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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 215 / 272
Preladenant DB11864
small molecule | CAS: 377727-87-2

Preladenant has been used in trials studying the treatment of Brain Diseases, Parkinson Disease, Movement Disorders, Antipsychotic Agents, and Parkinsonian Disorders, among others.

Target Protein:
Adenosine receptor A2a
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenalterol DB13777
small molecule | CAS: 57526-81-5

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic and Dopaminergic Agents +20
Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenoxdiazine DB13397
small molecule | CAS: 47543-65-7

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenylamine Approved DB04825
small molecule | CAS: 390-64-7

Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.

Kategori:
Adrenergic AgentsAgents causing hyperkalemiaAmines +19
Target Protein:
Myosin light chain kinase 2, skeletal/cardiac muscleCalmodulin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Presatovir DB12165
small molecule | CAS: 1353625-73-6

Presatovir has been used in trials studying the treatment of RSV Infection, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus Infections, and Respiratory Syncytial Virus (RSV) Infections.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles +2
Target Protein:
Fusion glycoprotein F0
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prethcamide DB13447
small molecule | CAS: 8015-51-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pretomanid Approved DB05154
small molecule | CAS: 187235-37-6

Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of thi…

Kategori:
Antiinfectives for Systemic UseAntimycobacterialsCytochrome P-450 CYP3A Substrates +7
Target Protein:
Cyclopropane mycolic acid synthase 1Cyclopropane mycolic acid synthase 2Cyclopropane mycolic acid synthase 3 +5
Waktu ParuhThe elimination hal…
Vol. DistribusiA pharmacokinetic m…
KlirensThe clearance of pr…
Genetik -
Previtamin D(3) DB15614
small molecule | CAS: 1173-13-3

Deskripsi belum tersedia.

Kategori:
CholestanesCholestenesFused-Ring Compounds +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prexasertib DB12008
small molecule | CAS: 1234015-52-1

Prexasertib has been used in trials studying the treatment and basic science of mCRPC, Leukemia, Neoplasm, breast cancer, and Ovarian Cancer, among others.

Kategori:
Enzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prexigebersen DB17320
biotech | CAS: 202484-91-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prezatide DB11296
small molecule | CAS: 49557-75-7

Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in ch…

Kategori:
Amino Acids, Peptides, and ProteinsGrowth SubstancesPeptides
Waktu ParuhPrezatide is rapidl…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 89030-95-5

Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in ch…

Kategori:
Amino Acids, Peptides, and ProteinsNuclear Matrix-Associated ProteinsNuclear Proteins +1
Waktu ParuhPrezatide is rapidl…
Vol. Distribusi-
Klirens-
Genetik -
PRG-A01 DB18613
small molecule

PRG-A01 is a novel inhibitor of Cu, Zn-superoxide dismutase (SOD1) misfolding and aggregation.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRGN-2012 DB18342
biotech

PRGN-2012 is an adenoviral vector expressing human papillomavirus (HPV) 6 and HPV 11 antigens

Waktu Paruh-
Vol. Distribusi-
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Genetik -
PRGN-3006 DB17229
biotech

PRGN-3006 are autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane-bound interleukin-15, and a truncated form of human HER1T (kill switch) on the cell surface.

Waktu Paruh-
Vol. Distribusi-
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PRI-724 DB15034
small molecule | CAS: 1198780-38-9

PRI-724 is under investigation in clinical trial NCT03620474 (Safety and Effectiveness of PRI-724 for Hepatitis C or B Virus Derived Liver Cirrhosis).

Kategori:
Pyrimidines
Target Protein:
CREB-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pridinol DB13642
small molecule | CAS: 511-45-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsMuscle RelaxantsMuscle Relaxants, Centrally Acting Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pridopidine DB11947
small molecule | CAS: 346688-38-8

Pridopidine has been used in trials studying the treatment of Huntington's Disease.

Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prifinium DB13254
small molecule | CAS: 10236-81-4

Prifinium is an antimuscarinic agent with antispasmodic and antiemetic properties. It may be useful for the treatment of irritable bowel syndrome [A175027].

