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14063

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10481 (74.5%)
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8038 (57.2%)
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107 (0.8%)
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14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 213 / 282
Pepsin Approved DB13198
biotech | CAS: 9001-75-6

Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products [L2358]. Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach a…

Kategori:
Alimentary Tract and MetabolismAspartic Acid EndopeptidasesAspartic Acid Proteases +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 118997-30-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesHormones +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 123583-37-9

Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesHormones +3
Target Protein:
Neuropeptide Y receptor type 2Neuropeptide Y receptor type 1Neuropeptide Y receptor type 5 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peptide-T DB19279
small molecule | CAS: 106362-32-7

Peptide-T is under investigation in clinical trial NCT00000392 (Phase II Study of the Efficacy of Peptide T in Hiv-positive Individuals With Cognitive Impairment.).

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Peracetic acid DB14556
small molecule | CAS: 79-21-0

A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant.

Kategori:
AcetatesAcids, AcyclicAnti-Infective Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peramivir Approved DB06614
small molecule | CAS: 330600-85-6

Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir has been supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. B…

Kategori:
AmidinesAnti-Infective AgentsAntiinfectives for Systemic Use +6
Target Protein:
NeuraminidaseNeuraminidaseNeuraminidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perampanel Approved DB08883
small molecule | CAS: 380917-97-5

Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizu…

Kategori:
AMPA Receptor AntagonistsAnticonvulsantsCentral Nervous System Depressants +23
Target Protein:
Glutamate receptor 2Glutamate receptor 3Glutamate receptor 4 +1
Waktu ParuhPerampanel has a lo…
Vol. DistribusiThe volume of distr…
KlirensIn healthy patients…
Genetik -
Perazine Approved DB12710
small molecule | CAS: 84-97-9

Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +12
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perboric acid Approved DB13235
small molecule | CAS: 14034-78-7

Perboric acid is mainly found in its salt form of sodium perborate and it can be found as a monohydrate or tetrahydrate.[A33037] It is one of the peroxy acid salts with very wide functionalities in industrial settings.[F66] Perboric acid in the form of sodium…

Kategori:
AcidsAlimentary Tract and MetabolismAnions +7
Waktu ParuhAs perboric acid an…
Vol. DistribusiAs perboric acid an…
KlirensAs perboric acid an…
Genetik -
Perenostobart DB18602
biotech | CAS: 2643331-31-9

Perenostobart is an alpha-CD39 IgG4 monoclonal antibody.

Waktu Paruh-
Vol. Distribusi-
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Peresolimab DB18874
biotech | CAS: 2411580-63-5

Peresolimab is under investigation in clinical trial NCT04634253 (A Study of LY3462817 in Participants With Rheumatoid Arthritis).

Waktu Paruh-
Vol. Distribusi-
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Peretinoin DB16291
small molecule | CAS: 81485-25-8

Deskripsi belum tersedia.

Kategori:
AlkenesAnticarcinogenic AgentsBiological Factors +8
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Perflenapent DB11625
small molecule | CAS: 678-26-2

Dodecafluoropentane is also known as perfluoropentane or perflenapent.

Kategori:
AlkanesCompounds used in a research, industrial, or household settingContrast Media +5
Waktu Paruh-
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Perflexane Approved DB09531
small molecule | CAS: 355-42-0

Deskripsi belum tersedia.

Kategori:
Diagnostic AgentsHydrocarbons, FluorinatedHydrocarbons, Halogenated +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflubron DB05791
small molecule | CAS: 423-55-2

Perflubron (Oxygent) is being developed as an intravascular oxygen carrier designed to augment oxygen delivery in surgical patients.

Kategori:
Anti-Obesity AgentsCompounds used in a research, industrial, or household settingContrast Media +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflubutane Approved DB12821
small molecule | CAS: 355-25-9

Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclea…

Kategori:
AnionsCompounds used in a research, industrial, or household settingContrast Media +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 84808-64-0

Oxycyte has been used in trials studying the treatment of Traumatic Brain Injury.

