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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
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3253 (100.0%)

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Halaman 22 / 66
Eberconazole DB13656
small molecule | CAS: 128326-82-9

Deskripsi belum tersedia.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseCycloparaffins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ebselen DB12610
small molecule | CAS: 60940-34-3

Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus.

Kategori:
Agents that produce hypertensionAnalgesicsAnalgesics, Non-Narcotic +17
Target Protein:
AlbuminLysine-specific demethylase 4ABifunctional epoxide hydrolase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EC-17 DB12559
small molecule | CAS: 583037-91-6

Folate Fitc has been used in trials studying the diagnostic of Ovarian Cancer.

Target Protein:
Folate receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Echinomycin DB15582
small molecule | CAS: 512-64-1

Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from _Streptomyces echinatus_ that binds to DNA and inhibits RNA synthesis.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Econazole Approved DB01127
small molecule | CAS: 27220-47-9

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.

Kategori:
14-alpha Demethylase InhibitorsAnti-Infective AgentsAntifungal Agents +21
Target Protein:
Lanosterol 14-alpha demethylaseNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ecopipam DB12273
small molecule | CAS: 112108-01-7

Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +7
Target Protein:
D(1A) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ecromeximab DB12797
biotech | CAS: 292819-64-8

Ecromeximab has been used in trials studying the treatment of Cutaneous Melanoma and Metastatic Melanoma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eculizumab Approved DB01257
biotech | CAS: 219685-50-4

Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246] Eculizumab w…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +14
Target Protein:
Complement C5
Waktu ParuhThe half life of ec…
Vol. DistribusiThe volume of distr…
KlirensPharmacokinetic pro…
Genetik -
Edaravone Approved DB12243
small molecule | CAS: 89-25-8

Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers.[A19140] Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophi…

Kategori:
AntioxidantsCentral Nervous System AgentsCompounds used in a research, industrial, or household setting +14
Target Protein:
Apoptosis regulator Bcl-2
Waktu ParuhThe mean terminal e…
Vol. DistribusiAfter intravenous a…
KlirensFollowing intraveno…
Genetik -
Edasalonexent DB15010
small molecule | CAS: 1204317-86-1

Edasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).

Kategori:
AmidesEicosanoidsFatty Acids +3
Target Protein:
Nuclear factor NF-kappa-B p105 subunitTranscription factor RelBNuclear factor NF-kappa-B p100 subunit +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 62-33-9

Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body.[L12774] It is on the World Health Organization Model List of Essential Medicines.[A204173] Edetate calcium disodium was granted FDA…

Kategori:
AcetatesAcids, AcyclicAmines +26
Target Protein:
LeadIronManganese cation
Waktu ParuhThe half life of ed…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
Edetic acid Approved DB00974
small molecule | CAS: 60-00-4

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Kategori:
AcetatesAcids, AcyclicAmines +19
Target Protein:
LeadIronManganese cation
Waktu ParuhThe half life of ed…
Vol. Distribusi-
Klirens-
Genetik -
EDIT-301 DB18645
biotech

EDIT-301 is an investigational cell therapy consisting of autologous CD34+ hematopoietic stem and progenitor cells edited by CRISPR/CAS12a at the gamma globin gene (HBG1 and HBG2).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Edivoxetine DB09184
small molecule | CAS: 1194508-25-2

Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment. Edivoxetine failed to be approved for maj…

Kategori:
Adrenergic Uptake InhibitorsAlcoholsAntidepressive Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Edodekin alfa DB15631
biotech | CAS: 187348-17-0

Edodekin alfa is under investigation in clinical trial NCT01468896 (Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery).

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAngiogenesis Inhibitors +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EDP1815 DB16486
biotech

EDP1815, was investigated in several clinical trials (NCT05066373, NCT05439941, NCT05682222, NCT03733353, NCT04603027, NCT04488575, NCT05121480, NCT04393246) to evaluate its safety and efficacy in conditions such as gastrointestinal behavior, atopic dermatiti…

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Edrophonium Approved DB01010
small molecule | CAS: 312-48-1

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Kategori:
AminesAntidotesCholinergic Agents +10
Target Protein:
CholinesteraseAcetylcholinesterase
Waktu ParuhDistribution half-l…
Vol. Distribusi* 1.6±0.4 L/kg [Adu…
Klirens* 6.8 +/- 2. mL/kg/…
Genetik -
Efepoetin alfa DB19197
biotech | CAS: 1905452-78-9

Efepoetin alfa is under investigation in clinical trial NCT04155125 (A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eflornithine Approved DB06243
small molecule | CAS: 70052-12-9

