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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 218 / 349
Methaqualone DB04833
small molecule | CAS: 72-44-6

Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in …

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Substrates +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Metharbital DB00463
small molecule | CAS: 50-11-3

Metharbital is a barbiturate anticonvulsant, similar to phenobarbital, marketed as Gemonil by Abbott Laboratories. It was patented in 1905 by Emil Fischer of Merck.

Kategori:
Anticholinergic AgentsAnticonvulsantsBarbiturates and Derivatives +5
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-3 +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methazolamide Approved DB00703
small molecule | CAS: 554-57-4

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Kategori:
Antiglaucoma Preparations and MioticsCarbonic Anhydrase InhibitorsCardiovascular Agents +15
Target Protein:
Carbonic anhydrase 1Carbonic anhydrase 4Carbonic anhydrase 2 +2
Waktu Paruh14 hours
Vol. Distribusi* 17 to 23 L
Klirens-
Genetik -
Methcathinone DB15339
small molecule | CAS: 5650-44-2

Methcathinone is under investigation in clinical trial NCT02617862 (PCI Imaging System in Pediatric Ophthalmology).

Kategori:
Ketones
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methdilazine Approved DB00902
small molecule | CAS: 1982-37-2

Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.

Kategori:
Agents that reduce seizure thresholdAntihistamines for Systemic UseHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methenamine Approved DB06799
small molecule | CAS: 100-97-0

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).

Kategori:
Acids, CarbocyclicAmidesAmines +14
Waktu ParuhElimination half-li…
Vol. Distribusi-
Klirens70-90% of a single…
Genetik -
Methfuroxam DB16231
small molecule | CAS: 28730-17-8

Methfuroxam is under investigation in clinical trial NCT01213407 (Dendritic Cell Cancer Vaccine for High-grade Glioma).

Kategori:
AmidesAminesAniline Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactam-inducible penicillin-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 26403-67-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methimazole Approved DB00763
small molecule | CAS: 60-56-0

Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now commonly used in the management of hyperthyroidism, particularl…

Kategori:
Antithyroid agentsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +30
Target Protein:
Thyroid peroxidase
Waktu ParuhFollowing a single …
Vol. DistribusiThe apparent volume…
KlirensFollowing a single …
Genetik -
Methiodal DB13321
small molecule | CAS: 143-47-5

Deskripsi belum tersedia.

Kategori:
AlkanesAlkanesulfonatesAlkanesulfonic Acids +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methionine Approved DB00134
small molecule | CAS: 63-68-3

A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.

Kategori:
Amino AcidsAmino Acids, EssentialAmino Acids, Neutral +7
Target Protein:
Methionine synthase reductaseMethionine synthaseMethionine aminopeptidase 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methionine C-11 DB17147
small molecule | CAS: 60305-58-0

Deskripsi belum tersedia.

Kategori:
Diagnostic RadiopharmaceuticalsTumour Detection
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Methionine--tRNA ligaseMethionine aminopeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Methionine--tRNA ligaseMethionine aminopeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15985-39-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, Sulfur +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 21752-32-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methocarbamol Approved DB00423
small molecule | CAS: 532-03-6

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether.[A178450] Methocarbamol tablets and intramuscular injections are prescription medicines indicated …

Kategori:
Acids, AcyclicBenzene DerivativesCarbamates +14
Target Protein:
Carbonic anhydrase 1
Waktu ParuhThe elimination hal…
Vol. DistribusiVolume of distribut…
Klirens0.2-0.8L/h/kg.[L626…
Genetik -
Methohexital Approved DB00474
small molecule | CAS: 151-83-7

An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Kategori:
AnestheticsAnesthetics, GeneralAnesthetics, Intravenous +10
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1
Waktu Paruh5.6 ± 2.7 mi…
Vol. Distribusi-
Klirens-
Genetik -
Methopterin DB16620
small molecule | CAS: 2410-93-7

Methopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction.[A229843]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methoserpidine DB13631
small molecule | CAS: 865-04-3

Deskripsi belum tersedia.

