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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 196 / 282
small molecule | CAS: 1239309-58-0

Neladenoson bialanate has been investigated for the treatment of Heart Failure.

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Target Protein:
Adenosine receptor A1
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Nelarabine Approved DB01280
small molecule | CAS: 121032-29-9

Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease h…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +8
Target Protein:
DNADNA polymerase alpha catalytic subunitDNA ligase 1 +2
Waktu ParuhNelarabine and ara-…
Vol. DistribusiNelarabine and ara-…
KlirensRenal clearance ave…
Genetik -
Nelatimotide DB17249
small molecule | CAS: 1629213-88-2

Deskripsi belum tersedia.

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Nelfinavir Approved DB00220
small molecule | CAS: 159989-64-7

Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, …

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +45
Target Protein:
HIV-1 protease
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensOral clearance esti…
Genetik -
Nelipepimut-S DB06226
biotech | CAS: 160212-35-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Surface +25
Target Protein:
Receptor tyrosine-protein kinase erbB-2HLA class I histocompatibility antigen, A-3 alpha chain
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Nelistotug DB19334
biotech | CAS: 2645437-82-5

Nelistotug is under investigation in clinical trial NCT06062420 (A Platform Study of Novel Immunotherapy Combinations as First-line Treatment in Participants With PD-L1 Positive Recurrent/metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-2…

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Nelivaptan DB12643
small molecule | CAS: 439687-69-1

Nelivaptan has been used in trials studying the treatment of Anxiety Disorders, Depressive Disorder, and Major Depressive Disorder.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Vasopressin V1b receptorVasopressin V2 receptorOxytocin receptor +1
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Nelmastobart DB19000
biotech | CAS: 2669823-48-5

Nelmastobart is under investigation in clinical trial NCT05990543 (Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer).

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Nelonicline DB19040
small molecule | CAS: 1026134-63-3

Nelonicline is under investigation in clinical trial NCT01678755 (A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia).

Kategori:
Sulfur CompoundsThiazoles
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Nelotanserin DB12555
small molecule | CAS: 839713-36-9

Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sl…

Kategori:
AmidesBenzene Derivatives
Target Protein:
5-hydroxytryptamine receptor 2A
Waktu Paruh-
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Neltenexine DB13239
small molecule | CAS: 99453-84-6

Neltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.

Kategori:
AminesAniline CompoundsCough and Cold Preparations +2
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Nemiralisib DB16253
small molecule | CAS: 1254036-71-9

Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors +1
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Nemolizumab Approved DB15252
biotech | CAS: 1476039-58-3

Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology of various skin inflammatory disorders.[A264254…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAmino Acids, Peptides, and ProteinsAntibodies +10
Target Protein:
Interleukin-31 receptor subunit alpha
Waktu ParuhThe estimated termi…
Vol. DistribusiThe estimated volum…
KlirensThe estimated syste…
Genetik -
Nemonapride DB19314
small molecule | CAS: 75272-39-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +9
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
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Nemtabrutinib DB18866
small molecule | CAS: 2095393-15-8

Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-0…

Target Protein:
Tyrosine-protein kinase BTK
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Genetik -
biotech | CAS: 2315268-27-8

Deskripsi belum tersedia.

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biotech | CAS: 1853254-97-3

Nendratareotide uzatansine is a peptide-drug conjugate comprising a peptide analog of somatostatin conjugated to the cytotoxin mertansine.

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NEO-212 DB17100
small molecule | CAS: 1361198-79-9

Deskripsi belum tersedia.

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Neoarsphenamine DB18729
small molecule | CAS: 457-60-3

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsArsenicalsHaptens
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Neocartilage DB05257
biotech

Neocartilage, a novel cartilage regeneration treatment. Neocartilage is generated from juvenile rather than adult chondrocytes. Neocartilage is the only scaffold-free living cartilage graft on the market.

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Neodymium DB15318
small molecule | CAS: 7440-00-8

Neodymium is under investigation in clinical trial NCT03525522 (Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus).

Kategori:
ElementsLanthanoid Series ElementsMetals +1
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Neomycin Approved DB00994
small molecule | CAS: 1404-04-2

Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_.[L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C.[A191529] Neomycin B, also known as [framyceti…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAminoglycoside Antibacterials +28
Target Protein:
30S ribosomal protein S1216S ribosomal RNAExtracellular calcium-sensing receptor
Waktu ParuhThere is limited in…
Vol. DistribusiThe small fraction …
KlirensThere is limited in…
Genetik -
Neon Approved DB11589
small molecule | CAS: 7440-01-9

Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a re…

Kategori:
ElementsGasesNoble Gases
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Neopterin DB15050
small molecule | CAS: 2009-64-5

Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke).

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +2
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Neosaxitoxin DB12989
small molecule | CAS: 64296-20-4

Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).

Kategori:
AgrochemicalsBacterial ToxinsBiological Factors +16
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Nepadutant DB12538
small molecule | CAS: 183747-35-5

Nepadutant has been used in trials studying the treatment of Colic, Infantile Colic, and Infantile Functional Gastrointestinal Disorders.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Asthmatic AgentsAutonomic Agents +5
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Nepafenac Approved DB06802
small molecule | CAS: 78281-72-8

Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.

