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11778

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8554 (72.6%)
Target
6383 (54.2%)
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96 (0.8%)
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11778 (100.0%)

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Halaman 215 / 236
Tesofensine DB06156
small molecule | CAS: 195875-84-4

Deskripsi belum tersedia.

Kategori:
Biogenic Monoamines, antagonists & inhibitors
Target Protein:
Insulin receptorSodium-dependent serotonin transporterSodium-dependent noradrenaline transporter +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Testolactone Approved DB00894
small molecule | CAS: 968-93-4

An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.

Kategori:
AndrostadienesAndrostanesAndrostenes +7
Target Protein:
Aromatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Testosterone Approved DB00624
small molecule | CAS: 58-22-0

Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and dev…

Kategori:
3-Oxoandrosten (4) DerivativesAnabolic SteroidsAndrogens +33
Target Protein:
Androgen receptorEstrogen receptorMineralocorticoid receptor
Waktu ParuhThe half life of te…
Vol. DistribusiThe volume of distr…
KlirensThe mean metabolic …
Genetik -
Testosterone cypionate Approved DB13943
small molecule | CAS: 58-20-8

Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It w…

Kategori:
Anabolic AgentsAndrogensAndrostanes +33
Target Protein:
Androgen receptorEstrogen receptorMineralocorticoid receptor
Waktu ParuhThe half-life of te…
Vol. DistribusiThe volume of distr…
KlirensTestosterone cypion…
Genetik -
small molecule | CAS: 5721-91-5

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18625-33-7

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Testosterone enanthate Approved DB13944
small molecule | CAS: 315-37-7

Testosterone enanthate is an esterified variant of testosterone that comes as an injectable compound with a slow-release rate. This slow release is achieved by the presence of the enanthate ester functional group attached to the testosterone molecule.[A31615…

Kategori:
Adrenal Cortex HormonesAndrogensAndrostanes +34
Target Protein:
Androgen receptorEstrogen receptorMineralocorticoid receptor
Waktu ParuhTestosterone enanth…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Testosterone propionate Approved DB01420
small molecule | CAS: 57-85-2

Testosterone propionate is a slower-releasing anabolic steroid with a short half-life. It is a synthetic androstane steroid derivative of testosterone in the form of 17? propionate ester of testosterone.[T83] Testosterone propionate was developed initially by…

Kategori:
AndrogensAndrostanesAndrostenes +17
Target Protein:
Androgen receptor
Waktu ParuhTestosterone propio…
Vol. DistribusiThe registered volu…
KlirensTestosterone propio…
Genetik -
small molecule | CAS: 521-15-3

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +9
Target Protein:
Neocarzinostatin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Testosterone undecanoate Approved DB13946
small molecule | CAS: 5949-44-0

Testosterone undecanoate is the ester prodrug of [testosterone] and has a mid-chain fatty acid at the carbon 17? position.[L35970] It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone.[A246594] Ther…

Kategori:
AndrogensAndrostanesAndrostenes +32
Target Protein:
Androgen receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThere is no informa…
KlirensWhile there is limi…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetomilast DB05298
small molecule | CAS: 145739-56-6

Tetomilast has been used in trials studying the treatment of Crohn Disease, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease.

Kategori:
Sulfur Compounds
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4D
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 12279-90-2

Tetraarsenic tetrasulfide is under investigation in clinical trial NCT05682131 (South China Children Cancer Group - Relapsed-acute Lymphoblastic Leukemia 2022 Protocol).

Kategori:
AnionsElectrolytesHydrogen Sulfide +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrabenazine Approved DB04844
small molecule | CAS: 58-46-8

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August…

Kategori:
Adrenergic AgentsCytochrome P-450 CYP2D6 SubstratesCytochrome P-450 Substrates +11
Target Protein:
Synaptic vesicular amine transporterD(2) dopamine receptor
Waktu ParuhThere is interindiv…
Vol. DistribusiSteady State, IV, i…
KlirensIV, 1.67 L/min in H…
Genetik -
Tetrachlorodecaoxide Approved DB05389
small molecule | CAS: 92047-76-2

WF10 is a chlorite-based, immunomodulating drug is developed by Nuvo Research Inc. Certain preclinical evidence and clinical pilot data suggest that WF10 may be effective in treating certain cancers. The Corporation believes the research to-date demonstrates …