Kategori:
Hydrocarbons, FluorinatedHydrocarbons, Halogenated
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 306-94-5

Perfluorodecalin is under investigation in clinical trial NCT03668665 (Influencing Wound Healing Through the Application of Hyaluronic Acid With Perfluorodecalin and Physalis Angulata Extract After Split Skin Removal From the Thigh - a Study in "Split Wound D…

Kategori:
Blood SubstitutesHydrocarbons, FluorinatedHydrocarbons, Halogenated +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Perfluorohexyloctane Approved DB17823
small molecule | CAS: 133331-77-8

Perfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight hydrogenated carbon atoms.[L46491] It is an inert, slightly amphiphilic compound.[A259746] Because it is a completely non-aqueous liquid, microbial growth…

Kategori:
Hydrocarbons, FluorinatedHydrocarbons, HalogenatedOphthalmic Solutions +3
Waktu Paruh-
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Genetik -
Perflutren Approved DB00556
small molecule | CAS: 76-19-7

Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the micro…

Kategori:
Amino Acids, Peptides, and ProteinsCompounds used in a research, industrial, or household settingContrast Media +10
Waktu ParuhThe mean half-life …
Vol. Distribusi-
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Genetik -
Perfosfamide DB12727
small molecule | CAS: 62435-42-1

Perfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.

Kategori:
Hydrocarbons, HalogenatedMustard CompoundsNitrogen Mustard Compounds +3
Waktu Paruh-
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Genetik -
Pergolide Approved DB01186
small molecule | CAS: 66104-22-1

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as …

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-2 Receptor Agonists +24
Target Protein:
D(2) dopamine receptorD(3) dopamine receptorD(4) dopamine receptor +12
Waktu Paruh27 hours
Vol. Distribusi-
Klirens-
Genetik -
Perhexiline Approved DB01074
small molecule | CAS: 6621-47-2

Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsBradycardia-Causing Agents +18
Target Protein:
Carnitine O-palmitoyltransferase 1, liver isoformCarnitine O-palmitoyltransferase 1, muscle isoformCarnitine O-palmitoyltransferase 2, mitochondrial +1
Waktu ParuhVariable and non-li…
Vol. Distribusi-
Klirens-
Genetik -
Periciazine Approved DB01608
small molecule | CAS: 2622-26-6

Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazin…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +12
Target Protein:
D(1A) dopamine receptorAlpha-2A adrenergic receptorAlpha-1B adrenergic receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peridinin DB03001
small molecule | CAS: 33281-81-1

Deskripsi belum tersedia.

Kategori:
AlkenesBiological FactorsCyclohexanes +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perifosine DB06641
small molecule | CAS: 157716-52-4

Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.

Kategori:
AminesOnium CompoundsQuaternary Ammonium Compounds +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformRAC-alpha serine/threonine-protein kinaseMitogen-activated protein kinase 1 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18457-55-1

Perillyl alcohol is under investigation in clinical trial NCT02704858 (Safety and Efficacy Study in Recurrent Grade IV Glioma).

Kategori:
Antineoplastic AgentsEnzyme InhibitorsPerilla +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perindopril Approved DB00790
small molecule | CAS: 82834-16-0

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a po…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +18
Target Protein:
Angiotensin-converting enzymeSecreted frizzled-related protein 4
Waktu ParuhPerindopril, 1.2 ho…
Vol. Distribusi-
Klirens* 219 - 362 mL/min …
Genetik -
Perindoprilat DB14213
small molecule | CAS: 95153-31-4

The active metabolite of the prodrug [Perindopril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Permethrin Approved DB04930
small molecule | CAS: 52645-53-1

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsBenzene Derivatives +22
Target Protein:
Sodium channel protein type 1 subunit alphaEstrogen receptorNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perospirone DB08922
small molecule | CAS: 150915-41-6

Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. Dainippon Sumitomo Pharma devel…

Kategori:
Antipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])Central Nervous System Agents +13
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +3
Gen Terkait:
HTR1A
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean volume of …
KlirensApparent clearance …
Genetik 1 Varian
Perphenazine Approved DB00850
small molecule | CAS: 58-39-9

An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.

