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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
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11778 (100.0%)

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Halaman 202 / 236
Silver nitrate Approved DB11080
small molecule | CAS: 7761-88-8

Silver nitrate is an inorganic compound with the chemical formula AgNO3. In its solid form, silver nitrate is coordinated in a trigonal planar arrangement. It is often used as a precursor to other silver-containing compounds. It is used in making photographic…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiseptics and Disinfectants +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Silver oxide DB15668
small molecule | CAS: 20667-12-3

Deskripsi belum tersedia.

Kategori:
AnionsAnti-Infective AgentsElectrolytes +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Simendan DB12286
small molecule | CAS: 131741-08-7

Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).

Kategori:
Antiarrhythmic agentsCardiotonic AgentsCardiovascular Agents +11
Waktu Paruh-
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Genetik -
small molecule | CAS: 910562-13-9

Simenepag isopropyl has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.

Waktu Paruh-
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Genetik -
Simeprevir Approved DB06290
small molecule | CAS: 923604-59-5

Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, w…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +37
Target Protein:
Genome polyproteinNS3 proteaseGenome polyprotein
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of si…
Genetik -
biotech | CAS: 1776942-10-9

RO6874281 is under investigation in clinical trial NCT03193190 (A Study of Multiple Immunotherapy-based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-pancreatic Cancer)).

Waktu Paruh-
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Genetik -
biotech

Simmondsia chinensis seed is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
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Simoctocog alfa Approved DB09108
biotech | CAS: 1219013-68-9

Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent use…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlycoconjugates +1
Target Protein:
von Willebrand factor
Waktu ParuhAt initial assessme…
Vol. DistribusiIt is observed that…
KlirensAt initial assessme…
Genetik -
Simotaxel DB15384
small molecule | CAS: 791635-59-1

Simotaxel is under investigation in clinical trial NCT00088647 (Study Evaluating MST-997 in Advanced Malignant Solid Tumors).

Kategori:
CyclodecanesCycloparaffinsDiterpenes +1
Waktu Paruh-
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Genetik -
Simpinicline DB17065
small molecule | CAS: 753015-44-0

Deskripsi belum tersedia.

Waktu Paruh-
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Simtuzumab DB12152
biotech | CAS: 1318075-13-6

Simtuzumab has been used in trials studying the treatment and basic science of Myelofibrosis, Pancreatic Cancer, Colorectal Cancer, and Idiopathic Pulmonary Fibrosis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Simufilam DB18817
small molecule | CAS: 1224591-33-6

Deskripsi belum tersedia.

Target Protein:
Filamin-A
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Simurosertib DB16330
small molecule | CAS: 1330782-76-7

Simurosertib is under investigation in clinical trial NCT03261947 (A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors).

Kategori:
Pyrazoles
Target Protein:
Cell division cycle 7-related protein kinase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Simvastatin Approved DB00641
small molecule | CAS: 79902-63-9

Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular dis…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBSEP/ABCB11 Substrates +37
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-LHistone deacetylase 2
Gen Terkait:
KIF6 HMGCR SLCO1B1
Waktu Paruh4.85 hours[A181571]
Vol. DistribusiRat studies indicat…
Klirens-
Genetik 3 Varian
Sinapic acid DB08587
small molecule | CAS: 7362-37-0

Sinapic acid is a matrix for matrix-assisted laser desorption technique for protein MW determination. It is also a constituent of propolis.

Kategori:
Acids, CarbocyclicCinnamatesCompounds used in a research, industrial, or household setting +2
Target Protein:
Endo-1,4-beta-xylanase Y
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Catechol O-methyltransferase domain-containing protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sinapultide Approved DB11332
small molecule | CAS: 138531-07-4

Sinapultide (also known as KL4 peptide) is a synthetic protein used to mimic human lung surfactant protein B.[L2502] This protein has a weight of 2469.40.[L2502] Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the se…

Kategori:
Amino Acids, Peptides, and ProteinsPulmonary Surfactants
Target Protein:
Lung epithelial cells
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sinbaglustat DB17619
small molecule | CAS: 441061-33-2

Deskripsi belum tersedia.

