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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 198 / 252
Prazosin Approved DB00457
small molecule | CAS: 19216-56-9

Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988.[L5828] It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of thi…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +16
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorAlpha-1D adrenergic receptor +4
Waktu ParuhThe plasma half-lif…
Vol. DistribusiAbout 0.6 L/kg [A17…
KlirensIn patients with co…
Genetik -
Prednisolone Approved DB00860
small molecule | CAS: 50-24-8

Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]

Kategori:
Adrenal Cortex HormonesAdrenalsAgents for Treatment of Hemorrhoids and Anal Fissures for Topical Use +45
Target Protein:
Glucocorticoid receptor
Waktu ParuhPrednisolone has a …
Vol. DistribusiA 0.15mg/kg dose of…
KlirensA 0.15mg/kg dose of…
Genetik -
Prednisolone acetate Approved DB15566
small molecule | CAS: 52-21-1

Prednisolone acetate is a [prednisolone] molecule bound to an acetate functional group by an ester bond.[L9449] Prednisolone acetate was granted FDA approval in 1955.[L9449]

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +14
Target Protein:
Glucocorticoid receptor
Waktu ParuhOral prednisolone a…
Vol. DistribusiThe volume of distr…
KlirensData regarding the …
Genetik -
small molecule | CAS: 69164-69-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisolone phosphate Approved DB14631
small molecule | CAS: 302-25-0

Prednisolone phosphate is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone phosphate was granted FDA Approval on 19 December 1973.[L14144]

Kategori:
Adrenal Cortex HormonesAdrenalsAnti-Inflammatory Agents +30
Target Protein:
Glucocorticoid receptorAnnexin A1
Waktu ParuhThe half life of pr…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Prednisone Approved DB00635
small molecule | CAS: 53-03-2

A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]

Kategori:
Adrenal Cortex HormonesAdrenalsAlimentary Tract and Metabolism +45
Target Protein:
Glucocorticoid receptor
Waktu ParuhPrednisone and its …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Prednisone acetate Approved DB14646
small molecule | CAS: 125-10-0

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsAntineoplastic Agents +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednylidene DB13208
small molecule | CAS: 599-33-7

Prednylidene is an experimental systemic glucocorticoid.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids for Systemic Use +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pregabalin Approved DB00230
small molecule | CAS: 148553-50-8

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.[A173995] It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions.[A187190] Although as per the FDA Label …

Kategori:
Acids, AcyclicAgents causing angioedemaAmino Acids +24
Target Protein:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Waktu ParuhThe elimination hal…
Vol. DistribusiAfter oral administ…
KlirensIn young healthy su…
Genetik -
Pregnenolone Approved DB02789
small molecule | CAS: 145-13-1

A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +11
Target Protein:
Steroid hormone receptor ERR1Nuclear receptor subfamily 1 group I member 2Sulfotransferase 2B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1778-02-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 485818-40-4

Preimplantation factor is under investigation in clinical trial NCT03593460 (Phase II Autoimmune Hepatitis).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenalterol DB13777
small molecule | CAS: 57526-81-5

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic and Dopaminergic Agents +20
Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenoxdiazine DB13397
small molecule | CAS: 47543-65-7

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenylamine Approved DB04825
small molecule | CAS: 390-64-7

Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.

Kategori:
Adrenergic AgentsAgents causing hyperkalemiaAmines +19
Target Protein:
Myosin light chain kinase 2, skeletal/cardiac muscleCalmodulin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prephenic acid DB08427
small molecule | CAS: 126-49-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicCyclohexanesCycloparaffins
Target Protein:
Chorismate mutase AroH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Presatovir DB12165
small molecule | CAS: 1353625-73-6

Presatovir has been used in trials studying the treatment of RSV Infection, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus Infections, and Respiratory Syncytial Virus (RSV) Infections.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles +2
Target Protein:
Fusion glycoprotein F0
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prethcamide DB13447
small molecule | CAS: 8015-51-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pretomanid Approved DB05154
small molecule | CAS: 187235-37-6

Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of thi…

Kategori:
Antiinfectives for Systemic UseAntimycobacterialsCytochrome P-450 CYP3A Substrates +7
Target Protein:
Cyclopropane mycolic acid synthase 1Cyclopropane mycolic acid synthase 2Cyclopropane mycolic acid synthase 3 +5
Waktu ParuhThe elimination hal…
Vol. DistribusiA pharmacokinetic m…
KlirensThe clearance of pr…
Genetik -
Previtamin D(3) DB15614
small molecule | CAS: 1173-13-3

Deskripsi belum tersedia.

