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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 223 / 349
Mitoguazone DB12967
small molecule | CAS: 459-86-9

Mitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin.

Kategori:
AmidinesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +2
Target Protein:
S-adenosylmethionine decarboxylase proenzyme
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitolactol DB12916
small molecule | CAS: 10318-26-0

Mitolactol has been used in trials studying the treatment of Brain and Central Nervous System Tumors.

Kategori:
AlcoholsAlkylating DrugsAntineoplastic Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitometh DB12117
small molecule | CAS: 107465-03-2

Mitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal Carcinoma, Non-small Cell Lung Cancer, and Stage IV Non-small Cell Lung Cancer, among others. Mitometh has been investigated for the treatment of Lung…

Kategori:
Hydrocarbons, ChlorinatedHydrocarbons, Halogenated
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitomycin Approved DB00305
small molecule | CAS: 50-07-7

Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protei…

Kategori:
Alkylating ActivityAlkylating DrugsAntibiotics, Antineoplastic +19
Target Protein:
DNA
Waktu Paruh8-48 min
Vol. Distribusi-
Klirens-
Genetik -
Mitomycin A DB19369
small molecule | CAS: 4055-39-4

Deskripsi belum tersedia.

Kategori:
AzirinesHeterocyclic Compounds, Fused-RingIndolequinones +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitoquinone DB05063
small molecule | CAS: 444890-41-9

Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. In 200…

Kategori:
BenzoquinonesCoenzymesEnzymes and Coenzymes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitotane Approved DB00648
small molecule | CAS: 53-19-0

Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 195…

Kategori:
Adrenal Cytotoxic AgentsAntineoplastic AgentsAntineoplastic Agents, Hormonal +15
Target Protein:
Cytochrome P450 11B1, mitochondrialEstrogen receptorProgesterone receptor +2
Waktu ParuhThe plasma terminal…
Vol. DistribusiMitotane is extensi…
Klirens-
Genetik -
Mitoxantrone Approved DB01204
small molecule | CAS: 65271-80-9

An anthracenedione-derived antineoplastic agent.

Kategori:
AnalgesicsAnthracenesAnthracyclines and Related Substances +30
Target Protein:
DNA topoisomerase 2-betaDNADNA topoisomerase 2-alpha
Waktu Paruh75 hours
Vol. Distribusi* 1000 L/m2
Klirens* 21.3 L/hr/m2 [Eld…
Genetik -
Mitsugumin-53 DB16969
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitumomab DB06462
biotech | CAS: 216503-58-1

Mitumomab, an anti-BEC-2 monoclonal antibody derived from mice, was previously studied to treat small cell lung carcinoma in combination with BCG vaccination.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MIV-701 DB05736
small molecule

MIV-701 is a selective, potent inhibitor of the protease Cathepsin K. It is developed for the treatment of osteoporosis.

Target Protein:
Cathepsin K
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MIV-711 DB15599
small molecule

Deskripsi belum tersedia.

Kategori:
Anti-Inflammatory AgentsAntineoplastic AgentsAntirheumatic Agents
Target Protein:
Cathepsin K
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mivacurium Approved DB01226
small molecule | CAS: 133814-19-4

Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsCentral Nervous System Depressants +13
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +1
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
Mivavotinib DB16849
small molecule | CAS: 1312691-33-0

Deskripsi belum tersedia.

Target Protein:
Receptor-type tyrosine-protein kinase FLT3Tyrosine-protein kinase SYK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mivelsiran DB19003
biotech | CAS: 2572991-83-2

Mivelsiran is under investigation in clinical trial NCT06393712 (A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
ATP-dependent dethiobiotin synthetase BioD 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizagliflozin DB19036
small molecule | CAS: 666843-10-3

Mizagliflozin is under investigation in clinical trial NCT05721729 (Effect of Mizagliflozin Repeat Dosing on Adverse Events and Postprandial Glucose Excursions).

Kategori:
CarbohydratesGlycosides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizolastine Approved DB12523
small molecule | CAS: 108612-45-9

Mizolastine is under investigation in clinical trial NCT01928316 (A Bioequivalence Study of Domestic (Made in China) and Imported Mizolastine Tablets in Healthy Volunteers).

Kategori:
Antihistamines for Systemic UseCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strength unknown) +9
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizoribine DB12617
small molecule | CAS: 50924-49-7

Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Infective Agents +15
Target Protein:
Inosine-5'-monophosphate dehydrogenase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0249 DB11910
small molecule | CAS: 1167574-41-5

MK0249 has been used in trials studying the treatment of Hypopnea Syndrome, Alzheimer's Disease, Paranoid Schizophrenia, Sleep Apnea, Obstructive, and Excessive Daytime Sleepiness, among others.

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Target Protein:
Histamine H3 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0354 DB05939
small molecule | CAS: 851776-28-8

MK-0354, is an orally administered drug candidate under development by Merck for the treatment of atherosclerosis and related disorders. It targets G protein-coupled receptor, or GPCR, that have the potential to regulate plasma lipid profiles, including HDL, …

Target Protein:
Hydroxycarboxylic acid receptor 2G-protein coupled estrogen receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0482 DB17453
biotech

MK-0482 is a novel humanized IgG4 monoclonal antibody targeting the immunoglobulin-like transcript (ILT) 3.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0533 DB15242
small molecule | CAS: 668455-28-5

MK-0533 is under investigation in clinical trial NCT00543959 (Efficacy and Tolerability of MK0533 in Patients With Type 2 Diabetes (0533-005)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0557 DB12168
small molecule | CAS: 328232-95-7

MK0557 has been investigated for the treatment of Schizophrenia and Paranoid Schizophrenia.

