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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

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Hasil Pencarian (14063)

Halaman 183 / 282
MM3122 DB16737
small molecule

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsExperimental Unapproved Treatments for COVID-19Heterocyclic Compounds, Fused-Ring +2
Target Protein:
Transmembrane protease serine 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MMDA DB01442
small molecule | CAS: 13674-05-0

MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen. MMDA bears resemblance to the psychopharmacologically active essential oils …

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAmines +11
Target Protein:
5-hydroxytryptamine receptor 2ASodium-dependent dopamine transporterSodium-dependent serotonin transporter +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MMI-175 DB02378
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-secretase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MN-246 DB05981
small molecule

MN-246 is a novel ß3-adrenergic receptor agonist developed for the treatment of urinary incontinence by MediciNova Inc.

Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mobocertinib Approved DB16390
small molecule | CAS: 1847461-43-1

Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the _EGFR_ gene,[L38368] which are typic…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +15
Target Protein:
Epidermal growth factor receptor
Waktu ParuhAt steady-state, th…
Vol. DistribusiThe mean apparent v…
KlirensAt steady-state, th…
Genetik -
Mocetinostat DB11830
small molecule | CAS: 726169-73-9

Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others.

Kategori:
Acids, CarbocyclicAmidesAntineoplastic Agents +6
Target Protein:
Histone deacetylase 1Histone deacetylase 3Histone deacetylase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Moclobemide Approved DB01171
small molecule | CAS: 71320-77-9

A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medic…

Kategori:
Acids, CarbocyclicAgents that produce hypertensionAgents that reduce seizure threshold +28
Target Protein:
Amine oxidase [flavin-containing] AMonoamine oxidaseAmine oxidase [flavin-containing] B
Waktu Paruh1-2 hours (4 hours …
Vol. Distribusi1-1.5 L/Kg [L1350]
KlirensClearance of 30-78 …
Genetik -
Mocravimod DB18151
small molecule | CAS: 509092-16-4

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MOD-5014 DB17715
biotech

MOD-5014 is a long-acting carboxy-terminal peptide (CTP)-modified Factor IIa.[A259088] It is being investigated for the treatment of hemophilia.[L46173]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modafinil Approved DB00745
small molecule | CAS: 68693-11-8

Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, w…

Kategori:
Benzene DerivativesBenzhydryl CompoundsCentral Nervous System Agents +35
Target Protein:
Sodium-dependent dopamine transporterAlpha-1B adrenergic receptor
Gen Terkait:
COMT COMT
Waktu Paruh23-215 hours
Vol. Distribusi* 0.9 L/kg
Klirens-
Genetik 2 Varian
Modakafusp alfa DB16399
biotech

Modakafusp alfa is under investigation in clinical trial NCT03215030 (A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-573 in Participants With Refractory Multiple Myeloma (MM)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Moderna COVID-19 Vaccine Approved DB15654
biotech

The Moderna COVID-19 Vaccine (mRNA-1273) is a novel mRNA-based vaccine encapsulated in a lipid nanoparticle that encodes for a full-length pre-fusion stabilized spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus dis…

Kategori:
Biological ProductsCOVID-19 VaccinesExperimental Unapproved Treatments for COVID-19 +5
Waktu ParuhThere is limited ph…
Vol. DistribusiThere is limited ph…
KlirensThere is limited ph…
Genetik -
Modified vaccinia ankara Approved DB15483
biotech

Modified Vaccinia Ankara (MVA) refers to an attenuated strain of the Vaccinia virus. Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN).[L42660,L42670]

Kategori:
Anti-Infective AgentsAntiviral AgentsBiological Products +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2171576-44-4

Modified vaccinia virus Ankara-85A antigen is under investigation in clinical trial NCT00953927 (A Study of MVA85A in Healthy Infants).

