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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
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11778 (100.0%)

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Halaman 188 / 236
Quavonlimab DB16422
biotech | CAS: 2254059-25-9

Quavonlimab is under investigation in clinical trial NCT03179436 (Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)).

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Quazepam Approved DB01589
small molecule | CAS: 36735-22-5

Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia.[L44913] It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinit…

Kategori:
BenzazepinesBenzodiazepine hypnotics and sedativesBenzodiazepines and benzodiazepine derivatives +13
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean eliminatio…
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Genetik -
Quemliclustat DB19160
small molecule | CAS: 2105904-82-1

Quemliclustat is under investigation in clinical trial NCT05329766 (A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies).

Kategori:
Antineoplastic AgentsAntineoplastic Agents, ImmunologicalImmune Checkpoint Inhibitors
Target Protein:
5'-nucleotidase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Quercetin DB04216
small molecule | CAS: 117-39-5

Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.

Kategori:
AntioxidantsBCRP/ABCG2 InhibitorsBenzopyrans +26
Target Protein:
Signal transducer and activator of transcription 3Lysophosphatidylcholine acyltransferase 2Lysophosphatidylcholine acyltransferase 1 +29
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 1111616-69-3

Quercetin-3'-O-phosphate has been used in trials studying the treatment of Insulin Resistance and Impaired Glucose Tolerance.

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Genetik -
biotech

Quercus acutissima whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Quercus agrifolia pollen Approved DB10374
biotech

Quercus agrifolia pollen is the pollen of the Quercus agrifolia plant. Quercus agrifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Genetik -
Quercus alba pollen Approved DB10376
biotech

Quercus alba pollen, or oak white pollen, is a non-standardized allergen extract used for the diagnosis and treatment of allergic disease to grass pollen. It can be subcutaneously administered to initiate an immune response in case of an allergic reaction. Di…

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quercus gambelii pollen Approved DB10740
biotech

Quercus gambelii pollen is the pollen of the Quercus gambelii plant. Quercus gambelii pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quercus kelloggii pollen Approved DB10739
biotech

Quercus kelloggii pollen is the pollen of the Quercus kelloggii plant. Quercus kelloggii pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Genetik -
Quercus lobata pollen Approved DB10741
biotech

Quercus lobata pollen is the pollen of the Quercus lobata plant. Quercus lobata pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quercus macrocarpa pollen Approved DB10738
biotech

Quercus macrocarpa pollen is the pollen of the Quercus macrocarpa plant. Quercus macrocarpa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quercus nigra pollen Approved DB10742
biotech

Quercus nigra pollen is the pollen of the Quercus nigra plant. Quercus nigra pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quercus palustris pollen Approved DB10887
biotech

Quercus palustris pollen is the pollen of the Quercus palustris plant. Quercus palustris pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quercus velutina pollen Approved DB10737
biotech

Quercus velutina pollen is the pollen of the Quercus velutina plant. Quercus velutina pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Genetik -
Quercus virginiana pollen Approved DB10375
biotech

Quercus virginiana pollen is the pollen of the Quercus virginiana plant. Quercus virginiana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Quetiapine Approved DB01224
small molecule | CAS: 111974-69-7

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +44
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +21
Waktu ParuhThe average termina…
Vol. DistribusiQuetiapine distribu…
KlirensThe clearance of qu…
Genetik -
Queuine DB14732
small molecule | CAS: 72496-59-4

Queuine is a derivative of [7-Deazaguanine]. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from human…

Kategori:
Heterocyclic Compounds, Fused-RingPurinesPurinones
Waktu ParuhData regarding the …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Quifenadine DB13713
small molecule | CAS: 10447-39-9

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UseBenzene DerivativesHistamine Agents +2
Waktu Paruh-
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Quilizumab DB15176
biotech | CAS: 1228538-47-3

Quilizumab is under investigation in clinical trial NCT01160861 (A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MEMP1972A in Patients With Allergic Rhinitis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
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Quilseconazole DB17758
small molecule | CAS: 1340593-70-5

Deskripsi belum tersedia.

Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
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Quinacrine DB01103
small molecule | CAS: 83-89-6

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an …

Kategori:
AcridinesAminoacridinesAnti-Infective Agents +15
Target Protein:
DNAPhospholipase A285/88 kDa calcium-independent phospholipase A2 +2
Waktu Paruh5 to 14 days
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Genetik -
small molecule | CAS: 64046-79-3

Deskripsi belum tersedia.

Kategori:
AcridinesAminoacridinesColoring Agents +9
Target Protein:
Trypanothione reductase
Waktu Paruh-
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Quinagolide Approved DB09097
small molecule | CAS: 87056-78-8

Quinagolide is a non-ergot-derived selective dopamine D2 receptor agonist used for the treatment of elevated levels of prolactin or hyperprolactinaemia. Hyperprolalctinaemia is associated with gonadal dysfunction, including infertility and reduced libido, as …

Kategori:
Dopamine AgentsDopamine AgonistsDopamine D2 Receptor Agonists +6
Target Protein:
D(2) dopamine receptorD(1) dopamine receptor
Waktu ParuhThe terminal half-l…
Vol. DistribusiApproximate volume …
Klirens-
Genetik -
Quinaldic Acid DB02428
small molecule | CAS: 93-10-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
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Quinaprilat DB14217
small molecule | CAS: 82768-85-2

The active metabolite of the prodrug [quinapril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +7
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Quinbolone DB13484
small molecule | CAS: 2487-63-0

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAnabolic Agents for Systemic UseAnabolic Steroids +5
Waktu Paruh-
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Quinestrol Approved DB04575
small molecule | CAS: 152-43-2

The 3-cyclopentyl ether of ethinyl estradiol.