Kategori:
Antipsychotic AgentsAntipsychotic Agents (First Generation [Typical])Central Nervous System Agents +28
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorCalmodulin
Waktu Paruh8-12 hours, but ran…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 17528-28-8

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pertussis vaccine Approved DB15274
biotech

Pertussis vaccine is under investigation in clinical trial NCT01698346 (Pertussis (Tdap) Vaccination in Pregnancy).

Kategori:
Bacterial VaccinesBiological ProductsComplex Mixtures +1
Waktu Paruh-
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Pertuzumab Approved DB06366
biotech | CAS: 380610-27-5

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +19
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu ParuhThe median half-lif…
Vol. DistribusiThe average steady-…
KlirensThe median clearanc…
Genetik -
Peruvoside DB13756
small molecule | CAS: 1182-87-2

Deskripsi belum tersedia.

Kategori:
CardanolidesCardiac GlycosidesCardiac Therapy +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perzinfotel DB12365
small molecule | CAS: 144912-63-0

Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.

Kategori:
Aza CompoundsOrganophosphorus Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Petesicatib DB15297
small molecule | CAS: 1252637-35-6

Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).

Kategori:
Enzyme Inhibitors
Target Protein:
Cathepsin S
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Petosemtamab DB18948
biotech | CAS: 2213450-26-9

Petosemtamab is under investigation in clinical trial NCT03526835 (A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors).

Waktu Paruh-
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Genetik -
Petrelintide DB19442
biotech | CAS: 2766385-23-1

Petrelintide is under investigation in clinical trial NCT06662539 (Once-weekly Petrelintide Versus Placebo for Obesity or Overweight With Co-morbidities).

Waktu Paruh-
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Genetik -
PEV3A DB05144
biotech

PEV3A is a prophylactic malaria vaccine that acts against various stages of the disease. It is a two-component vaccine that contains the virosome formulated peptide mimetics PEV301 and PEV302. The two synthetic peptide vaccine components mimic the native stru…

Kategori:
Vaccines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexacerfont DB12572
small molecule | CAS: 459856-18-9

Pexacerfont has been investigated for the treatment of Alcoholism, Anxiety Disorder, Alcohol Dependence, and Alcohol-Related Disorders.

Target Protein:
Corticotropin-releasing factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1058624-46-6

Pexastimogene devacirepvec is under investigation in clinical trial NCT00429312 (A Study of Recombinant Vaccinia Virus to Treat Malignant Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexelizumab DB04949
biotech | CAS: 219685-93-5

Pexelizumab is a humanized monoclonal antibody used as an immunosuppressive drug. It is being investigated by Alexion Pharmaceuticals.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +12
Waktu Paruh7.0 hours to 14.5 h…
Vol. Distribusi-
Klirens-
Genetik -
Pexidartinib Approved DB12978
small molecule | CAS: 1029044-16-3

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +34
Target Protein:
Macrophage colony-stimulating factor 1 receptorMast/stem cell growth factor receptor KitReceptor-type tyrosine-protein kinase FLT3 +1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Pexiganan DB16293
biotech | CAS: 147664-63-9

Pexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexmetinib DB16294
small molecule | CAS: 945614-12-0

Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab).

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles
Target Protein:
Angiopoietin-1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00217830 DB12998
small molecule | CAS: 846032-02-8

PF-00217830 has been used in trials studying the treatment of Schizophrenia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00356231 DB03367
small molecule | CAS: 766536-21-4

Deskripsi belum tersedia.

Target Protein:
Macrophage metalloelastase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00446687 DB12517
small molecule | CAS: 862281-92-3

PF-00446687 has been investigated for the treatment of Erectile Dysfunction.

Kategori:
Receptor, Melanocortin, Type 4, agonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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