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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 197 / 349
Kava Approved DB01322
small molecule | CAS: 9000-38-8

Deskripsi belum tersedia.

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KB-141 DB03176
small molecule | CAS: 219691-94-8

An anticholesteremic agent.

Kategori:
Acids, CarbocyclicBenzene DerivativesEthers +2
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor beta
Waktu Paruh-
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KB001 DB05222
biotech

KB001 is a Humaneered™ PEGylated monoclonal antibody fragment for the treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients.

Target Protein:
Low calcium response locus protein V
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KB002 DB05194
small molecule

KB002 is an engineered human IgG1k antibody engineered human. It is developed for the treatment of autoimmune diseases, initially rheumatoid arthritis.

Target Protein:
Granulocyte-macrophage colony-stimulating factor receptor subunit alphaGranulocyte-macrophage colony-stimulating factorGM-CSF receptor alpha subunit
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KB105 DB18224
biotech

Deskripsi belum tersedia.

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KB109 DB16531
biotech

KB109 is a prebiotic to feed healthy bacteria for them to to outcompete multi-drug resistance organisms.

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KB3305 DB06349
small molecule | CAS: 639520-46-0

KB3305 is an investigational liver selective antagonist for the glucocorticoid receptor, developed by Karo Bio for the treatment of Type 2 Diabetes.

Kategori:
17-KetosteroidsAdrenal Cortex HormonesBile Acids and Salts +11
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KB407 DB18223
biotech

Deskripsi belum tersedia.

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KBP-COVID-19 DB15858
biotech

The KBP-201 COVID-19 Vaccine was developed by British American Tobacco’s (BAT) U.S. biotech subsidiary, Kentucky BioProcessing (KBP). KBP cloned COVID-19’s genetic sequence, identified a potential antigen, and then inserted it into tobacco plants for reproduc…

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KC706 DB05157
small molecule

KC706 is a novel anti-inflammatory drug that works by inhibiting the activity of p38 MAP kinase. KC706 holds potential to treat inflammatory conditions such as rheumatoid arthritis, psoriasis, inflammatory bowel disease and cardiovascular disease.

Target Protein:
Mitogen-activated protein kinase 14Mitogen-activated protein kinase 11Mitogen-activated protein kinase 12 +1
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KD3010 DB05188
small molecule | CAS: 934760-90-4

KD3010 is a small molecule peroxisome proliferator-activator receptor delta (PPAR Delta) agonist for the treatment of metabolic disorders, including obesity.

Kategori:
AmidesPPAR delta, antagonists & inhibitorsSulfones +1
Target Protein:
Peroxisome proliferator-activated receptor delta
Waktu Paruh-
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KD7040 DB05214
small molecule

KD7040 is a topically-delivered inducible nitric oxide synthase (iNOS) inhibitor for the treatment of neuropathic pain. The KD7040 IND was filed in 4Q06, and a Phase Ib clinical trial began 2Q07. It is being developed by Kalypsys.

Target Protein:
Nitric oxide synthase, inducible
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KDT-3594 DB17085
small molecule

KDT-3594 is a non-ergot dopamine receptor agonist developed by Kissei Pharmaceutical.

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Kebuzone DB08940
small molecule | CAS: 853-34-9

Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +14
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Kelatorphan DB08040
small molecule | CAS: 92175-57-0

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsCentral Nervous System Agents +4
Target Protein:
Aminopeptidase NGlutamyl aminopeptidaseLeukotriene A-4 hydrolase
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KER-047 DB19111
small molecule | CAS: 2248154-85-8

KER-047 is under investigation in clinical trial NCT05927012 (A Study to Evaluate the Safety and Preliminary Efficacy of a Response-guided Dose Titration of KER-047 in the Treatment of Functional IDA (Iron Deficiency Anemia).).

