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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Halaman 203 / 236
SLx-4090 DB05678
small molecule | CAS: 913541-47-6

SLx-4090 is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes. [A33218]

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Microsomal triglyceride transfer protein large subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SM-1997 DB18670
biotech

SM-1997 is a protein-free solution derived from calf's blood comprising electrolytes, trace minerals, amino acids, peptides, nucleosides, and nucleotides.[A261816] It is under investigation for the treatment of cutaneous sulfur mustard-induced injury.

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SM-337 DB17112
small molecule | CAS: 1071992-61-4

Deskripsi belum tersedia.

Target Protein:
E3 ubiquitin-protein ligase XIAP
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations.[L12747] ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this s…

Kategori:
Actively Acquired ImmunityBiological ProductsComplex Mixtures +4
Waktu Paruh-
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Genetik -
biotech

Deskripsi belum tersedia.

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SMART101 DB18370
biotech

SMART101 is an investigational cell therapy comprising human allogeneic CD34-CD7+ T cell progenitors that were cultured ex vivo.

Waktu Paruh-
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SN-38 DB05482
small molecule | CAS: 86639-52-3

7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of …

Kategori:
AlkaloidsAntineoplastic AgentsCytochrome P-450 CYP3A Inhibitors +9
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 59734-15-5

Deskripsi belum tersedia.

Kategori:
GlycerophosphatesGlycerophospholipidsLipids +3
Target Protein:
Annexin A5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 17989-41-2

Deskripsi belum tersedia.

Target Protein:
Fructose-bisphosphate aldolase BPyridoxine 5'-phosphate synthaseTriosephosphate isomerase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SNS-032 DB05969
small molecule | CAS: 345627-80-7

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Target Protein:
Cyclin-dependent kinase 9Cyclin-dependent kinase 2Cyclin-dependent kinase 7 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SNS-314 DB06134
small molecule | CAS: 1057249-41-8

SNS-314 is a potent and selective inhibitor of Aurora kinases A, B, and C. Proliferating cells treated with SNS-314 bypass the mitotic spindle checkpoint and fail to undergo cytokinesis, leading to multiple rounds of endoreduplication and eventually cell deat…

Kategori:
AmidesBenzene DerivativesProtein Kinase Inhibitors +1
Target Protein:
Aurora kinase BAurora kinase CAurora kinase A
Waktu Paruh-
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Genetik -
SNS01-T DB17302
biotech

SNS01-T is a gene therapy nanoparticle. It is composed of three components: a B cell-specific plasmid expressing eIF5AK50R; an siRNA that targets the native eIF5A that promotes growth/anti-apoptosis of cancer cells; and polyethylenimine.[A254706]

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SNSP113 DB17910
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
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small molecule | CAS: 1226795-18-1

Snubh-nm-333 F-18 is under investigation in clinical trial NCT02149017 (Phase 1 and Phase 2 Clinical Trials of SNUBH-NM-333(18F)).

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SNX-2112 DB17055
small molecule | CAS: 908112-43-6

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor.[A253137]

Kategori:
Heterocyclic Compounds, Fused-RingHSP90 Heat-Shock Proteins, antagonists & inhibitors
Target Protein:
Heat shock protein HSP 90-alpha
Waktu Paruh-
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SNX-5422 DB06070
small molecule | CAS: 908115-27-5

SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.

Kategori:
Acids, CarbocyclicAmidesAmino Acids +5
Target Protein:
Heat shock protein HSP 90-alphaHeat shock protein HSP 90-beta
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SO-101 DB05345
small molecule

SO-101(Silenor) is a low-dose oral tablet formulation of doxepin hydrochloride that is patent protected for its use in insomnia. Doxepin has been prescribed for more than 40 years for the treatment of depression and anxiety at dosages typically ranging from 7…

Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sobetirome DB07425
small molecule | CAS: 211110-63-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicBenzene DerivativesFatty Acids +2
Target Protein:
Muscarinic acetylcholine receptor M1Thyroid hormone receptor, alpha isoform 1 variantThyroid hormone receptor beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Soblidotin DB12677
small molecule | CAS: 149606-27-9

Soblidotin has been used in trials studying the treatment of Sarcoma, Lung Cancer, and Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
Amino Acids, Peptides, and ProteinsAntineoplastic AgentsPeptides
Waktu Paruh-
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Genetik -
Sobrerol DB13315
small molecule | CAS: 42370-41-2

Deskripsi belum tersedia.

