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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
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12560 (100.0%)

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Halaman 215 / 252
Semzuvolimab DB18920
biotech | CAS: 2409099-32-5

Semzuvolimab is under investigation in clinical trial NCT03149211 (To Investigate the Efficacy and Safety of UB-421 Monotherapy in HIV-1 Infected Adults).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAnti-Retroviral Agents +9
Waktu Paruh-
Vol. Distribusi-
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Senaparib DB17163
small molecule | CAS: 1401682-78-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Senicapoc DB06280
small molecule | CAS: 289656-45-7

Senicapoc (ICA-17043) is a novel Gardos channel blocker.[A259068] It is being investigated for the treatment of sickle cell disease.

Kategori:
AcetatesAcids, AcyclicAmides +1
Target Protein:
Intermediate conductance calcium-activated potassium channel protein 4
Waktu Paruh-
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Senlizumab DB17894
biotech | CAS: 336128-48-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAnalgesics, Non-Narcotic +14
Waktu Paruh-
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Senna leaf Approved DB15889
biotech

Deskripsi belum tersedia.

Kategori:
AnthracenesAnthraquinonesBiological Products +6
Waktu Paruh-
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Sennosides DB11365
small molecule | CAS: 517-43-1

Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and empty the large intestine before surgery. The medication is taken by mouth or via the rectum[FDA Label]. It typically begins working in minutes…

Kategori:
Alimentary Tract and MetabolismAnthracenesAnthraquinones +13
Target Protein:
Aquaporin-3Reverse transcriptase/RNaseH
Waktu ParuhThe half life of ra…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ra…
Genetik -
Seocalcitol DB04258
small molecule | CAS: 134404-52-7

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsCholestanesCholestenes +11
Target Protein:
Vitamin D3 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
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SEP-363856 DB15665
small molecule | CAS: 1310426-33-5

SEP-363856 is a novel psychotropic drug being investigated for the treatment of schizophrenia. Unlike other drugs used for this condition, SEP-363856 does not bind to the dopamine D2 receptors, but exerts actions on the trace amine–associated receptor 1 (TAA…

Target Protein:
5-hydroxytryptamine receptor 1ATrace amine-associated receptor 1
Waktu Paruh-
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Sepantronium DB17062
small molecule | CAS: 753440-91-4

Sepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and causes broad-range apoptosis.[A253167]

Kategori:
NaphthalenesQuinones
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SEphB4-HSA DB14797
biotech

SEphB4-HSA is under investigation in clinical trial NCT02495896 (Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors).

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Genetik -
biotech

Deskripsi belum tersedia.

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Sepiapterin DB16326
small molecule | CAS: 17094-01-8

Sepiapterin is under investigation in clinical trial NCT03519711 (A Study of CNSA-001 in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia).

Kategori:
Biological FactorsHeterocyclic Compounds, Fused-RingPigments, Biological +1
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Sepranolone DB12972
small molecule | CAS: 516-55-2

Sepranolone has been investigated for the treatment of Premenstrual Dysphoric Disorder.

Kategori:
AnestheticsCentral Nervous System AgentsCentral Nervous System Depressants +3
Waktu Paruh-
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Sequifenadine DB13566
small molecule | CAS: 57734-69-7

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic Use
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Serabelisib DB14935
small molecule | CAS: 1268454-23-4

Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117) in Healthy Participants).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingOxazines
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Waktu Paruh-
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Seractide acetate Approved DB09334
biotech | CAS: 39295-97-1

Seractide acetate is the acetate salt of full length human corticotropin.

Target Protein:
Adrenocorticotropic hormone receptor
Waktu Paruh-
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Seralutinib DB18072
small molecule | CAS: 1619931-27-9

Deskripsi belum tersedia.

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Seratrodast DB06739
small molecule | CAS: 112665-43-7

Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Asthmatic Agents +27
Target Protein:
Thromboxane A2 receptor
Waktu Paruh-
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Serdemetan DB12027
small molecule | CAS: 881202-45-5

Serdemetan has been used in trials studying the treatment of Neoplasms.

