Hasil Filter

13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (13591)

Halaman 205 / 272
Pentaglyme DB02580
small molecule | CAS: 1191-87-3

Deskripsi belum tersedia.

Target Protein:
Profilin-2Restriction endonuclease R.BpuJICytochrome c-552 +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentamidine Approved DB00738
small molecule | CAS: 100-33-4

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAgents causing hyperkalemiaAmidines +20
Target Protein:
Tryptase alpha/beta-1tRNA (cytosine(38)-C(5))-methyltransferaseDNA
Waktu Paruh9.1-13.2 hours
Vol. Distribusi-
Klirens-
Genetik -
Pentamycin DB13571
small molecule | CAS: 6834-98-6

Deskripsi belum tersedia.

Kategori:
AlkenesAntifungal AgentsGenito Urinary System and Sex Hormones +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentanal DB01919
small molecule | CAS: 110-62-3

Pentanal is a solid. This compound belongs to the polyamines. These are compounds containing more than one amine group. This drug targets the protein cAMP-dependent protein kinase catalytic subunit alpha.

Target Protein:
cAMP-dependent protein kinase catalytic subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentapiperium DB19383
small molecule | CAS: 26372-86-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 22537-51-5

Pentavalent Antimony has been investigated for the treatment of Cutaneous Leishmaniasis.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentazocine Approved DB00652
small molecule | CAS: 359-83-1

The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)

Kategori:
Adjuvants, AnesthesiaAgents that reduce seizure thresholdAlkaloids +20
Target Protein:
Sigma non-opioid intracellular receptor 1Mu-type opioid receptorKappa-type opioid receptor
Waktu Paruh2 to 3 hours
Vol. Distribusi-
Klirens-
Genetik -
Pentetic acid Approved DB14007
small molecule | CAS: 67-43-6

Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calci…

Kategori:
AcetatesAcids, AcyclicAmines +10
Target Protein:
Transuranium elements
Waktu ParuhIn preclinical stud…
Vol. DistribusiThe volume of distr…
KlirensPentetic acid prese…
Genetik -
Pentetrazol DB13415
small molecule | CAS: 54-95-5

Pentetrazol, also known as pentylenetetrazole, is a gamma-aminobutyric acid type A (GABA<sub>A</sub>) receptor antagonist that was approved by the FDA until 1982.[A254437]

Kategori:
AzepinesCentral Nervous System AgentsCentral Nervous System Stimulants +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentetreotide Approved DB12602
small molecule | CAS: 138661-02-6

Pentetreotide has been used in trials studying the diagnosis of Cushing's syndrome.

Kategori:
AcetatesAcids, AcyclicAmines +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Penthienate DB13695
small molecule | CAS: 22064-27-3

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAmines +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentifylline DB13634
small molecule | CAS: 1028-33-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 Substrates +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentobarbital Approved DB00312
small molecule | CAS: 76-74-4

A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness…

Kategori:
Adjuvants, AnesthesiaAnticholinergic AgentsAnticonvulsants +23
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +10
Waktu Paruh5 to 50 hours (dose…
Vol. Distribusi-
Klirens-
Genetik -
Pentosan polysulfate Approved DB00686
small molecule | CAS: 37300-21-3

Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.

Kategori:
AnticoagulantsAntivaricose TherapyCarbohydrates +12
Target Protein:
Fibroblast growth factor 2Fibroblast growth factor 1Fibroblast growth factor 4
Waktu Paruh4.8 hours
Vol. Distribusi-
Klirens-
Genetik -
Pentostatin Approved DB00552
small molecule | CAS: 53910-25-1

A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Kategori:
Adenosine Deaminase InhibitorsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +18
Target Protein:
Adenosine deaminase
Waktu Paruh5.7 hours (with a r…
Vol. Distribusi-
Klirens* 68 mL/min/m2
Genetik -
Pentoxifylline Approved DB00806
small molecule | CAS: 6493-05-6

Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.[A226415, L30300] Although originally developed to treat intermittent claudicati…

Kategori:
AlkaloidsAntioxidantsAntiplatelet agents +23
Target Protein:
Adenosine receptor A2aTumor necrosis factorPhosphodiesterase enzymes +2
Waktu ParuhOverall, pentoxifyl…
Vol. DistribusiPentoxifylline has …
KlirensPentoxifylline give…
Genetik -
Pentoxyverine Approved DB11186
small molecule | CAS: 77-23-6

Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant [A32717], and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with …

Kategori:
Antitussive AgentsCentral Nervous System AgentsCough and Cold Preparations +2
Target Protein:
Sigma non-opioid intracellular receptor 1Voltage-gated inwardly rectifying potassium channel KCNH2Voltage-gated sodium channel alpha subunit +2
Waktu ParuhThe half-life is 2.…
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Peoniflorin DB16288
small molecule | CAS: 23180-57-6

Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis).

