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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 215 / 315
Neon Approved DB11589
small molecule | CAS: 7440-01-9

Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a re…

Kategori:
ElementsGasesNoble Gases
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Neopterin DB15050
small molecule | CAS: 2009-64-5

Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke).

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neosaxitoxin DB12989
small molecule | CAS: 64296-20-4

Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).

Kategori:
AgrochemicalsBacterial ToxinsBiological Factors +16
Waktu Paruh-
Vol. Distribusi-
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Neostigmine Approved DB01400
small molecule | CAS: 59-99-4

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Kategori:
AminesAntiglaucoma Preparations and MioticsAutonomic Agents +13
Target Protein:
Acetylcholinesterase
Waktu ParuhThe half-life range…
Vol. Distribusi-
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Genetik -
Nepadutant DB12538
small molecule | CAS: 183747-35-5

Nepadutant has been used in trials studying the treatment of Colic, Infantile Colic, and Infantile Functional Gastrointestinal Disorders.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Asthmatic AgentsAutonomic Agents +5
Waktu Paruh-
Vol. Distribusi-
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Nepafenac Approved DB06802
small molecule | CAS: 78281-72-8

Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.

Kategori:
AcetamidesAcetatesAcids, Acyclic +18
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
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Nepicastat DB12979
small molecule | CAS: 173997-05-2

Nepicastat has been investigated for the treatment of Cocaine Dependence and Posttraumatic Stress Disorder.

Kategori:
Dopamine beta-Hydroxylase, antagonists & inhibitorsSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
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Nepidermin DB14145
biotech | CAS: 62253-63-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsEGF Family of Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nepinalone DB13445
small molecule | CAS: 22443-11-4

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Nequinate DB11433
small molecule | CAS: 13997-19-8

Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. Nequinate belongs to the family of Hydroquinolones. These are compounds containing an hydrogenated quinoline bearing a ketone group.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Waktu Paruh-
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Neramexane DB04926
small molecule | CAS: 219810-59-0

Neramexane is a low-to-moderate affinity uncompetitive NMDA receptor antagonist.

Kategori:
Cycloparaffins
Target Protein:
Glutamate receptor ionotropic, NMDA 3A
Waktu Paruh-
Vol. Distribusi-
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Nerandomilast DB18237
small molecule | CAS: 1423719-30-5

Deskripsi belum tersedia.

Kategori:
Cycloparaffins
Waktu Paruh-
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Neratinib Approved DB11828
small molecule | CAS: 698387-09-6

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under inve…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A Substrates +11
Target Protein:
Vascular endothelial growth factor receptor 2Receptor tyrosine-protein kinase erbB-2Epidermal growth factor receptor
Waktu ParuhThe mean half life …
Vol. DistribusiThe apparent volume…
KlirensThe total clearance…
Genetik -
Neridronic Acid DB11620
small molecule | CAS: 79778-41-9

Deskripsi belum tersedia.

Kategori:
OrganophosphonatesOrganophosphorus Compounds
Target Protein:
Farnesyl pyrophosphate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nerinetide DB12595
biotech | CAS: 500992-11-0

Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).

Kategori:
Amino Acids, Peptides, and ProteinsNeuroprotective Agents
Waktu Paruh-
Vol. Distribusi-
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Nerispirdine DB12714
small molecule | CAS: 119229-65-1

Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2Sodium channel protein type 11 subunit alpha
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Nerofe DB14786
small molecule | CAS: 1311294-45-7

Nerofe is under investigation in clinical trial NCT03059615 (A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 9061-61-4

Nerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, Alzheimer's Disease, Traumatic Brain Injury, Cerebral Palsy Children, and Delayed Speech Development, among others.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Nesbuvir DB07238
small molecule | CAS: 691852-58-1

Nesbuvir has been investigated for the treatment of Hepatitis C.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
Genome polyproteinGenome polyproteinGenome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nesiritide Approved DB04899
biotech | CAS: 124584-08-3

Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.

Kategori:
Amino Acids, Peptides, and ProteinsCardiac TherapyCardiovascular Agents +11
Target Protein:
Atrial natriuretic peptide receptor 1Atrial natriuretic peptide receptor 2Atrial natriuretic peptide receptor 3
Waktu ParuhApproximately 18 mi…
Vol. Distribusi* 0.19 L/kg
Klirens* 9.2 mL/min/k [pat…
Genetik -
Nesolicaftor DB15239
small molecule | CAS: 1953130-87-4

Nesolicaftor (PTI-428) is under investigation in clinical trial NCT03258424 (Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background Therapy).

Waktu Paruh-
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Nesuparib DB18110
small molecule | CAS: 2055357-64-5

Deskripsi belum tersedia.

Waktu Paruh-
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Nesvacumab DB15330
biotech | CAS: 1296818-77-3

Nesvacumab is under investigation in clinical trial NCT01997164 (Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular (Wet) Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME)).

Waktu Paruh-
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Nesvategrast DB19337
small molecule | CAS: 1621332-91-9

Nesvategrast is under investigation in clinical trial NCT05409235 (Nesvategrast (OTT166) in Diabetic Retinopathy (DR)).

