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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 200 / 272
Oxycodone Approved DB00497
small molecule | CAS: 76-42-6

Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917.[A178696] It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requi…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +21
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor
Waktu ParuhThe apparent elimin…
Vol. Distribusi2.6L/kg.[Label]
KlirensTotal plasma cleara…
Genetik -
Oxyfedrine DB13398
small molecule | CAS: 15687-41-9

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-Agonists +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxymatrine DB16276
small molecule | CAS: 16837-52-8

Oxymatrine is under investigation in clinical trial NCT02202473 (Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects).

Kategori:
AlkaloidsAnti-Infective AgentsAntiarrhythmic agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxymetazoline Approved DB00935
small molecule | CAS: 1491-59-4

Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (?)-adrenergic agonist with affinity to both ?<sub>1</sub>- and ?<sub>2</sub>-adrenoceptors.[A215542] Oxymetazoline is available in various formulations with a wide variety of clinical…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +25
Target Protein:
Alpha-1A adrenergic receptorAlpha-2A adrenergic receptorAlpha-2B adrenergic receptor +7
Waktu ParuhFollowing ocular ad…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
Oxymetholone Approved DB06412
small molecule | CAS: 434-07-1

Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth in malnourished or underdeveloped patients. Anabolic…

Kategori:
Alimentary Tract and MetabolismAnabolic AgentsAnabolic Agents for Systemic Use +20
Target Protein:
Androgen receptorNatriuretic peptides B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxymorphone Approved DB01192
small molecule | CAS: 76-41-5

An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia …

Kategori:
AdjuvantsAdjuvants, AnesthesiaAlkaloids +22
Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
Waktu Paruh1.3 (+/-0.7) hours
Vol. Distribusi-
Klirens-
Genetik -
Oxypertine DB13403
small molecule | CAS: 153-87-7

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsIndole Derivatives +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxyphenbutazone Approved DB03585
small molecule | CAS: 129-20-4

Oxyphenbutazone was withdrawn from the Canadian market in March 1985 due to concerns regarding bone marrow suppression.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +20
Target Protein:
AlbuminGroup IIE secretory phospholipase A2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxyphencyclimine Approved DB00383
small molecule | CAS: 125-53-1

Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Target Protein:
Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxyphenisatin DB04823
small molecule | CAS: 125-13-3

A laxative that undergoes enterohepatic circulation. It may cause jaundice.

Kategori:
Alimentary Tract and MetabolismContact LaxativesDrugs for Constipation +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxyphenisatin acetate Approved DB14627
small molecule | CAS: 115-33-3

Oxyphenisatin acetate is the pro-drug of [oxyphenisatin] (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). The FDA withdrew its approval for the use of oxyphenisatin acetate due to safety reasons.[L43942]

Kategori:
Gastrointestinal AgentsHeterocyclic Compounds, Fused-RingIndoles +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxypurinol DB05262
small molecule | CAS: 2465-59-0

Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol.

Kategori:
Enzyme InhibitorsPyrazolesPyrimidines +1
Target Protein:
Xanthine dehydrogenase/oxidase
Waktu Paruh23.3 +/- 6.0 hours
Vol. Distribusi-
Klirens-
Genetik -
Oxyquinoline Approved DB11145
small molecule | CAS: 148-24-3

Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.

Kategori:
Alimentary Tract and MetabolismAnti-Infective Agents, LocalAntiinfectives and Antiseptics for Local Oral Treatment +11
Target Protein:
Methionine aminopeptidase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxytocin Approved DB00107
biotech | CAS: 50-56-6

Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906.[A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues.[A…

Kategori:
Amino Acids, Peptides, and ProteinsGenito Urinary System and Sex HormonesHormones +15
Target Protein:
Oxytocin receptorVasopressin V1b receptorVasopressin V2 receptor +1
Waktu ParuhThe plasma half-lif…
Vol. Distribusi-
KlirensIn a study that obs…
Genetik -
Ozagrel DB12017
small molecule | CAS: 82571-53-7

Ozagrel has been used in trials studying the treatment of Dry Eye Syndromes.

Kategori:
Acids, AcyclicAcrylatesCardiovascular Agents +6
Target Protein:
Mitogen-activated protein kinase 14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ozanezumab DB12891
biotech | CAS: 1310680-64-8

Ozanezumab has been used in trials studying the treatment of Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis, Relapsing-Remitting.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ozanimod Approved DB12612
small molecule | CAS: 1306760-87-1

Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) [L11025] and was approved by the FDA …

Kategori:
Antineoplastic and Immunomodulating AgentsBCRP/ABCG2 SubstratesCytochrome P-450 CYP2C8 Substrates +13
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 5
Waktu ParuhThe half-life of oz…
Vol. DistribusiThe average volume …
KlirensThe mean apparent o…
Genetik -
Ozarelix DB12581
small molecule | CAS: 295350-45-7

Ozarelix has been used in trials studying the treatment of Prostate Cancer, Benign Prostatic Hypertrophy, and Benign Prostatic Hyperplasia (BPH).