Eflornithine is an irreversible ornithine decarboxylase inhibitor originally developed as a treatment for human African trypanosomiasis.[A262829] Further research has also implicated ornithine decarboxylase in other conditions like facial hirsutism and cancer…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAmino AcidsAmino Acids, Basic +15
Target Protein:
Ornithine decarboxylase
Waktu ParuhThe terminal plasma…
Vol. DistribusiEflornithine volume…
KlirensThe clearance (CL/F…
Genetik -
biotech | CAS: 1644543-31-6

Efmitermant alfa, a locally-acting GDF/activin ligand trap, is under investigation in clinical trial NCT03124459 (Study of ACE-083 in Patients With Charcot-marie-tooth Disease).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Efmoroctocog alfa Approved DB11607
biotech | CAS: 1270012-79-7

Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as [DB13999][A31551]. It is an antihem…

Kategori:
HemostaticsHuman Antihemophilic Factors
Target Protein:
von Willebrand factor
Waktu ParuhFollowing a single …
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Efpeglenatide DB15650
biotech | CAS: 1296200-77-5

Efpeglenatide is under investigation in clinical trial NCT03713684 (Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Alone or in Combination With Oral Antidiabetic Drug(s)…

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +2
Target Protein:
Glucagon-like peptide 1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Efruxifermin DB19012
biotech | CAS: 2375240-92-7

Efruxifermin is under investigation in clinical trial NCT06215716 (A Study Evaluating Efruxifermin in Subjects With Non-cirrhotic Nonalcoholic Steatohepatitis (Nash)/metabolic Dysfunction-associated Steatohepatitis (MASH) and Fibrosis).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eftrenonacog alfa Approved DB11608
biotech | CAS: 1270012-74-2

Eftrenonacog alfa is a long-acting recombinant fusion protein used in the treatment of hemophilia B. It is comprised of a single molecule of human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 via recombinant DNA technolog…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +15
Target Protein:
IgG receptor FcRn large subunit p51
Waktu ParuhFollowing administr…
Vol. DistribusiFollowing administr…
KlirensFollowing administr…
Genetik -
EGEN-001 DB05953
small molecule

EGEN-001 is a novel non-viral vector consisting of a plasmid DNA encoding the human gene for interleukin 12 (IL-12) and a biocompatible, biodegradable delivery polymer with potential antineoplastic activity.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCytokines +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elacridar DB04881
small molecule | CAS: 143664-11-3

Elacridar (GW120918) is an oral bioenhancer that targets multiple drug resistance in tumors. In many cases, the appearance of multidrug resistance in cancer is due to a change in expression of protein inhibitors. As of August 2007 elacridar was not listed on …

Kategori:
BCRP/ABCG2 InhibitorsBenzocycloheptenesDrug Resistance, Multiple +3
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elapegademase Approved DB14712
biotech | CAS: 1709806-75-6

Elapegademase is a PEGylated recombinant adenosine deaminase. It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbo…

Kategori:
Adenosine Deaminase InhibitorsAdjuvants, ImmunologicAmino Acids, Peptides, and Proteins +12
Target Protein:
Adenosine
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Elbasvir Approved DB11574
small molecule | CAS: 1370468-36-2

Elbasvir is a direct-acting antiviral medication used as part of combination therapy to treat chronic hepatitis C, an infectious liver disease caused by infection with hepatitis C virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine d…

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +18
Target Protein:
Nonstructural protein 5A
Waktu ParuhThe geometric mean …
Vol. DistribusiElbasvir has an est…
KlirensThe clearance of el…
Genetik -
Eldecalcitol DB05295
small molecule | CAS: 104121-92-8

Eldecalcitol (ED-71), a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis. Eldecalcitol, effectively and safely increased lumbar and hip bone mineral density (BMD) in osteopor…

Kategori:
Bone Density Conservation AgentsFused-Ring CompoundsSecosteroids +4
Target Protein:
Vitamin D3 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eleclazine DB12394
small molecule | CAS: 1443211-72-0

Eleclazine has been used in trials studying the treatment of LQT2 Syndrome, Long QT Syndrome, Ischemic Heart Disease, Ventricular Arrhythmia, and Long QT Syndrome Type 3, among others.