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Primaquine Approved DB01087
small molecule | CAS: 90-34-6

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas …

Kategori:
AminoquinolinesAnti-Infective AgentsAntibiotics for Pneumocystis Pneumonia +24
Target Protein:
Fe(II)-protoporphyrin IXKeratin, type II cytoskeletal 7Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh3.7-7.4 hours
Vol. Distribusi-
Klirens-
Genetik -
Primidone Approved DB00794
small molecule | CAS: 125-33-7

Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures.[L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 Marc…

Kategori:
Anti-epileptic AgentAnticholinergic AgentsAnticonvulsants +36
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-4 +8
Waktu ParuhThe half life of pr…
Vol. DistribusiThe volume of distr…
KlirensPrimidone is cleare…
Genetik -
Prinaberel DB06832
small molecule | CAS: 524684-52-4

Prinaberel is an estrogen receptor beta agonist.

Kategori:
Receptors, Estrogen, agonists
Target Protein:
Estrogen receptor betaNuclear receptor coactivator 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prinomastat DB05100
small molecule | CAS: 192329-42-3

Prinomastat is a synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angioge…

Kategori:
Enzyme InhibitorsMatrix Metalloproteinase InhibitorsProtease Inhibitors
Target Protein:
72 kDa type IV collagenaseInterstitial collagenaseMatrilysin
Waktu Paruh2-5 hours
Vol. Distribusi-
Klirens-
Genetik -
Priralfinamide DB06649
small molecule | CAS: 133865-88-0

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicBenzene DerivativesFatty Acids +4
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pristimerin DB17049
small molecule | CAS: 1258-84-0

Pristimerin is a quinone methide triterpenoid researched for its anti-cancer potential.[A253107]

Kategori:
TerpenesTriterpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pristinamycin DB13704
small molecule | CAS: 270076-60-3

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pritelivir DB11844
small molecule | CAS: 348086-71-5

Pritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.

Kategori:
AmidesAnti-Infective AgentsAntiviral Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

C-CAR039 is an autologous Chimeric Antigen Receptors (CAR) T-cell therapy expressing CD19/CD20 bi-specific CAR.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRLX 93936 DB06098
small molecule

PRLX 93936 is selectively toxic to cancer cells.

Target Protein:
Voltage-dependent anion-selective channel protein 2Voltage-dependent anion-selective channel protein 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRO 2000 DB05385
small molecule | CAS: 29321-75-3

PRO 2000 is an investigational medicine that is not yet approved by the FDA for use outside of clinical trials. It is being studied for the prevention of HIV infection and other sexually transmitted diseases. This medicine does not cure HIV infection or AIDS …

Kategori:
ArylsulfonatesArylsulfonic AcidsCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRO-542 DB05793
biotech

PRO 542 belongs to a new class of drugs, viral-entry inhibitor, which is intended to prevent HIV from entering and infecting cells. PRO 542 (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isola…

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Surface +21
Target Protein:
Free fatty acid receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Probenecid Approved DB01032
small molecule | CAS: 57-66-9

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other…

Kategori:
Adjuvants, PharmaceuticAmidesAntigout Preparations +29
Target Protein:
Solute carrier family 22 member 6Solute carrier family 22 member 11Organic anion transporter 3 +2
Waktu Paruh6-12 hours
Vol. Distribusi-
Klirens-
Genetik -
Probiorinse DB15870
biotech

Probiorinse is an intranasal probiotic treatment composed of a pre-mixed and buffered sinus irrigation solution that contains the probiotic bacteria Lactococcus lactis W136.[L16368] This strain of bacteria is said to have salubrious effects on the microbiome …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Probucol Approved DB01599
small molecule | CAS: 23288-49-5

A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).

Kategori:
Anticholesteremic AgentsAntioxidantsBenzene Derivatives +10
Target Protein:
Phospholipid-transporting ATPase ABCA1Liver carboxylesterase 1
Waktu ParuhRanges from 12 hour…
Vol. Distribusi-
Klirens-
Genetik -
Procainamide Approved DB01035
small molecule | CAS: 51-06-9

A derivative of procaine with less CNS action.

