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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 186 / 252
Pantoprazole Approved DB00213
small molecule | CAS: 102625-70-7

Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatmen…

Kategori:
2-PyridinylmethylsulfinylbenzimidazolesAcid ReducersAlimentary Tract and Metabolism +27
Target Protein:
Potassium-transporting ATPase alpha chain 1Potassium-transporting ATPase subunit betaN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Waktu ParuhAbout 1 hour[F3202]
Vol. DistribusiThe apparent volume…
Klirens**Adults**: With in…
Genetik -
Pantothenic acid Approved DB01783
small molecule | CAS: 79-83-4

Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient as it is required to synthesize coenzyme-A (CoA), as well a…

Kategori:
AlanineAlimentary Tract and MetabolismAmino Acids +9
Target Protein:
Pantothenate kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Acetyl-CoA acetyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Papaverine Approved DB01113
small molecule | CAS: 58-74-2

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodila…

Kategori:
Alimentary Tract and MetabolismAlkaloidsBenzylisoquinolines +18
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4DcGMP-specific 3',5'-cyclic phosphodiesterase3',5'-cyclic-AMP phosphodiesterase 4B +2
Waktu Paruh0.5-2 hours
Vol. Distribusi-
Klirens-
Genetik -
Papaya Approved DB10658
biotech

Papaya allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityHerbs and Natural ProductsIncreased Histamine Release +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 873-75-6

Deskripsi belum tersedia.

Kategori:
AlcoholsBenzene DerivativesBenzyl Compounds
Target Protein:
Alcohol dehydrogenase 1C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parachlorophenol Approved DB13154
small molecule | CAS: 106-48-9

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalBenzene Derivatives +4
Target Protein:
Sodium channel protein type 4 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paramethadione Approved DB00617
small molecule | CAS: 115-67-3

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.

Kategori:
AnticonvulsantsCentral Nervous System DepressantsCytochrome P-450 CYP2C8 Substrates +7
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1GVoltage-dependent T-type calcium channel subunit alpha-1I
Waktu Paruh12 to 24 hours (how…
Vol. Distribusi-
Klirens-
Genetik -
Paramethasone DB01384
small molecule | CAS: 53-33-8

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +27
Target Protein:
Corticosteroid-binding globulinGlucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paramethasone acetate Approved DB14657
small molecule | CAS: 1597-82-6

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paraoxon DB13495
small molecule | CAS: 311-45-5

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiglaucoma Preparations and MioticsCholinergic Agents +12
Target Protein:
Carbonic anhydrase 1Cannabinoid receptor 1Acetylcholinesterase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parasorbic acid DB14121
small molecule | CAS: 10048-32-5

Sole constituent of "Vogelbeerol" oil obtained by steam distillation of the acidified juice of the ripe berries of the mountain ash.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parathiazine DB15978
small molecule | CAS: 84-08-2

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parathyroid hormone Approved DB05829
biotech | CAS: 9002-64-6

Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleava…

Kategori:
Amino Acids, Peptides, and ProteinsCalcium HomeostasisCalcium-Regulating Hormones and Agents +7
Target Protein:
Parathyroid hormone 2 receptorParathyroid hormone/parathyroid hormone-related peptide receptor
Waktu Paruh1.5 hours.
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
biotech | CAS: 172867-62-8

Parathyroid Hormone-Related Protein 1-36 is under investigation in clinical trial NCT00853723 (Comparison Study of Pthrp and PTH to Treat Osteoporosis).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsHormones +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
AmidesAmino AcidsAmino Acids, Aromatic +5
Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pardoprunox DB12061
small molecule | CAS: 269718-84-5

Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease. Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptorD(3) dopamine receptorD(4) dopamine receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parecoxib Approved DB08439
small molecule | CAS: 198470-84-7

Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be use…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +18
Target Protein:
Prostaglandin G/H synthase 2Lactotransferrin
Waktu Paruh22 minutes (parecox…
Vol. Distribusi-
Klirens-
Genetik -
Parethoxycaine DB19380
small molecule | CAS: 94-23-5

Parethoxycaine is a local anesthetic that was previously approved in the US.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pargeverine DB15783
small molecule | CAS: 13479-13-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pargyline Approved DB01626
small molecule | CAS: 555-57-7

Pargyline is a monoamine oxidase inhibitor with antihypertensive properties.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAmines +12
Target Protein:
Amine oxidase [flavin-containing] BAmine oxidase [flavin-containing] A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paricalcitol Approved DB00910
small molecule | CAS: 131918-61-1

Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.

Kategori:
Anti-Parathyroid AgentsBone Density Conservation AgentsCalcium Homeostasis +16
Target Protein:
Vitamin D3 receptor
Waktu Paruh4 to 6 hours
Vol. Distribusi* 30.8 ± 7.5 L [CKD…
Klirens* 1.49 +/- 0.60 L/h…
Genetik -
biotech | CAS: 2259927-72-3

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paritaprevir Approved DB09297
small molecule | CAS: 1216941-48-8

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into ni…

Kategori:
AmidesAmino AcidsAmino Acids, Cyclic +27
Target Protein:
Genome polyproteinGag-Pol polyprotein
Waktu Paruh5.5 hr [FDA Label]
Vol. DistribusiVolume of distribut…
Klirens-
Genetik -
Parnaparin Approved DB09260
small molecule | CAS: 9005-49-6

Parnaparin is an heparin of low molecular weight with antithrombotic effects.

