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2279

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Halaman 21 / 46
Human C1-esterase inhibitor Approved DB06404
biotech

C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathway…

Kategori:
Amino Acids, Peptides, and ProteinsBlood and Blood Forming OrgansBlood Proteins +19
Target Protein:
Complement C1r subcomponentComplement C1s subcomponentPlasma kallikrein +4
Waktu ParuhFollowing intraveno…
Vol. Distribusi-
KlirensFollowing intraveno…
Genetik -
Human calcitonin Approved DB06773
biotech | CAS: 21215-62-3

Calcitonin was first discovered in isolated parathyroid tissue as a substance with a serum-calcium-lowering effect.[A32099] It is constituted as a 32-amino acid single chain polypeptide structure that gets secreted as a regulatory agent in calcium-phosphorus …

Kategori:
Bone Density Conservation AgentsCalcitonin PreparationsCalcium Homeostasis +1
Target Protein:
Alpha-actinin-1
Waktu ParuhIntravenous adminis…
Vol. Distribusi-
KlirensThe metabolic clear…
Genetik -
biotech

Human ciliary neurotrophic factor, recombinant was investigated for macular telangiectasia in two clinical trials. The trials were NCT03071965, an extension study of the NT-501 CNTF implant for macular telangiectasia, and NCT01949324, a Phase 2 multicenter ra…

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Human colostrum DB19286
biotech

Deskripsi belum tersedia.

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biotech

Human cord blood hematopoietic progenitor cells consist of hematopoietic progenitor cells, monocytes, lymphocytes, and granulocytes from human cord blood. They are used during allogeneic unrelated and related hematopoietic stem cell transplantation procedures…

Kategori:
Allogeneic Cord Blood Hematopoietic Progenitor Cell Therapy
Waktu ParuhPharmacokinetic par…
Vol. DistribusiPharmacokinetic par…
KlirensPharmacokinetic par…
Genetik -
biotech | CAS: 339086-15-6

Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntiinfectives for Systemic Use +15
Waktu ParuhIgG1 has a half-lif…
Vol. DistribusiIgG is distributed …
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Genetik -
biotech

Deskripsi belum tersedia.

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biotech

CAStem is composed of immunity- and matrix-regulatory cells (IMRCs), also known as M cells, which can be administered through injection. These IMRCs are differentiated from human embryonic stem cells that are expanded and then harvested. These cells are curre…

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biotech

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biotech | CAS: 259230-56-3

Human growth hormone-releasing peptide 3 is under investigation in clinical trial NCT00846872 (Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance).

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Human immunoglobulin G Approved DB00028
biotech | CAS: 308067-58-5

Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatogra…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntigen Neutralization +13
Target Protein:
High affinity immunoglobulin gamma Fc receptor IPutative high affinity immunoglobulin gamma Fc receptor IBLow affinity immunoglobulin gamma Fc region receptor II-a +8
Waktu Paruh>20 hours (mammalia…
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Human interferon beta Approved DB14999
biotech | CAS: 74899-71-1

Human interferon beta is a polypeptide used in the management of relapsing forms of Multiple Sclerosis (MS), and was initially approved by the FDA in 1992.[L12081] Multiple Sclerosis is a devastating neurodegenerative disease that is usually progressive and s…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsBiological Factors +7
Target Protein:
Interferon alpha/beta receptor 1
Waktu ParuhThe mean terminal e…
Vol. DistribusiThe average state v…
KlirensAverage serum clear…
Genetik -
biotech

Human interferon omega 1 (IFN-omega 1 = IFN-alpha II1) is a recently discovered protein structurally related to IFN-alpha and -beta. It occurs naturally in the human body and is currently being manufactured by Intarcia through genetic engineering. There are m…

Kategori:
Immunosuppressive AgentsMyelosuppressive Agents
Target Protein:
Interferon alpha/beta receptor 1Interferon alpha/beta receptor 2
Waktu Paruh-
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biotech

Interleukin-8 is under investigation in clinical trial NCT05148234 (BMS-986253 in Myelodysplastic Syndromes).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
Interleukin-8
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biotech

Human interleukin-2 is under investigation in clinical trial NCT03475134 (TIL-ACT After NMA Chemo With IL-2 and Nivo Rescue in mMEL).

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAnalgesics, Non-Narcotic +12
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biotech

Human interleukin-6 is under investigation in clinical trial NCT03170245 (Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCytokines +4
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biotech | CAS: 183623-03-2

Human Lactoferrin Peptide hLF1-11 is under investigation in clinical trial NCT00509834 (A Study on the Tolerability and Early Efficacy of Hlf1-11 in Patients With Proven Candidaemia).