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Ketamine Approved DB01221
small molecule | CAS: 6740-88-1

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect.[A31869] It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1…

Kategori:
Agents producing tachycardiaAmino AcidsAmino Acids, Acidic +35
Target Protein:
Glutamate receptor ionotropic, NMDA 3A5-hydroxytryptamine receptor 3ANeuronal acetylcholine receptor subunit alpha-7 +11
Waktu ParuhThe reported half-l…
Vol. DistribusiThe apparent volume…
KlirensThe clearance rate …
Genetik -
Ketanserin DB12465
small molecule | CAS: 74050-98-9

Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer.

Kategori:
Antidepressive AgentsAntihypertensive AgentsAntiplatelet agents +11
Target Protein:
5-hydroxytryptamine receptor 2A
Waktu Paruh-
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Ketazolam Approved DB01587
small molecule | CAS: 27223-35-4

Ketazolam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity. Ketazolam is not approved in Canada or America.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +16
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh26-200 hours
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Ketobemidone DB06738
small molecule | CAS: 469-79-4

Ketobemidone is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemi…

Kategori:
AnalgesicsCentral Nervous System AgentsCentral Nervous System Depressants +20
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor +1
Waktu ParuhPlasma half-life: 2…
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Ketocaine DB16020
small molecule | CAS: 1092-46-2

Deskripsi belum tersedia.

Kategori:
Ketones
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Ketoconazole Approved DB01026
small molecule | CAS: 65277-42-1

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity…

Kategori:
14-alpha Demethylase InhibitorsAgents causing hyperkalemiaAnti-Infective Agents +55
Target Protein:
Lanosterol 14-alpha demethylaseLanosterol 14-alpha demethylaseSteroid 17-alpha-hydroxylase/17,20 lyase +5
Waktu ParuhKetoconazole experi…
Vol. DistribusiKetoconazole has an…
KlirensKetoconazole has an…
Genetik -
small molecule | CAS: 1297537-33-7

Ketodarolutamide, a nonsteroidal antiandrogen (NSAA), is the major active metabolite of [darolutamide].

Kategori:
AntiandrogensAntiandrogens, non-steroidal
Target Protein:
Androgen receptor
Waktu Paruh-
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Ketoprofen Approved DB01009
small molecule | CAS: 22071-15-4

Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +38
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1C-X-C chemokine receptor type 1
Waktu ParuhConventional capsul…
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Klirens* Oral-dose cl=6.9 …
Genetik -
Ketorolac Approved DB00465
small molecule | CAS: 74103-06-3

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.[L6358][L6508][L11055][L3674][L11070] It's analgesic properties make it a useful pain manage…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +26
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhKetorolac trometham…
Vol. DistribusiThe apparent volume…
KlirensThe plasma clearanc…
Genetik -
Ketotifen Approved DB00920
small molecule | CAS: 34580-13-7

Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].[A231204] Ketotif…

Kategori:
Anti-Allergic AgentsAnti-Asthmatic AgentsAntihistamine Drugs +15
Target Protein:
Histamine H1 receptor6-phosphogluconate dehydrogenase, decarboxylating
Waktu ParuhKetotifen clearance…
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Keyhole limpet hemocyanin Approved DB05299
biotech

Keyhole limpet hemocyanin is an immune modulator, given as a vaccine to help the body respond to cancer. A natural protein isolated from the marine mollusc keyhole limpet. Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases an…

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntigens +7
Target Protein:
Interleukin-2
Waktu Paruh-
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KF-0210 DB17476
small molecule

KF-0210 is a small molecule developed by Keythera Pharmaceuticals. It is being investigated for cancers.

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KF-1601 DB18297
small molecule | CAS: 2699634-21-2

Deskripsi belum tersedia.

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KH064 DB04287
small molecule | CAS: 393569-31-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Target Protein:
Phospholipase A2, membrane associated
Waktu Paruh-
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KHK2455 DB17524
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
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Khuskia oryzae Approved DB10581
biotech

Khuskia oryzae is a fungus which can provoke allergic reactions. Khuskia oryzae extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Kidney bean Approved DB10639
biotech

Kidney bean allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
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Kifunensine DB02742
small molecule | CAS: 109944-15-2

Deskripsi belum tersedia.