Kategori:
CarbohydratesImines
Waktu Paruh-
Vol. Distribusi-
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Sincalide Approved DB09142
biotech | CAS: 25126-32-3

Sincalide is a medication given by injection to assist in the diagnosis of gallbladder and pancreas disorders. It is identified as the 8-amino acid C-terminal segment of cholecystokinin and is also known as _CCK-8_. Naturally occurring cholecystokinin is a ga…

Kategori:
Amino Acids, Peptides, and ProteinsCholecystokinin AnalogDiagnostic Agents +7
Target Protein:
Cholecystokinin receptor type AGastrin/cholecystokinin type B receptor
Waktu ParuhLimited information…
Vol. DistribusiLimited information…
Klirens-
Genetik -
Sinefungin DB01910
small molecule | CAS: 58944-73-3

Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include RdmB, modification methylase TaqI, rRNA (adenine-N6-)-m…

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiparasitic Agents +7
Target Protein:
Modification methylase RsrIAclacinomycin 10-hydroxylase RdmBrRNA adenine N-6-methyltransferase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sinomenine DB16892
small molecule | CAS: 115-53-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntirheumatic AgentsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sintilimab DB15765
biotech | CAS: 2072873-06-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Programmed cell death protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siplizumab DB06371
biotech | CAS: 288392-69-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
T-cell surface antigen CD2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siponimod Approved DB12371
small molecule | CAS: 1230487-00-9

Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 [L5792] and by Health Canada on February 20, 2020.[L12171] This drug is considered a _sphingo…

Kategori:
Agents that produce hypertensionAntineoplastic and Immunomodulating AgentsAzetines +18
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 5
Waktu ParuhThe apparent elimin…
Vol. DistribusiSiponimod distribut…
KlirensApparent systemic c…
Genetik -
Sipuleucel-T Approved DB06688
biotech | CAS: 917381-47-6

Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expres…

Kategori:
Adjuvants, ImmunologicAntineoplastic and Immunomodulating AgentsAutologous Cellular Immunotherapy +6
Target Protein:
Prostatic acid phosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Siramesine DB06555
small molecule | CAS: 147817-50-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Alpha-1A adrenergic receptorAlpha-1D adrenergic receptorAlpha-1B adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Siremadlin DB16331
small molecule | CAS: 1448867-41-1

Deskripsi belum tersedia.

Target Protein:
E3 ubiquitin-protein ligase Mdm2Cellular tumor antigen p53
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sirexatamab DB17515
biotech | CAS: 2414962-49-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sirna-027 DB05896
small molecule

Sirna-027 is a chemically modified short interfering RNA(siRNA) targeting Vascular Endothelial Growth Factor Receptor-1(VEGFR-1). VEGFR-1 is a key component of the clinically validated vascular endothelial growth factor (VEGF) pathway. Sirna-027 is developed …

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sirolimus Approved DB00877
small molecule | CAS: 53123-88-9

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island).[A242412] It was first isolated and identified as a…

Kategori:
Agents causing angioedemaAnti-Bacterial AgentsAnti-Infective Agents +35
Target Protein:
Serine/threonine-protein kinase mTOR
Waktu ParuhThe mean ± SD termi…
Vol. DistribusiThe mean (± SD) blo…
KlirensIn adult renal tran…
Genetik -
Sirpiglenastat DB17536
small molecule | CAS: 2079939-05-0

Sirpiglenastat, also known as DRP-104, is a prodrug of [6-diazo-5-oxo-L-norleucine] (DON), which is a broad-acting glutamine antagonist. It is under investigation in clinical trial NCT04471415 (Study to Investigate DRP-104 in Adults With Advanced Solid Tumors…

Kategori:
AcetatesAcids, AcyclicAmides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sisunatovir DB15674
small molecule | CAS: 1903763-82-5

Sisunatovir is under investigation in clinical trial NCT04267822 (Study of RV521 in the Treatment of Adult Subjects Who Have Undergone HCT With an URTI With RSV).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Fusion glycoprotein F0
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sitamaquine DB04909
small molecule | CAS: 57695-04-2