Kategori:
Azepines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elexacaftor Approved DB15444
small molecule | CAS: 2216712-66-0

Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.[A187361] It received FDA approval in October 2019 in combination with [tezacaftor] and [ivacaftor] as the…

Kategori:
Cystic Fibrosis Transmembrane Conductance Regulator CorrectorsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +24
Target Protein:
Cystic fibrosis transmembrane conductance regulator
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe apparent volume…
KlirensThe mean apparent c…
Genetik -
Elezanumab DB15240
biotech | CAS: 1791416-49-3

Elezanumab is under investigation in clinical trial NCT03737812 (A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elgemtumab DB15430
biotech | CAS: 1512559-37-3

Elgemtumab is under investigation in clinical trial NCT02167854 (Open-Label Study Evaluating the Safety and Tolerability of LJM716, BYL719 and Trastuzumab in Patients With Metastatic HER2+ Breast Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elimusertib DB19041
small molecule | CAS: 1876467-74-1

Elimusertib is under investigation in clinical trial NCT05071209 (Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors).

Target Protein:
Serine/threonine-protein kinase ATR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elinogrel DB06350
small molecule | CAS: 936500-94-6

A P2Y12 inhibitor and platelet aggregation inhibitor.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingQuinazolines +2
Target Protein:
P2Y purinoceptor 12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eliprodil DB12869
small molecule | CAS: 119431-25-3

Eliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.

Kategori:
Central Nervous System AgentsCompounds used in a research, industrial, or household settingExcitatory Amino Acid Agents +5
Target Protein:
Glutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elobixibat DB12486
small molecule | CAS: 439087-18-0

Elobixibat has been used in trials studying the treatment and basic science of Dyslipidemia, Constipation, Chronic Constipation, Functional Constipation, and Chronic Idiopathic Constipation.

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAzepines +5
Target Protein:
Ileal sodium/bile acid cotransporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elsamitrucin DB05129
small molecule | CAS: 97068-30-9

The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and human origin. (PMID: 8150873)

Kategori:
Antibiotics, AntineoplasticAntineoplastic AgentsCarbohydrates +1
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-betaDNA +1
Waktu Paruh36–60 h
Vol. Distribusi-
Klirens-
Genetik -
Eltanolone DB12308
small molecule | CAS: 128-20-1

Eltanolone is under investigation in clinical trial NCT02603926 (Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone).

Kategori:
AnestheticsCentral Nervous System AgentsCentral Nervous System Depressants +3
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eltoprazine DB12883
small molecule | CAS: 98224-03-4

Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +6
Target Protein:
5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eltrombopag Approved DB06210
small molecule | CAS: 496775-61-2

Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bru…

Kategori:
Acids, CarbocyclicBCRP/ABCG2 InhibitorsBenzene Derivatives +25
Target Protein:
Thrombopoietin receptor
Gen Terkait:
F5 SERPINC1
Waktu ParuhAbout 21-32 hours i…
Vol. DistribusiBased on a radiolab…
Klirens-
Genetik 2 Varian
Elubrixin DB12135
small molecule | CAS: 688763-64-6

Elubrixin has been used in trials studying the treatment of Cystic Fibrosis, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesBenzene DerivativesReceptors, Interleukin-8B, antagonists & inhibitors +2
Target Protein:
C-X-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Elvitegravir Approved DB09101
small molecule | CAS: 697761-98-1

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibitio…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +22
Target Protein:
IntegraseGag-Pol polyprotein
Waktu ParuhThe median terminal…
Vol. Distribusi-
Klirens-
Genetik -
Elzovantinib DB18918
small molecule | CAS: 2271119-26-5

Elzovantinib is under investigation in clinical trial NCT03993873 (Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emapunil DB12666
small molecule | CAS: 226954-04-7

Emapunil has been used in trials studying the basic science and diagnostic of Baseline, Blocking Receptor Binding, and Neurodegenerative Disorders.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Translocator protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EMD-1201081 DB06181
biotech | CAS: 847484-35-9

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsNucleic Acids, Nucleotides, and NucleosidesNucleotides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emeramide DB12192
small molecule | CAS: 351994-94-0

Emeramide has been used in trials studying the treatment of Mercury Poisoning.

Kategori:
Chelating AgentsCompounds used in a research, industrial, or household settingSequestering Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emicerfont DB12910
small molecule | CAS: 786701-13-1

Emicerfont has been used in trials studying the diagnostic and treatment of Social Anxiety Disorder and Irritable Bowel Syndrome (IBS).

Kategori:
Corticotropin-Releasing Hormone, antagonists & inhibitors
Target Protein:
Corticotropin-releasing factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emicizumab Approved DB13923
biotech | CAS: 1610943-06-0

Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three differen…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Coagulation factor IXCoagulation factor X
Waktu ParuhEmcicizumab present…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Emixustat DB12608
small molecule | CAS: 1141777-14-1

Emixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration.

Kategori:
AlcoholsAminesAmino Alcohols +4
Target Protein:
Retinoid isomerohydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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