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biotech

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biotech

Stem cells are self-renewing and proliferate without differentiation, with the two major groups being embryonic stem cells (ESCs) and adult stem cells (ASC). Differentiation occurs under different conditions into different cell types. ESCs are from the inner …

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biotech

Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age …

Kategori:
Actively Acquired ImmunityCancer immunotherapyImmunotherapy +1
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biotech

Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age …

Kategori:
Actively Acquired ImmunityAmino Acids, Peptides, and ProteinsCancer immunotherapy +9
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biotech

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biotech

Human papillomavirus type 18 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age …

Kategori:
Actively Acquired ImmunityCancer immunotherapyImmunotherapy +1
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biotech

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biotech

Human papillomavirus type 31 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 45 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 52L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 5…

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 58 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age f…

Kategori:
Actively Acquired ImmunityCancer immunotherapyImmunotherapy +1
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biotech

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Human Rho(D) immune globulin Approved DB11597
biotech

Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilize…

Kategori:
Amino Acids, Peptides, and ProteinsAntiinfectives for Systemic UseBlood Proteins +9
Target Protein:
Rhesus blood group D antigen
Waktu ParuhThe half life is 16…
Vol. DistribusiA single dose of 30…
KlirensMean systemic clear…
Genetik -
Human thrombin Approved DB11571
biotech | CAS: 9002-04-4

Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This tra…

Kategori:
Blood Coagulation FactorsIncreased Coagulation Factor Activity
Target Protein:
Coagulation factor VCoagulation factor VIIICoagulation factor XI +5
Waktu ParuhDue to the nature o…
Vol. DistribusiDue to the nature o…
KlirensDue to the nature o…
Genetik -
biotech

Transplantation with human umbilical cord blood mononuclear cells (HUCBC) has demonstrated promising results in various disease states. While some of the positive results are credited to HUCBCs’ differentiation potential, the growth factors and cytokines thes…

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biotech

Stem cells obtained from amniotic fluid, the umbilical cord (UC), and placenta are gaining in popularity. Stem cells from the umbilical cord offer several advantages, including: non-invasive collection procedures, more hearty and steady growth than bone-marro…

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biotech

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biotech

Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +10
Waktu ParuhThe mean half-life …
Vol. DistribusiThe volume of distr…
KlirensReadily accessible …
Genetik -
biotech

Human varicella-zoster immune globulin is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV). It is prepared from pools of healthy human donors' plasma vi…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBiological Products +13
Waktu ParuhHuman Varicella-Zos…
Vol. DistribusiFollowing intraveno…
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Genetik -
biotech

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biotech

The humanized anti-IL-12 antibody is an important addition to PDL's already strong pipeline of humanized antibodies being developed for the treatment of autoimmune diseases. SMART Anti-IL-12 Antibody was humanized at PDL from a murine anti-IL-12 antibody that…

Target Protein:
Interleukin-12 subunit beta
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Hyaluronic acid Approved DB08818
small molecule | CAS: 9004-61-9

Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluron…

Kategori:
Adjuvants, ImmunologicBiocompatible MaterialsCarbohydrates +16
Target Protein:
CD44 antigenIntercellular adhesion molecule 1Hyaluronan mediated motility receptor +12
Waktu ParuhWhen injected by th…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
biotech | CAS: 757971-58-7

A purified preparation of the enzyme recombinant human hyaluronidase. Hyaluronidase (human recombinant) (INN Vorhyaluronidase alfa) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragmen…

Kategori:
Blood and Blood Forming OrgansCarbon-Oxygen LyasesEnzymes +6
Target Protein:
Hyaluronic acidTransforming growth factor beta-1 proprotein
Waktu ParuhHyaluronidase has a…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Hydrochlorothiazide Approved DB00999
small molecule | CAS: 58-93-5

Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A18513…

Kategori:
AmidesAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +25
Target Protein:
Solute carrier family 12 member 3Angiotensin-converting enzymeCalcium-activated potassium channel subunit alpha-1
Waktu ParuhThe plasma half lif…
Vol. DistribusiThe volume of distr…
KlirensThe renal clearance…
Genetik -
Hydrogen DB15127
small molecule | CAS: 1333-74-0

Hydrogen is under investigation in clinical trial NCT02830854 (Molecular Hydrogen for Cognitive Function and Performance in Elderly).

Kategori:
ElementsGases
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Hydroxycitronellal Approved DB14187
small molecule | CAS: 107-75-5

Hydroxycitronellal is a synthetic fragrance that is widely used in many cosmetics and hygiene products such as deodorants, soaps, antiseptics, and other household items. It has the smell of lilac, lily, and lily of the valley [A34269]. Hydroxycitronellal has …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleasePerfume +1
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu ParuhThe mean eliminatio…
Vol. DistribusiTmax was found to b…
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Hydroxyethyl cellulose Approved DB11602
small molecule | CAS: 9004-62-0

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ion…

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +6
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Hydroxyproline DB08847
small molecule | CAS: 51-35-4

Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline i…

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +1
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small molecule | CAS: 128446-35-5

Hydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).

Kategori:
beta-CyclodextrinsCarbohydratesCompounds used in a research, industrial, or household setting +10
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