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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 189 / 236
R107474 DB06553
small molecule | CAS: 214548-46-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
R112 DB06252
small molecule | CAS: 575474-82-7

R112 is an investigational compound developed to treat Allergic Rhinitis. It's mechanism of action is to inhibit SYK kinase.

Target Protein:
Tyrosine-protein kinase SYK
Waktu Paruh-
Vol. Distribusi-
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R343 DB06316
small molecule | CAS: 575484-78-5

R343, was investigated in clinical trial NCT01591044 to evaluate its safety and efficacy in patients with mild to moderate asthma.

Target Protein:
Tyrosine-protein kinase SYK
Waktu Paruh-
Vol. Distribusi-
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R3R01 DB18078
small molecule

R3R01 is an investigational lipid-modifying drug.

Waktu Paruh-
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R411 DB05468
small molecule

R411 is a non-steroid oral medicine for the treatment of asthma. It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory inflammation. It is a dual-acting competitive integrin antagonist (as compared to previous…

Target Protein:
Integrin alpha-4
Waktu Paruh-
Vol. Distribusi-
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R673 DB05466
small molecule

R673 is a novel NK1 antagonist that penetrates the blood-brain barrier, has excellent safety and tolerability and shows low P450-based drug interaction potential. The phase II program for treatment of depression and anxiety is ongoing in the US and EU.It is n…

Target Protein:
Substance-P receptor
Waktu Paruh-
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R906289 DB19126
small molecule | CAS: 2602614-45-7

R906289 is under investigation in clinical trial NCT05308264 (Study of R289 in Participants With Lower-risk Myelodysplastic Syndromes (LR MDS)).

Waktu Paruh-
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rAAV1-CB-hAAT DB18724
biotech

rAAV1-CB-hAAT is a recombinant adeno-associated virus alpha 1-antitrypsin vector.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
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rAAV9-rsATP7A DB17664
biotech

A recombinant adeno-associated viral vector gene therapy under investigation for the treatment of Menkes disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Rabacfosadine DB12762
small molecule | CAS: 859209-74-8

Rabacfosadine has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin's Lymphoma, and Chronic Lymphocytic Leukemia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsHeterocyclic Compounds, Fused-Ring
Target Protein:
DNA polymerase catalytic subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rabeprazole Approved DB01129
small molecule | CAS: 117976-89-3

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-depend…

Kategori:
2-PyridinylmethylsulfinylbenzimidazolesAcetatesAcid Reducers +47
Target Protein:
Potassium-transporting ATPase alpha chain 1
Waktu Paruh1-2 hours (in plasm…
Vol. Distribusi-
Klirens-
Genetik -
Rabeximod DB05772
small molecule | CAS: 872178-65-9

Rabeximod is an orally administered compound for treatment of moderate or severe active rheumatoid arthritis that is currently undergoing phase II clinical testing in eight European countries.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Deskripsi belum tersedia.

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biotech

Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure prophylaxis against rabies.[L12795]

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseImmune Sera +4
Waktu Paruh-
Vol. Distribusi-
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Raceanisodamine DB16896
small molecule | CAS: 85760-60-7

Deskripsi belum tersedia.

Waktu Paruh-
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Racecadotril DB11696
small molecule | CAS: 81110-73-8

Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.

Kategori:
Alimentary Tract and MetabolismAmino AcidsAmino Acids, Peptides, and Proteins +9
Waktu Paruh-
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Racemethionine Approved DB13972
small molecule | CAS: 59-51-8

A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
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Racemetyrosine DB16306
small molecule | CAS: 658-48-0

Racemetyrosine is under investigation in clinical trial NCT03512756 (A Randomized Phase 2/3 Multi-center Study of SM-88 in Patients With Metastatic Pancreatic Cancer).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Waktu Paruh-
Vol. Distribusi-
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Racephedrine Approved DB14752
small molecule | CAS: 90-81-3

Deskripsi belum tersedia.

Kategori:
Adrenergic AgonistsAdrenergic alpha-AgonistsAdrenergic beta-Agonists +4
Waktu Paruh-
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Racepinephrine Approved DB11124
small molecule | CAS: 329-65-7

Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. Epinephrine is a non-selective ?- and ?-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma includi…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +30
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorAlpha-2A adrenergic receptor +6
Waktu ParuhTo refer to the pha…
Vol. DistribusiTo refer to the pha…
KlirensTo refer to the pha…
Genetik -
Racivir DB12753
small molecule | CAS: 143491-54-7

Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of [emtricitabine] and its positive enantiomer. Racivir has been used in trials studying the preventio…

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxycytidine +5
Target Protein:
Reverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
RAD 502 DB17328
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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RAD-140 DB13939
small molecule | CAS: 1182367-47-0

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.

Kategori:
Oxazoles
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radafaxine DB11790
small molecule | CAS: 192374-14-4

Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.

Kategori:
KetonesPropiophenones
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radalbuvir DB12065
small molecule | CAS: 1314795-11-3

Radalbuvir has been used in trials studying the treatment of Chronic Hepatitis C, Chronic HCV Infection, and Chronic Hepatitis C Infection.

Kategori:
Sulfur Compounds
Waktu Paruh-
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Radavirsen DB15332
biotech | CAS: 1228284-45-4

Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).

