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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
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12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 210 / 252
Roxarsone DB11458
small molecule | CAS: 121-19-7

Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use i…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +3
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Royal jelly DB14250
biotech | CAS: 8031-67-2

Royal jelly is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
BeesLipids
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Rozanolixizumab Approved DB14919
biotech | CAS: 1584645-37-3

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange.…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
IgG receptor FcRn large subunit p51
Waktu Paruh-
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Rozibafusp Alfa DB19233
biotech | CAS: 2143449-47-0

Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)).

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
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Rozrolimupab DB05209
biotech | CAS: 909402-77-3

Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Target Protein:
Rhesus blood group D antigen
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RP-67580 DB16742
small molecule | CAS: 135911-02-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingNeurokinin-1 Receptor AntagonistsNeurotransmitter Agents
Target Protein:
Substance-P receptor
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RP-72 DB17156
biotech

Deskripsi belum tersedia.

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RP-A501 DB17647
biotech

RP-A501 is a gene therapy product consisting of a recombinant adeno-associated virus serotype 9 (rAAV9) capsid containing the human LAMP2B transgene (AAV9:LAMP2B), which encodes lysosome-associated membrane protein 2 (LAMP-2). It is being investigated for Dan…

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RP-L201 DB17595
biotech

Deskripsi belum tersedia.

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RP01 DB05751
small molecule

RP01 is a novel anti-IgE immunotherapy for allergic individuals. It is designed to induce the immune system to produce antibodies that block Immunoglobulin E (IgE), the key mediator of an allergic response. It could offer benefit to millions of asthma and all…

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RPI-78M DB05740
small molecule

RPI-78M is being developed for the treatment of multiple sclerosis (MS). Other neurological disorders that may be served by RPI-78M include myasthenia gravis (MG), muscular dystrophy (MD) and amyotrophic lateral sclerosis (ALS).

Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit beta-2Neuronal acetylcholine receptor subunit alpha-7 +3
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RPI-MN DB17957
biotech

RPI-MN is a detoxified or chemically modified alpha-cobratoxin with antiviral properties.[A260132] Being developed by Nutra Pharma under the trade name PEPTERON, it is being investigated for the treatment of neurological and immune disorders.[L47107]

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RPR128515 DB04424
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
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rPSGL-Ig DB06256
biotech

Recombinant P-selectin glycoprotein ligand IgG fusion protein (rPSGL-Ig) is a fusion protein of human P-selectin ligand and IgG1-Fc.

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RRx-001 DB12060
small molecule | CAS: 925206-65-1

RRx-001 has been used in trials studying the treatment of Lymphomas, Brain Metastases, Cholangiocarcinoma, Colorectal Neoplasms, and Malignant Solid Tumor, among others.

Kategori:
AzetinesCarbon Radioisotopes
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RS-39604 DB17050
small molecule | CAS: 161362-65-8

RS-39604 is a selective 5-HT4 receptor antagonist.[A253112]

Kategori:
AlkanesHydrocarbons, Acyclic
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Genetik -
rsATP7A cDNA DB17854
biotech

Deskripsi belum tersedia.

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rsPSMA Vaccine Approved DB06361
biotech

Prostate-specific membrane antigen (PSMA) is an ?100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPS…

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RSV-604 DB15197
small molecule | CAS: 676128-63-5

RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.).

Kategori:
AmidesBenzazepinesBenzene Derivatives +1
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RTA 744 DB05920
small molecule

RTA 744 is a novel anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of primary and metastatic brain cancers. Anthracyclines are one of the most broadly used and effective classes of cancer therapi…

Target Protein:
DNA topoisomerase 2-alpha
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RTL-1000 DB17946
biotech | CAS: 1391875-03-8

RTL-1000 is a recombinant T-Cell receptor ligand being investigated for the treatment of multiple sclerosis.

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RU79073 DB03525
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU79256 DB01866
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU82209 DB03591
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU85053 DB03712
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU85493 DB01908
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
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RU90395 DB02432
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
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Rubitecan DB06159
small molecule | CAS: 91421-42-0

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntineoplastic AgentsEnzyme Inhibitors +2
Target Protein:
DNA topoisomerase 1
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Rucaparib Approved DB12332
small molecule | CAS: 283173-50-2

Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair.[A18745] Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +47
Target Protein:
Poly [ADP-ribose] polymerase 1Poly [ADP-ribose] polymerase 2Protein mono-ADP-ribosyltransferase PARP3
Waktu ParuhThe mean (coefficie…
Vol. DistribusiThe mean (coefficie…
KlirensThe mean (coefficie…
Genetik -
Rufinamide Approved DB06201
small molecule | CAS: 106308-44-5

Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.