Kategori:
AcetamidesAcetatesAcids, Acyclic +18
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
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Nepicastat DB12979
small molecule | CAS: 173997-05-2

Nepicastat has been investigated for the treatment of Cocaine Dependence and Posttraumatic Stress Disorder.

Kategori:
Dopamine beta-Hydroxylase, antagonists & inhibitorsSulfur Compounds
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Nepidermin DB14145
biotech | CAS: 62253-63-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsEGF Family of Proteins +6
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Nepinalone DB13445
small molecule | CAS: 22443-11-4

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
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Neramexane DB04926
small molecule | CAS: 219810-59-0

Neramexane is a low-to-moderate affinity uncompetitive NMDA receptor antagonist.

Kategori:
Cycloparaffins
Target Protein:
Glutamate receptor ionotropic, NMDA 3A
Waktu Paruh-
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Nerandomilast DB18237
small molecule | CAS: 1423719-30-5

Deskripsi belum tersedia.

Kategori:
Cycloparaffins
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Neratinib Approved DB11828
small molecule | CAS: 698387-09-6

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under inve…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A Substrates +11
Target Protein:
Vascular endothelial growth factor receptor 2Receptor tyrosine-protein kinase erbB-2Epidermal growth factor receptor
Waktu ParuhThe mean half life …
Vol. DistribusiThe apparent volume…
KlirensThe total clearance…
Genetik -
Neridronic Acid DB11620
small molecule | CAS: 79778-41-9

Deskripsi belum tersedia.

Kategori:
OrganophosphonatesOrganophosphorus Compounds
Target Protein:
Farnesyl pyrophosphate synthase
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Nerinetide DB12595
biotech | CAS: 500992-11-0

Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).

Kategori:
Amino Acids, Peptides, and ProteinsNeuroprotective Agents
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Nerispirdine DB12714
small molecule | CAS: 119229-65-1

Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2Sodium channel protein type 11 subunit alpha
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Nerofe DB14786
small molecule | CAS: 1311294-45-7

Nerofe is under investigation in clinical trial NCT03059615 (A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS).

Kategori:
Amino Acids, Peptides, and Proteins
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biotech | CAS: 9061-61-4

Nerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, Alzheimer's Disease, Traumatic Brain Injury, Cerebral Palsy Children, and Delayed Speech Development, among others.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +4
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Nesbuvir DB07238
small molecule | CAS: 691852-58-1

Nesbuvir has been investigated for the treatment of Hepatitis C.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
Genome polyproteinGenome polyproteinGenome polyprotein
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Nesiritide Approved DB04899
biotech | CAS: 124584-08-3

Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.

Kategori:
Amino Acids, Peptides, and ProteinsCardiac TherapyCardiovascular Agents +11
Target Protein:
Atrial natriuretic peptide receptor 1Atrial natriuretic peptide receptor 2Atrial natriuretic peptide receptor 3
Waktu ParuhApproximately 18 mi…
Vol. Distribusi* 0.19 L/kg
Klirens* 9.2 mL/min/k [pat…
Genetik -
Nesolicaftor DB15239
small molecule | CAS: 1953130-87-4

Nesolicaftor (PTI-428) is under investigation in clinical trial NCT03258424 (Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background Therapy).

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Nesuparib DB18110
small molecule | CAS: 2055357-64-5

Deskripsi belum tersedia.

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Nesvacumab DB15330
biotech | CAS: 1296818-77-3

Nesvacumab is under investigation in clinical trial NCT01997164 (Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular (Wet) Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME)).

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Nesvategrast DB19337
small molecule | CAS: 1621332-91-9

Nesvategrast is under investigation in clinical trial NCT05409235 (Nesvategrast (OTT166) in Diabetic Retinopathy (DR)).

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Netarsudil Approved DB13931
small molecule | CAS: 1254032-66-0

A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elev…

Kategori:
Acids, CarbocyclicAlanineAmino Acids +8
Target Protein:
Rho-associated protein kinase 1Rho-associated protein kinase 2Sodium-dependent noradrenaline transporter
Waktu ParuhThe half-life of ne…
Vol. DistribusiAs netarsudil and i…
KlirensThe clearance of ne…
Genetik -
Netazepide DB12355
small molecule | CAS: 155488-25-8

Netazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others.

Kategori:
AmidesBenzazepinesBenzene Derivatives +2
Target Protein:
Gastrin/cholecystokinin type B receptor
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Netivudine DB12606
small molecule | CAS: 84558-93-0

Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections.

Kategori:
Anti-Infective AgentsAntiviral AgentsArabinonucleosides +4
Target Protein:
DNA polymerase catalytic subunit
Waktu Paruh-
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Netupitant Approved DB09048
small molecule | CAS: 290297-26-6

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant …

Kategori:
AcetamidesAmidesBCRP/ABCG2 Inhibitors +15
Target Protein:
Substance-P receptor
Waktu Paruh96 hours with CV% o…
Vol. DistribusiIn cancer patients,…
KlirensEstimated systemic …
Genetik -
Neuropeptide Y Approved DB11788
biotech | CAS: 82785-45-3

Neuropeptide Y is under investigation for the basic science of Type 2 Diabetes Mellitus.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsNeuropeptide Y, drug effects +3
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Neurospora crassa Approved DB10821
biotech

Neurospora crassa is a fungus which can provoke allergic reactions. Neurospora crassa extract is used in allergenic testing.

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