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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 223 / 252
Sulfanilamide Approved DB00259
small molecule | CAS: 63-74-1

Sulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline.

Kategori:
AmidesAminesAniline Compounds +21
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfaperin DB13320
small molecule | CAS: 599-88-2

Deskripsi belum tersedia.

Kategori:
Antibacterials for Systemic UseAntiinfectives for Systemic UseLong-Acting Antibacterial Sulfonamides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfaphenazole Approved DB06729
small molecule | CAS: 526-08-9

Sulfaphenazole is a sulfonamide antibacterial.

Kategori:
AmidesAminesAniline Compounds +27
Target Protein:
Dihydropteroate synthaseCytochrome P450 2C9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 59-40-5

Sulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K as potential treatment of coccidiosis.

Kategori:
AmidesAminesAniline Compounds +9
Waktu Paruh-
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Genetik -
Sulfasalazine Approved DB00795
small molecule | CAS: 599-79-1

Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metab…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAlimentary Tract and Metabolism +23
Target Protein:
Broad substrate specificity ATP-binding cassette transporter ABCG2Transcription factor RelBTranscription factor p65 +12
Waktu ParuhThe observed plasma…
Vol. DistribusiFollowing intraveno…
KlirensThe calculated clea…
Genetik -
Sulfate ion DB14546
small molecule | CAS: 14808-79-8

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIncreased Large Intestinal Motility +9
Target Protein:
Carbonic anhydrase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfathiourea DB13699
small molecule | CAS: 515-49-1

Deskripsi belum tersedia.

Kategori:
AmidesAminesAniline Compounds +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfatolamide DB13547
small molecule | CAS: 1161-88-2

Deskripsi belum tersedia.

Kategori:
AmidesAminesAniline Compounds +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfinpyrazone Approved DB01138
small molecule | CAS: 57-96-5

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Kategori:
Antigout PreparationsAntiplatelet agentsBSEP/ABCB11 Substrates +19
Target Protein:
Solute carrier family 22 member 12Multidrug resistance-associated protein 1ATP-binding cassette sub-family C member 2 +1
Waktu ParuhApproximately 4-6 h…
Vol. Distribusi-
Klirens-
Genetik -
Sulfisoxazole Approved DB00263
small molecule | CAS: 127-69-5

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Kategori:
AmidesAminesAniline Compounds +26
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 297-83-6

Sulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans [A174970].

Kategori:
Benzene DerivativesColoring AgentsCompounds used in a research, industrial, or household setting +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfogaiacol DB15992
small molecule | CAS: 7134-11-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sulfopyruvate DB02156
small molecule | CAS: 98022-26-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Sulforaphane DB12422
small molecule | CAS: 142825-10-3

Sulforaphane is under investigation for the treatment of Autism Spectrum Disorder. It is a naturally occurring isothiocyanate found in high concentration in a variety of broccoli.

Kategori:
Anticarcinogenic AgentsAntineoplastic AgentsCompounds used in a research, industrial, or household setting +3
Waktu Paruh-
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Sulfotep DB11497
small molecule | CAS: 3689-24-5

Deskripsi belum tersedia.

Kategori:
Organophosphorus CompoundsSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfoxone Approved DB01145
small molecule | CAS: 144-76-3

Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.

Kategori:
Antiinfectives for Systemic UseAntimycobacterialsDrugs for Treatment of Lepra +2
Target Protein:
Dihydropteroate synthetase
Waktu Paruh3-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Sulfur chloride DB14647
small molecule | CAS: 10025-67-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfur dioxide DB16426
small molecule | CAS: 7446-09-5

Deskripsi belum tersedia.

