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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Halaman 214 / 272
Poziotinib DB12114
small molecule | CAS: 1092364-38-9

Poziotinib has been used in trials studying the treatment of Breast Cancer, Metastatic Breast Cancer, Increased Drug Resistance, Adenocarcinoma of Lung Stage IV, and Adenocarcinoma of Lung Stage IIIB, among others.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Receptor tyrosine-protein kinase erbB-2Epidermal growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PP-121 DB08052
small molecule | CAS: 1092788-83-4

Deskripsi belum tersedia.

Target Protein:
Epidermal growth factor receptorDNA-dependent protein kinase catalytic subunitVascular endothelial growth factor receptor 2 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1771736-69-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
PPI-1019 DB05832
small molecule | CAS: 290828-45-4

Apan (PPI-1019) is developed by Praecis Pharmaceuticals to treat Alzheimer's Disease.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
PPI-1040 DB17620
small molecule | CAS: 1436673-69-6

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
PQ-10 DB08391
small molecule | CAS: 927691-21-2

Deskripsi belum tersedia.

Target Protein:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PR-15 DB06037
small molecule

PR-15 is a novel anti-platelet protein with the potential to treat arterial thrombosis occurring during acute coronary syndromes without the bleeding risk associated with existing agents.

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsCarbohydrates +10
Target Protein:
Collagen alpha-1(I) chainCollagen alpha-2(I) chainCollagen alpha-1(III) chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 182253-77-6

PR1 leukemia peptide vaccine is under investigation in clinical trial NCT00513578 (Vaccine Therapy and GM-CSF in Treating Patients With Low-Risk or Intermediate-Risk Myelodysplastic Syndrome).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Pracinostat DB05223
small molecule | CAS: 929016-96-6

Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in clinical trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and effective anti-tumor drug with potential as an oral …

Kategori:
Antineoplastic AgentsHeterocyclic Compounds, Fused-RingHistone Deacetylase Inhibitors +2
Target Protein:
Histone deacetylase 1Histone deacetylase 2Histone deacetylase 3 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Praconase DB05584
biotech | CAS: 1186547-12-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ProteinsBacterial Toxins +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Practolol Approved DB01297
small molecule | CAS: 6673-35-4

A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.

Kategori:
AcetanilidesAdrenergic AgentsAdrenergic Antagonists +20
Target Protein:
Beta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 625095-61-6

Pradefovir mesilate (previously known as MB-06886, Hepavir B and remofovir mesylate) is an orally administered small molecule compound that belongs to a novel series of phosphate and phosphonate prodrugs of adefovir. [Adefovir] (Hepsera) is an acyclic phospho…

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +3
Target Protein:
Cytochrome P450 3A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pradigastat DB12866
small molecule | CAS: 956136-95-1

Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD).

Kategori:
Acids, AcyclicAminesFatty Acids +4
Target Protein:
Diacylglycerol O-acyltransferase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pradofloxacin DB11453
small molecule | CAS: 195532-12-8

Pradofloxacin is a 3rd generation fluoroquinolone antibiotic developed by Bayer HealthCare AG, Animal Health GmBH. It was approved by the European Commission in April 2011 for bacterial infections in dogs and cats.

Kategori:
4-QuinolonesAnti-Bacterial AgentsFluoroquinolone Antibacterial +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prajmaline DB13555
small molecule | CAS: 35080-11-6

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntiarrhythmic agentsAntiarrhythmics, Class I +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralatrexate Approved DB06813
small molecule | CAS: 146464-95-1

Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674]. Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy for their B-cells counterparts.[A246693]…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +10
Target Protein:
Dihydrofolate reductasePeptide deformylase, mitochondrialFolylpolyglutamate synthase, mitochondrial +1
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe steady-state vo…
KlirensThe total systemic …
Genetik -
Praliciguat DB16300
small molecule | CAS: 1628730-49-3

Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).

