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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
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3253 (100.0%)

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Halaman 18 / 66
CT120 DB18181
biotech

CT120 is an investigational autologous CD19/22 targeted CAR-T cell immunotherapy.

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CTX120 DB18625
biotech

CTX120 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting B-cell maturation antigen.

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CUDC-101 DB12174
small molecule | CAS: 1012054-59-9

CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others.

Kategori:
AminesAntineoplastic AgentsHeterocyclic Compounds, Fused-Ring +5
Target Protein:
Epidermal growth factor receptorReceptor tyrosine-protein kinase erbB-2
Waktu Paruh-
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Genetik -
biotech

_Curcuma xanthorrhiza_ oil is extracted from _Curcuma xanthorrhiza_ Roxb., a member of the ginger family (_Zingiberaceae_) that is widely distributed in the region of Southeastern Asia [A33162]. _Curcuma xanthorrhiza_ is also known as Javanese Turmeric or Te…

Waktu ParuhThere are no pharma…
Vol. DistribusiThere are no pharma…
KlirensThere are no pharma…
Genetik -
Cusatuzumab DB15100
biotech | CAS: 1864871-20-4

CD70 is a ligand expressed on the surface of activated lymphocytes and mature dendritic cells that, in its binding to CD27 receptors, plays an important role in cell proliferation and survival. An overexpression of CD70 can result in the proliferation of mali…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Target Protein:
CD70 antigen
Waktu Paruh-
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Klirens-
Genetik -
CXD101 DB16182
small molecule | CAS: 934828-12-3

CXD101 is under investigation in clinical trial NCT03873025 (A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-cell Lymphoma).

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Cyanocobalamin Approved DB00115
small molecule | CAS: 68-19-9

Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria [A175276], and is necessary for DNA synthesis and cellular e…

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansCorrinoids +10
Target Protein:
Methionine synthaseMethylmalonyl-CoA mutase, mitochondrialMethionine synthase reductase +3
Waktu ParuhApproximately 6 day…
Vol. DistribusiCobalamin is distri…
KlirensDuring vitamin load…
Genetik -
Cyanocobalamin Co-57 Approved DB09385
small molecule | CAS: 13115-03-2

Deskripsi belum tersedia.

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
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Cyanocobalamin Co-60 Approved DB09387
small molecule | CAS: 13422-53-2

Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in the US for unknown reasons.

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Cyclobutyrol DB13493
small molecule | CAS: 512-16-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismBile and Liver Therapy +4
Waktu Paruh-
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Cyclomethicone DB14124
small molecule | CAS: 69430-24-6

Deskripsi belum tersedia.

Kategori:
Compounds used in a research, industrial, or household settingMacromolecular SubstancesOrganosilicon Compounds +2
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small molecule | CAS: 541-02-6

Cyclomethicone 5 is member of cyclomethicone, which are a group of liquid methyl siloxanes that have low viscosity and high volatility. Cyclomethicones are cyclic in structure with a monomer backbone of one silicon and two oxygen atoms bonded together. Cyclom…

Kategori:
Macromolecular SubstancesOrganosilicon CompoundsPolymers +1
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Cyclopentolate Approved DB00979
small molecule | CAS: 512-15-2

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.

Kategori:
Acids, CarbocyclicAnticholinergic AgentsAutonomic Agents +11
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5
Waktu Paruh-
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small molecule | CAS: 129033-04-1

Cyclotheonamide A is a cyclic peptide isolated from the marine sponge Theonella.

Kategori:
Amino Acids, Peptides, and ProteinsPeptidesThrombin, antagonists & inhibitors
Target Protein:
Serine protease 1
Waktu Paruh-
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Cyproheptadine Approved DB00434
small molecule | CAS: 129-03-3

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors.[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the tr…

Kategori:
Agents producing tachycardiaAgents that reduce seizure thresholdAnti-Allergic Agents +28
Target Protein:
Histamine H1 receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2C +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytochlor DB12383
small molecule | CAS: 32387-56-7

Cytochlor has been used in trials studying the treatment of Head and Neck Cancer and Brain and Central Nervous System Tumors.

Waktu Paruh-
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D-alpha-Tocopherol acetate Approved DB14002
small molecule | CAS: 58-95-7

Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is conside…

Kategori:
AntioxidantsBenzopyransBiological Factors +12
Target Protein:
SEC14-like protein 3SEC14-like protein 2Nuclear receptor subfamily 1 group I member 2 +3
Waktu Paruh_In addition to any…
Vol. Distribusi_In addition to any…
Klirens_In addition to any…
Genetik -
small molecule | CAS: 643-12-9

D-chiro-Inositol is under investigation in clinical trial NCT03201601 (Evaluation of the Mixture Myoinositol:D-chiro-inositol 3.6:1 in Women With Polycystic Ovary Syndrome).

