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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 216 / 349
Menaquinone 7 DB13075
small molecule | CAS: 2124-57-4

Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).

Kategori:
CoagulantsDiterpenesHematologic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menatetrenone DB12148
small molecule | CAS: 863-61-6

Menatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.

Kategori:
CoagulantsDiterpenesDrugs Affecting Bone Structure and Mineralization +12
Target Protein:
Cruzipain
Waktu Paruh-
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Menglytate DB15983
small molecule | CAS: 579-94-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine is used to prevent invasive meningococcal disease, which is caused by bacteria _Neisseria meningitidis_ entering the bloodstream and invading the blood-brain barrier …

Kategori:
Diphtheria VaccinesMeningococcal VaccinesVaccines
Waktu Paruh-
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Genetik -
biotech

Meningococcal group A polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup A. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia…

Kategori:
Actively Acquired ImmunityAntigensAntigens, Bacterial +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup C. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia…

Kategori:
Actively Acquired ImmunityAntigensAntigens, Bacterial +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal group W-135 polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup W-135. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningo…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
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Genetik -
biotech

Meningococcal group Y polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup Y. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
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Genetik -
Menotropins Approved DB00032
biotech | CAS: 9002-68-0

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 …

Kategori:
Amino Acids, Peptides, and ProteinsBiological ProductsComplex Mixtures +14
Target Protein:
Follicle-stimulating hormone receptorLutropin-choriogonadotropic hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Genetik -
biotech

Mentha arvensis top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Menthol Approved DB14123
small molecule | CAS: 1490-04-6

Deskripsi belum tersedia.

Kategori:
AlcoholsAntipruriticsCyclohexane Monoterpenes +9
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menthone DB15920
small molecule | CAS: 89-80-5

Deskripsi belum tersedia.

Kategori:
AlcoholsCyclohexane MonoterpenesCyclohexanes +7
Waktu Paruh-
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Menthyl salicylate Approved DB11201
small molecule | CAS: 89-46-3

Menthyl salicylate is an ester of menthol and salicylic acid [L2808]. This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) [L2810].

Kategori:
Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-Steroidal
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
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Mepartricin DB13633
small molecule | CAS: 11121-32-7

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAlkenesAnti-Bacterial Agents +19
Waktu Paruh-
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Genetik -
Mepenzolate Approved DB04843
small molecule | CAS: 25990-43-6

Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous …

Kategori:
Acids, CarbocyclicAgents producing tachycardiaAlimentary Tract and Metabolism +7
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meperidine Approved DB00454
small molecule | CAS: 57-42-1

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with mor…

Kategori:
AdjuvantsAdjuvants, AnesthesiaAgents that reduce seizure threshold +34
Target Protein:
Kappa-type opioid receptorGlutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2B +9
Waktu ParuhInitial distributio…
Vol. DistribusiMeperidine crosses …
Klirens-
Genetik -
Mephedrone DB13108
small molecule | CAS: 1189805-46-6

Mephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders.

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAmines +7
Waktu Paruh-
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Mephenesin Approved DB13583
small molecule | CAS: 59-47-2

Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression [A32760]. It first entered use in the 1950s.

Kategori:
AlcoholsCentral Nervous System AgentsCentral Nervous System Depressants +7
Waktu Paruh-
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Genetik -
small molecule | CAS: 533-06-2

Deskripsi belum tersedia.

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Mephenoxalone DB13754
small molecule | CAS: 70-07-5

Deskripsi belum tersedia.

Kategori:
Anti-Anxiety AgentsCentral Nervous System DepressantsMuscle Relaxants +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mephentermine Approved DB01365
small molecule | CAS: 100-92-5

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than tho…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +17
Target Protein:
Alpha adrenergic receptorD(2) dopamine receptorBeta adrenergic receptor
Waktu Paruh17 to 18 hours.
Vol. Distribusi-
Klirens-
Genetik -
Mephenytoin Approved DB00532
small molecule | CAS: 50-12-4

Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephen…

Kategori:
Anti-epileptic AgentAnticonvulsantsCentral Nervous System Agents +17
Target Protein:
Sodium channel protein type 5 subunit alphaNuclear receptor subfamily 1 group I member 2
Gen Terkait:
CYP2C19 CYP2C19 CYP2C19
Waktu ParuhApproximately 7 hou…
Vol. Distribusi* 1.4 L/kg
Klirens-
Genetik 3 Varian
Mepindolol DB13530
small molecule | CAS: 23694-81-7

Mepindolol is a 2-methyl derivative of pindolol. It is a beta blocker.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +12
Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Mepiprazole DB09197
small molecule | CAS: 20326-12-9