Kategori:
Enzyme ActivatorsGastrointestinal AgentsGuanylyl Cyclase C Agonists
Target Protein:
Guanylate cyclase soluble subunit alpha-1Guanylate cyclase soluble subunit beta-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralidoxime Approved DB00733
small molecule | CAS: 6735-59-7

Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate expos…

Kategori:
AminesAntidotesCholinergic Agents +8
Target Protein:
AcetylcholinesteraseCholinesterase
Waktu Paruh74-77 minutes
Vol. Distribusi-
Klirens-
Genetik -
Pralmorelin DB18252
small molecule | CAS: 158861-67-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsGrowth Hormone-Releasing HormoneGrowth Substances +1
Target Protein:
Growth hormone secretagogue receptor type 16-phosphogluconate dehydrogenase, decarboxylating
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralsetinib Approved DB15822
small molecule | CAS: 2097132-94-8

Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +38
Target Protein:
Proto-oncogene tyrosine-protein kinase receptor RetEpithelial discoidin domain-containing receptor 1NT-3 growth factor receptor +8
Waktu ParuhPralsetinib has a p…
Vol. DistribusiPralsetinib has a m…
KlirensPralsetinib has a m…
Genetik -
Pralurbactam DB19437
small molecule | CAS: 2163782-59-8

Pralurbactam is under investigation in clinical trial NCT06633718 (Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in CIAI).

Waktu Paruh-
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Genetik -
Pramiconazole DB06295
small molecule | CAS: 219923-85-0

Deskripsi belum tersedia.

Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pramipexole Approved DB00413
small molecule | CAS: 104632-26-0

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) [A176867]. It was …

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson Agents (Dopamine Agonist)Anti-Parkinson Drugs +17
Target Protein:
D(3) dopamine receptorD(2) dopamine receptorD(4) dopamine receptor +2
Waktu ParuhAbout 8.5-12 hours …
Vol. DistribusiThis drug is extens…
KlirensRenal clearance is …
Genetik -
Pramiracetam Approved DB13247
small molecule | CAS: 68497-62-1

Pramiracetam has been previously approved in some eastern European countries under the brand names Pramistar, Neupramir, and Remen. It was also previously approved in the United States with orphan drug designation [L1469]. Pramiracetam has been studied for th…

Kategori:
Nervous SystemPsychoanalepticsPsychostimulants, Agents Used for ADHD and Nootropics
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pramlintide Approved DB01278
small molecule | CAS: 151126-32-8

Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, a…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAmylin Agonists +12
Target Protein:
Glucagon-like peptide 1 receptorCalcitonin receptorReceptor activity-modifying protein 1 +2
Waktu ParuhApproximately 48 mi…
Vol. Distribusi-
Klirens-
Genetik -
Pramocaine Approved DB09345
small molecule | CAS: 140-65-8

Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoi…

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnestheticsAnesthetics for Topical Use +10
Target Protein:
Voltage-gated sodium channel alpha subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pranlukast DB01411
small molecule | CAS: 103177-37-3

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Kategori:
Agents to Treat Airway DiseaseAnti-Asthmatic AgentsBenzopyrans +14
Target Protein:
Cysteinyl leukotriene receptor 1Tumor necrosis factorInterleukin-5 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pranoprofen DB13514
small molecule | CAS: 52549-17-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prasinezumab DB14788
biotech | CAS: 1960462-19-4

Prasinezumab is under investigation in clinical trial NCT03100149 (A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prasterone Approved DB01708
small molecule | CAS: 53-43-0

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione…

Kategori:
17-KetosteroidsAdjuvants, ImmunologicAdrenal Cortex Hormones +32
Target Protein:
Glucose-6-phosphate 1-dehydrogenaseEstrogen receptorEstrogen receptor beta +7
Waktu Paruh12 hours
Vol. Distribusi-
Klirens-
Genetik -
Prasterone enantate Approved DB16625
small molecule | CAS: 23983-43-9

Deskripsi belum tersedia.

Kategori:
17-KetosteroidsAdrenal Cortex HormonesAndrostanes +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 651-48-9

DHEA sulfate is the major steroid of the fetal adrenal. DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.