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D-Lactic acid DB03066
small molecule | CAS: 10326-41-7

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)

Kategori:
Hydroxy AcidsLactates
Target Protein:
(S)-2-haloacid dehalogenase
Waktu Paruh-
Vol. Distribusi-
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D-Leucine DB01746
small molecule | CAS: 328-38-1

An essential branched-chain amino acid important for hemoglobin formation. [PubChem]

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D-norleucine DB04419
small molecule | CAS: 327-56-0

An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.

Target Protein:
Phenylalanine-4-hydroxylaseParathyroid hormoneHepatocyte nuclear factor 1-alpha
Waktu Paruh-
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Genetik -
small molecule | CAS: 2226-71-3

Deskripsi belum tersedia.

Kategori:
Sulfhydryl CompoundsSulfur Compounds
Target Protein:
Phosphopantetheine adenylyltransferasePhosphopantetheine adenylyltransferasePhosphopantetheine adenylyltransferase
Waktu Paruh-
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D-Serine Approved DB03929
small molecule | CAS: 312-84-5

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. [PubChem]

Target Protein:
Glutamate receptor ionotropic, NMDA 1Glycine receptor subunit alpha-1Serpin B3 +1
Waktu Paruh-
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Genetik -
D-tartaric acid DB01694
small molecule | CAS: 147-71-7

Deskripsi belum tersedia.

Target Protein:
2,3-diketo-L-gulonate reductaseGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1Triggering receptor expressed on myeloid cells 1 +10
Waktu Paruh-
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D3S-001 DB19008
small molecule | CAS: 2706637-43-4

D3S-001 is under investigation in clinical trial NCT05410145 (A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.g12c Mutation).

Waktu Paruh-
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DA-6886 DB12853
small molecule | CAS: 1342815-16-0

DA-6886 has been used in trials studying the treatment of Irritable Bowel Syndrome.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dabrafenib Approved DB08912
small molecule | CAS: 1195765-45-7

Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation.[L41955] It was also used for metastatic non-small cell …

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +64
Target Protein:
Serine/threonine-protein kinase B-rafRAF proto-oncogene serine/threonine-protein kinaseSerine/threonine-protein kinase SIK1 +2
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe apparent volume…
KlirensThe clearance of da…
Genetik -
Dacetuzumab DB12589
biotech | CAS: 880486-59-9

Dacetuzumab has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin Lymphoma, Leukemia, Lymphocytic, Chronic, and Lymphoma, Large B-Cell, Diffuse. It is a humanized anti-CD40 antibody and induces cytotoxicity in human multiple myeloma …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
Target Protein:
Tumor necrosis factor receptor superfamily member 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Daclatasvir Approved DB09102
small molecule | CAS: 1009119-64-5

Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. It is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . Hep…

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Branched-Chain +21
Target Protein:
Genome polyproteinNonstructural protein 5A
Waktu ParuhFollowing multiple …
Vol. DistribusiThe approximate vol…
KlirensIn subjects who rec…
Genetik -
Daclizumab DB00111
biotech | CAS: 152923-56-3

Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
Interleukin-2 receptor subunit alphaInterleukin-2 receptor subunit betaLow affinity immunoglobulin gamma Fc region receptor III-B +9
Waktu Paruh11-38 days
Vol. Distribusi-
Klirens-
Genetik -
Dalcetrapib DB12181
small molecule | CAS: 211513-37-0

Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome.

Kategori:
Anticholesteremic AgentsHypolipidemic AgentsLipid Regulating Agents +1
Target Protein:
Cholesteryl ester transfer protein
Waktu Paruh-
Vol. Distribusi-
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Dalfopristin Approved DB01764
small molecule | CAS: 112362-50-2

Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits th…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +8
Target Protein:
Streptogramin A acetyltransferase
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Danburstotug DB19064
biotech | CAS: 2307144-65-4

Danburstotug is under investigation in clinical trial NCT04809012 (Study of STI-3031 in Patients With Selected Relapsed or Refractory Solid Tumors).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Daniquidone DB12804
small molecule | CAS: 67199-66-0

Daniquidone has been used in trials studying the treatment of Neoplasms.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
DNA topoisomerase 1DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Danirixin DB11922
small molecule | CAS: 954126-98-8

Danirixin has been used in trials studying the treatment and basic science of Virus Diseases, Nutritional Status, Pulmonary Disease, Chronic Obstructive, and Infections, Respiratory Syncytial Virus.

