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11778

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8554 (72.6%)
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6383 (54.2%)
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11778 (100.0%)

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Halaman 195 / 236
Romlusevimab DB16494
biotech | CAS: 2509447-08-7

Romlusevimab (BRII-198) was under investigation in clinical trials (NCT04479644 and NCT04691180) to treat COVID-19, focusing on its safety, tolerability, and pharmacokinetics.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Romosozumab Approved DB11866
biotech | CAS: 909395-70-6

Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies[L9554]. Romosozumab …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +12
Target Protein:
Sclerostin
Waktu Paruh12.8 days[L9554].
Vol. Distribusi3.92L[L9554].
Klirens0.38mL/hr/kg[L9554].
Genetik -
Ronacaleret DB05255
small molecule | CAS: 753449-67-1

Ronacaleret is a calcium-sensing receptor antagonist.

Kategori:
Acids, CarbocyclicIndenes
Target Protein:
Extracellular calcium-sensing receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Roneparstat DB17153
biotech | CAS: 1407492-04-9

Deskripsi belum tersedia.

Kategori:
CarbohydratesGlycosaminoglycansPolysaccharides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Roniciclib DB12974
small molecule | CAS: 1223498-69-8

Roniciclib has been investigated for the treatment of Small Cell Lung Carcinoma.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ronifibrate DB13460
small molecule | CAS: 42597-57-9

Deskripsi belum tersedia.

Kategori:
Agents Causing Muscle ToxicityFibric AcidsLipid Modifying Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ronopterin DB12575
small molecule | CAS: 185243-78-1

Ronopterin has been used in trials studying the treatment of Traumatic Brain Injury.

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rontalizumab DB12844
biotech | CAS: 948570-30-7

Rontalizumab has been used in trials studying the treatment of Systemic Lupus Erythematosus.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ropanicant DB19134
small molecule | CAS: 2414674-70-5

Ropanicant is under investigation in clinical trial NCT06126497 (Study Evaluating Safety and Efficacy of Ropanicant in MDD Patients).

Waktu Paruh-
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Genetik -
Ropeginterferon alfa-2b Approved DB15119
biotech | CAS: 1335098-50-4

Polycythemia vera (PV) is the most common Philadelphia chromosome-negative myeloproliferative neoplasm (MPN), characterized by increased hematocrit and platelet/leukocyte counts, an increased risk for hemorrhage and thromboembolic events, and a long-term prop…

Kategori:
Adjuvants, ImmunologicAlfa InterferonsAntineoplastic and Immunomodulating Agents +12
Target Protein:
Interferon alpha/beta receptor (IFNAR)
Waktu ParuhRopeginterferon alf…
Vol. DistribusiRopeginterferon alf…
KlirensRopeginterferon alf…
Genetik -
Ropidoxuridine DB06485
small molecule | CAS: 93265-81-7

Ropidoxuridine is a novel, orally available, thymidine analogue and prodrug for IUdR, which demonstrated a survival advantage in Phase II studies in anaplastic astrocytoma, a type of brain tumor.

Kategori:
Antineoplastic AgentsNucleic Acids, Nucleotides, and NucleosidesNucleosides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ropinirole Approved DB00268
small molecule | CAS: 91374-21-9

Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], [A174547]. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA…

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson Agents (Dopamine Agonist)Anti-Parkinson Drugs +10
Target Protein:
D(3) dopamine receptorD(2) dopamine receptorD(4) dopamine receptor +1
Waktu ParuhApproximately 6 hou…
Vol. DistribusiRopinirole is found…
KlirensThe clearance of ro…
Genetik -
Ropivacaine Approved DB00296
small molecule | CAS: 84057-95-4

Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.[L42140]

Kategori:
AmidesAminesAnesthetics +19
Target Protein:
Sodium channel protein type 10 subunit alpha
Waktu ParuhThe mean terminal h…
Vol. DistribusiFollowing intravasc…
KlirensFollowing intraveno…
Genetik -
Ropsacitinib DB18709
small molecule | CAS: 2127109-84-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rose bengal I-131 Approved DB09388
small molecule | CAS: 99689-97-1

Deskripsi belum tersedia.

Kategori:
Radiopharmaceuticals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 4159-77-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Rosemary DB14272
biotech

Rosemary is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosemary oil Approved DB14689
biotech | CAS: 8000-25-7

Deskripsi belum tersedia.

Kategori:
Biological ProductsLipidsOils +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosiglitazone Approved DB00412
small molecule | CAS: 122320-73-4

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like ot…

Kategori:
Alimentary Tract and MetabolismBlood Glucose Lowering AgentsBSEP/ABCB11 Substrates +33
Target Protein:
Peroxisome proliferator-activated receptor gammaLong-chain-fatty-acid--CoA ligase 4Peroxisome proliferator-activated receptor alpha +4
Waktu Paruh3-4 hours (single o…
Vol. Distribusi* 17.6 L [oral volu…
Klirens* Oral clearance (C…
Genetik -
Rosin Approved DB11165
biotech | CAS: 8050-09-7

Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin is used in various commercial and industrial applications, including…

Kategori:
Biological ProductsBiopolymersCell-mediated Immunity +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosnilimab DB18851
biotech | CAS: 2412764-40-8

Rosnilimab is under investigation in clinical trial NCT06041269 (A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Rheumatoid Arthritis (RENOIR)).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Rosomidnar DB17154
biotech | CAS: 871597-03-4

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosoxacin Approved DB00817
small molecule | CAS: 40034-42-2

Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose …

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-betaDNA gyrase subunit B +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rostafuroxin DB12350
small molecule | CAS: 156722-18-8

Rostafuroxin has been used in trials studying the treatment of Essential Hypertension.