Kategori:
Cycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0668 DB15791
small molecule | CAS: 865110-07-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Integrin beta-1Integrin alpha-4VLA-4 (very late antigen-4)
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0686 DB12563
small molecule | CAS: 578727-68-1

MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic.

Kategori:
AcetatesAcids, AcyclicAcids, Carbocyclic +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0731 DB08037
small molecule | CAS: 845256-65-7

MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent.

Target Protein:
Kinesin-like protein KIF11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0736 DB15209
small molecule | CAS: 719272-79-4

MK-0736 is under investigation in clinical trial NCT00679055 (A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0752 DB12852
small molecule | CAS: 471905-41-6

Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).

Kategori:
Acids, AcyclicAmyloid Precursor Protein Secretases, antagonists & inhibitorsEnzyme Inhibitors +5
Target Protein:
Gamma-secretase subunit PEN-2NicastrinGamma-secretase subunit APH-1B +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0767 DB12055
small molecule | CAS: 934017-32-0

MK0767 has been used in trials studying the treatment of Dyslipidemia, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Diabetes Mellitus, Type II, among others.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0773 DB16244
small molecule | CAS: 606101-58-0

MK-0773 is under investigation in clinical trial NCT00529659 (A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(mk-0773-005)).

Kategori:
Fused-Ring CompoundsSteroids
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0777 DB12238
small molecule | CAS: 252977-51-8

MK-0777 has been used in trials studying the treatment of Schizophrenia, Anxiety Disorder, and Generalized Anxiety Disorder.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0812 DB11990
small molecule | CAS: 624733-88-6

MK0812 has been used in trials studying the treatment of Relapsing-Remitting Multiple Sclerosis.

Target Protein:
C-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0873 DB13029
small molecule | CAS: 500355-52-2

MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingPhosphodiesterase 4 Inhibitors +1
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4D
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0893 DB12044
small molecule

MK0893 has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1064 DB15028
small molecule | CAS: 1207253-08-4

MK-1064 is under investigation in clinical trial NCT02549014 (A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1454 DB14721
small molecule

A synthetic cyclic dinucleotide (CDN) and agonist of stimulator of interferon genes protein (STING), with potential immunoactivating and antineoplastic activities. Upon intratumoral (IT) administration, STING agonist MK-1454 binds to STING and activates the S…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1496 DB12763
small molecule | CAS: 1037254-47-9

MK-1496 has been used in trials studying the treatment of Neoplasms and Malignant.

Target Protein:
Serine/threonine-protein kinase PLK1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-212 DB12111
small molecule | CAS: 64022-27-1

MK-212 has been used in trials studying the treatment of Alcoholism.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +3
Target Protein:
5-hydroxytryptamine receptor 2C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-2206 DB16828
small molecule | CAS: 1032349-93-1

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Ubiquitin-conjugating enzyme E2 TRAC-gamma serine/threonine-protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-2225 DB18240
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-2748 DB15371
small molecule | CAS: 1193902-95-2

MK-2748 is under investigation in clinical trial NCT01593735 (A Multiple Dose Study to Evaluate the Safety and Efficacy of MK-2748 in Hepatitis C-Infected Participants (MK-2748-002 AM1)).

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-3207 DB12424
small molecule | CAS: 957118-49-9

Mk3207 has been used in trials studying the treatment of Migraine and Migraine Disorders.

Kategori:
Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitors
Target Protein:
Calcitonin gene-related peptide type 1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-3577 DB14957
small molecule | CAS: 1019112-29-8

MK-3577 is under investigation in clinical trial NCT00868790 (A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4541 DB17016
small molecule | CAS: 796885-38-6

MK-4541 is a 4-azasteroid and a selective androgen receptor modulator (SARM). MK-4541 acts as a dual selective SARM and is both a potent androgen receptor antagonist and a 5?-reductase inhibitor.[A252687]

Kategori:
Acids, AcyclicFused-Ring CompoundsSteroids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4721 DB05933
biotech

MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and bladder…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Prostate stem cell antigen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4830 DB17454
biotech

MK-4830 is a monoclonal antibody that targets the myeloid-specific immunoglobulin-like transcript (ILT) 4 receptor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4965 DB08460
small molecule | CAS: 920035-77-4

MK-4965 is an HIV-1 reverse transcriptase inhibitor.

Kategori:
HIV Reverse Transcriptase, antagonists & inhibitors
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-5108 DB12556
small molecule | CAS: 1010085-13-8

MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors.

Kategori:
Acids, CarbocyclicCyclohexanesCycloparaffins +2
Target Protein:
Aurora kinase BAurora kinase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-6186 DB12999
small molecule | CAS: 1034474-19-5

MK6186 has been used in trials studying the treatment of HIV-1 Infection.

Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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