Kategori:
AminesBiogenic AminesBiogenic Monoamines +3
Target Protein:
E3 ubiquitin-protein ligase Mdm2
Waktu Paruh-
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Serelaxin DB05794
biotech | CAS: 99489-94-8

Recombinant human relaxin is a hormone produced during pregnancy that facilitates the birth process by causing a softening and lengthening of the cervix and the pubic symphysis (the place where the pubic bones come together).It is a heterodimer protein secret…

Kategori:
Cardiac TherapyVasodilators Used in Cardiac Diseases
Waktu Paruh-
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Seribantumab DB11857
biotech | CAS: 1334296-12-6

Seribantumab has been used in trials studying the treatment of NSCLC, Heregulin, Adenocarcinoma, Colorectal Cancer, and Solid Tumor Cancers, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
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Serine DB00133
small molecule | CAS: 56-45-1

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +3
Target Protein:
Cystathionine beta-synthaseL-serine dehydratase/L-threonine deaminaseSerine racemase +4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Serinus canaria feather Approved DB10857
biotech

Canary feather is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Serotonin DB08839
small molecule | CAS: 50-67-9

For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.

Kategori:
AminesAntidepressive AgentsAutacoids +19
Target Protein:
5-hydroxytryptamine receptor 1B5-hydroxytryptamine receptor 75-hydroxytryptamine receptor 2B +12
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SerpinPC DB17698
biotech

SerpinPC is a mutated alpha-1-antitrypsin (?1AT) and serine protease inhibitor being investigated for the treatment of hemophilia.[A258993]

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Serplulimab DB17451
biotech | CAS: 2231029-82-4

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsMonoclonal antibodies and antibody drug conjugates +1
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Serrapeptase DB13131
biotech | CAS: 95077-02-4

Serrapeptase is a proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections. Serratiopeptidase is under investigation in clinical trial NCT02493179 (Efficacy Evaluation of the (Serodase 5 mg Tablet) in the Treatment of …

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +7
Waktu Paruh-
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Sertaconazole Approved DB01153
small molecule | CAS: 99592-32-2

Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available in topical formulations for the treatment of skin infections such as athlete's foot.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +8
Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
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Sertindole Approved DB06144
small molecule | CAS: 106516-24-9

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 …

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical]) +22
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2C +5
Waktu Paruh3 days
Vol. Distribusi-
Klirens-
Genetik -
Sertraline Approved DB01104
small molecule | CAS: 79617-96-2

Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSR…

Kategori:
Agents that reduce seizure thresholdAminesAntidepressive Agents +39
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent dopamine transporterSigma receptor +2
Gen Terkait:
CYP2C19 CYP2C19
Waktu ParuhThe elimination hal…
Vol. DistribusiSertraline is widel…
KlirensIn pharmacokinetic …
Genetik 2 Varian
Sesame oil DB11172
biotech | CAS: 8008-74-0

Sesame oil is a commonly used vegetable oil in Asia and flavoring enhancer in various culinary practices. It is extracted from sesame seeds and contains linoleic acid, oleic acid, palmitic acid, stearic acid and other fatty acids. Sesame oil is reported to po…

Kategori:
Biological ProductsComplex MixturesDiet, Food, and Nutrition +10
Waktu Paruh-
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Sesame seed Approved DB10566
biotech

Sesame seed allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
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Setanaxib DB16869
small molecule | CAS: 1218942-37-0

Deskripsi belum tersedia.

Kategori:
PyrazolesPyridines
Target Protein:
NADPH oxidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setipiprant DB12562
small molecule | CAS: 866460-33-5

Setipiprant has been investigated for the treatment of Seasonal Allergic Rhinitis, asthma and scalp hair loss (Androgenetic Alopecia).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Prostaglandin D2 receptorProstaglandin D2 receptor 2
Waktu Paruh-
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Setiptiline DB09304
small molecule | CAS: 57262-94-9

Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). In Japan, the company Mochida started its commercialization for the treatment of depression started in 1989.

