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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 183 / 236
small molecule | CAS: 868-14-4

Potassium bitartate, also referred to as potassium acid tartrate or cream of tartar, is the potassium acid salt of l-( + )-tartaric acid. It is obtained as a byproduct of wine manufacture during the fermentation process. Approved by the FDA as a direct food s…

Kategori:
LaxativesPotassium Salt
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Potassium carbonate Approved DB13977
small molecule | CAS: 584-08-7

Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. It presents a large capacity to absor…

Kategori:
AlkaliesAnionsCarbon Compounds, Inorganic +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Potassium chloride Approved DB00761
small molecule | CAS: 7447-40-7

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products contain…

Kategori:
Agents causing hyperkalemiaAlimentary Tract and MetabolismBlood and Blood Forming Organs +12
Target Protein:
Solute carrier family 12 member 2Solute carrier family 12 member 1Solute carrier family 12 member 5 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Potassium gluconate Approved DB13620
small molecule | CAS: 299-27-4

Potassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA [L2654]. It is also used as a potassium supplement [L2657]. Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it …

Kategori:
Alimentary Tract and MetabolismMineral SupplementsPotassium Salt
Waktu Paruh-
Vol. DistribusiDistribution is lar…
KlirensPotassium is freely…
Genetik -
Potassium guaiacolsulfonate Approved DB13735
small molecule | CAS: 1321-14-8

Guaiacolsulfonate is an aromatic sulfonic acid. Potassium guaiacolsulfonate salt is an expectorant that thins the mucus in the lungs and reduces chest congestion.

Kategori:
Benzene DerivativesCatecholsEthers +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7758-05-6

Deskripsi belum tersedia.

Kategori:
AnionsAnti-Infective AgentsAntifungal Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Potassium Iodide Approved DB06715
small molecule | CAS: 7681-11-0

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination …

Kategori:
AnionsAntidotesAntithyroid agents +12
Target Protein:
Tyrosine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 16731-55-8

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIons +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Potassium nitrate Approved DB11090
small molecule | CAS: 7757-79-1

Potassium nitrate is an inorganic salt with a chemical formula of KNO3. It is a natural source of nitrate and has been used as a constituent for several different purposes, including food preservatives, fertilizers, tree stump removal, rocket propellants, and…

Kategori:
AnionsCompounds used in a research, industrial, or household settingDrugs that are Mainly Renally Excreted +5
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2
Waktu Paruh-
Vol. DistribusiNitrates are absorb…
Klirens-
Genetik -
Potassium perchlorate Approved DB09418
small molecule | CAS: 7778-74-7

Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags [A32609]. The use of potassium pe…

Kategori:
AcidsAcids, NoncarboxylicAntithyroid agents +6
Target Protein:
Sodium/iodide cotransporter
Waktu ParuhPerchlorate has a h…
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
small molecule | CAS: 7722-64-7

Deskripsi belum tersedia.

Kategori:
AntidotesAntiseptics and DisinfectantsCompounds used in a research, industrial, or household setting +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 16788-57-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Potassium sulfate Approved DB14499
small molecule | CAS: 7778-80-5

Deskripsi belum tersedia.

Kategori:
AnionsDrugs that are Mainly Renally ExcretedElectrolytes +7
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Povetacicept DB18996
biotech | CAS: 2490217-42-8

Povetacicept is under investigation in clinical trial NCT05757570 (An Open-label Study of Povetacicept in Subjects With Autoimmune Cytopenias).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Povidone K30 Approved DB14478
small molecule | CAS: 9003-39-8

A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See [povidone] for full details.

Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Povorcitinib DB18855
small molecule | CAS: 1637677-22-5

Povorcitinib is under investigation in clinical trial NCT06113445 (A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pozanicline DB05458
small molecule | CAS: 161417-03-4

ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for the treatment of several neurological disorders including Alzheimer, Attention Deficit Hyperactivity Disorder and Schizophrenia/Schizoaffective disorders. In …

Target Protein:
Neuronal acetylcholine receptor subunit alpha-4Neuronal acetylcholine receptor subunit beta-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pozelimab Approved DB15218
biotech | CAS: 2096328-94-6

CD55-deficient protein-losing enteropathy (PLE), or CHAPLE disease, is an ultra-rare hereditary disease, with fewer than 100 patients diagnosed worldwide or fewer than 10 patients in the US.[L47880] The pathophysiology of this disease is mainly attributed to …

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsComplement Inactivating Agents +3
Target Protein:
Complement C5
Waktu ParuhIn healthy adult su…
Vol. DistribusiIn healthy adult su…
KlirensThere is limited in…
Genetik -
PP-121 DB08052
small molecule | CAS: 1092788-83-4

Deskripsi belum tersedia.

Target Protein:
Epidermal growth factor receptorDNA-dependent protein kinase catalytic subunitVascular endothelial growth factor receptor 2 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1771736-69-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PPI-1040 DB17620
small molecule | CAS: 1436673-69-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PPL-100 DB05961
small molecule | CAS: 612547-11-2

Deskripsi belum tersedia.

Target Protein:
Gag-Pol polyproteinPlasma protease C1 inhibitorPlasma serine protease inhibitor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PQ-10 DB08391
small molecule | CAS: 927691-21-2

Deskripsi belum tersedia.

Target Protein:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PR-104 DB05968
small molecule | CAS: 851627-62-8

Deskripsi belum tersedia.

Kategori:
Hydrocarbons, HalogenatedMustard Compounds
Target Protein:
Tumor necrosis factor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PR-15 DB06037
small molecule

PR-15 is a novel anti-platelet protein with the potential to treat arterial thrombosis occurring during acute coronary syndromes without the bleeding risk associated with existing agents.

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsCarbohydrates +10
Target Protein:
Collagen alpha-1(I) chainCollagen alpha-2(I) chainCollagen alpha-1(III) chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PR006 DB17002
biotech

PR006 is a non-replicating recombinant adeno-associated virus serotype 9 containing the progranulin gene. It is being investigated for the treatment of dementia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 182253-77-6

PR1 leukemia peptide vaccine is under investigation in clinical trial NCT00513578 (Vaccine Therapy and GM-CSF in Treating Patients With Low-Risk or Intermediate-Risk Myelodysplastic Syndrome).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Praconase DB05584
biotech | CAS: 1186547-12-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ProteinsBacterial Toxins +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Practolol Approved DB01297
small molecule | CAS: 6673-35-4

A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.

Kategori:
AcetanilidesAdrenergic AgentsAdrenergic Antagonists +20
Target Protein:
Beta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 625095-61-6

Pradefovir mesilate (previously known as MB-06886, Hepavir B and remofovir mesylate) is an orally administered small molecule compound that belongs to a novel series of phosphate and phosphonate prodrugs of adefovir. [Adefovir] (Hepsera) is an acyclic phospho…

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +3
Target Protein:
Cytochrome P450 3A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2088280-15-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralatrexate Approved DB06813
small molecule | CAS: 146464-95-1

Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674]. Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy for their B-cells counterparts.[A246693]…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +10
Target Protein:
Dihydrofolate reductasePeptide deformylase, mitochondrialFolylpolyglutamate synthase, mitochondrial +1
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe steady-state vo…
KlirensThe total systemic …
Genetik -
Praliciguat DB16300
small molecule | CAS: 1628730-49-3

Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).

Kategori:
Enzyme ActivatorsGastrointestinal AgentsGuanylyl Cyclase C Agonists
Target Protein:
Guanylate cyclase soluble subunit alpha-1Guanylate cyclase soluble subunit beta-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralidoxime Approved DB00733
small molecule | CAS: 6735-59-7

Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate expos…

Kategori:
AminesAntidotesCholinergic Agents +8
Target Protein:
AcetylcholinesteraseCholinesterase
Waktu Paruh74-77 minutes
Vol. Distribusi-
Klirens-
Genetik -
Pralmorelin DB18252
small molecule | CAS: 158861-67-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsGrowth Hormone-Releasing HormoneGrowth Substances +1
Target Protein:
Growth hormone secretagogue receptor type 16-phosphogluconate dehydrogenase, decarboxylating
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralnacasan DB04875
small molecule | CAS: 192755-52-5