Kategori:
Sulfur Compounds
Target Protein:
C-X-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Danofloxacin DB11393
small molecule | CAS: 112398-08-0

Danofloxacin is an antibiotic agent from the family of the fluoroquinolones used in veterinary medicine.

Kategori:
4-QuinolonesAnti-Infective AgentsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
DNA gyrase subunit ADNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dantrolene Approved DB01219
small molecule | CAS: 7261-97-4

Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.

Kategori:
Agents causing hyperkalemiaAgents that produce neuromuscular block (indirect)Central Nervous System Agents +15
Target Protein:
Ryanodine receptor 1
Waktu ParuhThe mean biologic h…
Vol. Distribusi-
Klirens-
Genetik -
Dapaconazole DB11985
small molecule | CAS: 1269726-67-1

Dapaconazole has been used in trials studying the treatment of Tinea Pedis.

Waktu Paruh-
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Dapiprazole Approved DB00298
small molecule | CAS: 72822-12-9

Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +12
Target Protein:
D(2) dopamine receptorAlpha-1A adrenergic receptorAlpha-1D adrenergic receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Daporinad DB12731
small molecule | CAS: 658084-64-1

Daporinad has been used in trials studying the treatment of Melanoma, Cutaneous T-cell Lymphoma, and B-cell Chronic Lymphocytic Leukemia.

Kategori:
Acids, AcyclicAcrylatesAmides
Target Protein:
Nicotinamide phosphoribosyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Daptomycin Approved DB00080
small molecule | CAS: 103060-53-3

Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, …

Kategori:
Agents Causing Muscle ToxicityAmino Acids, Peptides, and ProteinsAnti-Bacterial Agents +11
Target Protein:
Dihydropteroate synthaseCytoplasmic membrane
Waktu ParuhDaptomycin has a re…
Vol. DistribusiDaptomycin has a ve…
KlirensDaptomycin administ…
Genetik -
Darbepoetin alfa Approved DB00012
biotech | CAS: 209810-58-2

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Kategori:
Amino Acids, Peptides, and ProteinsAntianemic PreparationsBlood and Blood Forming Organs +10
Target Protein:
Erythropoietin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Darexaban DB12289
small molecule | CAS: 365462-23-3

Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.

Kategori:
Acids, CarbocyclicAmidesAnticoagulants +8
Target Protein:
Coagulation factor X
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Darglitazone DB14034
small molecule | CAS: 141200-24-0

Deskripsi belum tersedia.

Kategori:
Sulfur CompoundsThiazoles
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Darolutamide Approved DB12941
small molecule | CAS: 1297538-32-9

Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen r…

Kategori:
Androgen Receptor InhibitorsAntiandrogensAntiandrogens, non-steroidal +14
Target Protein:
Androgen receptorProgesterone receptor
Waktu ParuhThe half-life of da…
Vol. DistribusiAfter intravenous a…
KlirensThe clearance of da…
Genetik -
Darunavir Approved DB01264
small molecule | CAS: 206361-99-1

Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as [ritonavir] for the effective management of HIV-1 infection.[L9227] As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard HIV…

Kategori:
AmidesAnti-HIV AgentsAnti-Infective Agents +33
Target Protein:
Pol polyproteinGag-Pol polyprotein
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe volume of distr…
KlirensDarunavir has a low…
Genetik -
Dasabuvir Approved DB09183
small molecule | CAS: 1132935-63-7

Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine …

Kategori:
AmidesAminesAntiinfectives for Systemic Use +20
Target Protein:
Genome polyproteinNonstructural protein 5b
Waktu ParuhThe half-life of el…
Vol. DistribusiDasabuvir has a vol…
KlirensClearance of Dasabu…
Genetik -
Dasatinib Approved DB01254
small molecule | CAS: 302962-49-8

Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocyti…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors +31
Target Protein:
Tyrosine-protein kinase ABL1Proto-oncogene tyrosine-protein kinase SrcEphrin type-A receptor 2 +20
Waktu ParuhThe terminal half-l…
Vol. DistribusiDasatinib has an ap…
KlirensThe clearance of da…
Genetik -
small molecule | CAS: 503291-52-9

Dasolampanel etibutil has been used in trials studying the treatment of Diabetic Neuropathy, Painful.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dasotraline DB12305
small molecule | CAS: 675126-05-3

Dasotraline is a serotonin, norepinephrine and dopamine reuptake inhibitor (SNDRI) that is under investigation for the treatment of Binge Eating Disorder, Adult Attention Hyperactivity Disorder, Attention Deficit Hyperactivity Disorder, and Adult Attention De…

Kategori:
AminesCycloparaffinsNaphthalenes
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporterSodium-dependent serotonin transporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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