Hasil Filter

16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (16004)

Halaman 200 / 321
Mefenamic acid Approved DB00784
small molecule | CAS: 61-68-7

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +37
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh2 hours
Vol. Distribusi* 1.06 L/kg [Normal…
Klirens* Oral cl=21.23 L/h…
Genetik -
Mefenorex DB13852
small molecule | CAS: 17243-57-1

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAlimentary Tract and Metabolism +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mefloquine Approved DB00358
small molecule | CAS: 53230-10-7

Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019.[L30618] Despi…

Kategori:
Agents Causing Muscle ToxicityAgents that reduce seizure thresholdAminoquinolines +20
Target Protein:
Fe(II)-protoporphyrin IX80S ribosomal subunitAdenosine receptor A2a
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe apparent volume…
KlirensThe systemic cleara…
Genetik -
Mefruside DB13405
small molecule | CAS: 7195-27-9

Deskripsi belum tersedia.

Kategori:
AmidesDiureticsLow-Ceiling Diuretics, Excl. Thiazides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mefuparib DB18248
small molecule | CAS: 1392502-82-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Megestrol Approved DB19378
small molecule | CAS: 3562-63-8

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsAntineoplastic Agents, Hormonal +19
Target Protein:
Progesterone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Megestrol acetate Approved DB00351
small molecule | CAS: 595-33-5

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative …

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsAntineoplastic Agents, Hormonal +31
Target Protein:
Progesterone receptorGlucocorticoid receptor
Waktu Paruh34 hours
Vol. Distribusi-
Klirens-
Genetik -
Meglumine Approved DB09415
small molecule | CAS: 6284-40-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAlcoholsAmino Sugars +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 133-51-7

Deskripsi belum tersedia.

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAlcoholsAmino Sugars +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meglutol DB04377
small molecule | CAS: 503-49-1

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activi…

Kategori:
Acids, AcyclicAnticholesteremic AgentsAntimetabolites +7
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meladrazine DB13272
small molecule | CAS: 13957-36-3

Deskripsi belum tersedia.

Kategori:
Drugs for Urinary Frequency and IncontinenceGenito Urinary System and Sex HormonesUrologicals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melagatran DB13616
small molecule | CAS: 159776-70-2

Deskripsi belum tersedia.

Kategori:
AminesAnticoagulantsAntithrombins +8
Target Protein:
ProthrombinPlasminogenSerine protease 1 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Melaleuca alternifolia leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Melanoma antigen recognized by T-cells 1 is under investigation in clinical trial NCT01748747 (Vaccine Therapy and Resiquimod in Treating Patients With Stage II-IV Melanoma That Has Been Removed By Surgery).

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Neoplasm +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melarsomine DB11528
small molecule | CAS: 128470-15-5

Melarsomine is a trypanocidal agent marketed by Merial under the trade name Immiticide. It is the only FDA-approved treatment for adult heartworm infection in dogs, however, is is not approved for use in dogs with late-stage infection.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melarsoprol DB12864
small molecule | CAS: 494-79-1

Melarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis).

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAnti-Infective AgentsAntiparasitic Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melatonin Approved DB01065
small molecule | CAS: 73-31-4

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pin…

Kategori:
AminesAntioxidantsBiogenic Amines +21
Target Protein:
Melatonin receptor type 1AMelatonin receptor type 1BRibosyldihydronicotinamide dehydrogenase [quinone] +7
Waktu Paruh35 to 50 minutes
Vol. Distribusi-
Klirens-
Genetik -
Meldonium DB13723
small molecule | CAS: 76144-81-5

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicCardiac TherapyCardiovascular Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melengestrol DB11529
small molecule | CAS: 5633-18-1

Melengestrol is a steroidal progestin and antineoplastic agent which was never marketed. An acylated derivative, melengestrol acetate, is used as a growth promoter in animals.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids for Systemic Use +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2919-66-6

A 6-methyl progesterone acetate with reported glucocorticoid activity and effect on estrus.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCytochrome P-450 CYP3A Inducers +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melevodopa DB13313
small molecule | CAS: 7101-51-1

Deskripsi belum tersedia.

Kategori:
AminesAmino AcidsAmino Acids, Aromatic +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Melitracen DB13384
small molecule | CAS: 5118-29-6

Deskripsi belum tersedia.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meloxicam Approved DB00814
small molecule | CAS: 71125-38-7

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis.[A190189] With a longer half-life than most other NSAIDS, it is a f…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAmides +28
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhThe half-life of me…
Vol. DistribusiThe volume of distr…
KlirensAfter an oral dose,…
Genetik -
Melperone DB09224
small molecule | CAS: 3575-80-2

Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. Melperone has been used for a span of greater than 30 years in the European Union [L1316]. It has been well e…

Kategori:
Antiarrhythmic agentsAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical]) +17
Target Protein:
D(2) dopamine receptor
Waktu ParuhApproximately 3-4 h…
Vol. Distribusi-
Klirens-
Genetik -
Melphalan Approved DB01042
small molecule | CAS: 148-82-3

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent.[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of…