Kategori:
CholestanesCholestenesFused-Ring Compounds +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prexasertib DB12008
small molecule | CAS: 1234015-52-1

Prexasertib has been used in trials studying the treatment and basic science of mCRPC, Leukemia, Neoplasm, breast cancer, and Ovarian Cancer, among others.

Kategori:
Enzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prezatide DB11296
small molecule | CAS: 49557-75-7

Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in ch…

Kategori:
Amino Acids, Peptides, and ProteinsGrowth SubstancesPeptides
Waktu ParuhPrezatide is rapidl…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 89030-95-5

Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in ch…

Kategori:
Amino Acids, Peptides, and ProteinsNuclear Matrix-Associated ProteinsNuclear Proteins +1
Waktu ParuhPrezatide is rapidl…
Vol. Distribusi-
Klirens-
Genetik -
PRGN-3006 DB17229
biotech

PRGN-3006 are autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane-bound interleukin-15, and a truncated form of human HER1T (kill switch) on the cell surface.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRI-724 DB15034
small molecule | CAS: 1198780-38-9

PRI-724 is under investigation in clinical trial NCT03620474 (Safety and Effectiveness of PRI-724 for Hepatitis C or B Virus Derived Liver Cirrhosis).

Kategori:
Pyrimidines
Target Protein:
CREB-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pridinol DB13642
small molecule | CAS: 511-45-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsMuscle RelaxantsMuscle Relaxants, Centrally Acting Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prifinium DB13254
small molecule | CAS: 10236-81-4

Prifinium is an antimuscarinic agent with antispasmodic and antiemetic properties. It may be useful for the treatment of irritable bowel syndrome [A175027].

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prilocaine Approved DB00750
small molecule | CAS: 721-50-6

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

Kategori:
AmidesAminesAnesthetics +11
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Primidone Approved DB00794
small molecule | CAS: 125-33-7

Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures.[L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 Marc…

Kategori:
Anti-epileptic AgentAnticholinergic AgentsAnticonvulsants +36
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-4 +8
Waktu ParuhThe half life of pr…
Vol. DistribusiThe volume of distr…
KlirensPrimidone is cleare…
Genetik -
Prinaberel DB06832
small molecule | CAS: 524684-52-4

Prinaberel is an estrogen receptor beta agonist.

Kategori:
Receptors, Estrogen, agonists
Target Protein:
Estrogen receptor betaNuclear receptor coactivator 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prinomastat DB05100
small molecule | CAS: 192329-42-3

Prinomastat is a synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angioge…

Kategori:
Enzyme InhibitorsMatrix Metalloproteinase InhibitorsProtease Inhibitors
Target Protein:
72 kDa type IV collagenaseInterstitial collagenaseMatrilysin
Waktu Paruh2-5 hours
Vol. Distribusi-
Klirens-
Genetik -
Priralfinamide DB06649
small molecule | CAS: 133865-88-0

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicBenzene DerivativesFatty Acids +4
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pristimerin DB17049
small molecule | CAS: 1258-84-0

Pristimerin is a quinone methide triterpenoid researched for its anti-cancer potential.[A253107]

Kategori:
TerpenesTriterpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pritelivir DB11844
small molecule | CAS: 348086-71-5

Pritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.