Pralnacasan is an orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Caspase-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pralsetinib Approved DB15822
small molecule | CAS: 2097132-94-8

Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +38
Target Protein:
Proto-oncogene tyrosine-protein kinase receptor RetEpithelial discoidin domain-containing receptor 1NT-3 growth factor receptor +8
Waktu ParuhPralsetinib has a p…
Vol. DistribusiPralsetinib has a m…
KlirensPralsetinib has a m…
Genetik -
Pralurbactam DB19437
small molecule | CAS: 2163782-59-8

Pralurbactam is under investigation in clinical trial NCT06633718 (Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in CIAI).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pramipexole Approved DB00413
small molecule | CAS: 104632-26-0

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) [A176867]. It was …

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson Agents (Dopamine Agonist)Anti-Parkinson Drugs +17
Target Protein:
D(3) dopamine receptorD(2) dopamine receptorD(4) dopamine receptor +2
Waktu ParuhAbout 8.5-12 hours …
Vol. DistribusiThis drug is extens…
KlirensRenal clearance is …
Genetik -
Pramiracetam Approved DB13247
small molecule | CAS: 68497-62-1

Pramiracetam has been previously approved in some eastern European countries under the brand names Pramistar, Neupramir, and Remen. It was also previously approved in the United States with orphan drug designation [L1469]. Pramiracetam has been studied for th…

Kategori:
Nervous SystemPsychoanalepticsPsychostimulants, Agents Used for ADHD and Nootropics
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pramlintide Approved DB01278
small molecule | CAS: 151126-32-8

Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, a…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAmylin Agonists +12
Target Protein:
Glucagon-like peptide 1 receptorCalcitonin receptorReceptor activity-modifying protein 1 +2
Waktu ParuhApproximately 48 mi…
Vol. Distribusi-
Klirens-
Genetik -
Pranlukast DB01411
small molecule | CAS: 103177-37-3

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Kategori:
Agents to Treat Airway DiseaseAnti-Asthmatic AgentsBenzopyrans +14
Target Protein:
Cysteinyl leukotriene receptor 1Tumor necrosis factorInterleukin-5 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pranoprofen DB13514
small molecule | CAS: 52549-17-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prasinezumab DB14788
biotech | CAS: 1960462-19-4

Prasinezumab is under investigation in clinical trial NCT03100149 (A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prasterone Approved DB01708
small molecule | CAS: 53-43-0

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione…

Kategori:
17-KetosteroidsAdjuvants, ImmunologicAdrenal Cortex Hormones +32
Target Protein:
Glucose-6-phosphate 1-dehydrogenaseEstrogen receptorEstrogen receptor beta +7
Waktu Paruh12 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 651-48-9

DHEA sulfate is the major steroid of the fetal adrenal. DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.

Kategori:
17-KetosteroidsAdrenal Cortex HormonesAndrostanes +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prasugrel Approved DB06209
small molecule | CAS: 150322-43-3

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the …

Kategori:
AnticoagulantsAntiplatelet agentsBlood and Blood Forming Organs +15
Target Protein:
P2Y purinoceptor 12
Waktu ParuhThe active metaboli…
Vol. Distribusi44-68L
KlirensApparent clearance …
Genetik -
Pravastatin Approved DB00175
small molecule | CAS: 81093-37-0

Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This dr…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBCRP/ABCG2 Inhibitors +20
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHistone deacetylase 2
Gen Terkait:
KIF6 HMGCR
Waktu ParuhThe reported elimin…
Vol. DistribusiThe reported steady…
KlirensThe reported cleara…
Genetik 2 Varian
Pravibismane DB17784
small molecule | CAS: 175880-68-9

Deskripsi belum tersedia.

Kategori:
AlcoholsSulfhydryl CompoundsSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Praziquantel Approved DB01058
small molecule | CAS: 55268-74-1

Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis.[A263201…

Kategori:
AnthelminticsAnti-Infective AgentsAntihelminthic +12
Target Protein:
Hematopoietic prostaglandin D synthaseSchistosome calcium ion (Ca2+) channels
Waktu ParuhFollowing oral admi…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
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