Kategori:
AnticonvulsantsCarboxamide DerivativesCardiovascular Agents +14
Target Protein:
Sodium channel protein type 9 subunit alphaMetabotropic glutamate receptor 5
Waktu ParuhElimination half-li…
Vol. DistribusiRufinamide was even…
Klirens-
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Rugonersen DB18662
biotech | CAS: 2591587-57-2

Rugonersen is a locked nucleic acid antisense oligonucleotide under investigation for the treatment of Angelman Syndrome.

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Rulonilimab DB18922
biotech | CAS: 2417124-95-7

Rulonilimab is under investigation in clinical trial NCT05408221 (The Efficacy and Safety of Rulonilimab in Combination With Lenvatinib in Hepatocellular Carcinoma).

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Rumex acetosella pollen Approved DB10359
biotech

Rumex acetosella pollen is the pollen of the Rumex acetosella plant. Rumex acetosella pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Rupatadine Approved DB11614
small molecule | CAS: 158876-82-5

Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria. It was approved for marketing in Canada under the tr…

Kategori:
Antihistamines for Systemic UseBenzocycloheptenesCytochrome P-450 CYP2C19 Substrates +13
Target Protein:
Platelet-activating factor receptorHistamine H1 receptor
Waktu ParuhThe half life of el…
Vol. DistribusiThe apparent volume…
KlirensSystemic clearance …
Genetik -
Rupintrivir DB05102
small molecule | CAS: 223537-30-2

Rupintrivir is a rhinovirus 3C protease inhibitor in development for use against human rhinoviral (HRV) infections. Rupintrivir was active against all 48 HRV serotypes tested in a cell protection assay in H1-HeLa cells. It is designed to combat colds caused b…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Branched-Chain +8
Target Protein:
Genome polyproteinGenome polyprotein
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Ruplizumab DB06475
biotech | CAS: 220651-94-5

Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive drug and is a component of Antova.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Target Protein:
CD40 ligand
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Rurioctocog alfa pegol Approved DB16007
biotech | CAS: 1417412-83-9

Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor. Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated r…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +9
Target Protein:
von Willebrand factorCoagulation factor VIII
Waktu ParuhFollowing intraveno…
Vol. DistribusiFollowing intraveno…
KlirensFollowing intraveno…
Genetik -
RUS 3108 DB05911
small molecule

RUS 3108 is being developed for the treatment of atherosclerosis, the major cause of cardiovascular disorders such as heart attacks and stroke by Dr. Reddy’s Laboratories. The drug’s Phase I clinical trials have been initiated in Europe to assess safety of …

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biotech | CAS: 875455-82-6

Chrysalin has been used in trials studying the treatment of Radius Fracture.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +11
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Ruscogenin DB15830
small molecule | CAS: 472-11-7

Deskripsi belum tersedia.

Kategori:
CholestanesFused-Ring CompoundsSapogenins +1
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Rutin Approved DB01698
small molecule | CAS: 153-18-4

A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.

Kategori:
BenzopyransCapillary Stabilizing AgentsChromones +12
Target Protein:
Aldo-keto reductase family 1 member C3Carbonyl reductase [NADPH] 1
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RUTI® Vaccine DB15853
biotech

The RUTI® Vaccine contains fragmented, purified and liposomed heat-inactivated Mycobacterium tuberculosis bacilli. The vaccine has demonstrated a reasonable safety profile and potent stimulation of the immune response against tuberculosis. Much like the BCG v…

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Ruxolitinib Approved DB08877
small molecule | CAS: 941678-49-5

Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor. It is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved in cytokine signalling and hematopoiesis.[A745…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +18
Target Protein:
Urokinase plasminogen activator surface receptorTyrosine-protein kinase JAK2Tyrosine-protein kinase JAK1 +2
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean volume of …
KlirensRuxolitinib clearan…
Genetik -
Ruzinurad DB19209
small molecule | CAS: 1638327-48-6

Ruzinurad is under investigation in clinical trial NCT04956432 (A Multicentre, Randomized, Double-blind, Allopurinol Controlled Study to Evaluate the Efficacy and Safety of SHR4640 in Subjects With Gout).

Kategori:
CycloparaffinsHeterocyclic Compounds, Fused-Ring
Target Protein:
Solute carrier family 22 member 12
Waktu Paruh-
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RVT-3101 DB18718
biotech

RVT-3101 is a fully human monoclonal antibody targeting vascular endothelial growth inhibitor, also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15. It is being investigated for ulcerative colitis.

Target Protein:
Tumor necrosis factor ligand superfamily member 15
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RWJ-51084 DB03251
small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +4
Target Protein:
Serine protease 1
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RWJ-56423 DB02812
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
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RWJ-800088 DB18693
biotech | CAS: 257287-15-3

RWJ-800088 is a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous TPO.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsPeptides +2
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Rye Approved DB10564
biotech

Rye allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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small molecule

Deskripsi belum tersedia.

Target Protein:
Thymidylate synthaseDelta-aminolevulinic acid dehydratase3',5'-cyclic-AMP phosphodiesterase 4B +15
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