Kategori:
AmidesAnti-Infective AgentsAntiviral Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRO 2000 DB05385
small molecule | CAS: 29321-75-3

PRO 2000 is an investigational medicine that is not yet approved by the FDA for use outside of clinical trials. It is being studied for the prevention of HIV infection and other sexually transmitted diseases. This medicine does not cure HIV infection or AIDS …

Kategori:
ArylsulfonatesArylsulfonic AcidsCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRO-542 DB05793
biotech

PRO 542 belongs to a new class of drugs, viral-entry inhibitor, which is intended to prevent HIV from entering and infecting cells. PRO 542 (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isola…

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Surface +21
Target Protein:
Free fatty acid receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Probenecid Approved DB01032
small molecule | CAS: 57-66-9

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other…

Kategori:
Adjuvants, PharmaceuticAmidesAntigout Preparations +29
Target Protein:
Solute carrier family 22 member 6Solute carrier family 22 member 11Organic anion transporter 3 +2
Waktu Paruh6-12 hours
Vol. Distribusi-
Klirens-
Genetik -
Probiorinse DB15870
biotech

Probiorinse is an intranasal probiotic treatment composed of a pre-mixed and buffered sinus irrigation solution that contains the probiotic bacteria Lactococcus lactis W136.[L16368] This strain of bacteria is said to have salubrious effects on the microbiome …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Probucol Approved DB01599
small molecule | CAS: 23288-49-5

A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).

Kategori:
Anticholesteremic AgentsAntioxidantsBenzene Derivatives +10
Target Protein:
Phospholipid-transporting ATPase ABCA1Liver carboxylesterase 1
Waktu ParuhRanges from 12 hour…
Vol. Distribusi-
Klirens-
Genetik -
Procainamide Approved DB01035
small molecule | CAS: 51-06-9

A derivative of procaine with less CNS action.

Kategori:
Acids, CarbocyclicAgents Causing Muscle ToxicityAgents that produce neuromuscular block (indirect) +32
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2Sodium channel protein type 5 subunit alphaDNA (cytosine-5)-methyltransferase 1
Waktu Paruh~2.5-4.5 hours
Vol. Distribusi* 2 L/kg
Klirens-
Genetik -
Procaine Approved DB00721
small molecule | CAS: 59-46-1

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also b…

Kategori:
Acids, CarbocyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAgents that reduce seizure threshold +25
Target Protein:
Sodium channel protein type 10 subunit alphaGlutamate receptor ionotropic, NMDA 3A5-hydroxytryptamine receptor 3A +8
Waktu Paruh7.7 minutes
Vol. Distribusi-
Klirens-
Genetik -
Procaine benzylpenicillin Approved DB09320
small molecule | CAS: 54-35-3

Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent pro…

Kategori:
Acids, CarbocyclicAmidesAminobenzoates +16
Target Protein:
Penicillin-binding protein
Waktu ParuhIntramuscular injec…
Vol. DistribusiThe drug is distrib…
Klirens-
Genetik -
Procalcitonin DB14812
biotech | CAS: 56645-65-9

Procalcitonin is under investigation in clinical trial NCT03440060 (Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPD).

Kategori:
Amino Acids, Peptides, and ProteinsBone Density Conservation AgentsCalcitonin Preparations +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prochlorperazine Approved DB00433
small molecule | CAS: 58-38-8

Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psyc…

Kategori:
AntiemeticsAntipsychotic AgentsAntipsychotic Agents (First Generation [Typical]) +28
Target Protein:
D(2) dopamine receptorHistamine H1 receptorAlpha-1 adrenergic receptors +1
Waktu ParuhFollowing intraveno…
Vol. DistribusiIn a preliminary ph…
KlirensThe mean plasma cle…
Genetik -
Procinonide Approved DB18737
small molecule | CAS: 58497-00-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Profadol DB17993
small molecule | CAS: 428-37-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Profenamine Approved DB00392
small molecule | CAS: 522-00-9

Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada.[L46812] In the US, the marketing of profenamine has been…

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAgents producing tachycardia +12
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Glutamate receptor ionotropic, NMDA 3A +1
Waktu Paruh1 to 2 hours
Vol. Distribusi-
Klirens-
Genetik -
Progesterone Approved DB00396
small molecule | CAS: 57-83-0

Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can caus…

Kategori:
Adrenal Cortex HormonesBCRP/ABCG2 InducersBCRP/ABCG2 Inhibitors +47
Target Protein:
Progesterone receptorMineralocorticoid receptorEstrogen receptor +7
Waktu ParuhAbsorption half-lif…
Vol. DistribusiWhen administered v…
Klirens**Apparent clearanc…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Proglumetacin DB13527
small molecule | CAS: 57132-53-3

Deskripsi belum tersedia.

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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