Kategori:
17-KetosteroidsAdrenal Cortex HormonesAndrostanes +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prasugrel Approved DB06209
small molecule | CAS: 150322-43-3

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the …

Kategori:
AnticoagulantsAntiplatelet agentsBlood and Blood Forming Organs +15
Target Protein:
P2Y purinoceptor 12
Waktu ParuhThe active metaboli…
Vol. Distribusi44-68L
KlirensApparent clearance …
Genetik -
Pravastatin Approved DB00175
small molecule | CAS: 81093-37-0

Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This dr…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBCRP/ABCG2 Inhibitors +20
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHistone deacetylase 2
Gen Terkait:
KIF6 HMGCR
Waktu ParuhThe reported elimin…
Vol. DistribusiThe reported steady…
KlirensThe reported cleara…
Genetik 2 Varian
Pravibismane DB17784
small molecule | CAS: 175880-68-9

Deskripsi belum tersedia.

Kategori:
AlcoholsSulfhydryl CompoundsSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prazepam Approved DB01588
small molecule | CAS: 2955-38-6

Prazepam is a benzodiazepine that is used in the treatment of anxiety disorders. It is a schedule IV drug in the U.S.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +14
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh36-200 hours
Vol. Distribusi-
Klirens-
Genetik -
Praziquantel Approved DB01058
small molecule | CAS: 55268-74-1

Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis.[A263201…

Kategori:
AnthelminticsAnti-Infective AgentsAntihelminthic +12
Target Protein:
Hematopoietic prostaglandin D synthaseSchistosome calcium ion (Ca2+) channels
Waktu ParuhFollowing oral admi…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Prednicarbate Approved DB01130
small molecule | CAS: 73771-04-7

Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as [hydrocortisone]. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammator…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +18
Target Protein:
Glucocorticoid receptorSteroid hormone receptor ERR2Estrogen-related receptor gamma +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednimustine DB12832
small molecule | CAS: 29069-24-7

Prednimustine has been used in trials studying the treatment of Lymphoma.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisolone Approved DB00860
small molecule | CAS: 50-24-8

Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]

Kategori:
Adrenal Cortex HormonesAdrenalsAgents for Treatment of Hemorrhoids and Anal Fissures for Topical Use +45
Target Protein:
Glucocorticoid receptor
Waktu ParuhPrednisolone has a …
Vol. DistribusiA 0.15mg/kg dose of…
KlirensA 0.15mg/kg dose of…
Genetik -
small molecule | CAS: 2920-86-7

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCytochrome P-450 CYP3A Inducers +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisolone phosphate Approved DB14631
small molecule | CAS: 302-25-0

Prednisolone phosphate is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone phosphate was granted FDA Approval on 19 December 1973.[L14144]

Kategori:
Adrenal Cortex HormonesAdrenalsAnti-Inflammatory Agents +30
Target Protein:
Glucocorticoid receptorAnnexin A1
Waktu ParuhThe half life of pr…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Prednisolone tebutate Approved DB14632
small molecule | CAS: 7681-14-3

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisone Approved DB00635
small molecule | CAS: 53-03-2

A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]

Kategori:
Adrenal Cortex HormonesAdrenalsAlimentary Tract and Metabolism +45
Target Protein:
Glucocorticoid receptor
Waktu ParuhPrednisone and its …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Prednisone acetate Approved DB14646
small molecule | CAS: 125-10-0

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsAntineoplastic Agents +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednylidene DB13208
small molecule | CAS: 599-33-7

Prednylidene is an experimental systemic glucocorticoid.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids for Systemic Use +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pregabalin Approved DB00230
small molecule | CAS: 148553-50-8

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.[A173995] It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions.[A187190] Although as per the FDA Label …

Kategori:
Acids, AcyclicAgents causing angioedemaAmino Acids +24
Target Protein:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Waktu ParuhThe elimination hal…
Vol. DistribusiAfter oral administ…
KlirensIn young healthy su…
Genetik -
Pregnenolone Approved DB02789
small molecule | CAS: 145-13-1

A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +11
Target Protein:
Steroid hormone receptor ERR1Nuclear receptor subfamily 1 group I member 2Sulfotransferase 2B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1778-02-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 485818-40-4

Preimplantation factor is under investigation in clinical trial NCT03593460 (Phase II Autoimmune Hepatitis).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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Sebelumnya Halaman 214 / 272 Berikutnya