Kategori:
Agents causing hyperkalemiaAnticoagulantsBlood and Blood Forming Organs +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paromomycin Approved DB01421
small molecule | CAS: 7542-37-2

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAmebicides +10
Target Protein:
30S ribosomal protein S1016S ribosomal RNASmall ribosomal subunit protein uS2 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paroxetine Approved DB00715
small molecule | CAS: 61869-08-7

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653]…

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntidepressive Agents +39
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporter5-hydroxytryptamine receptor 2A +9
Gen Terkait:
ABCB1 CYP2D6 CYP2D6 +4
Waktu ParuhThe mean eliminatio…
Vol. DistribusiParoxetine has a la…
KlirensThe apparent oral c…
Genetik 7 Varian
PARPI F-18 DB18657
small molecule | CAS: 1883580-48-0

PARPI F-18 is a diagnostic agent under investigation for use in the management of glioblastoma multiforme.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parsaclisib DB14867
small molecule | CAS: 1426698-88-5

Parsaclisib is under investigation in clinical trial NCT03126019 (An Open-Label Study of Parsaclisib in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)).

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsPhosphatidylinositol-3-kinase (Pi3K) inhibitors +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parthenolide Approved DB13063
small molecule | CAS: 20554-84-1

Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +8
Target Protein:
Proto-oncogene c-RelTranscription factor RelBInhibitor of nuclear factor kappa-B kinase subunit beta +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pascolizumab DB06560
biotech | CAS: 331243-22-2

Pascolizumab (SB 240683) is a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Target Protein:
Interleukin-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAT-1251 DB16735
small molecule | CAS: 2098884-52-5

PAT-1251 is under investigation in clinical trial NCT04054245 (PAT-1251 in Treating Patients With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocytosis Myelofibrosis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pateclizumab DB14997
biotech | CAS: 1202526-59-7

Pateclizumab is under investigation in clinical trial NCT01225393 (A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients Wi…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patent Blue Approved DB13967
small molecule | CAS: 25305-77-5

Patent blue is aniline dye and it is one of the most common dyes used.[A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt.[A32574] It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cy…

Kategori:
AminesAniline CompoundsColoring Agents +4
Target Protein:
Albumin
Waktu ParuhThe elimination hal…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Patidegib DB12655
small molecule | CAS: 1037210-93-7

Patidegib has been investigated for the treatment of Conventional Chondrosarcoma.

Kategori:
Alkaloids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patiromer Approved DB09263
small molecule | CAS: 1260643-52-4

Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding poly…

Kategori:
Cation Exchange ResinsCompounds used in a research, industrial, or household settingMacromolecular Substances +3
Target Protein:
Potassium
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patisiran Approved DB14582
biotech | CAS: 1420706-45-1

Patisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis [L4220]. It is marketed as Onpattro which is formulated as patisiran within a liposome envelope for b…

Kategori:
Antisense Elements (Genetics)Compounds used in a research, industrial, or household settingDecreased RNA Integrity +12
Target Protein:
Transthyretin mRNA
Waktu ParuhPatisiran has a ter…
Vol. DistribusiThe steady state vo…
KlirensThe total body clea…
Genetik -
Patulin DB15586
small molecule | CAS: 149-29-1

Deskripsi belum tersedia.

Kategori:
Biological FactorsCompounds used in a research, industrial, or household settingMutagens +6
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patupilone DB03010
small molecule | CAS: 152044-54-7

Epothilone B is a 16-membered macrolide that mimics the biological effects of taxol.

Kategori:
Anti-Bacterial AgentsAntimitotic AgentsAntineoplastic Agents +9
Target Protein:
Tubulin beta chainTubulin beta-1 chainTubulin beta-4B chain +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pavinetant DB11692
small molecule | CAS: 941690-55-7

Pavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingQuinolines +3
Target Protein:
Neuromedin-K receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paxalisib DB15186
small molecule | CAS: 1382979-44-3

GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).

Kategori:
Enzyme Inhibitors
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pazopanib Approved DB06589
small molecule | CAS: 444731-52-6

Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.

Kategori:
AmidesAngiogenesis InhibitorsAntineoplastic Agents +36
Target Protein:
Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3 +7
Gen Terkait:
UGT1A1 HCP5
Waktu Paruh35 hours. Oral abso…
Vol. DistribusiVd steady state, IV…
KlirensCL, cancer patient,…
Genetik 2 Varian
Pazufloxacin DB11774
small molecule | CAS: 127045-41-4

Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +15
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA topoisomerase 4 subunit A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBFT02 DB18580
biotech

PBFT02 is a non-replicating recombinant adeno-associated virus serotype 1 vector delivering human GRN gene encoding the protein progranulin.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBGM01 DB18581
biotech

PBGM01 is a non-replicating recombinant adeno-associated virus serotype hu68 vector, which contains human GLB1 transgene encoding the galactosidase beta 1 enzyme.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBI-1402 DB05480
small molecule

PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils, enhancing their survival and activation with comparable efficacy to GM-CSF, G-CSF and EPO, which are currently used to treat anemia. However, it ha…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBR-06 F-18 DB17020
small molecule | CAS: 1003581-94-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBT-1033 DB05565
small molecule | CAS: 747408-78-2

Deskripsi belum tersedia.

Target Protein:
Microtubule-associated protein tau
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBT-434 Approved DB16965
small molecule | CAS: 1232840-87-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCLX-001 DB15567
small molecule | CAS: 1215011-08-7

PCLX-001 is a first-in-kind N-Myristoyltransferase (NMT) inhibitor being developed by [Pacylex Pharmaceuticals](https://pacylex.com). Current studies have shown that PCLX-001 works differently than other known cancer drugs and has high activity and positive r…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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