Kategori:
Antidepressive Agents, TetracyclicDibenzazepinesHeterocyclic Compounds, Fused-Ring
Target Protein:
Alpha-2 adrenergic receptorsSerotonin Receptors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setmelanotide Approved DB11700
small molecule | CAS: 920014-72-8

Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies.[L24474] It is an agonist of the melanocortin 4 receptor.[A224449] Earlier attempts at agonizing MC4R (such as LY2…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Obesity Agents +19
Target Protein:
Melanocortin receptor 4
Waktu ParuhThe elimination had…
Vol. DistribusiThe apparent volume…
KlirensA 3mg subcutaneous …
Genetik -
Setogepram DB15447
small molecule | CAS: 1002101-19-0

Setogepram is under investigation in clinical trial NCT03184584 (Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
G-protein coupled receptor 84Free fatty acid receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Setrobuvir DB12051
small molecule | CAS: 1071517-39-9

Setrobuvir has been used in trials studying the treatment of Hepatitis C, Chronic.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolinesSulfonamides +2
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Setrusumab DB14778
biotech | CAS: 1847394-95-9

Setrusumab is under investigation in clinical trial NCT01406548 (Safety and Efficacy of Multiple Dosing Regimens of BPS804 in Post Menopausal Women With Low Bone Mineral Density).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
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Sevasemten DB18983
small molecule | CAS: 2417395-15-2

Sevasemten is under investigation in clinical trial NCT05291091 (Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)).

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Sevelamer Approved DB00658
small molecule | CAS: 52757-95-6

Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.

Kategori:
AminesBile Acid SequestrantsChelating Agents +9
Target Protein:
Phosphate
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Seviprotimut-L DB16328
biotech

Seviprotimut-L is under investigation in clinical trial NCT01546571 (Study of a Melanoma Vaccine in Stage Iib, Iic, and III Melanoma Patients).

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Sevirumab DB17771
biotech | CAS: 138660-96-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Seviteronel DB12275
small molecule | CAS: 1610537-15-9

Seviteronel has been used in trials studying the treatment of CRPC, Prostate Cancer, and Castration-resistant Prostate Cancer.

Kategori:
Antineoplastic AgentsCytochrome P-450 Enzyme InhibitorsEnzyme Inhibitors
Target Protein:
Steroid 17-alpha-hydroxylase/17,20 lyase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sevoflurane Approved DB01236
small molecule | CAS: 28523-86-6

Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia.[L42340] It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient.[L42340] Sevoflurane was patented in 1972, w…

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +17
Target Protein:
GABA(A) ReceptorGlycine receptor subunit alpha-1Glutamate receptor 1 +3
Waktu ParuhThe terminal elimin…
Vol. DistribusiPatients given low-…
KlirensIn patients given l…
Genetik -
Sevuparin DB15007
small molecule

Sevuparin is under investigation in clinical trial NCT03853421 (Placebo-controlled Study to Determine the Safety and Tolerability of Subcutaneous Doses of Sevuparin).

Kategori:
CarbohydratesGlycosaminoglycansPolysaccharides
Waktu Paruh-
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SF1126 DB05210
small molecule

SF1126 is an integrin-targeted PI3 kinase inhibitor.

Kategori:
Amino Acids, Peptides, and ProteinsBenzopyransHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Phosphatidylinositol 3-kinase regulatory subunit alphaPhosphatidylinositol 3-kinase regulatory subunit betaPhosphatidylinositol 3-kinase regulatory subunit gamma +2
Waktu Paruh-
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Genetik -
SGI-1776 DB12494
small molecule | CAS: 1025065-69-3

SGI-1776 has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.

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SGN-1 DB18135
biotech

SGN-1 is a genetically modified strain of _Salmonella enterica_ comprising methioninase.

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SGN-15 DB05818
biotech

SGN-15 is studied in the treatment of cancer. It combines a monoclonal antibody with the anticancer drug doxorubicin. Monoclonal antibodies are substances that are made in the laboratory and that can locate and bind to cancer cells. Doxorubicin is a type of a…

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