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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 205 / 349
LI-301 DB05509
small molecule

LI 301 is an orally bio-available compound delivered in a fast melt mechanism with taste masking enabling it to be taken anytime without water. It has a novel mode of action combining both the light effect of a Selective Serotonin Reuptake Inhibitor ("SSRI")(…

Target Protein:
Mu-type opioid receptor5-hydroxytryptamine receptor 1A
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Liafensine DB14878
small molecule | CAS: 1198790-53-2

Liafensine is under investigation in clinical trial NCT00892840 (Multiple-Ascending Dose Study).

Kategori:
Heterocyclic Compounds, Fused-Ring
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Liarozole DB13066
small molecule | CAS: 115575-11-6

Liarozole has been used in trials studying the treatment of Ichthyosis, Lamellar.

Kategori:
Antineoplastic AgentsAntineoplastic Agents, HormonalDermatologicals +3
Target Protein:
Cytochrome P450 26A1Aromatase
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Liatermin DB06489
small molecule | CAS: 188630-14-0

Deskripsi belum tersedia.

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Libivirumab DB17748
biotech | CAS: 569658-79-3

Libivirumab is an investigational monoclonal antibody. It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies to the hepatitis B virus (HBV) surface antigen.[A259202]

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LIC-477 DB05363
small molecule

LIC-477is indicated to be suitable for the treatment of psychosomatic disturbances, epilepsy, trigeminal neuralgia and cerebral spasticity.

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Licaminlimab DB18936
biotech | CAS: 1688648-13-6

Licaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease).

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Licochalcone A DB19281
small molecule | CAS: 58749-22-7

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesFabaceae +5
Target Protein:
Tyrosine-protein phosphatase non-receptor type 1
Waktu Paruh-
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Licofelone DB04725
small molecule | CAS: 156897-06-2

Developed by the German pharmaceutical company, Merckle GmbH, together with EuroAlliance partners Alfa Wassermann and Lacer, licofelone (ML3000) is a dual COX/LOX inhibitor and the first member of this new class of analgesic and anti-inflammatory drugs. It is…

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +15
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenaseProstaglandin G/H synthase 2Group IIE secretory phospholipase A2
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Licogliflozin DB15048
small molecule | CAS: 1291094-73-9

Licogliflozin is under investigation in clinical trial NCT03320941 (A Dose-finding Study to Evaluate the Change in Weight After Treatment With LIK066 in Japanese Patients With Obesity).

Kategori:
AlcoholsBlood Glucose Lowering AgentsCarbohydrates +2
Target Protein:
Sodium/glucose cotransporter 1Sodium/glucose cotransporter 2
Waktu Paruh-
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Licorice Approved DB10675
biotech

Licorice allergenic extract is used in allergenic testing.

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Lidocaine Approved DB00281
small molecule | CAS: 137-58-6

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication [T583]. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations …

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAgents that reduce seizure thresholdAmides +49
Target Protein:
Sodium channel protein type 11 subunit alphaSodium channel protein type 10 subunit alphaSodium channel protein type 9 subunit alpha +5
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe mean systemic c…
Genetik -
Lidoflazine Approved DB13766
small molecule | CAS: 3416-26-0

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsBradycardia-Causing Agents +13
Target Protein:
Sodium channel protein type 3 subunit alphaEquilibrative nucleoside transporter 1
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Lidorestat DB07063
small molecule | CAS: 245116-90-9

Deskripsi belum tersedia.

Kategori:
Aldehyde Reductase, antagonists & inhibitorsHeterocyclic Compounds, Fused-RingIndoles +1
Target Protein:
Aldo-keto reductase family 1 member B1
Waktu Paruh-
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biotech | CAS: 1401812-88-1

Lifastuzumab vedotin is under investigation in clinical trial NCT01363947 (Safety and Pharmacokinetics of Escalating Doses of DNIB0600A in Participants With Non-Small Cell Lung Cancer (NSCLC) and Platinum Resistant Ovarian Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Lifibrol DB12448
small molecule | CAS: 96609-16-4

Lifibrol has been used in trials studying the basic science of Hyperlipoproteinemia and Hypercholesterolemia.