Kategori:
Air PollutantsEnvironmental PollutantsGases +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfur hexafluoride Approved DB11104
small molecule | CAS: 2551-62-4

Sulfur hexafluoride is an ultrasound contrast agent indicated for use •in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms …

Kategori:
AnionsElectrolytesFluorides +6
Waktu ParuhThe terminal half-l…
Vol. DistribusiIn a study of healt…
Klirens-
Genetik -
Sulglicotide DB13299
small molecule | CAS: 54182-59-1

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Ulcer Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulindac Approved DB00605
small molecule | CAS: 38194-50-2

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a pro…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +20
Target Protein:
Prostaglandin G/H synthase 2Aldo-keto reductase family 1 member B1Prostaglandin G/H synthase 1 +4
Waktu ParuhThe mean half-life …
Vol. Distribusi-
Klirens* Renal cl=68.12 +/…
Genetik -
Sulisobenzone DB11185
small molecule | CAS: 4065-45-6

Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations [F38]. It works to filter out both UVA and UVB rays, protecting the skin from sun UV damage [L2153]. The UV-filter s…

Kategori:
Benzene DerivativesDrugs that are Mainly Renally ExcretedKetones +1
Target Protein:
Skin epithelial cells
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Suloctidil DB13340
small molecule | CAS: 54767-75-8

Deskripsi belum tersedia.

Kategori:
AlcoholsAminesAmino Alcohols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulodexide Approved DB06271
biotech | CAS: 57821-29-1

Sulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).

Kategori:
Agents causing hyperkalemiaAnticoagulantsBlood and Blood Forming Organs +8
Target Protein:
Heparin cofactor 2Antithrombin-III
Waktu ParuhThe elimination hal…
Vol. DistribusiCmax=516+/-77.54ng/…
Klirens2.70+/-0.58L/h
Genetik -
Sulopenem DB15284
small molecule | CAS: 120788-07-0

Sulopenem is a penem antibacterial. It is marketed as the prodrug [sulopenem etzadroxil] in combination with [probenecid].[L51768]

Kategori:
Amides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulopenem etzadroxil Approved DB16335
small molecule | CAS: 1000296-70-7

Sulopenem etzadroxil is a prodrug of the penem antibacterial [sulopenem]. Like other beta-lactam antibacterials, it is a time-dependent inhibitor of bacterial cell wall synthesis.[L51768] Sulopenem etzadroxil was approved by the FDA in October 2024 for the…

Kategori:
OAT3/SLC22A8 SubstratesPenem Antibacterial
Target Protein:
Penicillin-binding protein 2Penicillin-binding protein 1APenicillin-binding protein 1B +4
Waktu ParuhIn the fasted state…
Vol. DistribusiIn the fasted state…
KlirensIn the fasted state…
Genetik -
Sulpiride Approved DB00391
small molecule | CAS: 15676-16-1

Sulpiride first appeared in published literature in 1967.[A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses.[A229683…

Kategori:
Acids, CarbocyclicAmidesAntidepressive Agents +26
Target Protein:
D(2) dopamine receptorD(3) dopamine receptorCarbonic anhydrase 2 +2
Waktu ParuhReports of the half…
Vol. DistribusiThe average volume …
KlirensThe total systemic …
Genetik -
Sulprostone DB12708
small molecule | CAS: 60325-46-4

Sulprostone has been used in trials studying Abortion, Induced.

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAutacoids +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulthiame Approved DB08329
small molecule | CAS: 61-56-3

Deskripsi belum tersedia.

Kategori:
AmidesAnticonvulsantsBenzene Derivatives +8
Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sultopride Approved DB13273
small molecule | CAS: 53583-79-2

Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics [L5626].

Kategori:
Acids, CarbocyclicAmidesAntidepressive Agents +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sumatriptan Approved DB00669
small molecule | CAS: 103628-46-2

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines.[A179761] S…

Kategori:
Agents that produce hypertensionAmidesAmines +33
Target Protein:
5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1B +1
Gen Terkait:
GNB3
Waktu ParuhSubcutaneous sumatr…
Vol. DistribusiSumatriptan has a v…
KlirensSubcutaneous sumatr…
Genetik 1 Varian
Sunitinib Approved DB01268
small molecule | CAS: 557795-19-4

Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stroma…

Kategori:
Angiogenesis InhibitorsAngiogenesis Modulating AgentsAntineoplastic Agents +31
Target Protein:
Platelet-derived growth factor receptor betaVascular endothelial growth factor receptor 1Mast/stem cell growth factor receptor Kit +6
Gen Terkait:
CYP3A4
Waktu ParuhFollowing administr…
Vol. Distribusi* 2230 L (apparent …
Klirens* 34 - 62 L/h [Tota…
Genetik 1 Varian
Sunobinop DB18955
small molecule | CAS: 1126793-40-5

Sunobinop is under investigation in clinical trial NCT04035200 (Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sunvozertinib DB18925
small molecule | CAS: 2370013-12-8

Sunvozertinib is under investigation in clinical trial NCT03974022 (Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Supinoxin DB19010
small molecule | CAS: 888478-45-3

Supinoxin is under investigation in clinical trial NCT02003092 (RX-5902 Treatment of Subjects With Triple Negative Breast Cancer).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Probable ATP-dependent RNA helicase DDX5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Suplatast DB19138
small molecule | CAS: 94055-75-1

Suplatast is under investigation in clinical trial NCT05983471 (Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF)).

Kategori:
Anti-Allergic AgentsArylsulfonic AcidsHistamine Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Suptavumab DB12759
biotech | CAS: 1629615-23-1

Suptavumab has been used in trials studying the treatment and basic science of Respiratory Syncytial Virus Infections.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Suramin DB04786
small molecule | CAS: 145-63-1

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p164…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAnti-Infective AgentsAntinematodal Agents +12
Target Protein:
HeparanaseP2Y purinoceptor 2NAD-dependent protein deacylase sirtuin-5, mitochondrial +5
Waktu ParuhApproximately 36 to…
Vol. Distribusi-
Klirens-
Genetik -
Suratadenoturev DB18672
biotech | CAS: 1268642-13-2

Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase gene.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Surotomycin DB12076
small molecule | CAS: 1233389-51-9

Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection. It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections.…

Kategori:
Amino Acids, Peptides, and ProteinsLipidsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Surufatinib DB15106
small molecule | CAS: 1308672-74-3

Surufatinib is under investigation in clinical trial NCT02588170 (Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors).

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +4
Target Protein:
Fibroblast growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SurVaxM DB17397
biotech | CAS: 2416847-76-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Survodutide DB18989
biotech | CAS: 2805997-46-8

Survodutide is under investigation in clinical trial NCT06077864 (A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Surzebiclimab DB16669
biotech | CAS: 2342597-90-2

Surzebiclimab is under investigation in clinical trial NCT03744468 (Study of BGB-A425 in Combination With Tislelizumab in Advanced Solid Tumors).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Susoctocog alfa Approved DB11606
biotech | CAS: 1339940-90-7

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare blee…

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
von Willebrand factor
Waktu ParuhThe terminal half-l…
Vol. DistribusiFollowing intraveno…
KlirensFollowing intraveno…
Genetik -
Sutetinib DB18841
small molecule | CAS: 1259519-20-4

Sutetinib is under investigation in clinical trial NCT05168566 (Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sutezolid DB11905
small molecule | CAS: 168828-58-8

Sutezolid has been used in trials studying the treatment of Tuberculosis.

Kategori:
AcetatesAcids, AcyclicAmides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sutilain Approved DB09379
biotech | CAS: 12211-28-8

Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. Sutilain contains proteolytic enzymes derived from _Bacillus subtilis_ and it is available as a cr…

Kategori:
EndopeptidasesEnzymesEnzymes and Coenzymes +4
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Sutimlimab Approved DB14996
biotech | CAS: 2049079-64-1

Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Complement C1s subcomponent
Waktu ParuhAt the approved rec…
Vol. DistribusiAt steady-state, th…
KlirensAt the approved rec…
Genetik -
Suvecaltamide DB19139
small molecule | CAS: 953778-58-0

Suvecaltamide is under investigation in clinical trial NCT05122650 (A Study to Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)).

Waktu Paruh-
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Genetik -
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