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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
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12560 (100.0%)

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Halaman 196 / 252
Polydatin Approved DB11263
small molecule | CAS: 27208-80-6

Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of *Picea sitchensis* or *Polygonum cuspidatum*, polydatin may be detected in grape, peanut, hop cones, red win…

Kategori:
Benzene DerivativesBenzylidene CompoundsCarbohydrates +3
Target Protein:
Pyruvate kinase PKM
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Polydextrose DB14836
small molecule | CAS: 68424-04-4

Polydextrose is under investigation in clinical trial NCT02258750 (Assessing a Polydextrose Containing Soup on Food Intake, Appetite and Biomarkers of Satiation and Satiety).

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +8
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Polyestradiol phosphate Approved DB09369
small molecule | CAS: 28014-46-2

Polymeric phosphoric acid ester of estradiol.

Kategori:
Antineoplastic and Immunomodulating AgentsEndocrine TherapyEstradiol Congeners +10
Target Protein:
Estrogen receptor
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Polyethylene glycol Approved DB09287
small molecule | CAS: 25322-68-3

Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.[A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of …

Kategori:
AlcoholsAlimentary Tract and MetabolismCompounds used in a research, industrial, or household setting +21
Waktu ParuhFollowing a two-day…
Vol. DistribusiFollowing a two-day…
KlirensThere is limited in…
Genetik -
Polyethylene glycol 300 Approved DB11161
small molecule | CAS: 25322-68-3

Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116]. Polyethylene glycols are widely used in biochemistry…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +3
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
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small molecule | CAS: 25322-68-3

Deskripsi belum tersedia.

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Polyethylene glycol 400 Approved DB11077
small molecule | CAS: 25322-68-3

Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily …

Kategori:
AlcoholsArtificial TearsCompounds used in a research, industrial, or household setting +8
Target Protein:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1Oxidoreductase HTATIP2
Waktu ParuhGreat than 24h [L17…
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KlirensIn mice, lease than…
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Polygeline DB15879
biotech | CAS: 66455-30-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood SubstitutesHematologic Agents +4
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small molecule | CAS: 31961-54-3

Deskripsi belum tersedia.

Kategori:
AmidinesFlocculation
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small molecule | CAS: 81859-24-7

Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.

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Polysilicone-15 Approved DB11271
small molecule | CAS: 207574-74-1

Polysilicone-15 is a silicone based UVB absorber [L2796, L2797, L2799, F87, F88, F89]. The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89…

Kategori:
Sunscreen Agents
Waktu ParuhPolysilicone-15 is …
Vol. DistribusiPolysilicone-15 is …
KlirensPolysilicone-15 is …
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Polysorbate 20 Approved DB11178
small molecule | CAS: 9005-64-5

Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is a wetting agent in food products, as well a…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
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Polysorbate 60 DB14153
small molecule | CAS: 9005-67-8

Deskripsi belum tersedia.

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Polysorbate 80 Approved DB11063
small molecule | CAS: 9005-65-6

Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide, is used in many foreign countries, including the U.S. and the EU, where it acts as an emulsifier, a solubilizer in many foods, includ…

Kategori:
AlcoholsArtificial TearsCompounds used in a research, industrial, or household setting +10
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small molecule

Deskripsi belum tersedia.

Kategori:
CarbohydratesPolysaccharides
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biotech

Polyvalent antigen-KLH conjugate vaccine is a multivalent cancer vaccine comprised of the five tumor-associated antigens (TAAs) globo H, GM2 ganglioside, Tn-MUC1, TF, and sTn conjugated with the immunoadjuvant keyhole limpet hemocyanin (KLH). It is under inve…

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Polyvinyl alcohol Approved DB11060
small molecule | CAS: 9002-89-5

Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. Polyvinyl alcohol is found in ophthalmic solutions …

Kategori:
AlcoholsAlkenesArtificial Tears +8
Waktu ParuhWhen injected intra…
Vol. DistribusiThis drug does not …
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Pomotrelvir DB18975
small molecule | CAS: 2713437-86-4

Pomotrelvir is under investigation in clinical trial NCT05543707 (PBI-0451 (Pomotrelvir) Phase 2 Study in Nonhospitalized Symptomatic Adults With COVID-19).

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Ponatinib Approved DB08901
small molecule | CAS: 943319-70-8

Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors +23
Target Protein:
Tyrosine-protein kinase ABL1Breakpoint cluster region proteinMast/stem cell growth factor receptor Kit +12
Waktu ParuhAfter oral administ…
Vol. DistribusiAfter oral administ…
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Ponazuril DB11452
small molecule | CAS: 69004-04-2

Ponazuril, sold by the Bayer Corporation under the trade name Marquis, is a drug currently approved for the treatment of equine protozoal myeloencephalitis in horses, caused by Sarcocystis neurona.

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Ponesimod Approved DB12016
small molecule | CAS: 854107-55-4

Ponesimod is a selective sphingosine 1-phosphate receptor 1 modulator indicated in the treatment of relapsing forms of multiple sclerosis in adults.[A232079,L32709] Ponesimod was developed out of a need for a more selective modulator of sphingosine 1-phosphat…

Kategori:
Antineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +13
Target Protein:
Sphingosine 1-phosphate receptor 1
Waktu ParuhPonesimod has an el…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of po…
Genetik -
Ponezumab DB15135
biotech | CAS: 1178862-65-1

Ponezumab is under investigation in clinical trial NCT00607308 (A Phase I, Single Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Ponsegromab DB18943
biotech | CAS: 2368950-15-4

Ponsegromab is under investigation in clinical trial NCT05492500 (A Study of Ponsegromab in People With Heart Failure).