Kategori:
Cough and Cold PreparationsExpectorantsRespiratory System Agents
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Socazolimab DB18845
biotech | CAS: 2305043-30-3

Socazolimab is under investigation in clinical trial NCT04878016 (A Study of Carboplatin Plus Etoposide With or Without ZKAB001 (Anti-pd-l1 Antibody) in Patients With ES-SCLC).

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Sodelglitazar DB16332
small molecule | CAS: 447406-78-2

Sodelglitazar is under investigation in clinical trial NCT00196989 (Study in People With Type 2 Diabetes).

Target Protein:
Peroxisome proliferator-activated receptor deltaPeroxisome proliferator-activated receptor gammaPeroxisome proliferator-activated receptor alpha
Waktu Paruh-
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Genetik -
small molecule | CAS: 200880-41-7

Deskripsi belum tersedia.

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Sodium acetate Approved DB09395
small molecule | CAS: 127-09-3

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important compo…

Kategori:
AcetatesAcids, AcyclicBlood and Blood Forming Organs +5
Waktu Paruh-
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Sodium apolate DB13477
small molecule | CAS: 25053-27-4

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAlkenes +12
Waktu Paruh-
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Genetik -
Sodium arsenite DB18508
small molecule | CAS: 7784-46-5

Deskripsi belum tersedia.

Kategori:
AnionsArsenicalsElectrolytes +3
Waktu Paruh-
Vol. Distribusi-
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Sodium aurothiomalate Approved DB09276
small molecule | CAS: 12244-57-4

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in act…

Kategori:
Acids, AcyclicAntiinflammatory and Antirheumatic ProductsAntirheumatic Agents +13
Waktu Paruh12.5 days
Vol. DistribusiThe apparent volume…
Klirens7.0 ml/ kg/day
Genetik -
Sodium aurotiosulfate Approved DB13743
small molecule | CAS: 33614-49-2

Deskripsi belum tersedia.

Kategori:
Antiinflammatory and Antirheumatic ProductsGold PreparationsLaxatives +2
Waktu Paruh-
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Klirens-
Genetik -
Sodium bisulfite Approved DB14015
small molecule | CAS: 7631-90-5

Sodium bisulfite has been used externally for parasitic skin diseases and as a gastrointestinal antiseptic.

Kategori:
AnionsAnti-Infective AgentsAnti-Infective Agents, Local +10
Waktu Paruh-
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Sodium camphorsulfonate Approved DB15950
small molecule | CAS: 21791-94-6

Deskripsi belum tersedia.

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Sodium carbonate Approved DB09460
small molecule | CAS: 497-19-8

Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.

Kategori:
AlkaliesAnionsCarbon Compounds, Inorganic +3
Target Protein:
Carbonic anhydrase 1Carbonic anhydrase 2Carbonic anhydrase 4 +1
Waktu Paruh-
Vol. DistribusiDistribution occurs…
Klirens-
Genetik -
Sodium cation DB14516
small molecule | CAS: 17341-25-2

Deskripsi belum tersedia.

Kategori:
Increased Large Intestinal MotilityInhibition Large Intestine Fluid/Electrolyte AbsorptionLaxatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium cellulose phosphate Approved DB06776
small molecule | CAS: 9038-41-9

Sodium cellulose phosphate is used to treat hypercalcemia and hypercalciuria. It has been used to prevent kidney stones. [A31694] This compound is an ion-exchange resin that can not be absorbed by the body. However, it can be used to restore normal intesti…

Kategori:
BiopolymersCalcium BinderCalcium Chelating Activity +8
Target Protein:
Calcium ions
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium chloride Approved DB09153
small molecule | CAS: 7647-14-5

Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid o…

Kategori:
Alimentary Tract and MetabolismBlood and Blood Forming OrgansBlood Substitutes and Perfusion Solutions +14
Waktu Paruh17 minutes
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Sodium chlorite DB13210
small molecule | CAS: 7758-19-2

Used as an agent for cleaning drinking water. It is also used as an additive in products like toothpaste and mouthwash. Acidified sodium chlorite was approved by the U.S. Food and Drug Administration as of 2004, as an anti-microbial agent which is non-toxic, …

