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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
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104 (0.8%)
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13591 (100.0%)

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Halaman 192 / 272
Nivatrotamab DB16654
biotech | CAS: 2278244-14-5

Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3f8-bsab) in Patients With Relapsed/refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers).

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Nivocasan DB12720
small molecule | CAS: 908253-63-4

Nivocasan has been used in trials studying the treatment of HCV Infection and Nonalcoholic Steatohepatitis.

Target Protein:
Caspase-1
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Nivolumab Approved DB09035
biotech | CAS: 946414-94-4

Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1).[L12129] This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation _S228P_ for additional stability…

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntibodies +20
Target Protein:
Programmed cell death protein 1Programmed cell death 1 ligand 1
Waktu ParuhThe serum half life…
Vol. DistribusiThe volume of distr…
KlirensThe estimated clear…
Genetik -
Nix-0699 DB17732
biotech

Deskripsi belum tersedia.

Kategori:
Anemia, Sickle Cell, drug therapyBiological ProductsComplex Mixtures +2
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Nizatidine Approved DB00585
small molecule | CAS: 76963-41-2

A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

Kategori:
Acid ReducersAgents Causing Muscle ToxicityAlimentary Tract and Metabolism +13
Target Protein:
Histamine H2 receptor
Waktu Paruh1-2 hours
Vol. Distribusi* 0.8 to 1.5 L/kg
Klirens* 40-60 L/h * 7 – …
Genetik -
Nizofenone DB13546
small molecule | CAS: 54533-85-6

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsCardiovascular AgentsCentral Nervous System Agents +8
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NKTT-120 DB17730
biotech

NKTT-120 is a recombinant humanized IgG1k monoclonal antibody to human invariant T cell receptor (iTCR).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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NKX101 DB18131
biotech

NKX101 is an investigational allogeneic chimeric antigen receptor (CAR)-natural killer cell therapy.

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NM-004 DB18066
small molecule | CAS: 402934-69-4

Deskripsi belum tersedia.

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NM-3 DB12818
small molecule | CAS: 181427-78-1

NM-3 has been used in trials studying the treatment of Neoplasms.

Target Protein:
Vascular endothelial growth factor A, long formVascular endothelial growth factor BVascular endothelial growth factor C +1
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NM3086 DB17719
biotech

NM3086 is a recombinant, humanized, aglycosylated, IgG1-kappa anti-properdin monoclonal antibody being developed by Novelmed Therapeutics Inc.[L46193]

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NMD-670 DB18466
small molecule | CAS: 2354321-33-6

Deskripsi belum tersedia.

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NN344 DB05115
small molecule

NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection. NN344 has a very flat and predictable action profile. The product is intended for basal insulin treatment of diabetes mellitus.

Kategori:
Amino Acids, Peptides, and ProteinsBlood Glucose Lowering AgentsCytochrome P-450 CYP1A2 Inducers +9
Target Protein:
Insulin receptor
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small molecule | CAS: 357400-14-7

NNC-55-0396 is a T-type Ca(2+) channel inhibitor.[A253047]

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NNC0114-0006 DB18361
biotech

NNC0114-0006 is an anti-interleukin 21 monoclonal antibody

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NNI-351 DB18048
small molecule | CAS: 929607-23-8

Deskripsi belum tersedia.

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NNZ-2591 DB15601
small molecule | CAS: 847952-38-9

NNZ-2591 (cyclo-L-glycyl-L-2-allylproline)[A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stabili…

Kategori:
Amino Acids, Peptides, and ProteinsPeptidesPiperazines
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Nocodazole DB08313
small molecule | CAS: 31430-18-9

Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.