Kategori:
Amino Acids, Peptides, and ProteinsAntigensBacterial Vaccines +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modimelanotide DB15314
small molecule | CAS: 926277-68-1

Modimelanotide is under investigation in clinical trial NCT01897519 (A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery).

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modipafant DB16237
small molecule | CAS: 122957-06-6

Modipafant is under investigation in clinical trial NCT02569827 (Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore).

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modithromycin DB16238
small molecule | CAS: 736992-12-4

Modithromycin is under investigation in clinical trial NCT00270517 (Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia).

Kategori:
LactonesPolyketides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modotuximab DB14827
biotech | CAS: 1310460-86-6

Modotuximab is under investigation in clinical trial NCT03549338 (Sym004 Versus Futuximab or Modotuximab in Patients With mCRC).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modufolin DB12676
small molecule | CAS: 31690-11-6

Modufolin is under investigation for the treatment of Osteosarcoma.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Moexiprilat DB14210
small molecule | CAS: 103775-14-0

The active metabolite of the prodrug [Moexipril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAngiotensin-Converting Enzyme Inhibitors +2
Target Protein:
Angiotensin-converting enzyme
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mofebutazone DB13629
small molecule | CAS: 2210-63-1

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mogamulizumab Approved DB12498
biotech | CAS: 1159266-37-1

Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occu…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +15
Target Protein:
C-C chemokine receptor type 4
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe central volume …
KlirensClearance is 12 mL/…
Genetik -
MOL-4239 DB16051
small molecule | CAS: 1204306-34-2

MOL-4239 is under investigation in clinical trial NCT01826201 (Paired Psoriasis Lesion, Comparative, Study to Evaluate MOL4239 in Psoriasis).

Target Protein:
Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molgramostim DB12525
biotech | CAS: 99283-10-0

Molgramostim has been used in trials studying the treatment of Bronchiectasis, Cystic Fibrosis, Pulmonary Alveolar Proteinosis, Acute Respiratory Distress Syndrome, and Autoimmune Pulmonary Alveolar Proteinosis.

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntineoplastic Agents +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molibresib DB16239
small molecule | CAS: 1260907-17-2

Molibresib is under investigation in clinical trial NCT01943851 (A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies).

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-Ring
Target Protein:
Bromodomain-containing protein 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molidustat DB15642
small molecule | CAS: 1154028-82-6

Molidustat is under investigation in clinical trial NCT03350321 (A Study of Molidustat for Correction of Renal Anemia in Non-dialysis Subjects).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molindone Approved DB01618
small molecule | CAS: 7416-34-4

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a re…

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (First Generation [Typical]) +18
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2A +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molnupiravir DB15661
small molecule | CAS: 2349386-89-4

Molnupiravir (EIDD-2801, MK-4482) is the isopropylester prodrug of [N4-hydroxycytidine].[A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed _in vivo_, and distributes into tissues where it becomes the active 5’-triphos…

Kategori:
AminesAnti-Infective AgentsAntiinfectives for Systemic Use +13
Waktu ParuhThe half life of th…
Vol. Distribusi-
Klirens-
Genetik -
Molsidomine Approved DB09282
small molecule | CAS: 25717-80-0

Molsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones. Interestingly, it is being studied as being a preventive measure in cerebral infarction [A31932].

Kategori:
Cardiac TherapyCardiovascular AgentsMorpholines +7
Target Protein:
Guanylate cyclase soluble subunit alpha-2
Waktu Paruh-
Vol. Distribusi98 L [L1369]
Klirensrenal excretion is …
Genetik -
Molybdate DB15878
small molecule | CAS: 14259-85-9

Deskripsi belum tersedia.