Kategori:
Estradiol CongenersEstrogenic Steroids, AlkylatedEstrogens +11
Target Protein:
Estrogen receptor
Waktu Paruh-
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Quinethazone Approved DB01325
small molecule | CAS: 73-49-4

Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.

Kategori:
AmidesCardiovascular AgentsDiuretics +10
Target Protein:
Solute carrier family 12 member 1Solute carrier family 12 member 2Solute carrier family 12 member 3 +2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Quinfamide DB12780
small molecule | CAS: 62265-68-3

Quinfamide has been used in trials studying the treatment of Amoebiasis and Helminthiasis.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Genetik -
small molecule | CAS: 3000-39-3

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesFused-Ring CompoundsNorpregnanes +3
Waktu Paruh-
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Quinidine Approved DB00908
small molecule | CAS: 56-54-2

Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species. This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.[A38016,A250050] Quinidine is considered the first antiar…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +81
Target Protein:
Sodium channel protein type 5 subunit alphaPotassium channel subfamily K member 1Potassium channel subfamily K member 6 +4
Waktu ParuhThe elimination hal…
Vol. DistribusiQuinidine has a vol…
KlirensThe clearance of qu…
Genetik -
Quinidine barbiturate Approved DB01346
small molecule

The administration of quinidine derivatives helps to observe various skin and mucosal reactions. A papulopurpuric eruption in a patient (without thrombopenia) can be developed who is taking quinidine phenylethyl barbiturate intermittently and at reintroducti…

Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Sodium channel protein type 5 subunit alpha +2
Waktu Paruh-
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Genetik -
Quinolinic Acid DB01796
small molecule | CAS: 89-00-9

A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. [PubChem]

Kategori:
PyridinesQuinolinic Acids
Target Protein:
Nicotinate-nucleotide pyrophosphorylase [carboxylating]Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 79647-29-3

Deskripsi belum tersedia.

Target Protein:
Phenylalanine-4-hydroxylase
Waktu Paruh-
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Quinupramine Approved DB13246
small molecule | CAS: 31721-17-2

Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant [A175003].

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +8
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Quisinostat DB12985
small molecule | CAS: 875320-29-9

Quisinostat has been used in trials studying the treatment of Lymphoma, Neoplasms, Myelodysplastic Syndromes, and Advanced or Refractory Leukemia.

Kategori:
AminesHydroxy AcidsHydroxylamines
Waktu Paruh-
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Quisovalimab DB16482
biotech

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Quisqualic acid DB02999
small molecule | CAS: 52809-07-1

Quisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is ob…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsExcitatory Amino Acid Agents +4
Target Protein:
Metabotropic glutamate receptor 1Glutamate receptor ionotropic, kainate 1Metabotropic glutamate receptor 2 +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quizartinib Approved DB12874
small molecule | CAS: 950769-58-1

Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated with other targets in mind.[A260641] Additionally, …

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +17
Target Protein:
Receptor-type tyrosine-protein kinase FLT3
Waktu ParuhThe mean (SD) effec…
Vol. DistribusiVolume of distribut…
KlirensTotal body clearanc…
Genetik -
small molecule | CAS: 37571-78-1

Deskripsi belum tersedia.

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R-1487 DB06518
small molecule | CAS: 449811-92-1

Deskripsi belum tersedia.

Kategori:
Mitogen-Activated Protein Kinase 14, antagonists & inhibitorsPyridines
Target Protein:
Mitogen-activated protein kinase 14
Waktu Paruh-
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R-30490 DB09179
small molecule | CAS: 60618-49-7

R-30490 is an opioid related to carfentanil used as an animal tranquilizer. It was first synthesized by Janssen Pharmaceutica as part of a structure-activity relationship study of fentanly and its derivatives. R-30490 was found to be the most selective agonis…

Kategori:
Piperidines
Waktu Paruh-
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R-306465 DB12382
small molecule | CAS: 604769-01-9

R306465 has been used in trials studying the treatment of Neoplasms.

Kategori:
AminesAntineoplastic AgentsEnzyme Inhibitors +4
Waktu Paruh-
Vol. Distribusi-
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R-348 DB06321
small molecule | CAS: 916742-11-5

Deskripsi belum tersedia.

Target Protein:
Tyrosine-protein kinase JAK3
Waktu Paruh-
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R-82913 DB08598
small molecule | CAS: 126347-69-1

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +7
Target Protein:
Gag-Pol polyproteinGag-Pol polyprotein
Waktu Paruh-
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Genetik -
R-851 DB05747
small molecule

R-851 is part of the family of immune response modifier (IRM) and it acts in a novel way to stimulate the human body's immnune system to attack virus-infected cells and tumor cells. It is expected to be topical treatment for cervical displasia and cervical hi…

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small molecule | CAS: 14047-28-0

Deskripsi belum tersedia.

Target Protein:
Thymidine kinase, cytosolicThymidine kinaseThymidine kinase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
R-95845 DB07327
small molecule | CAS: 163435-77-6

R-95845 is an inhibitor of HIV-1 reverse transcriptase.

Kategori:
AcetatesAcids, AcyclicAmides +1
Target Protein:
Gag-Pol polyproteinGag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
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Genetik -
R048-8071 DB02016
small molecule | CAS: 161582-11-2

Deskripsi belum tersedia.

Target Protein:
Lanosterol synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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