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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
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11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 182 / 236
Poloxamer 407 DB11252
small molecule | CAS: 691397-13-4

Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature. Poloxamer 407 is used a…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
Waktu Paruh-
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Poloxamine 1304 DB19167
small molecule | CAS: 11111-34-5

Poloxamine 1304 is under investigation in clinical trial NCT00483795 (Pilot Evaluation of Two Multipurpose Solutions in Regards to Corneal Staining).

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small molecule | CAS: 26811-96-1

Poly(lactic acid) is under investigation in clinical trial NCT00126308 (Facial Lipoatrophy Trial: Immediate Versus Deferred Injections of Poly-L-Lactic Acid for HIV Facial Lipoatrophy).

Kategori:
Dental ImplantsMacromolecular SubstancesPolymers
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small molecule | CAS: 9003-05-8

Polyacrylamide (crosslinked; 2 mole percent bisacrylamide) is under investigation in clinical trial NCT00629083 (Bulking Agents for the Treatment of Stress Urinary Incontinence in Females).

Kategori:
Biocompatible MaterialsColloidsComplex Mixtures +6
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small molecule | CAS: 133029-32-0

Deskripsi belum tersedia.

Kategori:
AmidinesGuanidinesPreservatives, Pharmaceutical
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Polycarbophil DB09311
small molecule | CAS: 9003-97-8

Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion. Polycarbophil calcium is a stool stabilizer used to treat constipation. This drug may also be used to help rel…

Kategori:
AntidiarrhealsBulk-Forming LaxativesCompounds used in a research, industrial, or household setting +6
Waktu ParuhCalcium polycarboph…
Vol. DistribusiCalcium polycarboph…
KlirensCalcium polycarboph…
Genetik -
Polydatin Approved DB11263
small molecule | CAS: 27208-80-6

Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of *Picea sitchensis* or *Polygonum cuspidatum*, polydatin may be detected in grape, peanut, hop cones, red win…

Kategori:
Benzene DerivativesBenzylidene CompoundsCarbohydrates +3
Target Protein:
Pyruvate kinase PKM
Waktu Paruh-
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Polydextrose DB14836
small molecule | CAS: 68424-04-4

Polydextrose is under investigation in clinical trial NCT02258750 (Assessing a Polydextrose Containing Soup on Food Intake, Appetite and Biomarkers of Satiation and Satiety).

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +8
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Polydioxanone DB14832
small molecule | CAS: 31621-87-1

Polydioxanone is under investigation in clinical trial NCT00998907 (PDS*Plus and Wound Infections After Laparotomy).

Kategori:
Biocompatible MaterialsMacromolecular SubstancesPolyesters +1
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Polyestradiol phosphate Approved DB09369
small molecule | CAS: 28014-46-2

Polymeric phosphoric acid ester of estradiol.

Kategori:
Antineoplastic and Immunomodulating AgentsEndocrine TherapyEstradiol Congeners +10
Target Protein:
Estrogen receptor
Waktu Paruh-
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Polyethylene glycol Approved DB09287
small molecule | CAS: 25322-68-3

Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.[A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of …

Kategori:
AlcoholsAlimentary Tract and MetabolismCompounds used in a research, industrial, or household setting +21
Waktu ParuhFollowing a two-day…
Vol. DistribusiFollowing a two-day…
KlirensThere is limited in…
Genetik -
Polyethylene glycol 400 Approved DB11077
small molecule | CAS: 25322-68-3

Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily …

Kategori:
AlcoholsArtificial TearsCompounds used in a research, industrial, or household setting +8
Target Protein:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1Oxidoreductase HTATIP2
Waktu ParuhGreat than 24h [L17…
Vol. Distribusi-
KlirensIn mice, lease than…
Genetik -
Polygala senega root Approved DB14749
biotech

Deskripsi belum tersedia.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +11
Waktu Paruh-
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biotech

Deskripsi belum tersedia.

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Polygeline DB15879
biotech | CAS: 66455-30-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood SubstitutesHematologic Agents +4
Waktu Paruh-
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small molecule | CAS: 31961-54-3

Deskripsi belum tersedia.