Kategori:
Antiadrenergic Agents, Centrally ActingAntihypertensive AgentsSecologanin Tryptamine Alkaloids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methotrexate Approved DB00563
small molecule | CAS: 59-05-2

Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis.[A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division.[A180322] Because of these effects, methotrexate is of…

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAgents Causing Muscle Toxicity +42
Target Protein:
Thymidylate synthaseReduced folate transporterProton-coupled folate transporter +2
Gen Terkait:
ABCC2 MTHFR
Waktu ParuhThe half life of lo…
Vol. DistribusiThe volume of distr…
KlirensMethotrexate cleara…
Genetik 2 Varian
Methotrimeprazine Approved DB01403
small molecule | CAS: 60-99-1

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Mart…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +46
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorD(1B) dopamine receptor +16
Waktu ParuhApproximately 20 ho…
Vol. Distribusi-
Klirens-
Genetik -
Methoxamine Approved DB00723
small molecule | CAS: 390-28-3

An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +19
Target Protein:
Alpha-1A adrenergic receptorAlpha-1D adrenergic receptorAlpha-1B adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methoxsalen Approved DB00553
small molecule | CAS: 298-81-7

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.

Kategori:
AntipsoriaticsAntipsoriatics for Systemic UseAntipsoriatics for Topical Use +24
Target Protein:
DNACytochrome P450 2A6
Waktu ParuhApproximately 2 hou…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 180509-15-3

Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with specia…

Kategori:
EicosanoidsEnzyme InhibitorsFatty Acids +5
Target Protein:
Fatty-acid amide hydrolase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Pegylated agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 677324-53-7

Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin. ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia.

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsAntianemic Preparations +20
Target Protein:
Erythropoietin receptor
Waktu ParuhIn CKD patients on …
Vol. Distribusi~94.74 ml/kg
KlirensIn CKD patients on …
Genetik -
Methoxyamine DB06328
small molecule | CAS: 67-62-9

Deskripsi belum tersedia.

Kategori:
Amines
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methoxyflurane Approved DB01028
small molecule | CAS: 76-38-0

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agen…

Kategori:
Agents that produce hypertensionAnalgesicsAnesthetics +18
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Glutamate receptor 1Glycine receptor subunit alpha-1 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methoxyphenamine Approved DB13624
small molecule | CAS: 93-30-1

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-Agonists +12
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Pancreatic triacylglycerol lipaseColipase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methscopolamine Approved DB11315
small molecule | CAS: 13265-10-6

Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunc…

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAlkaloids +16
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methscopolamine bromide Approved DB00462
small molecule | CAS: 155-41-9

A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.

Kategori:
Agents producing tachycardiaAlkaloidsAnticholinergic Agents +8
Target Protein:
Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methsuximide Approved DB05246
small molecule | CAS: 77-41-8

Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.

Kategori:
Agents causing hyperkalemiaAnti-epileptic AgentAntiarrhythmic agents +18
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1G
Waktu Paruh1.4-2.6 hours for m…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 135-07-9

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)

Kategori:
BenzothiadiazinesDiureticsDrugs causing inadvertant photosensitivity +12
Target Protein:
Solute carrier family 12 member 1Carbonic anhydrase 1Carbonic anhydrase 2 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Disintegrin and metalloproteinase domain-containing protein 17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 193744-04-6

This solid compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl group…

Target Protein:
Interleukin-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cytochrome c1, heme protein, mitochondrialCytochrome bCytochrome b-c1 complex subunit 1, mitochondrial +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Polyhydroxybutyrate depolymerase, putative
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Caspase-3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Putative dehydrogenase/reductase SDR family member 4-like 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Putative dehydrogenase/reductase SDR family member 4-like 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63177-57-1

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAntineoplastic AgentsCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Heat shock protein HSP 90-betaEndoplasmin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serum amyloid P-component
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lactoylglutathione lyase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Histone deacetylase-like amidohydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 10851–10900 dari 17430
Sebelumnya Halaman 218 / 349 Berikutnya