Kategori:
Alkylating ActivityAlkylating DrugsAmino Acids +17
Target Protein:
DNA
Waktu ParuhIn patients given a…
Vol. DistribusiThe volume of distr…
KlirensAverage total body …
Genetik -
Melphalan flufenamide Approved DB16627
small molecule | CAS: 380449-51-4

Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases.[A230123] _In vitro_ models sh…

Kategori:
Alkylating ActivityAlkylating DrugsAmino Acids +12
Target Protein:
DNA
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean volume of …
KlirensThe mean clearance …
Genetik -
Melrilimab DB16373
biotech | CAS: 2222865-46-3

Melrilimab is under investigation in clinical trial NCT03207243 (Efficacy and Safety Study of GSK3772847 in Subjects With Moderately Severe Asthma).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MEM 1003 DB05547
small molecule

MEM 10003 was under investigation in clinical trial NCT00257673 (Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease) for the treatment of Alzheimer's Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Memantine Approved DB01043
small molecule | CAS: 19982-08-2

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism t…

Kategori:
Anti-Dementia DrugsAnti-Dyskinesia AgentsAnti-Parkinson Drugs +20
Target Protein:
Glutamate (NMDA) receptor5-hydroxytryptamine receptor 3ANeuronal acetylcholine receptor subunit alpha-7 +3
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe mean volume of …
KlirensThis drug is cleare…
Genetik -
Menadiol diphosphate Approved DB14650
small molecule | CAS: 84-98-0

Deskripsi belum tersedia.

Kategori:
DiterpenesNaphthalenesNaphthoquinones +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menadione Approved DB00170
small molecule | CAS: 58-27-5

A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Kategori:
Antifibrinolytic AgentsBlood and Blood Forming OrgansCoagulants +45
Target Protein:
Aldehyde oxidaseVitamin K-dependent gamma-carboxylaseVitamin K epoxide reductase complex subunit 1 +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 130-36-9

Deskripsi belum tersedia.

Kategori:
Antifibrinolytic AgentsCoagulantsDiet, Food, and Nutrition +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menaquinone DB15381
small molecule | CAS: 1182-68-9

Menaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists).

Kategori:
CoagulantsDiet, Food, and NutritionDiterpenes +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menaquinone 6 DB14936
small molecule | CAS: 84-81-1

Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).

Kategori:
CoagulantsDiet, Food, and NutritionDiterpenes +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menaquinone 7 DB13075
small molecule | CAS: 2124-57-4

Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).

Kategori:
CoagulantsDiterpenesHematologic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menatetrenone DB12148
small molecule | CAS: 863-61-6

Menatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.

Kategori:
CoagulantsDiterpenesDrugs Affecting Bone Structure and Mineralization +12
Target Protein:
Cruzipain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menglytate DB15983
small molecule | CAS: 579-94-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine is used to prevent invasive meningococcal disease, which is caused by bacteria _Neisseria meningitidis_ entering the bloodstream and invading the blood-brain barrier …

Kategori:
Diphtheria VaccinesMeningococcal VaccinesVaccines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal group A polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup A. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia…

Kategori:
Actively Acquired ImmunityAntigensAntigens, Bacterial +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup C. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia…

Kategori:
Actively Acquired ImmunityAntigensAntigens, Bacterial +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal group W-135 polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup W-135. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningo…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Meningococcal group Y polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup Y. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia…

Kategori:
Actively Acquired ImmunityInactivated Meningococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menotropins Approved DB00032
biotech | CAS: 9002-68-0

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 …

Kategori:
Amino Acids, Peptides, and ProteinsBiological ProductsComplex Mixtures +14
Target Protein:
Follicle-stimulating hormone receptorLutropin-choriogonadotropic hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Mentha arvensis top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menthol Approved DB14123
small molecule | CAS: 1490-04-6

Deskripsi belum tersedia.

Kategori:
AlcoholsAntipruriticsCyclohexane Monoterpenes +9
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menthone DB15920
small molecule | CAS: 89-80-5

Deskripsi belum tersedia.

Kategori:
AlcoholsCyclohexane MonoterpenesCyclohexanes +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menthyl salicylate Approved DB11201
small molecule | CAS: 89-46-3

Menthyl salicylate is an ester of menthol and salicylic acid [L2808]. This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) [L2810].

Kategori:
Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-Steroidal
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mepartricin DB13633
small molecule | CAS: 11121-32-7

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAlkenesAnti-Bacterial Agents +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mepenzolate Approved DB04843
small molecule | CAS: 25990-43-6

Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous …

Kategori:
Acids, CarbocyclicAgents producing tachycardiaAlimentary Tract and Metabolism +7
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meperidine Approved DB00454
small molecule | CAS: 57-42-1

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with mor…

Kategori:
AdjuvantsAdjuvants, AnesthesiaAgents that reduce seizure threshold +34
Target Protein:
Kappa-type opioid receptorGlutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2B +9
Waktu ParuhInitial distributio…
Vol. DistribusiMeperidine crosses …
Klirens-
Genetik -
Menampilkan 9951–10000 dari 16004
Sebelumnya Halaman 200 / 321 Berikutnya