Kategori:
AmidinesFlocculation
Waktu Paruh-
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Polymyxin B Approved DB00781
biotech | CAS: 1404-26-8

Polymyxin B was discovered in the 1940s[A176429]. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes[A176426]. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and …

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Bacterial Agents +19
Target Protein:
Bacterial outer membraneDihydropteroate synthase
Waktu ParuhIn one study the ha…
Vol. Distribusi1 compartment model…
Klirens1 compartment model…
Genetik -
small molecule | CAS: 81859-24-7

Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.

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Polysilicone-15 Approved DB11271
small molecule | CAS: 207574-74-1

Polysilicone-15 is a silicone based UVB absorber [L2796, L2797, L2799, F87, F88, F89]. The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89…

Kategori:
Sunscreen Agents
Waktu ParuhPolysilicone-15 is …
Vol. DistribusiPolysilicone-15 is …
KlirensPolysilicone-15 is …
Genetik -
Polysorbate 20 Approved DB11178
small molecule | CAS: 9005-64-5

Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is a wetting agent in food products, as well a…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
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Polysorbate 60 DB14153
small molecule | CAS: 9005-67-8

Deskripsi belum tersedia.

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biotech

Polyvalent antigen-KLH conjugate vaccine is a multivalent cancer vaccine comprised of the five tumor-associated antigens (TAAs) globo H, GM2 ganglioside, Tn-MUC1, TF, and sTn conjugated with the immunoadjuvant keyhole limpet hemocyanin (KLH). It is under inve…

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Pomalidomide Approved DB08910
small molecule | CAS: 19171-19-8

Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.

Kategori:
Acids, CarbocyclicAngiogenesis InhibitorsAngiogenesis Modulating Agents +29
Target Protein:
Protein cereblonTumor necrosis factorProstaglandin G/H synthase 2
Waktu ParuhHealthy subjects = …
Vol. DistribusiMean apparent volum…
KlirensTotal body clearanc…
Genetik -
Pomegranate DB14317
biotech

Pomegranate is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Pomotrelvir DB18975
small molecule | CAS: 2713437-86-4

Pomotrelvir is under investigation in clinical trial NCT05543707 (PBI-0451 (Pomotrelvir) Phase 2 Study in Nonhospitalized Symptomatic Adults With COVID-19).

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Ponatinib Approved DB08901
small molecule | CAS: 943319-70-8

Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors +23
Target Protein:
Tyrosine-protein kinase ABL1Breakpoint cluster region proteinMast/stem cell growth factor receptor Kit +12
Waktu ParuhAfter oral administ…
Vol. DistribusiAfter oral administ…
Klirens-
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Ponesimod Approved DB12016
small molecule | CAS: 854107-55-4

Ponesimod is a selective sphingosine 1-phosphate receptor 1 modulator indicated in the treatment of relapsing forms of multiple sclerosis in adults.[A232079,L32709] Ponesimod was developed out of a need for a more selective modulator of sphingosine 1-phosphat…

Kategori:
Antineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +13
Target Protein:
Sphingosine 1-phosphate receptor 1
Waktu ParuhPonesimod has an el…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of po…
Genetik -
Ponezumab DB15135
biotech | CAS: 1178862-65-1

Ponezumab is under investigation in clinical trial NCT00607308 (A Phase I, Single Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Ponsegromab DB18943
biotech | CAS: 2368950-15-4

Ponsegromab is under investigation in clinical trial NCT05492500 (A Study of Ponsegromab in People With Heart Failure).

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biotech

Populus balsamifera subsp. trichocarpa pollen is the pollen of the Populus balsamifera subsp. trichocarpa plant. Populus balsamifera subsp. trichocarpa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Populus nigra pollen Approved DB10750
biotech

Populus nigra pollen is the pollen of the Populus nigra plant. Populus nigra pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Porfimer sodium Approved DB00707
small molecule | CAS: 87806-31-3

The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agen…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBiological Factors +13
Target Protein:
Low-density lipoprotein receptorHigh affinity immunoglobulin gamma Fc receptor I
Waktu Paruh10-452 hours
Vol. Distribusi* 0.49 ± 0.28 L/kg …
Klirens* Renal cl=199.7 +/…
Genetik -
Porfiromycin DB06478
small molecule | CAS: 801-52-5

Porfiromycin is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.

