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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 223 / 236
Triprolidine Approved DB00427
small molecule | CAS: 486-12-4

First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.

Kategori:
Anti-Allergic AgentsAntihistamines for Systemic UseCentral Nervous System Depressants +7
Target Protein:
Histamine H1 receptor
Waktu Paruh4 to 6 hours.
Vol. Distribusi-
Klirens-
Genetik -
biotech

Tripterygium wilfordii whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triptolide DB12025
small molecule | CAS: 38748-32-2

Triptolide has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others.

Kategori:
Adrenal Cortex HormonesAlkylating DrugsAntineoplastic Agents +10
Target Protein:
Transcription factor RelBNuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triptorelin Approved DB06825
small molecule | CAS: 57773-63-4

Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this age…

Kategori:
Adrenal Cortex HormonesAmino Acids, Peptides, and ProteinsAntineoplastic Agents +23
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu ParuhThe pharmacokinetic…
Vol. DistribusiAfter a single IV d…
KlirensIn healthy male vol…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Chlorocatechol 1,2-dioxygenaseAlpha-lytic protease
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
AzurinThiazole tautomerasePantothenate synthetase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trisaccharide A DB17689
small molecule | CAS: 49777-13-1

Deskripsi belum tersedia.

Kategori:
CarbohydratesOligosaccharidesPolysaccharides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trisaccharide B DB17690
small molecule | CAS: 49777-14-2

Deskripsi belum tersedia.

Kategori:
ABO Blood-Group SystemCarbohydratesOligosaccharides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tritoqualine Approved DB13711
small molecule | CAS: 14504-73-5

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UseCholagogues and CholereticsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TRK-001 DB18577
biotech

TRK-001 is an autologous regulatory T-cell therapy. It is being investigated for the prevention of graft rejection following solid organ transplantation.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TRO40303 DB16031
small molecule | CAS: 14291-24-8

TRO40303 is under investigation in clinical trial NCT01374321 (Safety and Efficacy Study of TRO40303 for Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction).

Kategori:
AminesFused-Ring CompoundsHydroxylamines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Troclosene DB15960
small molecule | CAS: 2782-57-2

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiviral Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trodusquemine DB06333
small molecule | CAS: 186139-09-3

Trodusquemine, a spermine metabolite of cholesterol, is a naturally occurring aminosterol that inhibits protein tyrosine phosphatase 1B. It has demonstrated the ability to stimulate regeneration of heart and multiple other tissues in animal models [A176600].

Kategori:
AminesBiogenic AminesBiogenic Polyamines +3
Target Protein:
Tyrosine-protein phosphatase non-receptor type 1Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trofinetide Approved DB06045
small molecule | CAS: 853400-76-7

Trofinetide is a novel synthetic analog of [glypromate], also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1).[A258438] Trofinetide was approved by the …

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +11
Waktu ParuhThe effective elimi…
Vol. DistribusiFollowing oral admi…
KlirensNo information is a…
Genetik -
Troglitazone Approved DB00197
small molecule | CAS: 97322-87-7

Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].

Kategori:
Alimentary Tract and MetabolismBenzopyransBlood Glucose Lowering Agents +38
Target Protein:
Peroxisome proliferator-activated receptor gammaEstrogen-related receptor gammaSteroid hormone receptor ERR1 +6
Waktu Paruh16-34 hours
Vol. Distribusi-
Klirens-
Genetik -
Trolamine Approved DB13747
small molecule | CAS: 102-71-6

Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine contains small amounts of diethanolamine and ethanolamine and may als…

Kategori:
AlcoholsAminesAmino Alcohols +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Various ear diseases and infections are treated with eardrops containing triethanolamine polypeptide oleate-condensate, such as Cerumenex in the United States and Canada.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trolamine salicylate Approved DB11079
small molecule | CAS: 2174-16-5

Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAnti-Inflammatory Agents +11
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. DistribusiTopical administrat…
Klirens-
Genetik -
Troleandomycin Approved DB13179
small molecule | CAS: 2751-09-9

A macrolide antibiotic that is similar to erythromycin.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +18
Target Protein:
50S ribosomal protein L3250S ribosomal protein L4Nuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trolnitrate DB13719
small molecule | CAS: 7077-34-1

Deskripsi belum tersedia.

Kategori:
AlcoholsAminesAmino Alcohols +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tromantadine Approved DB13288
small molecule | CAS: 53783-83-8

Tromantadine is marketed as Viru-Merz in the Czech Republic [L5740]. It is an antiviral used in the treatment of herpes zoster and simplex.

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tromethamine Approved DB03754
small molecule | CAS: 77-86-1

An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (Fro…

Kategori:
AlcoholsBlood and Blood Forming OrgansBlood Substitutes and Perfusion Solutions +12
Target Protein:
S-adenosylmethionine decarboxylase proenzymeAmyloid-beta precursor protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tropatepine DB13252
small molecule | CAS: 27574-24-9

Tropatepine has been used in France for its antiparkinsons activities [A175024].