Kategori:
AnionsChlorine CompoundsCicatrizants +4
Waktu Paruh-
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Genetik -
small molecule

Sodium copper chlorophyllin (SCC) is a water-soluble and bright green mixture derived from natural chlorophyll that has potential antimutagenic and antioxidant properties[A227718]. This compound is used as a food colorant and supplement[A227718]. SCC of t…

Kategori:
Anti-Infective Agents, LocalAntimutagenic AgentsChlorophyll +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium feredetate Approved DB13381
small molecule | CAS: 15708-41-5

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAmines +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 34089-81-1

Sodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography…

Kategori:
Iron PreparationsParenteral Iron Replacement
Target Protein:
Ferritin light chainHemoglobin subunit betaHemoglobin subunit alpha
Waktu ParuhThe terminal elimin…
Vol. DistribusiUsing single-dose p…
KlirensTotal clearance ran…
Genetik -
Sodium fluoride Approved DB09325
small molecule | CAS: 7681-49-4

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18].[L4894] Sodium fluoride's benefits on dental health were first o…

Kategori:
Alimentary Tract and MetabolismAnionsCaries Prophylactic Agents +13
Target Protein:
Hydroxyapatite
Waktu ParuhThe terminal plasma…
Vol. DistribusiFluoride distribute…
KlirensSodium fluoride is …
Genetik -
Sodium glycerophosphate Approved DB09561
small molecule | CAS: 1334-74-3

Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels [FDA Label]. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body [A32667]. The extent of this reaction …

Kategori:
AlcoholsBlood and Blood Forming OrgansBlood Substitutes and Perfusion Solutions +10
Waktu ParuhInorganic phosphate…
Vol. Distribusi-
Klirens-
Genetik -
Sodium hydroxide Approved DB11151
small molecule | CAS: 1310-73-2

Sodium hydroxide is also known as _lye_ or _soda_ , or _caustic soda_ [L1971]. At room temperature, sodium hydroxide is a white crystalline odorless solid that absorbs moisture from the air. It is a synthetically manufactured substance. When dissolved in w…

Kategori:
AlkaliesAnionsCaustics +7
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium iodide Approved DB11119
small molecule | CAS: 7681-82-5

Sodium iodide is a water-soluble ionic compound with a crystal lattice. Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition [L2065] but is more commonly used in veterinary medicine. Radiolabelled compound…

Kategori:
IodidesIodine CompoundsReplacement Preparations +2
Waktu Paruh-
Vol. DistribusiIodides are distrib…
Klirens-
Genetik -
Sodium lauryl sulfoacetate Approved DB13157
small molecule | CAS: 1847-58-1

Sodium lauryl sulfoacetate is a wetting agent and surfactant used in enema-type laxative products.

Kategori:
Alimentary Tract and MetabolismDrugs for ConstipationEnemas
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small molecule | CAS: 7681-57-4

Deskripsi belum tersedia.

Kategori:
AnionsAutonomic AgentsBronchoconstrictor Agents +6
Waktu Paruh-
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Sodium metavanadate Approved DB14702
small molecule | CAS: 13718-26-8

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIons +2
Waktu Paruh-
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Sodium molybdate Approved DB14496
small molecule | CAS: 7631-95-0

Deskripsi belum tersedia.

Kategori:
ElementsMetalsMetals, Heavy +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium nitrate DB15952
small molecule | CAS: 7631-99-4

Deskripsi belum tersedia.

Kategori:
AnionsCarcinogensElectrolytes +4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium oxybate Approved DB09072
small molecule | CAS: 502-85-2

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy.[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmit…

Kategori:
Acids, AcyclicAdjuvants, AnesthesiaAnesthetics +9
Target Protein:
GABA(B) ReceptorSolute carrier family 52, riboflavin transporter, member 2
Waktu ParuhGHB has an eliminat…
Vol. DistribusiThe apparent volume…
KlirensIn healthy GHB-naïv…
Genetik -
small molecule | CAS: 7601-89-0

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicChlorine Compounds
Waktu Paruh-
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Sodium phosphate P 32 Approved DB09370
small molecule | CAS: 7635-46-3

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsDiagnostic AgentsNarrow Therapeutic Index Drugs +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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