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +8
Target Protein:
Adenosine receptor A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pepinemab DB15155
biotech | CAS: 2097151-87-4

Pepinemab is under investigation in clinical trial NCT03769155 (VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peppermint oil Approved DB11198
biotech | CAS: 8006-90-4

Extracted from the stem, leaves, and flowers of _Mentha piperita_ L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. Mentha piperita is a hybrid of spearmint (Mentha spicata) and wate…

Kategori:
Alimentary Tract and MetabolismAngiospermsAntiemetics +31
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Pepsin Approved DB13198
biotech | CAS: 9001-75-6

Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products [L2358]. Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach a…

Kategori:
Alimentary Tract and MetabolismAspartic Acid EndopeptidasesAspartic Acid Proteases +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 118997-30-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesHormones +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 123583-37-9

Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesHormones +3
Target Protein:
Neuropeptide Y receptor type 2Neuropeptide Y receptor type 1Neuropeptide Y receptor type 5 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peptide-T DB19279
small molecule | CAS: 106362-32-7

Peptide-T is under investigation in clinical trial NCT00000392 (Phase II Study of the Efficacy of Peptide T in Hiv-positive Individuals With Cognitive Impairment.).

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peramivir Approved DB06614
small molecule | CAS: 330600-85-6

Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir has been supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. B…

Kategori:
AmidinesAnti-Infective AgentsAntiinfectives for Systemic Use +6
Target Protein:
NeuraminidaseNeuraminidaseNeuraminidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perampanel Approved DB08883
small molecule | CAS: 380917-97-5

Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizu…

Kategori:
AMPA Receptor AntagonistsAnticonvulsantsCentral Nervous System Depressants +23
Target Protein:
Glutamate receptor 2Glutamate receptor 3Glutamate receptor 4 +1
Waktu ParuhPerampanel has a lo…
Vol. DistribusiThe volume of distr…
KlirensIn healthy patients…
Genetik -
Perboric acid Approved DB13235
small molecule | CAS: 14034-78-7

Perboric acid is mainly found in its salt form of sodium perborate and it can be found as a monohydrate or tetrahydrate.[A33037] It is one of the peroxy acid salts with very wide functionalities in industrial settings.[F66] Perboric acid in the form of sodium…

Kategori:
AcidsAlimentary Tract and MetabolismAnions +7
Waktu ParuhAs perboric acid an…
Vol. DistribusiAs perboric acid an…
KlirensAs perboric acid an…
Genetik -
Perchlorate DB03138
small molecule | CAS: 14797-73-0

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicChlorine Compounds
Target Protein:
Protein ArsC
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perenostobart DB18602
biotech | CAS: 2643331-31-9

Perenostobart is an alpha-CD39 IgG4 monoclonal antibody.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peresolimab DB18874
biotech | CAS: 2411580-63-5

Peresolimab is under investigation in clinical trial NCT04634253 (A Study of LY3462817 in Participants With Rheumatoid Arthritis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflexane Approved DB09531
small molecule | CAS: 355-42-0

Deskripsi belum tersedia.

Kategori:
Diagnostic AgentsHydrocarbons, FluorinatedHydrocarbons, Halogenated +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflubron DB05791
small molecule | CAS: 423-55-2

Perflubron (Oxygent) is being developed as an intravascular oxygen carrier designed to augment oxygen delivery in surgical patients.