Kategori:
AnionsCompounds used in a research, industrial, or household settingElectrolytes +7
Target Protein:
E3 ubiquitin-protein transferase MAEAScavenger receptor cysteine-rich type 1 protein M130
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetracycline Approved DB00759
small molecule | CAS: 60-54-8

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from b…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +32
Target Protein:
30S ribosomal protein S730S ribosomal protein S1430S ribosomal protein S3 +6
Waktu Paruh6-12 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 300-52-7

Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins [L2031]. Sodium tetradecyl…

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Endothelial protein C receptor
Waktu Paruh-
Vol. DistribusiIn humans, a large …
Klirens-
Genetik -
small molecule | CAS: 66-40-0

Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental age…

Kategori:
AminesCardiovascular AgentsGanglion Blockers +9
Target Protein:
Potassium voltage-gated channel subfamily KQT member 3Potassium channel subfamily T member 2Potassium channel subfamily T member 1 +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 14874-70-5

Tetrafluoroborate is under investigation in clinical trial NCT02907073 (Positron Emission Tomography (PET) Imaging Studies With NIS Reporter).

Kategori:
AnionsBoric AcidsBoron Compounds +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 31262-37-0

Tetrahydrocannabivarin (THCV) is a propyl analogue of tetrahydrocannabinol (?9-THC), one of the primary pharmacological components of [Medical Cannabis]. ?9-THC is currently available in several synthetic forms, including [Dronabinol], while purified or isola…

Kategori:
Agents that produce hypertensionAntidepressive AgentsCentral Nervous System Depressants +3
Target Protein:
Transient receptor potential cation channel subfamily V member 3Cannabinoid receptor 1G-protein coupled receptor 55 +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 135-16-0

Tetrahydrofolic acid is a folic acid derivative that is produced from dihydrofolic acid after conversion by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a soluble coenzyme in many react…

Kategori:
CoenzymesDietary SupplementsEnzymes and Coenzymes +7
Target Protein:
C-1-tetrahydrofolate synthase, cytoplasmicBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialAminomethyltransferase, mitochondrial +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 618903-56-3

Deskripsi belum tersedia.

Kategori:
Anabolic AgentsAndrogensFused-Ring Compounds +6
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 483-14-7

Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).

Kategori:
Adrenergic AgentsAgents causing hyperkalemiaAlkaloids +29
Target Protein:
D(1A) dopamine receptorD(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrahydropyran DB02412
small molecule | CAS: 142-68-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18771-50-1

Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.

Kategori:
AntimetabolitesNoxaeNucleic Acids, Nucleotides, and Nucleosides +5
Target Protein:
Cytidine deaminase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 67-30-1

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 103694-84-4

Tetrakis (2-methoxyisobutylisocyanide) copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for assessing myocardial perfusion.[L12744]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetramethrin DB13752
small molecule | CAS: 7696-12-0

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsCompounds used in a research, industrial, or household setting +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 97-74-5

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicCarbamatesCell-mediated Immunity +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrasul DB12838
small molecule | CAS: 2227-13-6

Tetrasul has been used in trials studying the treatment of Erythematous (Type One) Rosacea.

Kategori:
Benzene DerivativesHydrocarbons, ChlorinatedHydrocarbons, Halogenated
Target Protein:
Alpha-2C adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrazepam DB13324
small molecule | CAS: 10379-14-3

Deskripsi belum tersedia.

Kategori:
BenzazepinesCentral Nervous System AgentsCentral Nervous System Depressants +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrofosmin Approved DB11180
small molecule | CAS: 127502-06-1

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofos…

Kategori:
Radioactive Diagnostic Agent
Waktu ParuhRefer to [DB09160]
Vol. DistribusiThis pharmacokineti…
KlirensRefer to [DB09160]
Genetik -
Tetroxoprim DB15976
small molecule | CAS: 53808-87-0

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetryzoline Approved DB06764
small molecule | CAS: 84-22-0

Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (?)-adrenergic properties.[A231769] Available since the 1950s, tetryzoline is a selective ?<sub>1</sub>-receptor agonist [A231774] that is used as a…

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-Agonists +20
Target Protein:
Alpha-1 adrenergic receptorsAlpha-2C adrenergic receptorAlpha-2 adrenergic receptors
Waktu ParuhFollowing ocular ad…
Vol. DistribusiNo information is a…
KlirensNo information is a…
Genetik -
small molecule

Betalutin has been used in trials studying the treatment of Non-Hodgkin Lymphoma and Relapsed, Diffuse Large B-cell Lymphoma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Teverelix DB05624
small molecule | CAS: 151272-78-5

A synthetic decapeptide, water-soluble Gonadotropin-releasing hormone antagonist. It has reached phase II clinical trials.