Kategori:
AndrostanesFused-Ring CompoundsSteroids
Target Protein:
Sodium/potassium-transporting ATPase subunit beta-1Sodium/potassium-transporting ATPase subunit beta-2Sodium/potassium-transporting ATPase subunit beta-3 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rostaporfin DB06659
small molecule | CAS: 284041-10-7

Deskripsi belum tersedia.

Kategori:
Biological FactorsDermatologicalsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rosuvastatin Approved DB01098
small molecule | CAS: 287714-41-4

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous prod…

Kategori:
Agents Causing Muscle ToxicityAlimentary Tract and MetabolismAmides +32
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-L
Gen Terkait:
KIF6 HMGCR ABCG2
Waktu ParuhThe elimination hal…
Vol. DistribusiRosuvastatin underg…
Klirens-
Genetik 3 Varian
Rotavirus vaccine Approved DB10276
biotech

Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration.[L1117] Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live …

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseBiological Products +6
Waktu ParuhThe median duration…
Vol. Distribusi-
Klirens-
Genetik -
Rotenone DB11457
small molecule | CAS: 83-79-4

Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.

Kategori:
AgrochemicalsBenzopyransChromones +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rotigaptide DB13067
small molecule | CAS: 355151-12-1

Rotigaptide is under investigation for the basic science of Heart Disease and Vascular Disease.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rotigotine Approved DB05271
small molecule | CAS: 99755-59-6

Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and const…

Kategori:
Agents that produce hypertensionAnti-Parkinson Agents (Dopamine Agonist)Anti-Parkinson Drugs +23
Target Protein:
D(3) dopamine receptorD(4) dopamine receptorD(2) dopamine receptor +4
Waktu ParuhAfter removal of th…
Vol. DistribusiThe weight normaliz…
Klirens-
Genetik -
small molecule | CAS: 912809-27-9

Rovafovir etalafenamide is under investigation in clinical trial NCT03472326 (Efficacy of GS-9131 Functional Monotherapy in HIV-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen).

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1613313-09-9

Rovalpituzumab Tesirine has been used in trials studying the treatment of GLIOBLASTOMA, Malignant Melanoma, Other Solid Tumors, Small Cell Lung Cancer, and Medullary Thyroid Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rovanersen DB16982
biotech | CAS: 2072901-32-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Rovatirelin DB15338
small molecule | CAS: 204386-76-5

Rovatirelin is under investigation in clinical trial NCT01384435 (A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)).

Kategori:
Oxazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rovazolac DB16320
small molecule | CAS: 1454288-88-0

Rovazolac is under investigation in clinical trial NCT03175354 (A Study in Subjects With Moderate Atopic Dermatitis).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 2163074-26-6

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Roxadustat Approved DB04847
small molecule | CAS: 808118-40-3

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that st…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntianemic Preparations +10
Target Protein:
Egl nine homolog 1Prolyl hydroxylase EGLN2Prolyl hydroxylase EGLN3
Waktu ParuhThe mean effective …
Vol. DistribusiThe blood-to-plasma…
KlirensThe apparent total …
Genetik -
Roxarsone DB11458
small molecule | CAS: 121-19-7

Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use i…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 78628-28-1

Roxatidine acetate is a specific and competitive H2 receptor antagonist. It is currently approved in South Africa under the tradename Roxit.

Kategori:
Acid ReducersAlimentary Tract and MetabolismAnti-Ulcer Agents +8
Target Protein:
Histamine H2 receptor
Waktu Paruh5-6 hours
Vol. Distribusi-
Klirens-
Genetik -
Roxithromycin Approved DB00778
small molecule | CAS: 80214-83-1

Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin]. It was shown to be more effective against certain Gram-negative bacteria, particularly _Legionel…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +19
Target Protein:
50S ribosomal protein L10ATP-dependent translocase ABCB1
Waktu Paruh12 hours
Vol. Distribusi-
Klirens-
Genetik -
Royal jelly DB14250
biotech | CAS: 8031-67-2

Royal jelly is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
BeesLipids
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Rozanolixizumab Approved DB14919
biotech | CAS: 1584645-37-3

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange.…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
IgG receptor FcRn large subunit p51
Waktu Paruh-
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Rozibafusp Alfa DB19233
biotech | CAS: 2143449-47-0

Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)).

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rozrolimupab DB05209
biotech | CAS: 909402-77-3

Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Target Protein:
Rhesus blood group D antigen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RP-67580 DB16742
small molecule | CAS: 135911-02-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingNeurokinin-1 Receptor AntagonistsNeurotransmitter Agents
Target Protein:
Substance-P receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RP-72 DB17156
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
RP-A501 DB17647
biotech

RP-A501 is a gene therapy product consisting of a recombinant adeno-associated virus serotype 9 (rAAV9) capsid containing the human LAMP2B transgene (AAV9:LAMP2B), which encodes lysosome-associated membrane protein 2 (LAMP-2). It is being investigated for Dan…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
RP-L201 DB17595
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
RP-L301 DB17661
biotech

RP-L301 is a lentiviral vector containing the human liver and erythroid pyruvate kinase gene.

Waktu Paruh-
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Genetik -
RP01 DB05751
small molecule

RP01 is a novel anti-IgE immunotherapy for allergic individuals. It is designed to induce the immune system to produce antibodies that block Immunoglobulin E (IgE), the key mediator of an allergic response. It could offer benefit to millions of asthma and all…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
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