Hasil Filter

14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (14063)

Halaman 210 / 282
Parsatuzumab DB14897
biotech | CAS: 1312797-14-0

Parsatuzumab is under investigation in clinical trial NCT01366131 (Study Evaluating the Safety and Efficacy of MEGF0444A in Combination With Carboplatin, Paclitaxel and Bevacizumab in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parthenolide Approved DB13063
small molecule | CAS: 20554-84-1

Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +8
Target Protein:
Proto-oncogene c-RelTranscription factor RelBInhibitor of nuclear factor kappa-B kinase subunit beta +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAS-004 DB18611
small molecule

PAS-004 is an allosteric MEK 1/2 inhibitor being developed by Pasithea Therapeutics. It is being investigated for the treatment of neurofibromatosis 1 and Noonan syndrome.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAS219 DB03114
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pascolizumab DB06560
biotech | CAS: 331243-22-2

Pascolizumab (SB 240683) is a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Target Protein:
Interleukin-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pasireotide Approved DB06663
small molecule | CAS: 396091-73-9

Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.

Kategori:
Amino Acids, Peptides, and ProteinsBradycardia-Causing AgentsCytochrome P-450 CYP3A Inhibitors +22
Target Protein:
Somatostatin receptor type 3Somatostatin receptor type 1Somatostatin receptor type 2 +1
Waktu ParuhThe half-life is 12…
Vol. DistribusiPasireotide is wide…
KlirensThe clearance in he…
Genetik -
PAT-1251 DB16735
small molecule | CAS: 2098884-52-5

PAT-1251 is under investigation in clinical trial NCT04054245 (PAT-1251 in Treating Patients With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocytosis Myelofibrosis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pateclizumab DB14997
biotech | CAS: 1202526-59-7

Pateclizumab is under investigation in clinical trial NCT01225393 (A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients Wi…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patent Blue Approved DB13967
small molecule | CAS: 25305-77-5

Patent blue is aniline dye and it is one of the most common dyes used.[A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt.[A32574] It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cy…

Kategori:
AminesAniline CompoundsColoring Agents +4
Target Protein:
Albumin
Waktu ParuhThe elimination hal…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Patidegib DB12655
small molecule | CAS: 1037210-93-7

Patidegib has been investigated for the treatment of Conventional Chondrosarcoma.

Kategori:
Alkaloids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2376210-48-7

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patiromer Approved DB09263
small molecule | CAS: 1260643-52-4

Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding poly…

Kategori:
Cation Exchange ResinsCompounds used in a research, industrial, or household settingMacromolecular Substances +3
Target Protein:
Potassium
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patisiran Approved DB14582
biotech | CAS: 1420706-45-1

Patisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis [L4220]. It is marketed as Onpattro which is formulated as patisiran within a liposome envelope for b…

Kategori:
Antisense Elements (Genetics)Compounds used in a research, industrial, or household settingDecreased RNA Integrity +12
Target Protein:
Transthyretin mRNA
Waktu ParuhPatisiran has a ter…
Vol. DistribusiThe steady state vo…
KlirensThe total body clea…
Genetik -
Patritumab DB12090
biotech | CAS: 1262787-83-6

Patritumab has been used in trials studying the treatment of LUNG CANCER, Solid Tumors, Neoplasms by Site, Head and Neck Neoplasms, and Non-small Cell Lung Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patulin DB15586
small molecule | CAS: 149-29-1

Deskripsi belum tersedia.

Kategori:
Biological FactorsCompounds used in a research, industrial, or household settingMutagens +6
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patupilone DB03010
small molecule | CAS: 152044-54-7

Epothilone B is a 16-membered macrolide that mimics the biological effects of taxol.

Kategori:
Anti-Bacterial AgentsAntimitotic AgentsAntineoplastic Agents +9
Target Protein:
Tubulin beta chainTubulin beta-1 chainTubulin beta-4B chain +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pavinetant DB11692
small molecule | CAS: 941690-55-7

Pavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingQuinolines +3
Target Protein:
Neuromedin-K receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paxalisib DB15186
small molecule | CAS: 1382979-44-3

GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).

Kategori:
Enzyme Inhibitors
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pazopanib Approved DB06589
small molecule | CAS: 444731-52-6

Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.

Kategori:
AmidesAngiogenesis InhibitorsAntineoplastic Agents +36
Target Protein:
Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3 +7
Gen Terkait:
UGT1A1 HCP5
Waktu Paruh35 hours. Oral abso…
Vol. DistribusiVd steady state, IV…
KlirensCL, cancer patient,…
Genetik 2 Varian
Pazufloxacin DB11774
small molecule | CAS: 127045-41-4

Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +15
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA topoisomerase 4 subunit A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PB-722 DB18447
biotech

PB-722 is a long-acting glucagon receptor agonist.[L48260]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PB127 DB06208
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBCAR20A DB17189
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBCAR269A DB17188
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBFT02 DB18580
biotech

PBFT02 is a non-replicating recombinant adeno-associated virus serotype 1 vector delivering human GRN gene encoding the protein progranulin.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBI-1402 DB05480
small molecule

PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils, enhancing their survival and activation with comparable efficacy to GM-CSF, G-CSF and EPO, which are currently used to treat anemia. However, it ha…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBR-06 F-18 DB17020
small molecule | CAS: 1003581-94-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBT-1033 DB05565
small molecule | CAS: 747408-78-2

Deskripsi belum tersedia.

