough and Cold Preparations +2
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Nelumbo nucifera flower Approved DB14333
biotech

Nelumbo nucifera flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesPharmaceutical Preparations +2
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Nemiralisib DB16253
small molecule | CAS: 1254036-71-9

Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors +1
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Nemolizumab Approved DB15252
biotech | CAS: 1476039-58-3

Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology of various skin inflammatory disorders.[A264254…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAmino Acids, Peptides, and ProteinsAntibodies +10
Target Protein:
Interleukin-31 receptor subunit alpha
Waktu ParuhThe estimated termi…
Vol. DistribusiThe estimated volum…
KlirensThe estimated syste…
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Nemonapride DB19314
small molecule | CAS: 75272-39-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +9
Target Protein:
D(2) dopamine receptor
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Nemonoxacin DB06600
small molecule | CAS: 378746-64-6

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
DNA gyrase subunit ADNA gyrase subunit B
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Nemtabrutinib DB18866
small molecule | CAS: 2095393-15-8

Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-0…

Target Protein:
Tyrosine-protein kinase BTK
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biotech | CAS: 2315268-27-8

Deskripsi belum tersedia.

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biotech | CAS: 1853254-97-3

Nendratareotide uzatansine is a peptide-drug conjugate comprising a peptide analog of somatostatin conjugated to the cytotoxin mertansine.

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NEO-212 DB17100
small molecule | CAS: 1361198-79-9

Deskripsi belum tersedia.

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biotech

Deskripsi belum tersedia.

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Neoarsphenamine DB18729
small molecule | CAS: 457-60-3

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsArsenicalsHaptens
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Neocartilage DB05257
biotech

Neocartilage, a novel cartilage regeneration treatment. Neocartilage is generated from juvenile rather than adult chondrocytes. Neocartilage is the only scaffold-free living cartilage graft on the market.

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Neocitrullamon DB13396
small molecule | CAS: 38964-88-4

Deskripsi belum tersedia.

Kategori:
AnticonvulsantsCentral Nervous System DepressantsHydantoins +2
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Neodymium DB15318
small molecule | CAS: 7440-00-8

Neodymium is under investigation in clinical trial NCT03525522 (Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus).

Kategori:
ElementsLanthanoid Series ElementsMetals +1
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Neomycin Approved DB00994
small molecule | CAS: 1404-04-2

Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_.[L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C.[A191529] Neomycin B, also known as [framyceti…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAminoglycoside Antibacterials +28
Target Protein:
30S ribosomal protein S1216S ribosomal RNAExtracellular calcium-sensing receptor
Waktu ParuhThere is limited in…
Vol. DistribusiThe small fraction …
KlirensThere is limited in…
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Neon Approved DB11589
small molecule | CAS: 7440-01-9

Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a re…

Kategori:
ElementsGasesNoble Gases
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Neopterin DB15050
small molecule | CAS: 2009-64-5

Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke).

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +2
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Neosaxitoxin DB12989
small molecule | CAS: 64296-20-4

Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).

Kategori:
AgrochemicalsBacterial ToxinsBiological Factors +16
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Neostigmine Approved DB01400
small molecule | CAS: 59-99-4

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Kategori:
AminesAntiglaucoma Preparations and MioticsAutonomic Agents +13
Target Protein:
Acetylcholinesterase
Waktu ParuhThe half-life range…
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Neovastat DB05387
small molecule

Neovastat is a naturally occurring anti-angiogenic compound, extracted from cartilage, with multiple anti-angiogenic mechanisms of action that provide broad therapeutic potential for a number of diseases. It is currently in international Phase III trials for …

Kategori:
CartilageComplex Mixtures
Target Protein:
72 kDa type IV collagenaseMatrix metalloproteinase-9Macrophage metalloelastase
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Nepadutant DB12538
small molecule | CAS: 183747-35-5

Nepadutant has been used in trials studying the treatment of Colic, Infantile Colic, and Infantile Functional Gastrointestinal Disorders.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Asthmatic AgentsAutonomic Agents +5
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Nepafenac Approved DB06802
small molecule | CAS: 78281-72-8

Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.

Kategori:
AcetamidesAcetatesAcids, Acyclic +18
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
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Nepicastat DB12979
small molecule | CAS: 173997-05-2

Nepicastat has been investigated for the treatment of Cocaine Dependence and Posttraumatic Stress Disorder.

Kategori:
Dopamine beta-Hydroxylase, antagonists & inhibitorsSulfur Compounds
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Nepidermin DB14145
biotech | CAS: 62253-63-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsEGF Family of Proteins +6
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Nepinalone DB13445
small molecule | CAS: 22443-11-4

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
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Nequinate DB11433
small molecule | CAS: 13997-19-8

Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. Nequinate belongs to the family of Hydroquinolones. These are compounds containing an hydrogenated quinoline bearing a ketone group.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
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Neramexane DB04926
small molecule | CAS: 219810-59-0

Neramexane is a low-to-moderate affinity uncompetitive NMDA receptor antagonist.

Kategori:
Cycloparaffins
Target Protein:
Glutamate receptor ionotropic, NMDA 3A
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Nerandomilast DB18237
small molecule | CAS: 1423719-30-5

Deskripsi belum tersedia.

Kategori:
Cycloparaffins
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Neratinib Approved DB11828
small molecule | CAS: 698387-09-6

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under inve…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A Substrates +11
Target Protein:
Vascular endothelial growth factor receptor 2Receptor tyrosine-protein kinase erbB-2Epidermal growth factor receptor
Waktu ParuhThe mean half life …
Vol. DistribusiThe apparent volume…
KlirensThe total clearance…
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Neridronic Acid DB11620
small molecule | CAS: 79778-41-9

Deskripsi belum tersedia.

Kategori:
OrganophosphonatesOrganophosphorus Compounds
Target Protein:
Farnesyl pyrophosphate synthase
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Nerinetide DB12595
biotech | CAS: 500992-11-0

Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).

Kategori:
Amino Acids, Peptides, and ProteinsNeuroprotective Agents
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Nerispirdine DB12714
small molecule | CAS: 119229-65-1

Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2Sodium channel protein type 11 subunit alpha
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Nerofe DB14786
small molecule | CAS: 1311294-45-7

Nerofe is under investigation in clinical trial NCT03059615 (A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS).

Kategori:
Amino Acids, Peptides, and Proteins
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biotech | CAS: 9061-61-4

Nerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, Alzheimer's Disease, Traumatic Brain Injury, Cerebral Palsy Children, and Delayed Speech Development, among others.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +4
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