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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 193 / 349
Iscalimab DB15260
biotech | CAS: 2031153-61-2

Iscalimab is under investigation in clinical trial NCT03905525 (Study of Safety and Efficacy of Multiple Doses of CFZ533 in Two Distinct Populations of Patients With Sjögren's Syndrome).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Iscotrizinol DB15468
small molecule | CAS: 154702-15-5

Deskripsi belum tersedia.

Kategori:
Sunscreen Agents
Waktu Paruh-
Vol. Distribusi-
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Iseganan DB16010
biotech | CAS: 257277-05-7

Iseganan is under investigation in clinical trial NCT00022373 (Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntimicrobial PeptidesMembrane Proteins +3
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Isepamicin DB13540
small molecule | CAS: 58152-03-7

Deskripsi belum tersedia.

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +9
Waktu Paruh-
Vol. Distribusi-
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ISF402 DB06315
small molecule | CAS: 484649-95-8

ISF402 is an investigational peptide tetramer which helps dispersal of insulin via zinc chelation, therefore allowing insulin hexamers to break free.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Insulin
Waktu Paruh-
Vol. Distribusi-
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ISIS 104838 DB16201
biotech | CAS: 250755-32-9

ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
Waktu Paruh-
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ISIS 113715 DB05506
small molecule

ISIS 113715 is our second-generation antisense inhibitor of protein tyrosine phosphatase 1b, or PTP?1b, for the treatment of type 2 diabetes. In early trials, ISIS 113715 induced statistically significant improvements in multiple measures of glucose control a…

Target Protein:
Tyrosine-protein phosphatase non-receptor type 1
Waktu Paruh-
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ISIS 14803 DB05803
small molecule

ISIS 14803 is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

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ISIS 2503 DB16181
biotech | CAS: 149957-14-2

ISIS 2503 is under investigation in clinical trial NCT00004193 (ISIS 2503 in Treating Patients With Metastatic And/or Locally Recurrent Colorectal Cancer).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
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Genetik -
ISIS 325568 DB06099
small molecule

ISIS 325568 is a generation 2.2 antisense drug that targets the glucagon receptor (GCGR). It was under investigation in clinical trial NCT00519727 (Safety Study of ISIS 325568 in Healthy Volunteers) for lowering blood glucose and helping control type 2 diabet…

Target Protein:
Glucagon receptor
Waktu Paruh-
Vol. Distribusi-
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ISIS-333611 DB17978
biotech | CAS: 937407-37-9

Deskripsi belum tersedia.

Waktu Paruh-
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Islatravir DB15653
small molecule | CAS: 865363-93-5

Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)).

Kategori:
AlcoholsAnti-Infective AgentsAnti-Retroviral Agents +15
Waktu Paruh-
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ISM6631 DB18832
small molecule

Deskripsi belum tersedia.

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ISO-1 F-18 DB14900
small molecule | CAS: 945992-47-2

ISO-1 F-18 is under investigation in clinical trial NCT00968656 (Assessment of Cellular Proliferation in Tumors by Positron Emission Tomography (PET) Using [18F]ISO-1).

Target Protein:
Sigma intracellular receptor 2
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ISO24 DB03628
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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Isoaminile Approved DB08944
small molecule | CAS: 77-51-0

Isoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.

Kategori:
Antitussive AgentsCentral Nervous System AgentsCough and Cold Preparations +2
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Genetik -
Isoamyl alcohol DB02296
small molecule | CAS: 123-51-3

Deskripsi belum tersedia.

Kategori:
AlcoholsFatty AlcoholsLipids
Target Protein:
Renin
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Isobromindione DB13545
small molecule | CAS: 1470-35-5

Deskripsi belum tersedia.

Kategori:
Antigout PreparationsMusculo-Skeletal SystemPreparations Increasing Uric Acid Excretion
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Isobutyramide DB17705
small molecule | CAS: 563-83-7

Deskripsi belum tersedia.

Kategori:
Antineoplastic Agents
Waktu Paruh-
Vol. Distribusi-
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Isobutyric acid DB02531
small molecule | CAS: 79-31-2

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicButyratesFatty Acids +2
Target Protein:
Free fatty acid receptor 22-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
Waktu Paruh-
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Genetik -
Isocaproic acid DB03993
small molecule | CAS: 646-07-1

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Branched-chain-amino-acid aminotransferase
Waktu Paruh-
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Genetik -
Isocarboxazid Approved DB01247
small molecule | CAS: 59-63-2

Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.[A31930] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +17
Target Protein:
Amine oxidase [flavin-containing] AAmine oxidase [flavin-containing] B
Waktu ParuhThe pharmacokinetic…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 22642-82-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicCyclohexanecarboxylic AcidsCyclohexanes +3
Target Protein:
Phenazine biosynthesis protein PhzD
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Isocitric Acid DB01727
small molecule | CAS: 320-77-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicCitratesTricarboxylic Acids
Target Protein:
Isocitrate dehydrogenase [NADP]Isocitrate dehydrogenase [NADP]Aconitate hydratase, mitochondrial +3
Waktu Paruh-
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Isoconazole Approved DB08943
small molecule | CAS: 27523-40-6

Isoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +9
Target Protein:
Steroid 17-alpha-hydroxylase/17,20 lyase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Isocyanomethane DB04337
small molecule | CAS: 593-75-9

Deskripsi belum tersedia.