Target Protein:
Microtubule-associated protein tau
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBT-434 Approved DB16965
small molecule | CAS: 1232840-87-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCI-27483 DB13000
small molecule | CAS: 871266-63-6

PCI-27483 has been used in trials studying the treatment of Pancreatic Cancer, Ductal Adrenocarcinoma, and Exocrine Pancreatic Cancer.

Kategori:
AmidesAmidinesAmino Acids +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCLX-001 DB15567
small molecule | CAS: 1215011-08-7

PCLX-001 is a first-in-kind N-Myristoyltransferase (NMT) inhibitor being developed by [Pacylex Pharmaceuticals](https://pacylex.com). Current studies have shown that PCLX-001 works differently than other known cancer drugs and has high activity and positive r…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCO-371 DB14946
small molecule | CAS: 1613373-33-3

PCO-371 is under investigation in clinical trial NCT02475616 (A Single Ascending Dose Study of PCO371 in Healthy Volunteers).

Kategori:
Imidazoles
Target Protein:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCS-499 DB15122
small molecule | CAS: 1268605-91-9

PCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients).

Kategori:
DeuteriumHeterocyclic Compounds, Fused-RingPurines +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-0299685 DB15264
small molecule | CAS: 313651-33-1

PD-0299685 is under investigation in clinical trial NCT00314964 (Study Evaluating PD-0299685 for the Treatment of Vasomotor Symptoms (Hot Flashes / Flushes) Associated With Menopause).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-166326 DB08339
small molecule | CAS: 185039-91-2

Deskripsi belum tersedia.

Target Protein:
Mast/stem cell growth factor receptor KitMitogen-activated protein kinase 14Tyrosine-protein kinase Lck +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-168393 DB07662
small molecule | CAS: 194423-15-9

PD-168393 is an epidermal growth factor receptor inhibitor.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Epidermal growth factor receptorReceptor tyrosine-protein kinase erbB-2Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-169316 DB17040
small molecule | CAS: 152121-53-4

PD-169316 is a p38 MAP kinase inhibitor.[A253062]

Kategori:
Enzyme Inhibitors
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-173952 DB17041
small molecule | CAS: 305820-75-1

PD-173952 is a potent Myt1 kinase inhibitor.[A253067]

Kategori:
Oxazines
Target Protein:
Platelet-derived growth factor receptor alphaProto-oncogene tyrosine-protein kinase SrcTyrosine-protein kinase Lck +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-217014 DB12493
small molecule | CAS: 444088-20-4

PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-98059 DB17042
small molecule | CAS: 167869-21-8

PD-98059 is an inhibitor of MAP-kinase kinase activation.[A253072]

Kategori:
BenzopyransCalcium-Calmodulin-Dependent Protein Kinases, antagonists & inhibitorsChromones +4
Target Protein:
Dual specificity mitogen-activated protein kinase kinase 1Dual specificity mitogen-activated protein kinase kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD150606 DB02570
small molecule

Deskripsi belum tersedia.

Kategori:
Acids, Acyclic
Target Protein:
Calpain small subunit 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD173955 DB02567
small molecule

Deskripsi belum tersedia.

Kategori:
PyridinesTyrosine Kinase Inhibitors
Target Protein:
Platelet-derived growth factor receptor alphaTyrosine-protein kinase LckProto-oncogene tyrosine-protein kinase Src +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peach Approved DB10552
biotech

Peach allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peanut oil Approved DB13964
biotech | CAS: 8002-03-7

Peanut oil is derived from _Arachis hypogaea_ which can be found in South America, Mexico, and Centro America. The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. The peanut oil represents about 45-52% of the k…

Kategori:
Basic Ointments and ProtectantsBiological ProductsDetergents +8
Waktu ParuhThe exact pharmacok…
Vol. DistribusiThe exact pharmacok…
KlirensThe exact pharmacok…
Genetik -
biotech

Pearl (hyriopsis cumingii) is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Calcium CompoundsCarbon Compounds, InorganicCarbonates +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2408734-39-2

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pecavaptan DB16279
small molecule | CAS: 1914998-56-3

Pecavaptan is under investigation in clinical trial NCT03901729 (A Trial to Study BAY1753011 in Patients With Congestive Heart Failure).

Target Protein:
Vasopressin V1a receptorVasopressin V2 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pectin Approved DB11158
biotech | CAS: 9000-69-5

Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants.[A32327] It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4.[L1961] The carboxylic group of the constituents of pectin can ex…

Kategori:
Alimentary Tract and MetabolismAntidiarrheals, Intestinal Antiinflammatory/antiinfective AgentsBiological Products +15
Waktu ParuhPharmacokinetic stu…
Vol. DistribusiPharmacokinetic stu…
KlirensPharmacokinetic stu…
Genetik -
Pefcalcitol DB11786
small molecule | CAS: 381212-03-9

Pefcalcitol has been investigated for the basic science of Psoriasis.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pefloxacin Approved DB00487
small molecule | CAS: 70458-92-3

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +14
Target Protein:
DNA topoisomerase 2-betaDNA topoisomerase 4 subunit ADNA gyrase subunit A +2
Waktu Paruh8.6 hours
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 10451–10500 dari 14063
Sebelumnya Halaman 210 / 282 Berikutnya