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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 204 / 321
small molecule | CAS: 50673-41-1

Methyl-D9-choline is under investigation in clinical trial NCT01807910 (ER Stress in NAFLD).

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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin kappa constantAlkaline phosphatase, placental type
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Squalene--hopene cyclase
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Methylamine DB01828
small molecule | CAS: 74-89-5

Deskripsi belum tersedia.

Kategori:
Amines
Target Protein:
Ammonia channel
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Neutrophil collagenaseInterstitial collagenase
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Methylatropine DB13833
small molecule | CAS: 31610-87-4

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAlkaloidsAutonomic Agents +10
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Genetik -
small molecule | CAS: 13473-61-5

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +1
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small molecule | CAS: 76970-78-0

Methylcantharidimide is under investigation in clinical trial NCT03996681 (TACE Combined With Methylcantharidimide Tablets in the Treatment of Large and Unresectable Hepatocellular Carcinoma).

Kategori:
BenzofuransHeterocyclic Compounds, Fused-Ring
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Methylcellulose Approved DB11228
small molecule | CAS: 9004-67-5

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of subst…

Kategori:
Alimentary Tract and MetabolismBulk-Forming LaxativesCarbohydrates +7
Waktu Paruh4.2 minutes
Vol. Distribusiaccumulation in liv…
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Methylchloroisothiazolinone Approved DB14197
small molecule | CAS: 26172-55-4

Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sen…

Kategori:
Anti-Infective AgentsCell-mediated ImmunityCompounds used in a research, industrial, or household setting +5
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Methyldiazene DB04361
small molecule | CAS: 26981-93-1

Deskripsi belum tersedia.

Target Protein:
Quinoprotein glucose dehydrogenase B
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Methyldopa Approved DB00968
small molecule | CAS: 555-30-6

Methyldopa, or ?-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent.[A231784] It is an analog of DOPA (3,4?hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for …

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-2 Receptor Agonists +28
Target Protein:
D(2) dopamine receptorAromatic-L-amino-acid decarboxylaseAlpha-2A adrenergic receptor
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe apparent volume…
KlirensThe renal clearance…
Genetik -
Methylecgonine DB04688
small molecule | CAS: 7143-09-1

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnalgesicsAza Compounds +7
Target Protein:
Immunoglobulin heavy constant gamma 2Immunoglobulin kappa constant
Waktu Paruh-
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Methylene blue Approved DB09241
small molecule | CAS: 61-73-4

Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, …

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +51
Target Protein:
Guanylate cyclase soluble subunit alpha-2Nitric oxide synthase 1
Waktu Paruh5–6.5 hours (after …
Vol. Distribusi10 mg/kg (in rats).
Klirens3.0 ± 0.7 L/min.
Genetik -
small molecule | CAS: 82801-81-8

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAminesAmphetamines +6
Waktu Paruh-
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Methylergometrine Approved DB00353
small molecule | CAS: 113-42-8

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

Kategori:
Agents that produce hypertensionAlkaloidsCytochrome P-450 CYP3A Inhibitors +14
Target Protein:
D(1A) dopamine receptor5-hydroxytryptamine receptor 2B
Waktu Paruh3.39 hours
Vol. Distribusi* 56.1 ± 0 L
Klirens-
Genetik -
small molecule | CAS: 514-61-4

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesEstranesEstren Derivatives +6
Waktu Paruh-
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small molecule | CAS: 624-78-2

Deskripsi belum tersedia.

Target Protein:
Myoglobin
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small molecule | CAS: 105-41-9

Deskripsi belum tersedia.

Kategori:
5-alpha Reductase InhibitorsAndrostanesAndrostanols +13
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Methylinositol DB12969
small molecule | CAS: 10284-63-6

Methylinositol has been used in trials studying the treatment of Dementia and Alzheimer's Disease.

Kategori:
AlcoholsCarbohydratesSugar Alcohols
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small molecule | CAS: 2682-20-4

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsCompounds used in a research, industrial, or household settingDisinfectants +2
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Methylliberine DB17930
small molecule | CAS: 51168-26-4

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
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small molecule | CAS: 516-05-2

A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylm…

Kategori:
Acids, AcyclicDicarboxylic AcidsMalonates
Target Protein:
Methylmalonyl-CoA carboxyltransferase 12S subunit
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small molecule | CAS: 1115-84-0

Methylmethionine chloride may be useful in helping the healing of gastric ulcers. In Japan, it is used as an over the counter product for gastrointestinal health support. It is also called "Vitamin U", but it is not a true vitamin.

Kategori:
Alimentary Tract and MetabolismDrugs for Acid Related DisordersDrugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)
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Methylnaltrexone Approved DB06800
small molecule | CAS: 916055-93-1

Methylnaltrexone is a pheriphally-acting ?-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008.

Kategori:
Alimentary Tract and MetabolismAlkaloidsAmines +16
Target Protein:
Mu-type opioid receptorMelanocortin receptor 4Kappa-type opioid receptor
Waktu Paruhterminal: 8.89 ± 2.…
Vol. DistribusiVolume of distribut…
Klirens10.5 ± 1.5 ml/min/k…
Genetik -
Methylone DB19192
small molecule | CAS: 186028-79-5

Methylone is under investigation in clinical trial NCT05741710 (A Study to Assess the use of Methylone in the Treatment of PTSD).

Kategori:
AminesAmphetaminesCentral Nervous System Stimulants +3
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Methylparaben Approved DB14212
small molecule | CAS: 99-76-3

Methylparaben is used in allergenic testing.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +10
Target Protein:
Transient receptor potential cation channel subfamily A member 1
Waktu Paruh-
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Methylpentynol DB13733
small molecule | CAS: 77-75-8

Deskripsi belum tersedia.