Kategori:
Acids, CarbocyclicAlcoholsBenzene Derivatives +5
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Lifileucel Approved DB17107
biotech | CAS: 2306267-74-1

Lifileucel is a tumour-derived autologous T cell immunotherapy composed of a suspension of tumour-derived T cells from the patient [L50171] which undergo isolation, ex vivo expansion, and activation[A263341] Lifileucel was granted accelerated approval by the …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsAntineoplastic cell and gene therapy +3
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Lifirafenib DB14773
small molecule | CAS: 1446090-79-4

Lifirafenib is under investigation in clinical trial NCT03641586 (The Study of BGB-283 in Chinese Subjects With Local Advanced or Metastatic Malignant Solid Tumor).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Serine/threonine-protein kinase B-raf
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Lifitegrast Approved DB11611
small molecule | CAS: 1025967-78-5

Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design p…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +18
Target Protein:
Intercellular adhesion molecule 1Integrin alpha-L
Waktu ParuhNot possible to cal…
Vol. Distribusi-
KlirensNot possible to cal…
Genetik -
Ligandrol DB13934
small molecule | CAS: 1165910-22-4

Ligandrol is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting and osteoporosis.

Target Protein:
Androgen receptor
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Ligelizumab DB11856
biotech | CAS: 1322627-61-1

Ligelizumab is a humanized IgG1k monoclonal antibody targeted against immunoglobulin E (IgE). Similar in mechanism to [omalizumab], another IgE-directed monoclonal antibody, ligelizumab has a distinct binding epitope as compared to its peer (with a small degr…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Immunoglobulin heavy constant epsilon
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Light green SF yellowish Approved DB11183
small molecule | CAS: 5141-20-8

Light green SF yellowish is a green triarylmethane dye that is used in the preparation of the staining solution which is widely used as a counterstain. It is used in histological applications and other labratory settings, and usually exists as a disodium salt…

Kategori:
AminesArylsulfonatesArylsulfonic Acids +5
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Light mineral oil Approved DB11579
small molecule | CAS: 92062-35-6

Deskripsi belum tersedia.

Kategori:
Basic Ointments and Protectants
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Ligufalimab DB17542
biotech | CAS: 2428381-55-7

Ligufalimab is a humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface antigen CD47. It is under investigation in clinical trial NCT04900350 (A Trial of AK117 (Anti-cd47) in Patients With Myelodysplastic Syndrome).

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Ligustrazine DB19074
small molecule | CAS: 1124-11-4

Ligustrazine is under investigation in clinical trial NCT05942352 (Clinical Study of Ligustrazine in Treating Alcohol Addiction).

Kategori:
Antiplatelet agentsCardiovascular AgentsVasodilating Agents
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Ligustrum vulgare pollen Approved DB10488
biotech

Ligustrum vulgare pollen is the pollen of the Ligustrum vulgare plant. Ligustrum vulgare pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Lilotomab DB19076
biotech | CAS: 1453362-55-4

Lilotomab is under investigation in clinical trial NCT01796171 (A Phase 1/2 Study of Betalutin for Treatment of Relapsed Non-hodgkin Lymphoma).

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Lima bean Approved DB10540
biotech

Lima bean allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Limaprost DB09211
small molecule | CAS: 74397-12-9

Limaprost (as Limaprost alfadex; CAS number 88852-12-4) is an oral prostaglandin E1 analog. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and …

Kategori:
AnticoagulantsAutacoidsBiological Factors +11
Target Protein:
Prostaglandin E2 receptor EP2 subtypeProstaglandin E2 receptor EP1 subtypeProstaglandin E2 receptor EP3 subtype +1
Waktu ParuhThe mean half life …
Vol. Distribusi-
KlirensMean total clearanc…
Genetik -
Lime (citrus) Approved DB10635
biotech

Lime (citrus) allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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small molecule | CAS: 138-86-3

Limonene, (+/-)- is under investigation in clinical trial NCT05525260 (Limonene for Pulmonary Nodule Chemoprevention).

Kategori:
Cyclohexane MonoterpenesCyclohexanesCyclohexenes +3
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Linaclotide Approved DB08890
small molecule | CAS: 851199-59-2

Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous act…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsDrugs for Constipation +7
Target Protein:
Guanylyl cyclase C
Waktu ParuhThere is no availab…
Vol. DistribusiGiven that linaclot…
KlirensNo information is a…
Genetik -
Linafexor DB18031
small molecule | CAS: 2499656-04-9

Deskripsi belum tersedia.