Kategori:
Amino Acids, Peptides, and ProteinsHormone AntagonistsHormones, Hormone Substitutes, and Hormone Antagonists +1
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tezacaftor Approved DB11712
small molecule | CAS: 1152311-62-0

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class.[L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to manage cystic fibrosis.[L6814] This drug was approv…

Kategori:
BCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesCytochrome P-450 CYP1A2 Inhibitors +33
Target Protein:
Cystic fibrosis transmembrane conductance regulator
Waktu ParuhThe apparent half-l…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Tezacitabine DB06433
small molecule | CAS: 171176-43-5

A synthetic purine nucleoside analogue with potential antineoplastic activity.

Kategori:
Antineoplastic AgentsDeoxyribonucleosidesEnzyme Inhibitors +6
Target Protein:
Ribonucleoside-diphosphate reductase subunit M2Ribonucleoside-diphosphate reductase large subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tezepelumab Approved DB15090
biotech | CAS: 1572943-04-4

Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate ple…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Target Protein:
Thymic stromal lymphopoietin
Waktu ParuhTezepelumab has an …
Vol. DistribusiTezepelumab has a c…
KlirensTezepelumab has an …
Genetik -
Tezosentan DB06558
small molecule | CAS: 180384-57-0

Tezosentan is an intravenous endothelin receptor A/B antagonist. Tezosentan was initially developed for vasodilation in patients with acute heart failure but studies have shown that it does not assist in the treatment of dyspnea or prevent cardiovascular even…

Kategori:
Cardiovascular AgentsReceptors, EndothelinVasodilating Agents
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhA pronounced and ra…
Vol. Distribusi-
Klirens-
Genetik -
TG-100801 DB05075
small molecule | CAS: 867331-82-6

TG100801 is a topically applied kinase inhibitor in macular degeneration patients. It is administered noninvasively as an eye drop and is designed to suppress VEGF mediated leakage and additional kinase targets associated with inflammation, edema, and angioge…

Kategori:
Benzene Derivatives
Target Protein:
Vascular endothelial growth factor CVascular endothelial growth factor DVascular endothelial growth factor A, long form +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TG01 vaccine DB17123
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TG100-115 DB05552
small molecule | CAS: 677297-51-7

An NSAID that inhibits PI-3K gamma and delta.

Kategori:
Benzene DerivativesHeterocyclic Compounds, Fused-RingPhosphatidylinositol 3-Kinases, antagonists & inhibitors
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TG4010 DB06584
biotech | CAS: 350485-85-7

A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. Originally developed for the eradication of smallpox, M…

Kategori:
Amino Acids, Peptides, and ProteinsBiological ProductsCarbohydrates +6
Target Protein:
Mucin-1Interleukin-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TGAAC09 DB06363
biotech

tgAAC09 is an investigational vaccine that utilizes an AAV vector to deliver genes that encode HIV proteins. It was under investigation in clinical trials NCT00482027 and NCT00888446 for the treatment of HIV Infection.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TGAAC94 DB06175
small molecule

tgAAC94 is a recombinant adeno-associated virus serotype 2 (AAV2) vector containing the cDNA for a human tumor necrosis factor receptor (TNFR)-immunoglobulin (IgG1) Fc fusion (TNFR:Fc) gene. It was under investigation in clinical trials to treat Inflammatory …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
tgAAG-76 DB18421
biotech

tgAAG-76 consists of a recombinant adeno-associated virus (serotype 2) (rAAV2) gene transfer agent expressing RPE65.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
tgAAVCF DB17849
biotech

tgAAVCF is an adeno-associated virus (AAV) vector encoding the human cystic fibrosis transmembrane conductance regulator protein (CFTR) cDNA. It is being investigated for the treatment of cystic fibrosis.[A259821, A259826]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1373958-68-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingXanthenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thalagen DB17714
biotech

Thalagen is a branded product developed by San Rocco Therapeutics. It consists of autologous CD34-positive hematopoietic progenitor cells transduced with TNS9.3.55, a lentiviral vector encoding the normal human beta-globin gene. It is being investigated for t…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Menampilkan 10701–10750 dari 11778
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