Kategori:
Enzyme Inhibitors
Target Protein:
Alpha-mannosidase 2Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseMannosyl-oligosaccharide alpha-1,2-mannosidase
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KIN-3248 DB17587
small molecule

KIN-3248 is a small molecule that targets and inhibits oncogenic fibroblast growth factor receptors (FGFRs). It was designed to mainly target FGFR2 and FGFR3 alterations, which act as oncogenic drivers in 10-20% of cholangiocarcinoma and 20-35% of urothelial …

Target Protein:
Fibroblast growth factor receptor 2Fibroblast growth factor receptor 3
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Kinetin Approved DB11336
small molecule | CAS: 525-79-1

Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. It was shown to naturally exist in DNA of organisms including humans and various plants. While kinetin is used in tissue cultures to produce new plants, it is also found …

Kategori:
CytokininsGrowth SubstancesHeterocyclic Compounds, Fused-Ring +2
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KIO-301 DB18465
small molecule | CAS: 1224953-72-3

Deskripsi belum tersedia.

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Kisspeptin DB19112
biotech | CAS: 388138-21-4

Kisspeptin is under investigation in clinical trial NCT03315325 (Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men).

Kategori:
Amino Acids, Peptides, and ProteinsIntercellular Signaling Peptides and ProteinsNeoplasm Proteins +4
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Kisspeptin-10 DB16210
biotech | CAS: 374675-21-5

Kisspeptin-10 is under investigation in clinical trial NCT03771326 (KP-10 and Insulin Secretion in Men).

Kategori:
Amino Acids, Peptides, and ProteinsGenes, Tumor SuppressorIntercellular Signaling Peptides and Proteins +5
Target Protein:
KiSS-1 receptor
Waktu Paruh-
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KIT-13 DB18093
small molecule | CAS: 103628-72-4

Deskripsi belum tersedia.

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Kitasamycin DB09309
small molecule | CAS: 1392-21-8

Kitasamycin is a macrolide antibiotic derived from <em>Streptomyces kitasatoensis</em>.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsCytochrome P-450 CYP3A Inhibitors +7
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KITE-222 DB17195
biotech

Deskripsi belum tersedia.

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KITE-585 DB17409
biotech

KITE-585 is an autologous, fully-human anti-B cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell therapy. It is being investigated in the treatment of multiple myeloma.

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Kiwi fruit Approved DB10641
biotech

Kiwi fruit allergenic extract is used in allergenic testing.

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KL1333 DB17622
small molecule | CAS: 1800405-30-4

Deskripsi belum tersedia.

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KN-001 DB18495
small molecule

Deskripsi belum tersedia.

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Koeleria macrantha pollen Approved DB10949
biotech

Koeleria macrantha pollen is the pollen of the Koeleria macrantha plant. Koeleria macrantha pollen is mainly used in allergenic testing.

Kategori:
Allergenic ExtractsCell-mediated ImmunityGrass Pollen Allergen Extracts +3
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Kojic acid DB01759
small molecule | CAS: 501-30-4

Deskripsi belum tersedia.

Kategori:
AntioxidantsBiological FactorsCompounds used in a research, industrial, or household setting +3
Target Protein:
Tyrosinase
Waktu Paruh-
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Konjac mannan DB14963
small molecule | CAS: 37220-17-0

Konjac mannan is under investigation in clinical trial NCT01709955 (The Effects of Glucomannan on Weight Loss).

Kategori:
CarbohydratesGastrointestinal AgentsLaxatives +2
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KOS-1584 DB05903
small molecule | CAS: 350493-61-7

KOS-1584 is a second-generation epothilone. Epothilones are anticancer agents with a taxane-like mechanism of action that have demonstrated activity in taxane-resistant tumors. KOS-1584 is a second-generation compound with increased potency, favorable tissue …

Kategori:
Anti-Bacterial AgentsAntineoplastic AgentsCytochrome P-450 CYP3A Inhibitors +6
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