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Linagliptin Approved DB08882
small molecule | CAS: 668270-12-0

Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [L9557]. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal sys…

Kategori:
Agents causing angioedemaAlimentary Tract and MetabolismBlood Glucose Lowering Agents +24
Target Protein:
Dipeptidyl peptidase 4
Waktu ParuhThe terminal half l…
Vol. DistribusiA single intravenou…
KlirensTotal clearance of …
Genetik -
Lincomycin Approved DB01627
small molecule | CAS: 154-21-2

Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska.[A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher eff…

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +11
Target Protein:
23S ribosomal RNA
Waktu ParuhLincomycin has a bi…
Vol. DistribusiLincomycin administ…
KlirensLincomycin administ…
Genetik -
Lindane Approved DB00431
small molecule | CAS: 58-89-9

An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Can…

Kategori:
Agents that reduce seizure thresholdAgrochemicalsAntiparasitic Products, Insecticides and Repellents +9
Target Protein:
Gamma-aminobutyric acid receptor subunit beta-1Glycine receptor subunit alpha-1Glycine receptor subunit alpha-2 +7
Waktu Paruh18 hours
Vol. Distribusi-
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Linerixibat DB11729
small molecule | CAS: 1345982-69-5

GSK2330672 has been investigated for the treatment of Diabetes Mellitus, Type 2.

Kategori:
AminesAzepinesSulfur Compounds +1
Target Protein:
Ileal sodium/bile acid cotransporter
Waktu Paruh-
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Linezolid Approved DB00601
small molecule | CAS: 165800-03-3

Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci.[L3296…

Kategori:
AcetamidesAcetatesAcids, Acyclic +22
Target Protein:
23S ribosomal RNA
Waktu ParuhThe elimination hal…
Vol. DistribusiAt steady-state, th…
KlirensTotal clearance of …
Genetik -
Linifanib DB06080
small molecule | CAS: 796967-16-3

Linifanib (ABT-869) is a small molecule vascular endothelial growth factor (VEGF) receptor-based kinase inhibitor that is designed to suppress tumor growth by preventing the formation of new blood vessels that supply the tumor with oxygen and nutrients and by…

Kategori:
AmidesBenzene DerivativesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Vascular endothelial growth factor receptor 3Receptor-type tyrosine-protein kinase FLT3Vascular endothelial growth factor receptor 1 +3
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Linoleic acid Approved DB14104
small molecule | CAS: 60-33-3

Deskripsi belum tersedia.

Kategori:
Fatty AcidsFatty Acids, EssentialFatty Acids, Omega-6 +3
Target Protein:
Fatty acid-binding protein, adipocyte
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Linopirdine DB13806
small molecule | CAS: 105431-72-9

Deskripsi belum tersedia.

Kategori:
Cardiovascular AgentsCentral Nervous System AgentsCompounds used in a research, industrial, or household setting +8
Target Protein:
Potassium voltage-gated channel subfamily KQT member 3
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Linopristin DB19296
small molecule | CAS: 325965-23-9

Linopristin is an antibiotic of the streptogramin B class. It is one part of the combination product NXL 103, along with [Virginiamycin M1]. The combination product was under investigation in clinical trials NCT00653172 and NCT00949130 for treatment of variou…

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Linperlisib DB17235
small molecule | CAS: 1702816-75-8

Deskripsi belum tersedia.

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Linrodostat DB14986
small molecule | CAS: 1923833-60-6

Linrodostat is under investigation in clinical trial NCT03247283 (Pharmacokinetics and Metabolism Study in Healthy Male Participants).

Kategori:
AcetatesAcids, AcyclicAmides +2
Waktu Paruh-
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Linseed oil DB11357
biotech | CAS: 66071-03-2

Linseed oil is a rich source of ?-Linolenic acid extracted from the dried, ripened seeds of the flax plant *Linum usitatissimum*. Other fatty acids contained in linseed oil include palmitic acid, stearic acid, oleic acid and linolenic acid. Linseed oil is par…

Kategori:
Biological ProductsComplex MixturesFats +5
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Linsidomine DB13400
small molecule | CAS: 33876-97-0

Deskripsi belum tersedia.

Kategori:
Antihypertensive AgentsAntiplatelet agentsCardiac Therapy +12
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Linsitinib DB06075
small molecule | CAS: 867160-71-2

An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation …

Target Protein:
Insulin receptorInsulin-like growth factor 1 receptor
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Lintitript DB04867
small molecule | CAS: 136381-85-6

Lintitript is a new, highly specific and potent CCK-A receptor antagonist.

Kategori:
Heterocyclic Compounds, Fused-RingHormone AntagonistsHormones, Hormone Substitutes, and Hormone Antagonists +2
Target Protein:
Cholecystokinin receptor type A
Waktu Paruh-
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Lintuzumab DB14877
biotech | CAS: 166089-32-3

Lintuzumab is under investigation in clinical trial NCT00016159 (Chemotherapy Plus Monoclonal Antibody in Treating Patients With Acute Promyelocytic Leukemia).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
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biotech | CAS: 2209911-94-2

Lintuzumab actinium Ac-225 is under investigation in clinical trial NCT00672165 (Targeted Atomic Nano-Generators (Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195) in Patients With Advanced Myeloid Malignancies).

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