Target Protein:
Myoglobin
Waktu Paruh-
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Isoetharine Approved DB00221
small molecule | CAS: 79490-84-9

Isoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. Isoetharine is a fast-acting bronchodilator used for emphysema, bronchitis and asthma.[A330]

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +16
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptor
Waktu Paruh-
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Isoeugenol Approved DB14188
small molecule | CAS: 97-54-1

Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted…

Kategori:
Acids, CarbocyclicAlkenesAllyl Compounds +8
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Isoferulic acid DB07109
small molecule | CAS: 537-73-5

Deskripsi belum tersedia.

Kategori:
Acids, Carbocyclic
Target Protein:
O-methyltransferase
Waktu Paruh-
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Isoflavone DB12007
small molecule | CAS: 574-12-9

Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa [A33103]. Soybean is an exceptionally rich source of dietary isoflavones, where the avera…

Kategori:
BenzopyransChromonesDrugs that are Mainly Renally Excreted +4
Target Protein:
Peroxisome proliferator-activated receptor alphaPeroxisome proliferator-activated receptor gamma
Waktu ParuhThe half-life of is…
Vol. DistribusiIsoflavones are rea…
KlirensIn a human study, t…
Genetik -
Isoflupredone DB11522
small molecule | CAS: 338-95-4

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 338-98-7

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Isoflurane Approved DB00753
small molecule | CAS: 26675-46-7

A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAnesthetics +19
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Calcium-transporting ATPase type 2C member 1Glycine receptor subunit alpha-1 +7
Waktu Paruh-
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Isoflurophate Approved DB00677
small molecule | CAS: 55-91-4

An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutical…

Kategori:
Cholinergic AgentsCholinesterase InhibitorsEnzyme Inhibitors +6
Target Protein:
AcetylcholinesteraseCholinesteraseSerotransferrin
Waktu Paruh-
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Isoformononetin DB04202
small molecule

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesFlavonoids +2
Target Protein:
Aldehyde dehydrogenase, mitochondrial
Waktu Paruh-
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Isoglutamine DB03091
small molecule | CAS: 636-65-7

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +2
Target Protein:
ATP synthase subunit b
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 18138-19-7

Deskripsi belum tersedia.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfur Compounds
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Isoleucine DB00167
small molecule | CAS: 73-32-5

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +4
Target Protein:
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialBranched-chain-amino-acid aminotransferase, cytosolicBranched-chain-amino-acid aminotransferase, mitochondrial +2
Waktu Paruh-
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small molecule | CAS: 961-29-5

Isoliquiritigenin is a precursor to several flavonones in many plants.

Kategori:
BenzopyransChromonesEnzyme Inhibitors +6
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Isoluminol DB02041
small molecule

Deskripsi belum tersedia.

Kategori:
Compounds used in a research, industrial, or household settingIndicators and ReagentsLaboratory Chemicals +3
Target Protein:
Queuine tRNA-ribosyltransferase
Waktu Paruh-
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Isometheptene Approved DB06706
small molecule | CAS: 503-01-5

Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches.

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-Agonists +6
Target Protein:
Alpha-1A adrenergic receptorSynaptic vesicular amine transporter
Waktu Paruh-
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Isoniazid Approved DB00951
small molecule | CAS: 54-85-3

Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.

Kategori:
Agents Causing Muscle ToxicityAgents that reduce seizure thresholdAnti-Bacterial Agents +39
Target Protein:
Catalase-peroxidaseEnoyl-[acyl-carrier-protein] reductase [NADH]Cytochrome P450 2C8 +4
Gen Terkait:
CYP2E1
Waktu ParuhFast acetylators: 0…
Vol. Distribusi-
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Genetik 1 Varian
small molecule | CAS: 55-22-1

Deskripsi belum tersedia.

Kategori:
Pyridines
Target Protein:
Hydroxycarboxylic acid receptor 2
Waktu Paruh-
Vol. Distribusi-
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Isopenicillin N DB03550
small molecule | CAS: 58678-43-6

Deskripsi belum tersedia.

Kategori:
Amidesbeta-LactamsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
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Klirens-
Genetik -
Isopentane DB16203
small molecule | CAS: 78-78-4

Isopentane is under investigation in clinical trial NCT00752089 (Experimental Dentifrice Remineralization/fluoride Uptake in an in Situ Model).

Kategori:
AlkanesHydrocarbons, Acyclic
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Terpenes
Target Protein:
Farnesyl pyrophosphate synthaseGeranylgeranyl pyrophosphate synthase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 19475-26-4

Isoamyl 2 Cyanoacrylate is under investigation in clinical trial NCT02698644 (Hysteroscopic Tubal Occlusion With the Use of Iso Amyl-2-cyanoacrylate).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Farnesyl pyrophosphate synthasePentaerythritol tetranitrate reductaseGeranyltranstransferase (Farnesyldiphosphate synthase) +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Isoprenaline Approved DB01064
small molecule | CAS: 7683-59-2

Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic and Dopaminergic Agents +31
Target Protein:
Beta-1 adrenergic receptorInterleukin-12 subunit betaBeta-2 adrenergic receptor +2
Waktu ParuhThe half life of in…
Vol. DistribusiIn pediatric patien…
KlirensIn pediatric patien…
Genetik -
Isopropamide Approved DB01625
small molecule | CAS: 7492-32-2

Isopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAmines +7
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M4
Waktu Paruh-
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Genetik -
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