Kategori:
Anti-Obesity AgentsCompounds used in a research, industrial, or household settingContrast Media +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflubutane Approved DB12821
small molecule | CAS: 355-25-9

Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclea…

Kategori:
AnionsCompounds used in a research, industrial, or household settingContrast Media +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 306-94-5

Perfluorodecalin is under investigation in clinical trial NCT03668665 (Influencing Wound Healing Through the Application of Hyaluronic Acid With Perfluorodecalin and Physalis Angulata Extract After Split Skin Removal From the Thigh - a Study in "Split Wound D…

Kategori:
Blood SubstitutesHydrocarbons, FluorinatedHydrocarbons, Halogenated +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perfluorohexyloctane Approved DB17823
small molecule | CAS: 133331-77-8

Perfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight hydrogenated carbon atoms.[L46491] It is an inert, slightly amphiphilic compound.[A259746] Because it is a completely non-aqueous liquid, microbial growth…

Kategori:
Hydrocarbons, FluorinatedHydrocarbons, HalogenatedOphthalmic Solutions +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perfluorooctane DB15997
small molecule | CAS: 307-34-6

Deskripsi belum tersedia.

Kategori:
Hydrocarbons, FluorinatedHydrocarbons, Halogenated
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflutren Approved DB00556
small molecule | CAS: 76-19-7

Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the micro…

Kategori:
Amino Acids, Peptides, and ProteinsCompounds used in a research, industrial, or household settingContrast Media +10
Waktu ParuhThe mean half-life …
Vol. Distribusi-
Klirens-
Genetik -
Perfosfamide DB12727
small molecule | CAS: 62435-42-1

Perfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.

Kategori:
Hydrocarbons, HalogenatedMustard CompoundsNitrogen Mustard Compounds +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pergolide Approved DB01186
small molecule | CAS: 66104-22-1

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as …

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-2 Receptor Agonists +24
Target Protein:
D(2) dopamine receptorD(3) dopamine receptorD(4) dopamine receptor +12
Waktu Paruh27 hours
Vol. Distribusi-
Klirens-
Genetik -
Periciazine Approved DB01608
small molecule | CAS: 2622-26-6

Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazin…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +12
Target Protein:
D(1A) dopamine receptorAlpha-2A adrenergic receptorAlpha-1B adrenergic receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peridinin DB03001
small molecule | CAS: 33281-81-1

Deskripsi belum tersedia.

Kategori:
AlkenesBiological FactorsCyclohexanes +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perindopril Approved DB00790
small molecule | CAS: 82834-16-0

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a po…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +18
Target Protein:
Angiotensin-converting enzymeSecreted frizzled-related protein 4
Waktu ParuhPerindopril, 1.2 ho…
Vol. Distribusi-
Klirens* 219 - 362 mL/min …
Genetik -
Perindoprilat DB14213
small molecule | CAS: 95153-31-4

The active metabolite of the prodrug [Perindopril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Permethrin Approved DB04930
small molecule | CAS: 52645-53-1

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsBenzene Derivatives +22
Target Protein:
Sodium channel protein type 1 subunit alphaEstrogen receptorNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perospirone DB08922
small molecule | CAS: 150915-41-6

Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. Dainippon Sumitomo Pharma devel…

Kategori:
Antipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])Central Nervous System Agents +13
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +3
Gen Terkait:
HTR1A
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean volume of …
KlirensApparent clearance …
Genetik 1 Varian
Perphenazine Approved DB00850
small molecule | CAS: 58-39-9

An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.

Kategori:
Antipsychotic AgentsAntipsychotic Agents (First Generation [Typical])Central Nervous System Agents +28
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorCalmodulin
Waktu Paruh8-12 hours, but ran…
Vol. Distribusi-
Klirens-
Genetik -
Pertussis vaccine Approved DB15274
biotech

Pertussis vaccine is under investigation in clinical trial NCT01698346 (Pertussis (Tdap) Vaccination in Pregnancy).

Kategori:
Bacterial VaccinesBiological ProductsComplex Mixtures +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pertuzumab Approved DB06366
biotech | CAS: 380610-27-5

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +19
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu ParuhThe median half-lif…
Vol. DistribusiThe average steady-…
KlirensThe median clearanc…
Genetik -
Peruvoside DB13756
small molecule | CAS: 1182-87-2

Deskripsi belum tersedia.

Kategori:
CardanolidesCardiac GlycosidesCardiac Therapy +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perzinfotel DB12365
small molecule | CAS: 144912-63-0

Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.

Kategori:
Aza CompoundsOrganophosphorus Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 10201–10250 dari 13591
Sebelumnya Halaman 205 / 272 Berikutnya