Kategori:
ElementsMetalsMetals, Heavy +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molybdate Mo-99 DB16587
small molecule | CAS: 72826-31-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molybdenum Approved DB11137
small molecule | CAS: 7439-98-7

Molybdenum is a chemical element with symbol Mo and atomic number 42. As it is not a naturally occuring free metal on Earth, molybdenum is found only in various oxidation states in minerals. Molybdenum is commonly used in metallurgy and other chemical applica…

Kategori:
Diet, Food, and NutritionElementsFood +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 872689-63-9

Absence of molybdenum cofactor leads to accumulation of toxic levels of sulphite and neurological damage usually leading to death within months of birth, due to the lack of active sulfite oxidase.

Kategori:
CoenzymesEnzymes and Coenzymes
Target Protein:
Aldehyde oxidoreductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1313-27-5

Deskripsi belum tersedia.

Kategori:
Air PollutantsAnionsElectrolytes +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Momelotinib Approved DB11763
small molecule | CAS: 1056634-68-4

Momelotinib is a Janus Kinase 1 (JAK1) and 2 (JAK2) inhibitor. It is a competitive inhibitor of JAK ATP binding.[A261566] First approved by the FDA on September 15, 2023,[L48206] momelotinib is used to treat myelofibrosis.[L48186] Myelofibrosis (MF) is a grou…

Kategori:
Acids, CarbocyclicAmidesAntineoplastic Agents +24
Target Protein:
Tyrosine-protein kinase JAK1Tyrosine-protein kinase JAK2Tyrosine-protein kinase JAK3 +3
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean (%CV) appa…
KlirensThe mean (%CV) clea…
Genetik -
Mometasone DB00764
small molecule | CAS: 105102-22-5

Mometasone is a corticosteroid not currently used in medical products. [Mometasone furoate] however, is still in use.

Kategori:
Adrenal Cortex HormonesAdrenalsAnti-Allergic Agents +29
Target Protein:
Glucocorticoid receptorProgesterone receptor
Waktu Paruh5.8 hours
Vol. Distribusi-
Klirens-
Genetik -
Mometasone furoate Approved DB14512
small molecule | CAS: 83919-23-7

Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than [dexamethasone] and higher than m…

Kategori:
Adrenal Cortex HormonesAdrenalsAdrenergics, Inhalants +28
Target Protein:
Glucocorticoid receptorProgesterone receptor
Waktu ParuhThe terminal half l…
Vol. DistribusiSteady state volume…
KlirensThe clearance rate …
Genetik -
biotech

Momordica charantia fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monalizumab DB12824
biotech | CAS: 1228763-95-8

Monalizumab has been used in trials studying the treatment of Gynecologic Cancer, Chronic Lymphocytic Leukemia, and Squamous Cell Carcinoma of the Oral Cavity.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monarsen DB16946
biotech | CAS: 864021-55-6

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monastrol DB04331
small molecule | CAS: 254753-54-3

Deskripsi belum tersedia.

Kategori:
Antimitotic AgentsAntineoplastic AgentsEnzyme Inhibitors +2
Target Protein:
Kinesin-like protein KIF11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monepantel DB18755
small molecule | CAS: 887148-69-8

Deskripsi belum tersedia.

Kategori:
AcetonitrilesNitriles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mongersen DB15019
biotech | CAS: 1443994-46-4

Mongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult Subjects).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monobenzone Approved DB00600
small molecule | CAS: 103-16-2

Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. It exerts a depigmenting effect on skin of mammal…

Kategori:
alpha-Galactosidase, antagonists & inhibitorsBenzene DerivativesDepigmenting Agents +3
Target Protein:
Tyrosinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monoctanoin DB06801
small molecule | CAS: 502-54-5

Monoctanoin is used to dissolve cholesterol gallstones.

Kategori:
Acids, AcyclicFatty AcidsLipids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15181-43-8

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +10
Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
CarbohydratesGlycoconjugatesGlycolipids +1
Target Protein:
Photosystem II protein D1 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monomethyl fumarate Approved DB14219
small molecule | CAS: 2756-87-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicDicarboxylic AcidsImmunosuppressive Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAntigensAntigens, Bacterial +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 9101–9150 dari 14063
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