Kategori:
Antimitotic AgentsAntineoplastic AgentsBenzimidazoles +3
Target Protein:
Hematopoietic prostaglandin D synthase
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Nofazinlimab DB18852
biotech | CAS: 2377845-98-0

Nofazinlimab is under investigation in clinical trial NCT04194775 (A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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Nogapendekin alfa Approved DB18740
biotech | CAS: 1622189-43-8

Nogapendekin alfa is a human IL-15N72D variant. It is one of the active ingredients in Anktiva, a combination product also containing [inbakicept], where a single inbakicept is complexed with two nogapendekin alfa components.[L50592] This combination product …

Kategori:
Amino Acids, Peptides, and ProteinsInterleukin-15Proteins +2
Target Protein:
Interleukin-2 receptor subunit betaCytokine receptor common subunit gamma
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Nolasiban DB16259
small molecule | CAS: 1477482-19-1

Nolasiban is under investigation in clinical trial NCT03081208 (Phase 3 Placebo Controlled Study of Nolasiban to Improve Pregnancy Rates in Women Undergoing IVF/ICSI).

Kategori:
AminesHydroxylamines
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Nolatrexed DB12912
small molecule | CAS: 147149-76-6

Nolatrexed is under investigation in clinical trial NCT00012324 (Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer).

Kategori:
AntimetabolitesAntineoplastic AgentsEnzyme Inhibitors +5
Target Protein:
Thymidylate synthase
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small molecule | CAS: 153050-21-6

Deskripsi belum tersedia.

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Nomacopan DB14991
biotech | CAS: 875125-19-2

Nomacopan is under investigation in clinical trial NCT03427060 (Coversin in PNH in Patients With Resistance to Eculizumab Due to Complement C5 Polymorphisms).

Kategori:
Recombinant Protein Inhibitor of Complement Factor 5
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Nomegestrol Approved DB11636
small molecule | CAS: 58691-88-6

Nomegestrol is an ingredient in the EMA-authorised product Zoely.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +12
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Nomegestrol acetate Approved DB13981
small molecule | CAS: 58652-20-3

Nomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +14
Target Protein:
Estrogen receptor
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Nomifensine Approved DB04821
small molecule | CAS: 24526-64-5

Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that …

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsDopamine Agents +8
Target Protein:
D(2) dopamine receptorSodium-dependent noradrenaline transporterSodium-dependent dopamine transporter +5
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Nomlabofusp DB17903
biotech | CAS: 2548202-05-5

Deskripsi belum tersedia.

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Nona-arginine DB12648
small molecule | CAS: 143413-47-2

Nona-arginine is under investigation in clinical trial NCT00264706 (PolyArginine Treated vEiN grafTs (PATENT)).

Kategori:
Amino Acids, Peptides, and ProteinsFurin, antagonists & inhibitorsPeptides
Target Protein:
Nitric oxide synthase, inducible
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Nonacog beta pegol Approved DB13933
biotech | CAS: 1175512-71-6

Nonacog beta pegol is a recombinant coagulation factor IX derivative. It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation. Once activated, the …

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +10
Target Protein:
Coagulation factor VIICoagulation factor VIIICoagulation factor X
Waktu ParuhThe mean half-life …
Vol. DistribusiThe volume of distr…
KlirensMean clearance in c…
Genetik -
Nonan-1-Ol DB03143
small molecule | CAS: 28473-21-4

Deskripsi belum tersedia.

Target Protein:
ATP synthase subunit c, sodium ion specific
Waktu Paruh-
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Nonivamide DB11324
small molecule | CAS: 2444-46-4

Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. The structures of [DB06774] and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl nonenoic acid versus nonanoic acid) [F31]. …

Kategori:
Acids, CarbocyclicAlkaloidsAlkenes +20
Target Protein:
Transient receptor potential cation channel subfamily V member 1
Waktu ParuhAbout 7 minutes [F3…
Vol. Distribusi-
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Nonoxynol-9 Approved DB06804
small molecule | CAS: 26027-38-3

Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic …

Kategori:
Adrenal Cortex HormonesAlcoholsAntispermatogenic Agents +14
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NOP-1A DB15208
small molecule | CAS: 1283095-70-4

NOP-1A is under investigation in clinical trial NCT01198197 (PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A).