Kategori:
Antibiotics, AntineoplasticAntineoplastic AgentsAzirines +5
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Porgaviximab DB17773
biotech | CAS: 1792982-55-8

Deskripsi belum tersedia.

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Pork collagen Approved DB14100
biotech

Pork Collagen is used within MACI® (autologous cultured chondrocytes on porcine collagen membrane) as an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or …

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Porphobilinogen DB02272
small molecule | CAS: 487-90-1

Porphobilinogen is a pyrrole involved in porphyrin metabolism. It is generated by the enzyme ALA dehydratase, and converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase.

Target Protein:
Delta-aminolevulinic acid dehydratase
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biotech

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Myoglobin
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Posaconazole Approved DB01263
small molecule | CAS: 171228-49-2

Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.

Kategori:
14-alpha Demethylase InhibitorsAnti-Infective AgentsAntifungal Agents +23
Target Protein:
Lanosterol 14-alpha demethylase
Waktu ParuhPosaconazole is eli…
Vol. Distribusi* 1774 L
Klirens* 32 L/hr * 51 L/h…
Genetik -
Posdinemab DB18941
biotech | CAS: 2517973-04-3

Posdinemab is under investigation in clinical trial NCT04619420 (A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease).

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Poseltinib DB16299
small molecule | CAS: 1353552-97-2

Poseltinib is under investigation in clinical trial NCT02628028 (A Study of LY3337641 in Rheumatoid Arthritis).

Kategori:
Amines
Target Protein:
Tyrosine-protein kinase BTK
Waktu Paruh-
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Posiphen DB15317
small molecule | CAS: 116839-68-0

Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).

Kategori:
Acids, AcyclicAlkaloidsCarbamates +11
Waktu Paruh-
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Posoleucel DB17974
biotech

Deskripsi belum tersedia.

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POT-4 DB06056
biotech

POT-4 is a peptide that specifically inhibits complement activation and is initially being developed for the treatment of age-related macular degeneration (AMD). The investigational drug was under investigation in clinical trial NCT00473928 (Safety of Intravi…

Target Protein:
Complement C3
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Potassium Approved DB14500
small molecule | CAS: 7440-09-7

Potassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans.[A186928] Many conditions and diseases interfere with normal body potassium b…

Kategori:
Agents causing hyperkalemiaDiureticsElements +8
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu ParuhIn one clinical stu…
Vol. DistribusiPotassium is presen…
KlirensPotassium is freely…
Genetik -
Potassium acetate Approved DB14498
small molecule | CAS: 127-08-2

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAgents causing hyperkalemia +8
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
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Potassium alum Approved DB09087
small molecule | CAS: 10043-67-1

Potassium alum is considered by the FDA as a generally recognized as safe (GRAS) substance.[L1070] It is an inorganic salt, also called potassium aluminum sulfate with a formula of AlK(SO4)2 that is predominantly produced in the dodecahydrate form (AlK(SO4)2 …

Kategori:
Adjuvants, ImmunologicAluminium CompoundsImmunologic Factors +7
Waktu ParuhStudies performed w…
Vol. DistribusiThe distribution of…
KlirensRenal clearance of …
Genetik -
Potassium aspartate Approved DB15819
small molecule | CAS: 7259-25-8

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +2
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Potassium bicarbonate Approved DB11098
small molecule | CAS: 298-14-6

Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. It is used in medicine as an antacid.[T141] It is registered in the FDA unde…

Kategori:
Agents causing hyperkalemiaAlimentary Tract and MetabolismAnions +8
Target Protein:
Hydrogen ions
Waktu ParuhSome reports have s…
Vol. Distribusi-
Klirens-
Genetik -
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