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ozekibart DB18675
biotech | CAS: 2539847-03-3

Ozekibart is a tetravalent recombinant humanized IgG1 agonist antibody targeting the human TRAIL death receptor 5 (DR5). It is being investigated for the treatment of chondrosarcoma.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2460400-11-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Target Protein:
Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-113D DB04987
biotech | CAS: 190673-60-0

P-113D is a novel 12 amino-acid antimicrobial peptide drug derived from histatins, which are compounds found naturally in human saliva. It is being pursued as a potential treatment for cystic fibrosis by Demegen, Inc.

Kategori:
Amino Acids, Peptides, and ProteinsAntimicrobial Cationic PeptidesAntimicrobial Peptides +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-2045 Re-188 DB17204
biotech | CAS: 934712-65-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-42 peptide DB18610
biotech

P-42 peptide is a synthetic 23 amino acid peptide AASSGVSTPGSAGHDIITEQPRS derived from the Huntingtin protein

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-57AS3 DB06569
small molecule | CAS: 384329-61-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Aminophenol DB14144
small molecule | CAS: 123-30-8

Deskripsi belum tersedia.

Kategori:
AminesAniline CompoundsBenzene Derivatives +4
Target Protein:
Carbonic anhydrase 14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Heat-labile enterotoxin B chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-BCMA-101 DB17371
biotech

P-BCMA-101 is an autologous CAR-T therapy developed using Poseida’s piggyBac platform technology.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 104504-45-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Tyrosine-protein phosphatase non-receptor type 1Tyrosine--tRNA ligase, cytoplasmic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 76410-58-7

p-Boronophenylalanine is under investigation in clinical trial NCT00039572 (Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 74-11-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates
Target Protein:
4-chlorobenzoyl CoA ligase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Coumaric acid DB04066
small molecule | CAS: 501-98-4

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAdrenal Cortex HormonesAnti-Infective Agents +7
Target Protein:
Carbonic anhydrase 12Carbonic anhydrase 2Carbonic anhydrase 14 +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 90736-23-5

p-Fluorofentanyl is an opioid analgesic being an analogue of fentanyl developed by Janssen Pharmaceutica in the 1960s. p-Fluorofentanyl was sold briefly on the US black market in the early 1980s, before the introduction of the Federal Analog Act which for the…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Heptylphenol DB03941
small molecule | CAS: 1987-50-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 123-08-0

Deskripsi belum tersedia.

Kategori:
Aldehydes
Target Protein:
4-aminobutyrate aminotransferase, mitochondrialAmine oxidase [flavin-containing] B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1126-48-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +9
Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Iodophenol DB03002
small molecule | CAS: 540-38-5

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesHydrocarbons, HalogenatedHydrocarbons, Iodinated
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-nitrobiphenyl Approved DB12300
small molecule | CAS: 92-93-3

Pnb has been used in trials studying the treatment of Pelvic Organ Prolapse.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 104-03-0

Deskripsi belum tersedia.

Kategori:
Acids, Carbocyclic
Target Protein:
Penicillin G acylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Phenylenediamine Approved DB14141
small molecule | CAS: 106-50-3

Deskripsi belum tersedia.

Kategori:
AminesAmino Acids, Peptides, and ProteinsAniline Compounds +16
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Quaterphenyl DB12794
small molecule | CAS: 135-70-6

p-Quaterphenyl has been used in trials studying the treatment of Malaria.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

p-tert-Butylphenol-formaldehyde resin is a widely used adhesive chemical used in a wide variety of commercially available products and a known dermatological sensitizer and allergen [A34290,A34291]. Sensitivity to p-tert-Butylphenol-formaldehyde resin may …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseStandardized Chemical Allergen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 70-55-3

Deskripsi belum tersedia.

Kategori:
AmidesBenzene DerivativesSulfonamides +2
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 12Carbonic anhydrase 6 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 104-15-4

Deskripsi belum tersedia.

Kategori:
ArylsulfonatesArylsulfonic AcidsBenzene Derivatives +3
Target Protein:
Lysozyme CPro-cathepsin H
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Thymidylate kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Thymidine kinase, cytosolicThymidylate kinaseThymidylate kinase +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
UMP-CMP kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PA-1050040 DB06039
small molecule

PA1050040, a second generation HIV-1 maturation inhibitor, is a chemical analog of Bevirimat (BVM). It inhibits virus replication by the same mechanism of action as BVM.

Target Protein:
Gag polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PA3-17 DB18569
biotech

PA3-17 is CD7-directed chimeric antigen receptor (CAR) T-cell therapy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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