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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 214 / 315
Nedocromil Approved DB00716
small molecule | CAS: 69049-73-6

A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.

Kategori:
4-QuinolonesAnti-Allergic AgentsAnti-Asthmatic Agents +16
Target Protein:
Cysteinyl leukotriene receptor 1Cysteinyl leukotriene receptor 2fMet-Leu-Phe receptor +2
Waktu Paruh~3.3 hours
Vol. Distribusi-
Klirens-
Genetik -
Nedometinib DB18102
small molecule | CAS: 2252314-46-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nedosiran Approved DB17635
biotech | CAS: 2266591-83-5

Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate.[A261690] Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore…

Target Protein:
L-lactate dehydrogenase A chain
Waktu ParuhThe half-life of ne…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ne…
Genetik -
Nefazodone Approved DB01149
small molecule | CAS: 83366-66-9

Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associate…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +44
Target Protein:
5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2CSodium-dependent serotonin transporter +7
Waktu Paruh2-4 hours
Vol. Distribusi* 0.22 to 0.87 L/kg
Klirens-
Genetik -
Nefiracetam DB13082
small molecule | CAS: 77191-36-7

Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease.

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neflamapimod DB07138
small molecule | CAS: 209410-46-8

Neflamapimod has been used in trials studying the treatment of Alzheimer's Disease and Mild Cognitive Impairment.

Target Protein:
Mitogen-activated protein kinase 11Mitogen-activated protein kinase 12Mitogen-activated protein kinase 14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nefopam Approved DB12293
small molecule | CAS: 13669-70-0

Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAzocines +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neihulizumab DB16698
biotech

Neihulizumab is a novel immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), thereby preferentially inducing apoptosis in late stage activated T cells.[L34450]

Target Protein:
P-selectin glycoprotein ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen is an active intramuscular immunization for the prophylaxis of invasive meningococcal disease caused by *Neisseria meningitidis* serogroup a. The vaccine contains *N. m…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group c capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group c capsular polysaccharide diphtheria toxoid conjugate antigen is an active intramuscular immunization for the prophylaxis of invasive meningococcal disease caused by *Neisseria meningitidis* serogroup c. The vaccine contains *N. m…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group w-135 capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group w-135 capsular polysaccharide diphtheria toxoid conjugate antigen is an active intramuscular immunization for the prophylaxis of invasive meningococcal disease caused by *Neisseria meningitidis* serogroup W-135. The vaccine contai…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group y capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis group y capsular polysaccharide diphtheria toxoid conjugate antigen is an active intramuscular immunization for the prophylaxis of invasive meningococcal disease caused by *Neisseria meningitidis* serogroup W-135. The vaccine contains* …

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Genetik -
biotech

Deskripsi belum tersedia.

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biotech

Deskripsi belum tersedia.

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biotech

Neisseria meningitidis serogroup B recombinant lp2086 a05 protein variant antigen is a sterile vaccine for intramuscular injection indicated for the active immunization to prevent invasive disease caused by *Neisseria meningitidis* serogroup B. It is containe…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Neisseria meningitidis serogroup b recombinant lp2086 b01 protein variant antigen is a sterile vaccine for intramuscular injection indicated for the active immunization to prevent invasive disease caused by *Neisseria meningitidis* serogroup B. It is containe…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Genetik -
small molecule | CAS: 1239309-58-0

Neladenoson bialanate has been investigated for the treatment of Heart Failure.

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Target Protein:
Adenosine receptor A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelarabine Approved DB01280
small molecule | CAS: 121032-29-9

Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease h…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +8
Target Protein:
DNADNA polymerase alpha catalytic subunitDNA ligase 1 +2
Waktu ParuhNelarabine and ara-…
Vol. DistribusiNelarabine and ara-…
KlirensRenal clearance ave…
Genetik -
Nelatimotide DB17249
small molecule | CAS: 1629213-88-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelfinavir Approved DB00220
small molecule | CAS: 159989-64-7

Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, …

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +45
Target Protein:
HIV-1 protease
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensOral clearance esti…
Genetik -
Nelipepimut-S DB06226
biotech | CAS: 160212-35-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Surface +25
Target Protein:
Receptor tyrosine-protein kinase erbB-2HLA class I histocompatibility antigen, A-3 alpha chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelistotug DB19334
biotech | CAS: 2645437-82-5

Nelistotug is under investigation in clinical trial NCT06062420 (A Platform Study of Novel Immunotherapy Combinations as First-line Treatment in Participants With PD-L1 Positive Recurrent/metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-2…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelivaptan DB12643
small molecule | CAS: 439687-69-1

Nelivaptan has been used in trials studying the treatment of Anxiety Disorders, Depressive Disorder, and Major Depressive Disorder.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Vasopressin V1b receptorVasopressin V2 receptorOxytocin receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelmastobart DB19000
biotech | CAS: 2669823-48-5

Nelmastobart is under investigation in clinical trial NCT05990543 (Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelonicline DB19040
small molecule | CAS: 1026134-63-3

Nelonicline is under investigation in clinical trial NCT01678755 (A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia).

Kategori:
Sulfur CompoundsThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelotanserin DB12555
small molecule | CAS: 839713-36-9

Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sl…

Kategori:
AmidesBenzene Derivatives
Target Protein:
5-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neltenexine DB13239
small molecule | CAS: 99453-84-6

Neltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.

Kategori:
AminesAniline CompoundsCough and Cold Preparations +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelumbo nucifera flower Approved DB14333
biotech

Nelumbo nucifera flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesPharmaceutical Preparations +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nemiralisib DB16253
small molecule | CAS: 1254036-71-9

Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nemolizumab Approved DB15252
biotech | CAS: 1476039-58-3

Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology of various skin inflammatory disorders.[A264254…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAmino Acids, Peptides, and ProteinsAntibodies +10
Target Protein:
Interleukin-31 receptor subunit alpha
Waktu ParuhThe estimated termi…
Vol. DistribusiThe estimated volum…
KlirensThe estimated syste…
Genetik -
Nemonapride DB19314
small molecule | CAS: 75272-39-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +9
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nemtabrutinib DB18866
small molecule | CAS: 2095393-15-8

Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-0…

Target Protein:
Tyrosine-protein kinase BTK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2315268-27-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 1853254-97-3

Nendratareotide uzatansine is a peptide-drug conjugate comprising a peptide analog of somatostatin conjugated to the cytotoxin mertansine.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NEO-212 DB17100
small molecule | CAS: 1361198-79-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Neoarsphenamine DB18729
small molecule | CAS: 457-60-3

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsArsenicalsHaptens
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neocitrullamon DB13396
small molecule | CAS: 38964-88-4

Deskripsi belum tersedia.

Kategori:
AnticonvulsantsCentral Nervous System DepressantsHydantoins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neodymium DB15318
small molecule | CAS: 7440-00-8

Neodymium is under investigation in clinical trial NCT03525522 (Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus).

Kategori:
ElementsLanthanoid Series ElementsMetals +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Neomycin Approved DB00994
small molecule | CAS: 1404-04-2

Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_.[L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C.[A191529] Neomycin B, also known as [framyceti…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAminoglycoside Antibacterials +28
Target Protein:
30S ribosomal protein S1216S ribosomal RNAExtracellular calcium-sensing receptor
Waktu ParuhThere is limited in…
Vol. DistribusiThe small fraction …
KlirensThere is limited in…
Genetik -
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