Kategori:
Agents producing tachycardiaAnti-Parkinson DrugsAnticholinergic Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tropicamide Approved DB00809
small molecule | CAS: 1508-75-4

Tropicamide is an alkaloid atropine?derived anticholinergic drug and a non?selective antagonist of muscarinic acetylcholine (mACh) receptors.[A230103] Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye…

Kategori:
Anticholinergic AgentsAutonomic AgentsCholinergic Agents +8
Target Protein:
Muscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +1
Waktu ParuhTropicamide has a p…
Vol. DistribusiNo information can …
KlirensNo information can …
Genetik -
Tropinone DB01874
small molecule | CAS: 532-24-1

Deskripsi belum tersedia.

Kategori:
AlkaloidsAza CompoundsAzabicyclo Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 931101-84-7

Troplasminogen alfa is under investigation in clinical trial NCT00144014 (Safety and Efficacy Study in Acute Ischaemic Stroke).

Kategori:
Amino Acids, Peptides, and ProteinsBeta-GlobulinsBlood Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Troriluzole DB15079
small molecule | CAS: 1926203-09-9

Troriluzole is under investigation in clinical trial NCT03701399 (Troriluzole in Adult Subjects With Spinocerebellar Ataxia).

Kategori:
Nervous System
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trospium Approved DB00209
small molecule | CAS: 47608-32-2

Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.[L6208] An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes,…

Kategori:
Acids, CarbocyclicAgents producing tachycardiaAlimentary Tract and Metabolism +22
Target Protein:
Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1
Waktu ParuhThe half-life of tr…
Vol. DistribusiThe volume of distr…
KlirensThe total apparent …
Genetik -
Trotabresib DB17421
small molecule | CAS: 1706738-98-8

Trotabresib is an oral, potent, and reversible inhibitor of the epigenetic target bromodomain and extra-terminal (BET) proteins.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trovafloxacin Approved DB00685
small molecule | CAS: 147059-72-1

Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase …

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +16
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA gyrase subunit A +2
Waktu ParuhFollowing oral admi…
Vol. Distribusi-
Klirens-
Genetik -
Troxacitabine DB04961
small molecule | CAS: 145918-75-8

Troxacitabine is a nucleoside analog with antineoplastic activity. There has been growing interest in its development for the treatment of patients with refractory lymphoproliferative conditions.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAntineoplastic Agents +3
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Troxerutin DB13124
small molecule | CAS: 7085-55-4

Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency.

Kategori:
AnticoagulantsBenzopyransCapillary Stabilizing Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Troxipide DB13419
small molecule | CAS: 30751-05-4

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Acid Related DisordersDrugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TRU-015 DB05580
small molecule | CAS: 1169717-01-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TRV-120027 DB12199
small molecule | CAS: 1234510-46-3

TRV120027 has been used in trials studying the treatment of Heart Failure and Kidney Disease.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Type-1 angiotensin II receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
AmicyaninMethylamine dehydrogenase heavy chainMethylamine dehydrogenase light chain +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TRX-518 DB17534
biotech | CAS: 1427683-53-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TRX-E-002-1 DB17264
small molecule | CAS: 1803036-93-2

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trypanothione DB03470
small molecule

Deskripsi belum tersedia.

Kategori:
AminesAmino Acids, Peptides, and ProteinsBiogenic Amines +5
Target Protein:
Trypanothione reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trypsin Approved DB11237
small molecule | CAS: 9002-07-7

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at …

Kategori:
Blood and Blood Forming OrgansDermatologicalsEndopeptidases +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tryptophan Approved DB00150
small molecule | CAS: 73-22-3

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precurso…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +14
Target Protein:
Indoleamine 2,3-dioxygenase 1Tryptophan--tRNA ligase, cytoplasmicTryptophan--tRNA ligase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tryptophanamide DB04537
small molecule | CAS: 20696-57-5

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Tryptophan--tRNA ligase, cytoplasmicTryptophan--tRNA ligase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TT 173 DB17717
biotech

TT 173 is a Modified Human Tissue Factor currently being investigated to treat bleeding disorders such as hemophilia and von Willebrand disease, as well as bleeding episodes in cutaneous injuries or dental procedures.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TT-232 DB12088
small molecule | CAS: 147159-51-1

Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma).

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +8
Target Protein:
Pyruvate kinase PKM
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TT-301 DB12899
small molecule | CAS: 886208-76-0

TT301 has been used in trials studying the treatment of Traumatic Brain Injury.

Target Protein:
Interleukin-1 beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TTAX01 DB17928
biotech

TTAX01 is a cryopreserved human umbilical cord product being developed by TissueTech.[L47246]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TTI-101 DB17578
small molecule | CAS: 432001-19-9

Deskripsi belum tersedia.

Kategori:
AmidesBenzene DerivativesNaphthalenes +3
Target Protein:
Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TU-100 DB12467
small molecule | CAS: 1310907-71-1

TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others.

Kategori:
DNA Topoisomerases, Type IINaphthalenesQuinones +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tubercidin DB03172
small molecule | CAS: 69-33-0

An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.

Kategori:
Antibiotics, AntineoplasticAntimetabolitesAntineoplastic Agents +8
Target Protein:
Purine nucleoside phosphorylase DeoD-type
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 92129-86-7

Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves t…

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Bacterial +12
Target Protein:
Toll-like receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 11101–11150 dari 11778
Sebelumnya Halaman 223 / 236 Berikutnya