Kategori:
AlcoholsCentral Nervous System DepressantsFatty Alcohols +4
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Methylphenidate Approved DB00422
small molecule | CAS: 113-45-1

Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with …

Kategori:
Acids, CarbocyclicAgents that produce hypertensionAgents that reduce seizure threshold +17
Target Protein:
Sodium-dependent dopamine transporter5-hydroxytryptamine receptor 1ASodium-dependent noradrenaline transporter
Waktu ParuhConcerta: The half-…
Vol. DistribusiConcerta: Plasma me…
KlirensThe apparent mean s…
Genetik -
Methylphenobarbital Approved DB00849
small molecule | CAS: 115-38-8

A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.

Kategori:
Anticholinergic AgentsAnticonvulsantsBarbiturates +20
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-4 +8
Waktu Paruh34 (range 11-67) ho…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 4206-94-4

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicCholinesterase Inhibitors +3
Target Protein:
AcetylcholinesteraseCholinesteraseEsterase
Waktu Paruh-
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Methylprednisolone Approved DB00959
small molecule | CAS: 83-43-2

Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957.[L1…

Kategori:
Adrenal Cortex HormonesAdrenalsAnti-Acne Preparations +50
Target Protein:
Glucocorticoid receptorAnnexin A1
Waktu ParuhMethylprednisolone …
Vol. DistribusiThe average volume …
KlirensThe average plasma …
Genetik -
Methylprednisolone aceponate Approved DB14643
small molecule | CAS: 86401-95-8

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +8
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small molecule | CAS: 2921-57-5

A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Kategori:
Adrenal Cortex HormonesAdrenalsAnti-Inflammatory Agents +21
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Methylprednisone Approved DB12952
small molecule | CAS: 91523-05-6

Methylprednisone has been used in trials studying the treatment of Leukemia, Rheumatoid Arthritis, Renal Transplantation, Kidney Transplantation, and Acute Lymphocytic Leukemia, among others.

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 CYP3A4 Substrates (strength unknown) +1
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small molecule | CAS: 10605-24-0

Deskripsi belum tersedia.

Kategori:
Antianginal AgentsCardiac TherapyOrganic Nitrates +2
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small molecule | CAS: 1119361-12-4

Methylsamidorphan is under investigation in clinical trial NCT01418092 (ALK37-007: Evaluation of Safety and Efficacy of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)).

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small molecule | CAS: 26046-90-2

Methylselenocysteine has been used in trials studying the prevention of Prostate Carcinoma and No Evidence of Disease.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, Sulfur +8
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Methyltestosterone Approved DB06710
small molecule | CAS: 58-18-4

A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a sched…

Kategori:
3-Oxoandrosten (4) DerivativesAnabolic AgentsAndrogens +20
Target Protein:
Androgen receptorEstrogen receptor
Waktu Paruh6-8 hours
Vol. Distribusi-
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Genetik -
small molecule | CAS: 342-69-8

An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.

Kategori:
Heterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and NucleosidesNucleosides +6
Target Protein:
Purine nucleoside phosphorylase DeoD-type
Waktu Paruh-
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small molecule | CAS: 7060-82-4

Deskripsi belum tersedia.

Kategori:
Oxidation-Reduction ActivityOxidation-Reduction AgentSerotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Target Protein:
AcetylcholinesteraseTranscriptional regulator
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 56-04-2

Deskripsi belum tersedia.

Kategori:
Antithyroid agentsHormone AntagonistsHormones, Hormone Substitutes, and Hormone Antagonists +6
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lysozyme C
Waktu Paruh-
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small molecule | CAS: 59322-44-0

Deskripsi belum tersedia.

Target Protein:
Trans-sialidase
Waktu Paruh-
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Methyprylon Approved DB01107
small molecule | CAS: 125-64-4

Methyprylon is a sedative of the piperidinedione derivative family that was previously used for the treatment of insomnia. However, with the introduction of newer drugs with fewer side effects, such as benzodiazepines, the clinical use of methyprylon is now l…

Kategori:
Central Nervous System DepressantsHypnotics and SedativesNervous System +3
Target Protein:
GABA(A) ReceptorGamma-aminobutyric acid receptor subunit alpha-1
Waktu Paruh6-16 hours
Vol. Distribusi-
Klirens-
Genetik -
Methysergide Approved DB00247
small molecule | CAS: 361-37-5

An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically i…

Kategori:
Agents that produce hypertensionAlkaloidsAnalgesics +20
Target Protein:
5-hydroxytryptamine receptor 2B5-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 2A +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Metiamide DB08805
small molecule | CAS: 34839-70-8

Metiamide is an H-2 receptor antagonist derived from burimamide. It was an intermediate product on the path to developing cimetidine.

Kategori:
Acid ReducersAmidesAnti-Ulcer Agents +8
Target Protein:
Histamine H2 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meticillin Approved DB01603
small molecule | CAS: 61-32-5

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
MecA PBP2' (penicillin binding protein 2')Penicillin-binding protein 2aPenicillin-binding protein 1b +3
Waktu Paruh25-60 minutes
Vol. Distribusi-
Klirens-
Genetik -
Meticrane Approved DB13284
small molecule | CAS: 1084-65-7

Meticrane is a diuretic medication. It has been marketed in Japan under the trade name Arresten and is used to lower blood pressure [L5647].

Kategori:
DiureticsGenito Urinary System and Sex HormonesGynecological Antiinfectives and Antiseptics +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 10151–10200 dari 16004
Sebelumnya Halaman 204 / 321 Berikutnya