Mepiprazole is a minor tranquilizer with a phenylpiperazine structure. It is a pyrazolyl-alkyl-piperazine derivative. Mepiprazole mediates a weak inhibitory action on the uptake of 5-HT on hypothalamic neurons [A7816]. Mepiprazole is marketed in Spain for th…

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Mepivacaine Approved DB00961
small molecule | CAS: 96-88-8

A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be…

Kategori:
AmidesAnestheticsAnesthetics, Local +10
Target Protein:
Sodium channel protein type 10 subunit alpha
Waktu ParuhThe half-life of me…
Vol. Distribusi-
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Genetik -
Mepixanox DB13579
small molecule | CAS: 17854-59-0

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingRespiratory System AgentsXanthenes
Waktu Paruh-
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Meplazumab DB16465
biotech

Meplazumab is a humanized anti-CD147 antibody being investigated as an add-on therapy in patients with COVID-19 pneumonia.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +9
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Mepolizumab Approved DB06612
biotech | CAS: 196078-29-2

Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granul…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Interleukin-5
Waktu ParuhMepolizumab has a m…
Vol. DistribusiMepolizumab has a p…
KlirensMepolizumab has an …
Genetik -
MePPEP C-11 DB19280
small molecule | CAS: 1022083-25-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Meprednisone Approved DB09383
small molecule | CAS: 1247-42-3

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids for Systemic Use +20
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1106-03-2

Deskripsi belum tersedia.

Waktu Paruh-
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Meprobamate Approved DB00371
small molecule | CAS: 57-53-4

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions aga…

Kategori:
Acids, AcyclicAnti-Anxiety AgentsCarbamates +10
Target Protein:
Peptide deformylase, mitochondrialProtein kinase C epsilon typeGABA(A) Receptor +6
Waktu ParuhPlasma half-life is…
Vol. Distribusi-
Klirens-
Genetik -
Meprotixol DB13822
small molecule | CAS: 4295-63-0

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
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Meptazinol DB13478
small molecule | CAS: 54340-58-8

Deskripsi belum tersedia.

Kategori:
AnalgesicsAzepinesCentral Nervous System Agents +10
Target Protein:
Cholinesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mepyramine Approved DB06691
small molecule | CAS: 91-84-9

Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menst…

Kategori:
AminesAminopyridinesAnti-Allergic Agents +19
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mequinol Approved DB09516
small molecule | CAS: 150-76-5

Mequinol is a phenol used in various applications. It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture…

Kategori:
AntioxidantsBenzene DerivativesBiological Factors +11
Waktu ParuhMequinol demonstrat…
Vol. DistribusiThe volume of distr…
KlirensReadily accessible …
Genetik -
Mequitazine DB01071
small molecule | CAS: 29216-28-2

Mequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, wa…

Kategori:
Anti-Allergic AgentsAntihistamines for Systemic UseBronchodilator Agents +15
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meradimate Approved DB11096
small molecule | CAS: 134-09-8

Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter.[T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and H…

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +2
Waktu ParuhAs meradimate is no…
Vol. DistribusiAs meradimate is no…
KlirensAs meradimate is no…
Genetik -
Merbromin DB13392
small molecule | CAS: 129-16-8

Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, except Switzerland, France, Germany, and the United States …

Kategori:
Antiseptics and DisinfectantsDermatologicalsFluoresceins +6
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactamase IMP-1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Mercaptoethanol DB03345
small molecule | CAS: 60-24-2

Deskripsi belum tersedia.

Kategori:
AlcoholsSulfhydryl CompoundsSulfur Compounds
Target Protein:
Lactoylglutathione lyaseFibroblast growth factor 2M-phase inducer phosphatase 2 +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Alkaline phosphatase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Mercaptopurine Approved DB01033
small molecule | CAS: 50-44-2

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs …

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +20
Target Protein:
Hypoxanthine-guanine phosphoribosyltransferaseInosine-5'-monophosphate dehydrogenase 1Amidophosphoribosyltransferase +1
Gen Terkait:
TPMT TPMT TPMT
Waktu ParuhTriphasic: 45 minut…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik 3 Varian
small molecule

Deskripsi belum tersedia.

Target Protein:
Carbonic anhydrase 2Divalent-cation tolerance protein CutA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10124-48-8

Deskripsi belum tersedia.

Kategori:
Antiseptics and DisinfectantsChloridesChlorine Compounds +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7487-94-7

Mercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant. Mercuric chloride was used to disinfec…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiseptics and Disinfectants +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mercuric iodide DB04445
small molecule | CAS: 7774-29-0

Deskripsi belum tersedia.

Kategori:
AnionsAntiseptics and DisinfectantsDermatologicals +4
Target Protein:
Sulfotransferase 2A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Merestinib DB12381
small molecule | CAS: 1206799-15-6

Merestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.

Kategori:
Antineoplastic AgentsHeterocyclic Compounds, Fused-RingNicotinic Acids +3
Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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