Kategori:
Acids, CarbocyclicAgents Causing Muscle ToxicityAgents that produce neuromuscular block (indirect) +32
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2Sodium channel protein type 5 subunit alphaDNA (cytosine-5)-methyltransferase 1
Waktu Paruh~2.5-4.5 hours
Vol. Distribusi* 2 L/kg
Klirens-
Genetik -
Procaine Approved DB00721
small molecule | CAS: 59-46-1

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also b…

Kategori:
Acids, CarbocyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAgents that reduce seizure threshold +25
Target Protein:
Sodium channel protein type 10 subunit alphaGlutamate receptor ionotropic, NMDA 3A5-hydroxytryptamine receptor 3A +8
Waktu Paruh7.7 minutes
Vol. Distribusi-
Klirens-
Genetik -
Procaine benzylpenicillin Approved DB09320
small molecule | CAS: 54-35-3

Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent pro…

Kategori:
Acids, CarbocyclicAmidesAminobenzoates +16
Target Protein:
Penicillin-binding protein
Waktu ParuhIntramuscular injec…
Vol. DistribusiThe drug is distrib…
Klirens-
Genetik -
Procaine merethoxylline Approved DB09364
small molecule | CAS: 60064-28-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Procalcitonin DB14812
biotech | CAS: 56645-65-9

Procalcitonin is under investigation in clinical trial NCT03440060 (Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPD).

Kategori:
Amino Acids, Peptides, and ProteinsBone Density Conservation AgentsCalcitonin Preparations +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Procarbazine Approved DB01168
small molecule | CAS: 671-16-9

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

Kategori:
Acids, CarbocyclicAgents Causing Muscle ToxicityAlkylating Activity +17
Target Protein:
Monoamine oxidaseDNA
Waktu Paruh10 minutes
Vol. Distribusi-
Klirens-
Genetik -
Procaterol Approved DB01366
small molecule | CAS: 72332-33-3

A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +21
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prochlorperazine Approved DB00433
small molecule | CAS: 58-38-8

Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psyc…

Kategori:
AntiemeticsAntipsychotic AgentsAntipsychotic Agents (First Generation [Typical]) +28
Target Protein:
D(2) dopamine receptorHistamine H1 receptorAlpha-1 adrenergic receptors +1
Waktu ParuhFollowing intraveno…
Vol. DistribusiIn a preliminary ph…
KlirensThe mean plasma cle…
Genetik -
Procinonide Approved DB18737
small molecule | CAS: 58497-00-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Procyclidine Approved DB00387
small molecule | CAS: 77-37-2

A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.

Kategori:
Agents producing tachycardiaAnti-Dyskinesia AgentsAnti-Parkinson Drugs +8
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Profadol DB17993
small molecule | CAS: 428-37-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Profenamine Approved DB00392
small molecule | CAS: 522-00-9

Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada.[L46812] In the US, the marketing of profenamine has been…

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAgents producing tachycardia +12
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Glutamate receptor ionotropic, NMDA 3A +1
Waktu Paruh1 to 2 hours
Vol. Distribusi-
Klirens-
Genetik -
Proflavine Approved DB01123
small molecule | CAS: 92-62-6

3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings.

Kategori:
AcridinesAminoacridinesAnti-Infective Agents +2
Target Protein:
DNAProthrombinHTH-type transcriptional regulator QacR +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Profoxydim DB14820
small molecule | CAS: 139001-49-3

Profoxydim is under investigation in clinical trial NCT02728011 (Pilot Trial Comparing Computerised Cognitive Exercises to Tetris in Adolescents With ADHD).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Progabide DB00837
small molecule | CAS: 62666-20-0

Progabide is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. In clinical trials, progabide has been investigated for Parkinson's disease, sch…

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +14
Target Protein:
Gamma-aminobutyric acid type B receptor subunit 2Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid type B receptor subunit 1
Waktu Paruh4 hours
Vol. Distribusi-
Klirens-
Genetik -
Progerinin DB17634
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 10701–10750 dari 13591
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