Waktu Paruh-
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Netakimab DB18870
biotech | CAS: 1796570-08-5

Netakimab is under investigation in clinical trial NCT03447704 (International Multicenter Comparative Randomized Placebo-controlled Clinical Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Netarsudil Approved DB13931
small molecule | CAS: 1254032-66-0

A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elev…

Kategori:
Acids, CarbocyclicAlanineAmino Acids +8
Target Protein:
Rho-associated protein kinase 1Rho-associated protein kinase 2Sodium-dependent noradrenaline transporter
Waktu ParuhThe half-life of ne…
Vol. DistribusiAs netarsudil and i…
KlirensThe clearance of ne…
Genetik -
Netazepide DB12355
small molecule | CAS: 155488-25-8

Netazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others.

Kategori:
AmidesBenzazepinesBenzene Derivatives +2
Target Protein:
Gastrin/cholecystokinin type B receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Netilmicin Approved DB00955
small molecule | CAS: 56391-56-1

Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S r…

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +14
Target Protein:
30S ribosomal protein S1216S ribosomal RNA
Waktu Paruh2.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Netivudine DB12606
small molecule | CAS: 84558-93-0

Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections.

Kategori:
Anti-Infective AgentsAntiviral AgentsArabinonucleosides +4
Target Protein:
DNA polymerase catalytic subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Netoglitazone DB09199
small molecule | CAS: 161600-01-7

Netoglitazone (MCC-555) is a hypoglycemic agent.

Kategori:
Blood Glucose Lowering AgentsCytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (strength unknown) +8
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Netupitant Approved DB09048
small molecule | CAS: 290297-26-6

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant …

Kategori:
AcetamidesAmidesBCRP/ABCG2 Inhibitors +15
Target Protein:
Substance-P receptor
Waktu Paruh96 hours with CV% o…
Vol. DistribusiIn cancer patients,…
KlirensEstimated systemic …
Genetik -
NeuroCell-HD DB17915
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
NeuroCell-PD DB17941
biotech

Deskripsi belum tersedia.

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Neuropeptide Y Approved DB11788
biotech | CAS: 82785-45-3

Neuropeptide Y is under investigation for the basic science of Type 2 Diabetes Mellitus.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsNeuropeptide Y, drug effects +3
Waktu Paruh-
Vol. Distribusi-
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Neurospora crassa Approved DB10821
biotech

Neurospora crassa is a fungus which can provoke allergic reactions. Neurospora crassa extract is used in allergenic testing.

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Neurospora intermedia Approved DB10438
biotech

Neurospora intermedia is a fungus which can provoke allergic reactions. Neurospora intermedia extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Neurospora sitophila Approved DB10969
biotech

Neurospora sitophila is a fungus which can provoke allergic reactions. Neurospora sitophila extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NeuroVax DB16941
biotech | CAS: 1007558-71-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 503621-56-5

Deskripsi belum tersedia.

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Nevanimibe DB16254
small molecule | CAS: 133825-80-6

Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome).

Kategori:
AmidesBenzene Derivatives
Target Protein:
Sterol O-acyltransferase 1Sterol O-acyltransferase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nevirapine Approved DB00238
small molecule | CAS: 129618-40-2

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemica…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +39
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh45 hours
Vol. Distribusi* 1.21 ± 0.09 L/kg …
Klirens-
Genetik -
Nezastomig DB19061
biotech | CAS: 2657613-60-8

Nezastomig is under investigation in clinical trial NCT06085664 (A Pilot Presurgical Trial of REGN5678 (Anti-psma X CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy).

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NFS-02 DB18422
biotech

NFS-02 is a recombinant adeno-associated virus serotype 2 containing human mitochondrial ND1 codon optimized gene (rAAV2-ND1).

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NGD-4715 DB06027
small molecule | CAS: 476322-70-0

NGD-4715 is an investigational compound developed for the treatment of Obesity. NGD-4715 functions as a melanin-concentrating hormone receptor 1 antagonist.

Target Protein:
Melanin-concentrating hormone receptor 1
Waktu Paruh-
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NGGT-002 DB17881
biotech

NGGT-002 is a recombinant adeno-associated virus serotype 8 vector encoding human phenylalanine hydroxylase (PAH).

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NGN-101 DB18335
biotech

NGN-101 is an adeno-associated virus serotype 9 vector with engineered transgene encoding the human CLN5 gene

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NGN-401 DB18594
biotech

NGN-401 is a recombinant serotype 9 adeno-associated virus (AAV) encoding an intron encoding a miRNA generating sequence, complementary miRNA binding sites and a full-length human methyl cytosine binding protein 2 (MECP2). Developed by Neurogene Inc., it is b…

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NGX267 DB05152
small molecule | CAS: 503431-81-0

NGX267 is a muscarinic agonist. It is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression.

Kategori:
Cholinergic AgentsCholinergic AgonistsMuscarinic Agonists +2
Target Protein:
Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
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Niacin Approved DB00627
small molecule | CAS: 59-67-6

Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565]

Kategori:
Agents Causing Muscle ToxicityCardiovascular AgentsCytochrome P-450 CYP2D6 Inhibitors +31
Target Protein:
Hydroxycarboxylic acid receptor 3Diacylglycerol O-acyltransferase 2Hydroxycarboxylic acid receptor 2 +2
Waktu ParuhThe half life of ni…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Niacinamide ascorbate Approved DB14486
small molecule | CAS: 1987-71-9

Deskripsi belum tersedia.

Kategori:
Urinary Acidifying AgentsVitamin B ComplexVitamin C and analogues +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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