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biotech

Populus balsamifera subsp. trichocarpa pollen is the pollen of the Populus balsamifera subsp. trichocarpa plant. Populus balsamifera subsp. trichocarpa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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biotech

Populus deltoides subsp. monilifera pollen is the pollen of the Populus deltoides subsp. monilifera plant. Populus deltoides subsp. monilifera pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Populus nigra pollen Approved DB10750
biotech

Populus nigra pollen is the pollen of the Populus nigra plant. Populus nigra pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Populus tremuloides pollen Approved DB10456
biotech

Populus tremuloides pollen is the pollen of the Populus tremuloides plant. Populus tremuloides pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Porfiromycin DB06478
small molecule | CAS: 801-52-5

Porfiromycin is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.

Kategori:
Antibiotics, AntineoplasticAntineoplastic AgentsAzirines +5
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Porgaviximab DB17773
biotech | CAS: 1792982-55-8

Deskripsi belum tersedia.

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Pork Approved DB10561
biotech

Pork allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Pork collagen Approved DB14100
biotech

Pork Collagen is used within MACI® (autologous cultured chondrocytes on porcine collagen membrane) as an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or …

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Porphobilinogen DB02272
small molecule | CAS: 487-90-1

Porphobilinogen is a pyrrole involved in porphyrin metabolism. It is generated by the enzyme ALA dehydratase, and converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase.

Target Protein:
Delta-aminolevulinic acid dehydratase
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Posdinemab DB18941
biotech | CAS: 2517973-04-3

Posdinemab is under investigation in clinical trial NCT04619420 (A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease).

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Poseltinib DB16299
small molecule | CAS: 1353552-97-2

Poseltinib is under investigation in clinical trial NCT02628028 (A Study of LY3337641 in Rheumatoid Arthritis).

Kategori:
Amines
Target Protein:
Tyrosine-protein kinase BTK
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Posiphen DB15317
small molecule | CAS: 116839-68-0

Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).

Kategori:
Acids, AcyclicAlkaloidsCarbamates +11
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Posizolid DB04850
small molecule | CAS: 252260-06-3

Posizolid (AZD2563) is an oxazolidinone antibiotic. In July 2002, after completion of phase I trials in December 2001, AstraZeneca announced that they were no longer pursuing the development of Posizolid, presumably due to negative trial results (though no r…

Kategori:
OATP1B1/SLCO1B1 InhibitorsOxazoles
Target Protein:
23S ribosomal RNAAmine oxidase [flavin-containing] A
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POT-4 DB06056
biotech

POT-4 is a peptide that specifically inhibits complement activation and is initially being developed for the treatment of age-related macular degeneration (AMD). The investigational drug was under investigation in clinical trial NCT00473928 (Safety of Intravi…

Target Protein:
Complement C3
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Potassium Approved DB14500
small molecule | CAS: 7440-09-7

Potassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans.[A186928] Many conditions and diseases interfere with normal body potassium b…

Kategori:
Agents causing hyperkalemiaDiureticsElements +8
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu ParuhIn one clinical stu…
Vol. DistribusiPotassium is presen…
KlirensPotassium is freely…
Genetik -
Potassium aspartate Approved DB15819
small molecule | CAS: 7259-25-8

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +2
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Potassium carbonate Approved DB13977
small molecule | CAS: 584-08-7

Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. It presents a large capacity to absor…

Kategori:
AlkaliesAnionsCarbon Compounds, Inorganic +8
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Potassium cation Approved DB01345
small molecule | CAS: 24203-36-9

Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells…

Kategori:
Agents causing hyperkalemiaDiureticsDrugs that are Mainly Renally Excreted +6
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
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Potassium citrate Approved DB09125
small molecule | CAS: 866-84-2

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste. It contains 38.3% potassium by mass. In the monohydrate form it is highly hygroscopic…

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAlimentary Tract and Metabolism +15
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Potassium gluconate Approved DB13620
small molecule | CAS: 299-27-4

Potassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA [L2654]. It is also used as a potassium supplement [L2657]. Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it …

Kategori:
Alimentary Tract and MetabolismMineral SupplementsPotassium Salt
Waktu Paruh-
Vol. DistribusiDistribution is lar…
KlirensPotassium is freely…
Genetik -
small molecule | CAS: 1319-69-3

Deskripsi belum tersedia.

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Potassium guaiacolsulfonate Approved DB13735
small molecule | CAS: 1321-14-8

Guaiacolsulfonate is an aromatic sulfonic acid. Potassium guaiacolsulfonate salt is an expectorant that thins the mucus in the lungs and reduces chest congestion.

Kategori:
Benzene DerivativesCatecholsEthers +4
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small molecule | CAS: 923-09-1

Deskripsi belum tersedia.

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Potassium hydroxide Approved DB11153
small molecule | CAS: 1310-58-3

Potassium hydroxide, also known as _lye_ is an inorganic compound with the chemical formula _KOH_. Also commonly referred to as _caustic potash_, it is a potent base that is marketed in several forms including pellets, flakes, and powders. It is used in vari…

Kategori:
AlkaliesAnionsCompounds used in a research, industrial, or household setting +5
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small molecule | CAS: 7758-05-6

Deskripsi belum tersedia.

Kategori:
AnionsAnti-Infective AgentsAntifungal Agents +3
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Potassium Iodide Approved DB06715
small molecule | CAS: 7681-11-0

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination …

Kategori:
AnionsAntidotesAntithyroid agents +12
Target Protein:
Tyrosine
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small molecule | CAS: 16731-55-8

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIons +1
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