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nor-NOHA DB02381
small molecule | CAS: 189302-40-7

N-Hydroxy-nor-L-arginine (nor-NOHA) is under investigation in clinical trial NCT02009527 (Arginase Inhibition in Ischemia-reperfusion Injury).

Target Protein:
Arginase-2, mitochondrialArginase-1
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Norbixin DB15201
small molecule | CAS: 542-40-5

Norbixin is under investigation in clinical trial NCT03820245 (Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals).

Kategori:
AlkenesBiological FactorsCyclohexanes +6
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Norcamphor DB03540
small molecule

Deskripsi belum tersedia.

Kategori:
Bridged-Ring Compounds
Target Protein:
Camphor 5-monooxygenase
Waktu Paruh-
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Norclobazam DB17092
small molecule | CAS: 22316-55-8

Deskripsi belum tersedia.

Kategori:
AnticonvulsantsBenzazepinesCentral Nervous System Agents +2
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Norelgestromin Approved DB06713
small molecule | CAS: 53016-31-2

Norelgestromin is a drug used in contraception. Norelgestromin is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.

Kategori:
Adrenal Cortex HormonesAminesCombination Contraceptives (with Estrogen and derivatives) +17
Target Protein:
Progesterone receptorAlbuminAndrogen receptor
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Norepinephrine Approved DB00368
small molecule | CAS: 51-41-2

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brai…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +34
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorAlpha-1D adrenergic receptor +9
Waktu Paruh-
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small molecule | CAS: 3836-23-5

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesContraceptive Agents, FemaleContraceptive Agents, Hormonal +14
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Norethisterone Approved DB00717
small molecule | CAS: 68-22-4

Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.[A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivati…

Kategori:
Adrenal Cortex HormonesAnti-Gonadotropin-Releasing HormonesCombination Contraceptives (with Estrogen and derivatives) +34
Target Protein:
Progesterone receptorAndrogen receptorGlucocorticoid receptor
Waktu ParuhThe half-life of no…
Vol. DistribusiThe volume of distr…
KlirensThe plasma clearanc…
Genetik -
Norethynodrel Approved DB09371
small molecule | CAS: 68-23-5

A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +18
Target Protein:
Estrogen receptorAndrogen receptorSex hormone-binding globulin
Waktu Paruh-
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Norfenefrine DB13378
small molecule | CAS: 536-21-0

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-Agonists +14
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Norfloxacin Approved DB01059
small molecule | CAS: 70458-96-7

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.

Kategori:
4-QuinolonesAgents Causing Muscle ToxicityAnti-Bacterial Agents +24
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA topoisomerase 4 subunit A +4
Waktu Paruh3-4 hours
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Norflurane Approved DB13116
small molecule | CAS: 811-97-2

Norflurane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).

Kategori:
Aerosol PropellantsAerosolsAlkanes +8
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Norgestimate Approved DB00957
small molecule | CAS: 35189-28-7

Norgestimate was first described in the literature in 1977.[A191068] It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects.[A191068] It is commonly formulated with [ethiny…

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +27
Target Protein:
Progesterone receptorEstrogen receptorAndrogen receptor
Waktu ParuhNorgestimate is rap…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Norgestrel Approved DB09389
small molecule | CAS: 6533-00-2

Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantio…

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +20
Target Protein:
Progesterone receptor3-oxo-5-alpha-steroid 4-dehydrogenase 1Androgen receptor
Waktu Paruh-
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Norgestrienone DB13563
small molecule | CAS: 848-21-5

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +13
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Norleucine DB15458
small molecule | CAS: 327-57-1

Norleucine is under investigation in clinical trial NCT00081952 (Amino Acid Therapy for Hot Flashes in Postmenopausal Women).

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAminocaproates
Target Protein:
Hepatocyte nuclear factor 1-alpha
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