Sitamaquine (WR-6026) is an orally active 8-aminoquinoline analog in development by the Walter Reed Army Institute, in collaboration with GlaxoSmithKline (formerly SmithKline Beecham), for the potential treatment of visceral leishmaniasis.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 898830-54-1

Sitimagene ceradenovec is a novel gene-based product for the treatment of patients with operable high grade glioma, a type of malignant brain tumour, given in addition to standard surgery and radiotherapy/chemotherapy. It is being developed by Ark Therapeutic…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsAntineoplastic cell and gene therapy +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sitravatinib DB15036
small molecule | CAS: 1123837-84-2

Sitravatinib is under investigation in clinical trial NCT03680521 (Neoadjuvant Sitravatinib in Combination With Nivolumab in Patients With Clear Cell Renal Cell Carcinoma).

Kategori:
AmidesAminesAniline Compounds +3
Target Protein:
Hepatocyte growth factor receptorVascular endothelial growth factor receptor 3Vascular endothelial growth factor receptor 2 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sivelestat DB12863
small molecule | CAS: 127373-66-4

Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult.

Kategori:
AmidesAmino AcidsAmino Acids, Peptides, and Proteins +5
Target Protein:
Neutrophil elastaseChymotrypsin-like elastase family member 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sivifene DB05686
small molecule | CAS: 2675-35-6

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesHydrazines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sizofiran DB13128
small molecule | CAS: 9050-67-3

A beta-D-glucan obtained from the Aphyllophoral fungus Schizophyllum commune. It is used as an immunoadjuvant in the treatment of neoplasms, especially tumors found in the stomach. Sizofiran has been used in trials studying the treatment of Cervical Cancer.

Kategori:
Adjuvants, ImmunologicAntineoplastic AgentsAntineoplastic Agents, Phytogenic +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SJ-733 DB12659
small molecule | CAS: 1424799-20-1

SJ-733 has been used in trials studying Malaria.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Genetik -
SJG-136 DB11965
small molecule | CAS: 232931-57-6

SJG-136 has been used in trials studying the treatment of Recurrent Fallopian Tube Cancer, Secondary Acute Myeloid Leukemia, de Novo Myelodysplastic Syndromes, Recurrent Ovarian Epithelial Cancer, and Secondary Myelodysplastic Syndromes, among others.

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Skf 107457 DB04191
small molecule | CAS: 144285-77-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SKF-91488 DB07106
small molecule | CAS: 68643-23-2

Deskripsi belum tersedia.

Kategori:
AmidesHistamine AgentsHistamine Agonists +4
Target Protein:
Histamine N-methyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 162849-90-3

SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium antagonists.[A253132]

Kategori:
Antiarrhythmic agentsAntiplatelet agentsCalcium Channel Blockers +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Skin-derived ABCB5-positive Mesenchymal Stem cells are under investigation in clinical trial NCT04971161 (Allogeneic Abcb5-positive Dermal Mesenchymal Stromal Cells for Treatment of CVU (Phase Iib)).

Waktu Paruh-
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Genetik -
SKL-27969 DB18168
small molecule | CAS: 2634762-24-4

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
SL017 DB05156
small molecule

SL017 formulated as a topical gel, has been combined with a widely available light source for permanent removal of unwanted hair and for treatment of actinic keratosis

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Genetik -
SLC-0111 DB18815
small molecule | CAS: 178606-66-1

Deskripsi belum tersedia.

Kategori:
AmidesAntineoplastic AgentsBenzene Derivatives +2
Waktu Paruh-
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Klirens-
Genetik -
SLC-391 DB18814
small molecule | CAS: 1783825-18-2

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
SLV-334 DB15356
small molecule | CAS: 182821-33-6

SLV-334 is under investigation in clinical trial NCT00735085 (A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.).

Target Protein:
Neprilysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SLV319 DB05077
small molecule

SLV319 belongs to a novel class of agents called CB1 antagonists, which work by blocking the cannabinoid type 1 (CB1) receptor. It is developed for the treatment of obesity and other metabolic disorders.

Kategori:
Agents producing tachycardiaAmidesCannabinoid Receptor Antagonists +4
Target Protein:
Cannabinoid receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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