Kategori:
Anti-Infective AgentsAntiviral AgentsMorpholines +5
Waktu Paruh-
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Rademikibart DB18995
biotech | CAS: 2648260-80-2

Rademikibart is under investigation in clinical trial NCT04773678 (Efficacy and Safety of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation).

Waktu Paruh-
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Radezolid DB12339
small molecule | CAS: 869884-78-6

Radezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsOxazoles
Target Protein:
Ribosome-binding protein 150S ribosomal protein L1
Waktu Paruh-
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Radgocitabine DB11667
small molecule | CAS: 135598-68-4

2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer.

Kategori:
ArabinonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Waktu Paruh-
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Radicicol DB03758
small molecule | CAS: 12772-57-5

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiparasitic Agents +5
Target Protein:
Heat shock protein HSP 90-alphaHeat shock protein HSP 90-betaEndoplasmin +3
Waktu Paruh-
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Radiprodil DB12260
small molecule | CAS: 496054-87-6

Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.

Kategori:
AcetatesAcids, AcyclicAmides
Target Protein:
Glutamate receptor ionotropic, NMDA 2B
Waktu Paruh-
Vol. Distribusi-
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Radium Ra-223 DB12813
small molecule | CAS: 15623-45-7

Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).

Kategori:
ElementsElements, RadioactiveIsotopes +4
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
alpha-Particle Emitting ActivityRadioactive alpha-Particle Emitting Therapeutic Agent
Waktu Paruh-
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Radotermin DB19127
biotech | CAS: 575458-75-2

Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the Treatment of Early Stage Lumbar Disc Degeneration).

Waktu Paruh-
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Radotinib DB12323
small molecule | CAS: 926037-48-1

Radotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Tyrosine-protein kinase ABL1
Waktu Paruh-
Vol. Distribusi-
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RAF-265 DB05984
small molecule | CAS: 927880-90-8

Deskripsi belum tersedia.

Target Protein:
Vascular endothelial growth factor receptor 2Serine/threonine-protein kinase B-raf
Waktu Paruh-
Vol. Distribusi-
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RAG-17 DB18503
biotech

RAG-17 is a siRNA oligonucleotide designed to target and knockdown the expression of superoxide dismutase (SOD).

Waktu Paruh-
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Ragifilimab DB18853
biotech | CAS: 2207590-51-8

Ragifilimab is under investigation in clinical trial NCT04225039 (Anti-gitr/anti-pd1/stereotactic Radiosurgery, in Recurrent Glioblastoma).

Waktu Paruh-
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Ralimetinib DB11787
small molecule | CAS: 862505-00-8

Ralimetinib has been used in trials studying the treatment of Postmenopausal, Advanced Cancer, Adult Glioblastoma, Fallopian Tube Cancer, and Metastatic Breast Cancer, among others.

Kategori:
Mitogen-Activated Protein Kinase 14, antagonists & inhibitors
Waktu Paruh-
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Ralinepag DB12462
small molecule | CAS: 1187856-49-0

Ralinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Prostacyclin receptor
Waktu Paruh-
Vol. Distribusi-
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Ralmitaront DB19128
small molecule | CAS: 2133417-13-5

Ralmitaront is under investigation in clinical trial NCT04512066 (A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder).

Waktu Paruh-
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Raloxifene Approved DB00481
small molecule | CAS: 84449-90-1

Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific …

Kategori:
BCRP/ABCG2 SubstratesBenzene DerivativesBenzylidene Compounds +23
Target Protein:
Estrogen receptorEstrogen receptor betaSerpin B9 +1
Waktu ParuhThe average plasma …
Vol. DistribusiFollowing oral admi…
KlirensFollowing intraveno…
Genetik -
Raltegravir Approved DB06817
small molecule | CAS: 518048-05-0

Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive suc…

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +13
Target Protein:
Gag-Pol polyproteinIntegrase
Waktu Paruh9 hours
Vol. DistribusiApproximately 83% b…
KlirensThe major mechanism…
Genetik -
Raltitrexed Approved DB00293
small molecule | CAS: 112887-68-0

Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +11
Target Protein:
Thymidylate synthaseThymidylate synthaseFolylpolyglutamate synthase, mitochondrial
Waktu Paruh198 hours
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2610074-57-0

Raludotatug deruxtecan is under investigation in clinical trial NCT06660654 (A Study of Raludotatug Deruxtecan in Participants With Advanced/metastatic Solid Tumors (Rejoice-pantumor01)).

Waktu Paruh-
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Ramatercept DB15116
biotech | CAS: 1169766-01-1

Ramatercept is under investigation in clinical trial NCT00952887 (A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women).

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Ramelteon Approved DB00980
small molecule | CAS: 196597-26-9

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has…

Kategori:
Central Nervous System DepressantsCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2C19 Substrates +9
Target Protein:
Melatonin receptor type 1BMelatonin receptor type 1A
Waktu Paruh~1-2.6 hours
Vol. Distribusi* 73.6 L
Klirens-
Genetik -
Ramipril Approved DB00178
small molecule | CAS: 87333-19-5

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsi…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +14
Target Protein:
Angiotensin-converting enzymeB1 bradykinin receptor
Gen Terkait:
ACE
Waktu ParuhPlasma concentratio…
Vol. Distribusi-
KlirensThe renal clearance…
Genetik 1 Varian
Ramiprilat DB14208
small molecule | CAS: 87269-97-4

The active metabolite of the prodrug [Ramipril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
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